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Acquisition of Annapurna - Summary of Identifiable Intangible Assets Acquired (Detail) - Annapurna Therapeutics SAS [Member]
$ in Thousands
May 11, 2016
USD ($)
Acquired Indefinite Lived Intangible Assets [Line Items]  
Acquired intangible assets $ 16,200
IPR&D [Member]  
Acquired Indefinite Lived Intangible Assets [Line Items]  
Acquired intangible assets 16,200
IPR&D [Member] | Alpha-1 Antitrypsin Deficiency [Member]  
Acquired Indefinite Lived Intangible Assets [Line Items]  
Acquired intangible assets 11,700
IPR&D [Member] | Hereditary Angioedema [Member]  
Acquired Indefinite Lived Intangible Assets [Line Items]  
Acquired intangible assets $ 4,500