10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

FORM 10-Q

(Mark One)

☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended June 30, 2017

or

☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission File Number: 001-36579

Adverum Biotechnologies, Inc.

(Exact name of registrant as specified in its charter)

Delaware	20-5258327
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)

1035 O’Brien Drive,

Menlo Park, CA

(Address of principal executive offices)

94025

(Zip Code)

(650) 272-6269

(Registrant’s telephone number, including area code)

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes  ☒    No  ☐

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).    Yes  ☒    No  ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer,  a smaller reporting company, or an emerging growth company. See definitions of “large accelerated filer,” “accelerated filer,”  “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act. (Check one):

Large accelerated filer	☐	Accelerated filer	☒
Non-accelerated filer	☐   (Do not check if a smaller reporting company)	Smaller reporting company	☐
		Emerging growth company	☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  ☒

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes  ☐    No  ☒

As of July 31, 2017 there were 43,286,786 shares of the registrant’s common stock, par value $0.0001 per share, outstanding.

Adverum Biotechnologies, Inc.

TABLE OF CONTENTS

	Page
PART I—FINANCIAL INFORMATION	3
Item 1. Unaudited Condensed Consolidated Financial Statements	3
Condensed Consolidated Balance Sheets as of June 30, 2017 and December 31, 2016	3
Condensed Consolidated Statements of Operations and Comprehensive Loss for the three and six months ended June 30, 2017 and 2016	4
Condensed Consolidated Statements of Cash Flows for the six months ended June 30, 2017 and 2016	5
Notes to Condensed Consolidated Financial Statements	6
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operation	21
Item 3. Quantitative and Qualitative Disclosures About Market Risk	27
Item 4. Controls and Procedures	27
PART II—OTHER INFORMATION	29
Item 1. Legal Proceedings	29
Item 1A. Risk Factors	29
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds	29
Item 3. Defaults Upon Senior Securities	30
Item 4. Mine Safety Disclosures	30
Item 5. Other Information	30
Item 6. Exhibits	30
SIGNATURES	31
EXHIBIT INDEX	32

2

PART I—FINANCIAL INFORMATION

Item 1. Unaudited Condensed Consolidated Financial Statements

Adverum Biotechnologies, Inc.

Condensed Consolidated Balance Sheets

(Unaudited)

(In thousands except share and per share data)

	June 30,			December 31,
	2017			2016
	(Unaudited)
Assets
Current assets:
Cash and cash equivalents	$	39,523		$	222,170
Short-term investments		157,895			—
Receivable from collaborative partner		—			886
Prepaid expenses and other current assets		2,223			2,218
Total current assets		199,641			225,274
Property and equipment, net		3,798			4,169
Deposit and other long-term assets		140			140
Intangible assets		5,000			5,000
Total assets	$	208,579		$	234,583
Liabilities and stockholders’ equity
Current liabilities:
Accounts payable	$	1,125		$	1,474
Restructuring liabilities		—			25
Accrued expenses and other current liabilities		5,226			6,451
Deferred rent, current portion		112			96
Deferred revenue, current portion		1,850			1,850
Total current liabilities		8,313			9,896
Long-term liabilities:
Deferred rent, net of current portion		293			352
Deferred revenue, net of current portion		6,174			7,099
Deferred tax liability		1,250			1,250
Other noncurrent liabilities		369			386
Total liabilities		16,399			18,983
Commitments and contingencies (Note 10)
Stockholders’ equity:
Preferred stock, $0.0001 par value, 5,000,000 shares authorized; no shares issued    and outstanding		—			—
Common stock, $0.0001 par value, 300,000,000 shares authorized at June 30,    2017 and December 31, 2016; 43,201,786 and 41,805,009 shares issued and    outstanding at June 30, 2017 and December 31, 2016, respectively		5			4
Additional paid-in capital		418,022			413,518
Accumulated other comprehensive loss		(403	)		(7	)
Accumulated deficit		(225,444	)		(197,915	)
Total stockholders’ equity		192,180			215,600
Total liabilities and stockholders’ equity	$	208,579		$	234,583

See accompanying notes to condensed consolidated financial statements

3

Adverum Biotechnologies, Inc.

Condensed Consolidated Statements of Operations and Comprehensive Loss

(Unaudited)

(In thousands except per share data)

	Three Months Ended June 30,						Six Months Ended June 30,
	2017			2016			2017			2016
	(Unaudited)
Collaboration revenue	$	463		$	307		$	925		$	572
Operating expenses:
Research and development		8,492			7,955			17,553			15,410
General and administrative		4,064			5,114			12,053			13,432
Goodwill impairment charge		—			49,120			—			49,120
Total operating expenses		12,556			62,189			29,606			77,962
Operating loss		(12,093	)		(61,882	)		(28,681	)		(77,390	)
Other income (expense), net
Other income (expense), net		663			222			1,152			338
Total other income (expense), net		663			222			1,152			338
Net loss	$	(11,430	)	$	(61,660	)	$	(27,529	)	$	(77,052	)
Other comprehensive loss:
Net unrealized (loss) gain on marketable securities		(49	)		—			(137	)		6
Foreign currency translation adjustment		(141	)		(4	)		(259	)		10
Comprehensive loss	$	(11,620	)	$	(61,664	)	$	(27,925	)	$	(77,036	)
Net loss per share attributable to common stockholders-basic and diluted	$	(0.27	)	$	(1.76	)	$	(0.65	)	$	(2.50	)
Weighted-average common shares outstanding-basic and diluted		43,009			35,044			42,579			30,825

See accompanying notes to condensed consolidated financial statements

4

Adverum Biotechnologies, Inc.

Condensed Consolidated Statements of Cash Flows

(Unaudited)

(In thousands)

	Six Months Ended June 30,
	2017			2016
	(Unaudited)
Cash flows from operating activities:
Net loss	$	(27,529	)	$	(77,052	)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization		1,056			663
Stock-based compensation expense		4,139			6,903
Goodwill impairment charge		—			49,120
Amortization of premium and accrued interest on marketable securities		203			—
Non-cash research and development expense		24			—
Changes in operating assets and liabilities:
Receivable from collaborative partner		886			(580	)
Prepaid expenses and other current assets		576			1,069
Accounts payable		(334	)		646
Accrued expenses and other current liabilities		(1,266	)		(1,706	)
Restructuring liabilities		(25	)		(988	)
Deferred revenue		(925	)		1,575
Deferred rent		(43	)		(27	)
Net cash used in operating activities		(23,238	)		(20,377	)
Cash flows from investing activities:
Purchases of investments		(172,788	)		—
Maturities of investments		14,000			37,738
Purchases of property and equipment		(732	)		(1,126	)
Cash acquired in business acquisition		—			3,449
Net cash provided by (used in) investing activities		(159,520	)		40,061
Cash flows from financing activities:
Proceeds from issuance of common stock pursuant to option exercises		342			349
Net cash provided by financing activities		342			349
Effect of foreign currency exchange rate on cash and cash equivalents		(231	)		(79	)
Net increase (decrease) in cash and cash equivalents		(182,647	)		19,954
Cash and cash equivalents at beginning of period		222,170			221,348
Cash and cash equivalents at end of period	$	39,523		$	241,302
Supplemental schedule of noncash investing and financing information
Issuance of common stock and exchange of stock options for business combination	$	-		$	64,845
Fixed assets in accounts payable, accrued expenses and other current liabilities	$	124		$	153

See accompanying notes to condensed consolidated financial statements.

5

Adverum Biotechnologies, Inc.

June 30, 2017

Notes to Condensed Consolidated Financial Statements

(Unaudited)

1. Organization and Basis of Presentation

Adverum Biotechnologies, Inc. (the “Company”, “we” or “us”) was incorporated in Delaware on July 17, 2006 as Avalanche Biotechnologies, Inc. and changed its name to Adverum Biotechnologies, Inc. on May 11, 2016. The Company is headquartered in Menlo Park, California. The Company is a gene therapy company advancing novel medicines that may offer life-changing benefits to patients living with serious rare and ocular diseases. Since the Company’s inception, it has devoted its efforts principally to performing research and development activities, including conducting preclinical studies and, early clinical trials, filing patent applications, obtaining regulatory agreements, hiring personnel, and raising capital to support these activities.

The Company has not generated any revenue from the sale of products since its inception. The Company has experienced net losses since its inception and had an accumulated deficit of $225.4 million as of June 30, 2017. The Company expects to incur losses and have negative net cash flows from operating activities as it engages in further research and development activities. The Company believes that it has sufficient funds to continue its operations through the end of 2019.

On May 11, 2016, the Company completed the acquisition of all the outstanding shares of Annapurna Therapeutics SAS, a French simplified joint stock company (“Annapurna”). As a result, Annapurna is now a wholly owned subsidiary of the Company.

Upon completion of the acquisition of Annapurna, the Company changed its name to “Adverum Biotechnologies, Inc.”. The Company’s shares of common stock listed on The NASDAQ Global Market, previously trading through the close of business on Wednesday, May 11, 2016 under the ticker symbol “AAVL,” commenced trading on The NASDAQ Global Market under the ticker symbol “ADVM” on Thursday, May 12, 2016.

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United States of America (“U.S. GAAP”) and follow the requirements of the Securities and Exchange Commission (“SEC”) for interim reporting. As permitted under those rules, certain footnotes or other financial information that are normally required by U.S. GAAP can be condensed or omitted. These unaudited condensed consolidated financial statements have been prepared on the same basis as the Company’s annual consolidated financial statements and, in the opinion of management, reflect all adjustments, consisting only of normal recurring adjustments, which are necessary for a fair statement of the Company’s consolidated financial information. The results of operations for the three and six months ended June 30, 2017, are not necessarily indicative of the results to be expected for the full year or any other future period. The balance sheet as of December 31, 2016 has been derived from audited consolidated financial statements at that date but does not include all of the information required by U.S. GAAP for complete consolidated financial statements.

The accompanying unaudited condensed consolidated financial statements and related financial information should be read in conjunction with the audited consolidated financial statements and the related notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016 filed with the SEC.

2. Summary of Significant Accounting Policies

The accounting policies followed in the preparation of the interim condensed consolidated financial statements are consistent in all material respects with those presented in Note 2 to the consolidated financial statements included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016.

Recently-Issued and Not Yet Adopted Accounting Pronouncements —In May 2014, the FASB issued ASU No. 2014-09, Revenue from Contracts with Customers (Topic 606), which supersedes the revenue recognition requirements in ASC 605, Revenue Recognition. This ASU is based on the principle that revenue is recognized to depict the transfer of goods or services to customers in an amount that reflects the consideration to which the entity expects to be entitled in exchange for those goods or services. ASU 2014-09 defines a five step process to achieve this core principle and, in doing so, it is possible more judgment and estimates may be required within the revenue recognition process than required under existing GAAP including identifying performance obligations in the contract, estimating the amount of variable consideration to include in the transaction price and allocating the transaction price to each separate performance obligation. ASU 2014-09 is required to be adopted, using either of two methods: (i) retrospective to each prior reporting period presented with the option to elect certain practical expedients as defined within ASU 2014-09; or (ii) retrospective with the cumulative effect of initially applying ASU 2014-09 recognized at the date of initial application and providing certain additional disclosures. In July 2015, the FASB voted to approve a one-year deferral of the effective date to

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December 15, 2017 for interim and annual reporting periods beginning after that date and permitted early adoption of the standard, but not before the original effective date of December 15, 2016.The FASB issued supplemental adoption guidance and clarification to ASU 2014-09 in March 2016, April 2016, May 2016 and December 2016 within ASU 2016-08 Revenue From Contracts With Customers: Principal vs. Agent Considerations, ASU 2016-10 Revenue From Contracts with Customers: Identifying Performance Obligations and Licensing, ASU 2016-12 Revenue from Contracts with Customers: Narrow-Scope Improvements and Practical Expedients and ASU 2016-20 Technical Corrections and Improvement to Topic 606 – Revenue from Contracts with Customers, respectively. The ASU will be effective for the Company in the first quarter of 2018. Preliminarily, the Company intends to adopt the new standard in the first quarter of 2018 using the retrospective approach noted in (ii) above. The Company is currently evaluating the impact of the adoption of this standard on its condensed consolidated financial statements and related disclosures.

In January 2016, the FASB issued ASU No. 2016-01, Recognition and Measurement of Financial Assets and Financial Liabilities, which amends the current guidance on the classification and measurement of financial instruments. Although this ASU retains many current requirements, it significantly revises an entity’s accounting related to (i) the classification and measurement of investments in equity securities and (ii) the presentation of certain fair value changes for financial liabilities measured at fair value. This ASU also amends certain disclosure requirements associated with the fair value of financial instruments. The new standard is effective for fiscal years and interim periods within those fiscal years beginning after December 15, 2017, with early adoption permitted for certain changes. This ASU will be effective for the Company in the first quarter of 2018 and must be adopted using a modified retrospective approach, with certain exceptions. The adoption of this standard is not expected to have a significant impact on the Company’s condensed consolidated financial statements and related disclosures.

In February 2016, the FASB issued ASU No. 2016-2, Leases, which amends the current guidance on leasing activities to provide more transparency and comparability, and requires that all leases be recognized by lessees on their balance sheet as a right-of-use asset and corresponding lease liability, which are currently accounted for as operating leases. The new standard is effective for fiscal years and interim periods within those fiscal years beginning after December 15, 2018, with early adoption permitted. This ASU will be effective for the Company in the first quarter of 2019 and must be adopted using a modified retrospective transition approach. The company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of this standard on its condensed consolidated financial statements and related disclosures.

In June 2016, the FASB issued ASU No. 2016-13 Measurement of Credit Losses on Financial Instruments. This ASU requires measurement and recognition of expected credit losses for financial assets held. The new standard is effective for fiscal years beginning after December 15, 2020 and interim periods beginning after December 15, 2021 with early adoption permitted beginning in the first quarter of 2019. This ASU will be effective for the Company in the first quarter of 2021 and must be adopted using a modified retrospective approach, with certain exceptions. The Company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of this standard on its condensed consolidated financial statements and related disclosures.

In August 2016, the FASB issued ASU No. 2016-15, Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and Cash Payments, which clarifies the presentation and classification of certain cash receipts and cash payments in the statement of cash flows. This ASU is effective for annual reporting periods beginning after December 15, 2017, and interim periods within that reporting period. Early adoption is permitted. This ASU will be effective for the Company in the first quarter of 2018. The Company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of this standard on its condensed consolidated financial statements and related disclosures.

In November 2016, the FASB issued ASU No. 2016-18, Statement of Cash Flows (Topic 230): Restricted Cash, which provides amendments to current guidance to address the classification and presentation of changes in restricted cash in the statement of cash flows. This ASU is effective for annual reporting periods beginning after December 15, 2017, and interim periods within that reporting period. Early adoption is permitted. This ASU will be effective for the Company in the first quarter of 2018. The Company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of these standards on its condensed consolidated financial statements and related disclosures.

7

In May 2017, the FASB issued ASU No. 2017-09, Scope of Modification Accounting, which provides amendments to the current guidance for modification accounting. This ASU clarifies that an entity should account for the effects ofa modification unless all the following criteriaare met: (1) the fair value of the modified award is the same as the fair value of the original award immediately before the original award is modified, (2) the vesting conditions of the modified award are the same as the vestingconditions of the original award immediately before the original award ismodified, and (3) the classification of the modifiedaward as an equity instrument or a liability instrument is the same as the classification of the original award immediately before the original award is modified. This ASU is effective for annual reporting periods beginning after December 15, 2017, and interim periods within that reporting period.Early adoption is permitted. This ASU will be effective for the Company in the first quarter of 2018.The Company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of these standards on its condensed consolidated financial statements and related disclosures.

The Company has reviewed other recent accounting pronouncements and concluded they are either not applicable to the business or no material effect is expected on the consolidated financial statements as a result of future adoption.

3. Acquisition of Annapurna

(a) Purchase Price Allocation

On May 11, 2016, the Company completed the acquisition of all outstanding equity interests of Annapurna. Annapurna was a privately held French limited liability company with two wholly-owned subsidiaries, Annapurna, Inc. in the U.S. and Annapurna Therapeutics Limited in Ireland. Annapurna is a biopharmaceutical company focused on discovering and developing novel gene therapy products for people living with severe rare diseases. The primary reasons for the acquisition were to expand the technology platforms within the Company’s research and development portfolio and to apply the Company’s resources and expertise in gene vectors development to advance Annapurna’s programs through development and clinical trials. Annapurna’s results of operations and fair value of assets acquired and liabilities assumed are included in the Company’s condensed consolidated financial statements from the date of acquisition.

The purchase price consideration was $64.8 million, which was based on the Company’s common stock closing price on NASDAQ on the acquisition closing date of $4.14 per share. A total of 14,087,246 shares of the Company’s common stock were issued to shareholders of Annapurna in exchange for all common and preferred stock outstanding at the closing date. Annapurna stockholders did not receive any fractional shares of the Company’s common stock in connection with the acquisition. Instead of receiving any fractional shares, each Annapurna stockholder was paid an amount in cash (without interest) equal to such fraction amount multiplied by the average 10 business days sale price of the Company’s common stock on NASDAQ from the acquisition date. Annapurna Series O preferred shares issued to founders were canceled prior to the acquisition date and were not included in the purchase price consideration. Vesting of certain of Annapurna’s options and unvested common stock shares was accelerated at the closing date. The fair value of awards related to the accelerated vesting of options and shares of $0.9 million was excluded from the purchase price consideration and included in the Company’s operating expenses post acquisition.

A portion of the purchase price was attributed to the exchange of Annapurna’s options and other rights to purchase capital stock outstanding at the acquisition closing date for corresponding common stock options of the Company at an exchange ratio of 9.54655.

The Company reserved 3,673,940 shares for the future exercise of the Company’s stock options. The total fair value of assumed Annapurna stock options and stock-based awards was estimated at $14.7 million on the acquisition date, using the Black-Scholes pricing model, assuming no dividends, expected volatilities of 80% and 89%, risk-free interest rates of 1.4% and 1.1%, and expected lives of six and ten years for employees and non-employees awards, respectively. Of the total fair value, $7.4 million was attributed as pre-combination service and included as part of the total purchase price consideration. The post-combination attribution of $7.2 million is recognized as compensation expense over the remaining requisite service period. The Company included $0.9 million in stock-based compensation expense related to the vesting of exchanged stock options and day-one post combination compensation expenses related to the accelerated vesting of options and shares in its condensed consolidated statement of operations during the three months ended June 30, 2016.

8

Total purchase price consideration was estimated as follows (in thousands):

Fair value of common shares issued	$	58,321
Fair value of the Company's common share options    exchanged for Annapurna stock options and other awards    attributable to pre-combination services		7,422
Less: value of common stock and options accelerated    vesting at the closing date		(898	)
Total purchase price consideration	$	64,845

The transaction was accounted for using the acquisition method based on ASC 805, Business Combinations, with Adverum identified as the acquirer, based onthe existence of a controlling financial interest of the combined entities. Under the acquisition method, assets acquired and liabilities assumed were recorded at their estimated fair values as of May 11, 2016. Goodwill, as well as intangible assets that do not qualify for separate recognition, is measured as of the acquisition date as the excess of consideration transferred, which is also measured at fair value, and the net of the fair values of the assets acquired and the liabilities assumed as of the acquisition closing date. Goodwill represented expected synergies of two combined companies. Acquisition costs of $0.6 million and $2.5 million for the three and six months ended June 30, 2016, respectively, were expensed as incurred and recorded as general and administrative expenses in the Company’s consolidated statement of operations.

The allocation of total purchase price consideration is as follows (in thousands):

Cash	$	3,449
Prepaid expenses and other assets		865
Property and equipment		185
Acquired intangible assets		16,200
Goodwill		49,514
Accounts payable		(1,118	)
Accrued liabilities		(1,848	)
Other noncurrent liabilities		(377	)
Deferred tax liabilities		(2,025	)
Total purchase price allocation	$	64,845

The identifiable intangible assets acquired consist of IPR&D assets related to products in development, as summarized in the table below (in thousands):

IPR&D - Alpha-1 antitrypsin deficiency	$	11,700
IPR&D - Hereditary angioedema		4,500
Total acquired intangible assets	$	16,200

The fair value of each IPR&D asset is estimated using the income approach and calculated using cash flow projections adjusted for inherent risks regarding regulatory approval, promotion, and distribution, discounted at a rate of approximately 11.0%. The Company acquired two additional intangible assets relating to the Friedreich’s Ataxia (FA) and severe allergy programs, but the fair value of each of these assets was determined to be nominal and is not included in the total acquired intangible assets. All IPR&D intangible assets acquired are currently classified as indefinite-lived and are not currently being amortized. During the year ended December 31, 2016, the Company recorded $11.2 million of IPR&D impairment charge related to these intangible assets.

Goodwill, which represents the excess of the purchase price over the fair values assigned to the net assets acquired, was estimated in the amount of $49.5 million on the acquisition date. The full amount of the preliminary value of goodwill has been assigned to the entire Company, since management has determined that the Company has only one reporting unit. The goodwill is not deductible for tax purposes. During the three months ended June 30, 2016, goodwill was fully impaired.

9

The pro forma financial information combines the results of operations of Adverum and Annapurna as though the businesses had been combined as of the beginning of fiscal 2016. The pro forma financial information is presented for informational purposes only, and is not indicative of the results of operations that would have been achieved in the current or any future periods. The following table presents the unaudited pro forma results for the three and six months ended June 30, 2016 (in thousands, except per share data).

	Three Months Ended June 30,			Six Months Ended June 30,
	2016			2016
Pro forma information
Collaboration revenue	$	307		$	572
Net loss	$	(62,572	)	$	(80,846	)
Basic and diluted loss per share	$	(1.52	)	$	(1.97	)

Pro-forma adjustments included the following:

• Actual acquisition-related transaction costs of $0.6 million and $2.5 million for the three and six months ended June 30, 2016, respectively were excluded from pro forma results above as these expenses were incurred prior to the closing of the acquisition.  

• Stock-based compensation expense related to accelerated vesting associated with the acquisition of $0.9 million was excluded from the pro forma results above.

• Stock-based compensation expense related to options granted to executives upon the acquisition closing of $0.1 million and $0.2 million for the three and six months ended June 30, 2016, respectively ,was included in pro forma results above.

• Interest expense related to convertible notes and changes in fair value of preferred stock warrants of $0.5 million and $1.0 million for the three and six months ended June 30, 2016, respectively, were excluded from the pro-forma results above, as the convertible notes and warrants were settled prior to the acquisition closing.

• $0.4 million bonuses paid in connection with the closing of the acquisition in May 2016 were excluded from the pro forma results above.

The unaudited condensed pro forma information does not include any anticipated synergies that may be achievable subsequent to the date of acquisition.

4. Cash Equivalents and Short-Term Investments

The following is a summary of the Company’s available-for-sale securities as of June 30, 2017 (in thousands):  

	June 30, 2017
	Amortized Cost Basis			Unrealized Gains		Unrealized Loses			Estimated Fair Value
Money market funds	$	3,003		$	—	$	—		$	3,003
Certificates of deposit		11,967			—		—			11,967
Commercial paper		50,947			—		—			50,947
U.S. government agency		63,262			1		(76	)		63,187
Corporate bonds		66,142			—		(62	)		66,080
Total cash equivalents and    short-term investments		195,321			1		(138	)		195,184
Less: cash equivalents		(37,289	)		—		—			(37,289	)
Total short-term investments	$	158,032		$	1	$	(138	)	$	157,895

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The following table is a summary of the cost and estimated fair value of the Company’s available-for-sale securities based on stated effective maturities as ofJune 30, 2017 (in thousands):

	June 30, 2017
	Amortized Cost Basis		Estimated Fair Value
Mature within one year	$	160,946	$	160,870
Mature after one year to three years		34,375		34,314
Total cash equivalents and short-term    investments	$	195,321	$	195,184

As of December 31, 2016, all of the Company’s investments were held in money market funds and were treated as cash equivalents. Management determined that the gross unrealized losses of $0.1 million on the Company’s available-for-sale securities as of June 30, 2017 were temporary in nature. Therefore, none of the Company’s available-for-sale securities were other-than-temporarily impaired as of June 30, 2017.

5. Fair Value Measurements and Fair Value of Financial Instruments

The authoritative guidance on fair value measurements establishes a three-tier fair value hierarchy for disclosure of fair value measurements as follows:

Level 1: Quoted prices in active markets for identical assets or liabilities.

Level 2: Observable inputs other than Level 1 prices, such as quoted prices for similar assets or liabilities, quoted prices in markets that are not active, or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

Level 3: Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

Assets and liabilities measured at fair value are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires management to make judgments and consider factors specific to the asset or liability.

The fair value of Level 1 securities are determined using quoted prices in active markets for identical assets. Level 1 securities consist of highly liquid money market funds. Financial assets and liabilities are considered Level 2 when their fair values are determined using inputs that are observable in the market or can be derived principally from or corroborated by observable market data such as pricing for similar securities, recently executed transactions, cash flow models with yield curves, and benchmark securities. In addition, Level 2 financial instruments are valued using comparisons to like-kind financial instruments and models that use readily observable market data as their basis. U.S. government and agency securities, commercial paper, corporate bonds and certificate of deposit are valued primarily using market prices of comparable securities, bid/ask quotes, interest rate yields and prepayment spreads and are included in Level 2.

In certain cases where there is limited activity or less transparency around inputs to valuation, securities are classified as Level 3 within the valuation hierarchy. Level 3 liabilities that were measured at estimated fair value on a recurring basis consist of a financing arrangement entered into during the year ended December 31, 2016.

During the periods presented, the Company has not changed the manner in which it values liabilities that are measured at estimated fair value using Level 3 inputs. There were no transfers within the hierarchy during the three and six months ended June 30, 2017.

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The following table summarizes, for assets recorded at fair value on a recurring basis, the respective fair value and the classification by level of input within the fair value hierarchy as described above (in thousands):

			Quoted Prices		Significant Other		Significant
	Total		In Active Markets		Observable Inputs		Unobservable Inputs
	Carrying Value		(Level 1)		(Level 2)		(Level 3)
June 30, 2017
Assets:
Money market funds	$	3,003	$	3,003	$	—	$	—
Certificates of deposit		11,967		—		11,967		—
Commercial paper		50,947		—		50,947		—
U.S. government agency		63,187		—		63,187		—
Corporate bonds		66,080		—		66,080		—
Total cash equivalents and short    term investments	$	195,184	$	3,003	$	192,181	$	—
Other noncurrent liability:
Financing arrangement	$	74	$	—	$	—	$	74
December 31, 2016
Assets:
Money market funds	$	215,916	$	215,916	$	—	$	—
Total cash equivalents	$	215,916	$	215,916	$	—	$	—
Other noncurrent liability:
Financing arrangement	$	74	$	—	$	—	$	74

Non-financial assets such as intangible assets, property, plant, and equipment are evaluated for impairment and adjusted to their fair value using Level 3 inputs, only when impairment is recognized. Fair values are considered Level 3 when management makes significant assumptions in developing a discounted cash flow model based upon a number of considerations including projections of revenues, earnings and a discount rate.

6. Significant Agreements

University of California— In May 2010, the Company entered into a license agreement with the Regents of University of California (“Regents”), as amended in September 2013. Under the license agreement, the Regents have granted to the Company an exclusive (even as to the Regents) license, with the right to grant sublicenses, under the Regents’ undivided interest in patent rights covering a method of using recombinant gene delivery vectors for treating or preventing diseases of the eye, to develop, make, have made, use offer for sale, import, export and sell products covered by such patent rights in all fields of use in the United States. The licensed patent rights are jointly owned by the Regents and Chiron Corporation, but the Company’s license extends only to the Regents’ interest in such patent rights.

Under the license agreement, the Company is required to diligently proceed with the development, manufacture and sale of licensed products, which includes obligations to meet certain development-stage milestones within specified periods of time, and to market the resulting licensed products in sufficient quantity to meet market demand. The Company has the right and option to extend the date by which it must meet any milestone by six-months up to two times by paying an extension fee for each such extension.

The Company has paid the Regents a license fee of $100,000. The Company is also obligated to make milestone payments totaling up to $900,000 upon reaching certain stages of development of the licensed products for one indication, and totaling up to $500,000 for each subsequent indication for which licensed products are developed, for up to a maximum of two additional indications. Through June 30, 2017, none of these goals had been achieved, and no milestones were payable. The Company must pay the Regents a low single-digit royalty on net sales of the licensed products by the Company or its sublicensees, subject to a minimum annual royalty payment of $50,000 beginning in the calendar year after the first commercial sale of a licensed product, until the patent rights upon which such royalties are based expire or are held invalid, which is currently expected to occur in 2020, subject to any potential patent term extensions. The Company is obligated to reimburse the Regents for expenses associated with the prosecution and maintenance of the licensed patents. Finally, the Company is obligated to pay the Regents a mid-teen percentage of non-royalty licensing revenue that the Company receives from sublicensees.

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The Company’s license agreement with the Regents continues in effect for the life of the last-to-expire patent. The Company may terminate this agreement without cause at any time upon 30 days’ prior written notice to the Regents. The Regents may terminate this agreement for a breach by the Company that remains uncured for 60 days, if the Company becomes insolvent, if the Company directly or through a third party files a claim that a licensed patent right is invalid or unenforceable or if the Company fails to meet or extend the date for meeting certain diligence milestones.

Regeneron—In May 2014, the Company entered into a research collaboration and license agreement with Regeneron to discover, develop and commercialize novel gene therapy products for the treatment of ophthalmologic diseases. The collaboration covers up to eight distinct therapeutic targets (“collaboration targets”). The Company and Regeneron collaborate during the initial research period of three years that can be extended by Regeneron for up to an additional five years. During the research period, Regeneron has the option to obtain an exclusive worldwide license for a collaboration target’s further development by giving written notice to the Company and paying $2.0 million per target. If Regeneron exercises its option, it will be responsible for all further development and commercialization of the target. The Company is then eligible to receive contingent payments of up to $80.0 million upon achievement of certain development and regulatory milestones for product candidates directed toward each collaboration target, for a combined total of up to $640.0 million in potential milestone payments for product candidates directed toward all eight collaboration targets, plus a royalty in the low- to mid-single-digits on worldwide net sales of collaboration products.

For any two collaboration targets, the Company has an option to share up to 35% of the worldwide product candidate development costs and profits. If the Company exercises this option, the Company will not be eligible for milestone and royalty payments as discussed above but rather the Company will share development costs and profits with Regeneron.

The agreement will expire with respect to each collaboration target upon the earlier of the (a) expiration of the research term if the option right has not been triggered by the end of the research term or (b) expiration of the option right if the option right has not been exercised by Regeneron. If the option right has been exercised, the agreement in connection with each collaboration target will expire upon expiration of all payment obligations by Regeneron. In addition, the agreement, or Regeneron’s rights to any target development under the agreement, may terminate early under the following situations:

• Regeneron may terminate the agreement for convenience at any time on a target by target basis or in totality upon a 30-day notice.

• Each party can terminate the agreement if another party commits a material breach or material default in performance of its obligations and such breach or default is not cured within 60 days.

• The agreement is automatically terminated upon initiation of any bankruptcy proceedings, reorganization or dissolution of either party.

• The Company can terminate the agreement upon 30-day notice if Regeneron challenges the validity, scope or enforceability of any Company patent.

On February 23, 2017, Regeneron notified Adverum that, pursuant to the terms of the research collaboration and license agreement, it extended the research term of the collaboration for an additional three years, through May 1, 2020.

Under the Company’s research, collaboration and license agreement with Regeneron, the Company is required to have a mutually agreed-on research plan with Regeneron in order to invoice Regeneron for services performed. The Company does not currently have a research plan in place, and, consequently, we are not currently receiving any reimbursements from Regeneron.

Editas—In August 2016, the Company entered into a collaboration, option and license agreement with Editas Medicine, Inc. (“Editas”) pursuant to which the Company and Editas will collaborate on certain studies using adeno-associated viral (“AAV”) vectors in connection with Editas’ genome editing technology and the Company will grant to Editas an exclusive option to obtain certain exclusive rights to use the Company’s proprietary vectors in up to five ophthalmic indications (“Indications”). The Company received a $1.0 million non-refundable upfront payment during the year ended December 31, 2016, with $0.5 million of such payment to be credited against Editas’ obligation to fund research and development costs. Under the terms of the agreement, both the Company and Editas will be subject to exclusivity obligations.

Editas may exercise the option, with respect to a designated initial Indication, until the first anniversary of the effective date of the agreement. With respect to the four other Indications, Editas may exercise the option until the third anniversary of the effective date, provided that the option will expire on the second anniversary of the effective date if Editas has not exercised the option with respect to the initial Indication or any other Indication by such date. Upon each exercise of the option, Editas will pay the Company a $1.0 million fee per Indication. If Editas elects to develop a product using certain of the Company’s proprietary vectors, the Company will be eligible to receive up to $15.5 million in development and commercialization milestone payments for such product, and tiered royalties between the mid-single digits and low teens on net sales of such product, subject to certain adjustments.

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Unless earlier terminated, the agreement will be in effect until the later of the expiration of the option exercise period or the expiration of the royalty term of the last product. At any time after the option is first exercised, Editas may terminate the agreement for convenience in its entirety or on an indication-by indication or country-by-country basis, upon prior written notice to the Company. The Company may also terminate the agreement if Editas challenges the Company’s patents relating to its proprietary vectors and does not withdraw such challenge within a defined period of time. In addition, either party may terminate the agreement with written notice upon a bankruptcy of the other party or upon an uncured material breach by the other party.

Cornell University—The Company had been a party to a master service agreement (“MSA”) with Cornell University (“Cornell”) originally established in August 2014 and amended in December 2015. In December 2016, the Company informed Cornell that the Company decided to terminate the MSA for material breach, effective January 6, 2017. Subsequently, Cornell informed the Company that it disputes the validity of the Company’s termination of the MSA. Although the Company intends to defend the validity of its termination of the MSA, the Company recorded $2.0 million of estimated costs associated with the termination of the MSA during the six months ended June 30, 2017. This MSA included services relating to the Company’s gene therapy programs ADVM-043, ADVM-053 and severe allergy. The Company’s three licensing agreements with Cornell for these programs remain unchanged.

The decision to terminate the MSA was due to Cornell’s failure to deliver therapeutic material of ADVM-043 suitable for use in human patients. As a result of this decision, the Company has contracted with a large-scale contract manufacturing organization that complies with current good manufacturing practice industry standards and can produce product quantities for both the Company’s planned clinical trials and potential commercial supply. This is part of the Company’s planned upgrade of the manufacturing process for ADVM-043, implementing its proprietary, highly-scalable baculovirus-based production system, in advance of the Company’s plans to begin patient enrollment in a Phase 1/2 clinical trial for ADVM-043 in the fourth quarter of 2017.

Under the MSA, Cornell provided assistance in regulatory affairs, overall project management, and parameter development. The MSA, as amended, provided for Annapurna to pay Cornell $13.3 million ratably over 4 years for these services as services were performed.

In December 2015, Annapurna entered into three licensing agreements with Cornell, pursuant to which Annapurna will advance its gene therapy programs ADVM-043, ADVM-053, and severe allergy, which originally were initiated at the Department of Genetic Medicine at Weill Cornell.

A1AT Deficiency License Agreement: Under this agreement, Annapurna holds an exclusive license to certain technology related to alpha-1 antitrypsin (A1AT) deficiency and rights to an Investigational New Drug (IND) application to initiate clinical studies of gene therapy for A1AT.

HAE License Agreement: Under this agreement, Annapurna holds an exclusive license to certain technology related to hereditary angioedema (HAE) and a non-exclusive license to certain other intellectual property related to the HAE program.

Allergy License Agreement: Under this agreement, Annapurna holds an exclusive license to certain patents related to allergens and a non-exclusive license to certain other technology related to allergens.

Across these three license agreements, Cornell is entitled to receive aggregate annual maintenance fees ranging from $30,000 to $300,000 per year, up to $16.0 million in aggregate milestone payments and royalties on sales in the low single-digits, subject to adjustments and minimum thresholds.

Annapurna may terminate any of these license agreements for convenience upon ninety days written notice. Cornell may terminate any of the license agreements for material breach if such breach is not cured within a specified number of days. Cornell may also terminate the HAE License Agreement and/or the Allergy License Agreement if Annapurna commences any action and files a written claim asserting that any portion of the licensed patent rights is invalid or unenforceable.

Dr. Crystal, Chairman of Genetic Medicine, the Bruce Webster Professor of Internal Medicine and a Professor of Genetic Medicine and of Medicine at Weill Cornell, served as a consultant to Annapurna since inception and continues to provide services to the Company for the annual compensation of $0.3 million. Dr. Crystal also owns common shares of the Company and he does not have significant influence on the Company’s operations.

REGENXBIO—A1AT Deficiency/Allergy License Agreement: In October 2015, Annapurna entered into an exclusive worldwide license to certain intellectual property in order to make, have made, use, import, sell and offer for sale certain licensed products for the treatment ofA1AT deficiency. Under this agreement, Annapurna has an option to be granted an exclusive worldwide license to certain intellectual property related to the treatment of severe allergies, which option expired in October 2016. Under this license agreement, REGENXBIO, Inc. (“REGENXBIO”) is eligible to receive annual maintenance fees, up to approximately $20.0 million in combined milestone payments and royalties in the mid-to-high single digits.

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Unless earlier terminated, this license agreement will be in effect on a country-by-country, licensed product-by-licensed product basis until the expiration, lapse, abandonment, or invalidation of the last claim of the licensed intellectual property to expire, lapse, or become abandoned or unenforceable for the applicable licensed product. Annapurna may terminate this license agreement for any reason upon six months’ prior written notice. REGENXBIO may terminate this license agreement if Annapurna is a specified number of days late in paying money due under the license agreement, or if Annapurna, its affiliates, or any sublicensees become insolvent or, effective immediately, if they commence any action against REGENEXBIO or its licensors to declare or render any claim of the licensed patent rights invalid or unenforceable. Either party may terminate this license agreement for material breach if such breach is not cured within a specified number of days.

In April 2017, the Company notified REGENXBIO that Annapurna exercised its right to terminate the license agreement for any reason upon six months’ prior written notice. The termination will be effective in October 2017.

Friedreich’s Ataxia License Agreement: In April 2014, Annapurna entered into an exclusive worldwide license to certain intellectual property related to the Friedreich’s Ataxia (“FA”) program to make, have made, use, import, sell and offer for sale licensed products using AAVrh10 for FA where the vector is administered by any route except directly to the central nervous system (“FA Systemic”). Under the terms of this license agreement, Annapurna also had an option to obtain a non-exclusive worldwide license to make, have made, use, import, sell and offer for sale licensed products using a single vector for each of FA where the vector is administered directly to the central nervous system (“FA CNS”) and FA Systemic. Under this license agreement, REGENXBIO is eligible to receive annual maintenance fees, up to $13.85 million in combined milestone fees and royalties in the mid-to-high single digits. The option to obtain a non-exclusive license to FA Systemic expired in April 2015 and the option to obtain a non-exclusive license for FA CNS expired in April 2016. Annapurna is obligated to achieve certain development milestones with respect to each licensed disease indication, including the filing of an Investigational New Drug application (“IND”) for each licensed disease indication within a specified time period, which Annapurna may extend for additional time for a specified number of extensions upon the payment of a fee.

Unless earlier terminated, this license agreement expires upon the expiration, lapse, abandonment, or invalidation of the last claim of the licensed intellectual property to expire, lapse, or become abandoned or unenforceable in all the countries of the world. Annapurna Therapeutics Limited may terminate this license agreement upon six months’ prior written notice. REGENXBIO may terminate this license agreement if Annapurna Therapeutics Limited is a specified number of days late in paying money due under the license agreement, or if Annapurna Therapeutics Limited, its affiliates, or any sublicensees become insolvent or, effective immediately, if they commence any action against REGENXBIO or its licensors to declare or render any claim of the licensed patent rights invalid or unenforceable. Either party may terminate this license agreement for material breach if such breach is not cured within a specified number of days.

During the six months ended June 30, 2017, expenses associated with the REGENXBIO agreements were $0.2 million.

Inserm Transfert—In July 2014, Annapurna entered into an agreement with Inserm Transfert (Inserm) whereby Annapurna holds an exclusive license to certain patents to develop, make, have made, use, import, offer for sale and sell or otherwise distribute products for the treatment of Friedreich’s ataxia and a non-exclusive license to certain other intellectual property related to the FA program. The agreement was amended in October 2015 to increase the scope of the intellectual property under the licenses. Under this agreement, Inserm is entitled to receive certain de minimis license payments, certain development milestone payments of up to approximately €2.0 million in the aggregate and royalties on sales in the low single-digits, subject to adjustments. No milestone payments were probable to achieve and none were recorded as of June 30, 2017.

Unless earlier terminated, this agreement will be in effect on a country-by-country, licensed product-by-licensed product basis until the later of the expiration of the last claim of the licensed intellectual property which cover the manufacture, use or sale of such product in such country or 10 years after the first commercial sale of such product in such country in which such product is sold. Upon a country-by-country and product-by-product basis, Annapurna will have a fully paid up, perpetual, irrevocable license with respect to such product in such country under the licensed intellectual property following expiration of this agreement with respect to such product in the applicable country. Annapurna may terminate this agreement upon 60 days’ prior written notice. Inserm may terminate this license agreement if Annapurna becomes the subject of a voluntary or involuntary petition in bankruptcy or fails to meet development milestones and such failure is not cured within a specified number of days. Inserm may also terminate the license granted to Annapurna in a given country if Annapurna (i) before regulatory approval of a product in any country, has ceased conducting any development of products in all countries for 12 consecutive months or (ii) after regulatory approval of a product in a given country, has ceased marketing such product in such country for 12 consecutive months.

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Pursuant to the terms of the agreement with Inserm, the Company’s acquisition of Annapurna triggered a one-time payment to Inserm of €250,000, which was recorded to research and development expense in the Company’s consolidated statement of operations during the year ended December 31, 2016.

7. Property and Equipment, Net

Property and equipment, net consists of the following (in thousands):

	June 30, 2017			December31,2016
Computer equipment and software	$	447		$	300
Laboratory equipment		4,838			4,285
Furniture and fixtures		552			552
Leasehold improvements		1,541			1,522
Construction in progress		64			104
Total property and equipment		7,442			6,763
Less accumulated depreciation and amortization		(3,644	)		(2,594	)
Property and equipment, net	$	3,798		$	4,169

Depreciation and amortization expense related to property and equipment for the three months ended June 30, 2017 and 2016 was $0.6 million and $0.3 million, respectively. Depreciation and amortization expense related to property and equipment for the six months ended June 30, 2017 and 2016 was $1.1 million and $0.7 million, respectively.

8. Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consist of the following (in thousands):

	June 30, 2017		December31, 2016
Employees’ compensation expenses	$	1,363	$	2,570
Accrued preclinical costs		676		1,683
Accrued clinical and process development costs		424		1,142
Accrued professional services		501		894
Accrued contract settlement		2,000		—
Other		262		162
Total accrued expenses and other current liabilities	$	5,226	$	6,451

During the six months ended June 30, 2017, the Company accrued approximately $2.0 million of estimated costs associated with the termination of its MSA with Cornell University (see Note 6, “Significant Agreements”).

9. Other non-current liabilities

In August 2015, Banque Publique d’Investissement (“BPI France”) granted Annapurna a €0.5 million interest free conditional advance. Payments are scheduled in equal quarterly amounts of €25,000 from September 30, 2017 to June 30, 2022. This payment schedule will be modified if the Company will receive revenue from license or product sales before advances are paid in full. The Company calculated 7% imputed interest expense on these advances that was recorded as a discount at the issuance date. The discount is amortized as an interest expense over the life of the advances. As of June 30, 2017 the carrying value of this interest-free conditional advance, which approximates its fair value, was $0.4 million, of which $0.3 million is recorded within other non-current liabilities and $0.1 million within accrued expenses and other current liabilities in the Company’s condensed consolidated balance sheets. Interest expense for this interest-free conditional advance was immaterial for the three and six months ended June 30, 2017.

In July 2016, the Company entered into a sponsored research agreement with The Alpha-1 Project, Inc. (“TAP”) to fund the Company’s A1AT research activities of up to $0.3 million, of which $0.1 million was received during the year ended December 31, 2016 (“TAP financing arrangement”). The Company may repay up to 4.5 times the received amount if and when certain product approval and sales milestones are achieved. As of June 30, 2017, the estimated fair value of the TAP financing arrangement was $0.1 million, which was recorded within other noncurrent liabilities in the Company’s condensed consolidated balance sheets.

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10. Commitments and Contingencies

Facility Lease Agreement

The Company leases its office building under a non-cancelable lease agreement, which expires on May 8, 2020. The Company may extend this lease for up to four years. The lease agreement provides for an escalation of rent payments each year. The Company records rent expense on a straight-line basis over the term of the lease.

Rent expense recognized under the operating lease, including additional rent charges for utilities, parking, maintenance, and real estate taxes was $1.0 million and $1.0 million for the six months ended June 30, 2017 and 2016, respectively.

Collaborations and License Agreements

The Company is a party to various agreements, principally relating to licensed technology that requires payment of annual maintenance fees and future payments relating to milestones or royalties on future sales of specified products. The Company expenses the annual maintenance fees on a straight-line basis and accrues the aggregate balances until invoiced or paid. Through June 30, 2017, none of the goals had been achieved under the license agreements and no cash milestones were accrued or payable. Since the achievement of these milestones is not fixed and determinable, such commitments have not been included in the Company’s condensed consolidated balance sheets.

Guarantees and Indemnifications

In the normal course of business, the Company enters into contracts and agreements that contain a variety of representations and warranties and provide for indemnification for certain liabilities. The exposure under these agreements is unknown because it involves claims that may be made against the Company in the future but have not yet been made. To date, the Company has not paid any claims or been required to defend any action related to its indemnification obligations. However, the Company may record charges in the future as a result of these indemnification obligations. The Company also has indemnification obligations to its directors and executive officers for specified events or occurrences, subject to some limits, while they are serving at the Company’s request in such capacities. There have been no claims to date and the Company believes the fair value of these indemnification agreements is minimal. Accordingly, the Company has not recorded any liabilities for these agreements as of June 30, 2017.

Legal Proceedings

From time to time, the Company may become involved in litigation and other legal actions. The Company estimates the range of liability related to any pending litigation where the amount and range of loss can be estimated. The Company records its best estimate of a loss when the loss is considered probable. Where a liability is probable and there is a range of estimated loss with no best estimate in the range, the Company records a charge equal to at least the minimum estimated liability for a loss contingency when both of the following conditions are met: (i) information available prior to issuance of the financial statements indicates that it is probable that a liability had been incurred at the date of the financial statements and (ii) the range of loss can be reasonably estimated.

In July 2015, three securities class action lawsuits were filed against the Company and certain of its officers in the United States District Court for the Northern District of California, each on behalf of a purported class of persons and entities who purchased or otherwise acquired the Company’s publicly traded securities between July 31, 2014 and June 15, 2015. The lawsuits assert claims under the Exchange Act and Securities Act and allege that the defendants made materially false and misleading statements and omitted allegedly material information related to, among other things, the Phase 2a clinical trial for AVA-101 and the prospects of AVA-101. The complaints seek unspecified damages, attorneys’ fees and other costs.

In December 2015, a putative securities class action lawsuit was filed against the Company, the Company’s board of directors, underwriters of the Company’s January 13, 2015, follow-on public stock offering, and two of the Company’s institutional stockholders, in the Superior Court of the State of California for the County of San Mateo. The complaint alleges that, in connection with the Company’s follow-on stock offering, the defendants violated the Securities Act of 1933, as amended, by allegedly making materially false and misleading statements and by allegedly omitting material information related to the Phase 2a clinical trial for AVA-101 and the prospects of AVA-101. The complaint seeks unspecified compensatory and rescissory damages, attorneys’ fees and other costs. The plaintiff has dismissed the two institutional stockholder defendants.

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On March 16, 2017, the Company reached an agreement to settle the asserted actions. The proposed aggregate amount of the settlement is $13.0 million, of which $1.0 million would be contributed by the Company to cover its indemnification obligations to the underwriters, and the remainder would be contributed by the Company’s insurers. The settlement is subject to definitive documentation, shareholder notice and court approval. The Company and the defendants have denied and continue to deny each and all of the claims alleged in the actions, and the settlement does not assign or reflect any admission of fault, wrongdoing or liability as to any defendant. If final court approval is not obtained with respect to the settlement or the settlement otherwise does not become effective and litigation resumes, adverse outcomes in the actions could result in substantial damages. The Company recorded $1.0 million as general and administrative expense during the three months ended March 31, 2017, when the amount and time of settlement became estimable and probable.

11. Stock Plans

The Company’s  2014 Equity Incentive Award Plan (2014 Plan) permits the issuance of stock options (options), restricted stock units (RSUs) and other types of awards to employees, directors, and consultants.

As of June 30, 2017, a total of 14,834,856 shares of common stock were authorized for issuance and 1,662,588 shares were available for future grants under the 2014 Plan.

In July 2014, the Company’s board of directors and its stockholders approved the establishment of the 2014 Employee Stock Purchase Plan (2014 ESPP).  During the three and six months ended June 30, 2017 and 2016, 35,954 shares and 32,425 shares, respectively, were issued under the 2014 ESPP.  A total of 1,000,783 shares of common stock were reserved for issuance under the 2014 ESPP and were available for issuance under the 2014 ESPP as of June 30, 2017.

The following table summarizes option activity under our stock plans and related information:

						Weighted-
	Number			Weighted-		Average Remaining		Aggregate
	of Options			Average Exercise		Contractual Life		Intrinsic Value (a)
	(in thousands)			Price		(In years)		(in thousands)
Balance at December 31, 2016		7,449		$	4.46
Options granted		1,716			2.81
Options exercised		(1,235	)		0.21
Options cancelled		(262	)		12.24
Balance at June 30, 2017		7,668		$	4.51		8.3	$	7,037
Vested and expected to vest as of June 30, 2017		7,668		$	4.51		8.3	$	7,037
Exercisable as of June 30, 2017		3,404		$	4.52		7.5	$	5,045

^(a) The aggregate intrinsic value is calculated as the difference between the option exercise price and the closing price of common stock of $2.50 per share as of June 30, 2017.

The options granted during 2016, include the Company’s stock options for 3,673,940 common stock shares issued in exchange for Annapurna stock options at $0.21 exercise price per share.

The weighted-average fair values of options granted during the six months ended June 30, 2017 and 2016 were $1.96 and $1.62, respectively. The total intrinsic value of options exercised during the six months ended June 30, 2017 and 2016 were $3.2 million and $6.3 million, respectively.

The Company has recorded aggregate stock-based compensation expense related to the issuance of stock awards to employees and nonemployees in the condensed consolidated statement of operations and comprehensive loss as follows (in thousands):

	Three Months Ended				Six Months Ended
	June 30,				June 30,
	2017		2016		2017		2016
Research and development	$	1,395	$	1,912	$	2,637	$	4,140
General and administrative		848		914		1,502		2,770
Total share-based compensation	$	2,243	$	2,826	$	4,139	$	6,910

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During the three and six months ended June 30, 2016, respectively, stock-based compensation expense included additional charges of $0.3 million, which was recorded within general and administrative expense, and $2.5 million, of which $1.4 million was recorded within research and development expense and $1.1 million within general and administrative expense, in the Company’s condensed consolidated statements of operations and comprehensive loss, related to stock modifications in connection with the separation agreements for two of the Company’s executive officers.

As of June 30, 2017, unrecognized compensation cost related to unvested employee options was $12.5 million, which is expected to be recognized over a weighted-average remaining period of 2.6 years.

Restricted Stock Units

Restricted stock units, or RSUs, are share awards that entitle the holder to receive freely tradable shares of our common stock upon vesting. The fair value of RSUs is based upon the closing sales price of our common stock on the grant date. RSUs granted to employees generally vest over a two to four year period.

The following table summarizes the RSUs activity under our stock plans and related information:

				Weighted-Average		Weighted-Average
	Number of			Grant-Date		Remaining
	Units (in thousands)			Fair Value (in dollars)		Contractual Term (in years)
Outstanding at December 31, 2016		1,049		$	5.47		1.7
Granted		1,966			2.72
Vested and released		(191	)		5.28
Forfeited		(331	)		3.69
Outstanding at June 30, 2017		2,493		$	3.56		1.9

The total fair value of RSUs that vested for the six months ended June 30, 2017 and 2016 was $1.0 million and $2.2 million, respectively. As of June 30, 2017, unrecognized compensation cost related to unvested RSUs was $7.3 million, which is expected to be recognized over a weighted-average remaining period of 3.2 years.

Stock Options Granted to Employees

The fair value of each option issued to employees was estimated at the date of grant using the Black-Scholes valuation model with the following weighted-average assumptions:

	Three Months Ended						Six Months Ended
	June 30,						June 30,
	2017			2016			2017			2016
Option grants:
Expected volatility		81	%		81	%		81	%		81	%
Expected term (in years)		5.7			5.9			6.0			5.9
Expected dividend yield		—			—			—			—
Risk-free interest rate		1.9	%		1.3	%		1.9	%		1.3	%

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Stock Options Granted to Non-Employees

Stock-based compensation related to options granted to non-employees is measured and recognized as the options are earned. The Company believes that the estimated fair value of the options is more readily measurable than the fair value of the services rendered. The following weighted-average assumptions were used in estimating non-employees’ stock-based compensation expenses:

	Three Months Ended						Six Months Ended
	June 30,						June 30,
	2017			2016			2017			2016
Option grants:
Expected volatility		82	%		84	%		82	%		83	%
Expected term (in years)		9.0			8.0			9.0			7.5
Expected dividend yield					—						—
Risk-free interest rate		2.2	%		1.6	%		2.3	%		1.6	%

As of June 30, 2017, unrecognized stock-based compensation expense related to non-employees’ options was $0.6 million, which was expected to be recognized over a weighted-average remaining period of 1.9 years.

12. 401(k) Savings Plan

The Company established a defined-contribution savings plan under Section 401(k) of the Code (the 401(k) Plan). The 401(k) Plan covers all employees who meet defined minimum age and service requirements, and allows participants to defer a portion of their annual compensation on a pretax basis. For the six months ended June 30, 2017 and 2016, the Company contributed $0.2 million and $0.2 million to the 401(k) Plan, respectively.

13. Net Loss per Share

Basic net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock outstanding for the period. Diluted net loss per share attributable is computed by giving effect to all potential dilutive common stock equivalents outstanding for the period. Diluted net loss per share is the same as basic net loss per share for all periods presented, since the effects of potentially dilutive securities are antidilutive.

We have excluded warrants and equity awards to purchase approximately 10.3 million and 9.9 million shares of our common stock that were outstanding as of June 30, 2017 and 2016, respectively, in the computation of diluted net loss per share attributable to common stockholders because their effect was antidilutive.

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operation

The interim financial statements included in this Quarterly Report on Form 10-Q and this Management’s Discussion and Analysis of Financial Condition and Results of Operations should be read in conjunction with the financial statements and notes thereto for the year ended December 31, 2016, and the related Management’s Discussion and Analysis of Financial Condition and Results of Operations, contained in our Annual Report on Form 10-K, as filed with the U.S. Securities and Exchange Commission (SEC) on March 9, 2017. In addition to historical information, this discussion and analysis contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended (Securities Act), and Section 21E of the Securities Exchange Act of 1934, as amended (Exchange Act). These forward-looking statements are subject to risks and uncertainties, including those discussed in the section titled “Risk Factors,” set forth in Part II – Other Information, Item 1A below and elsewhere in this report that could cause actual results to differ materially from historical results or anticipated results.

Overview

We are a gene therapy company advancing novel medicines that may offer life-changing benefits to patients living with serious rare and ocular diseases. We are leveraging our next-generation adeno-associated virus (AAV)-based directed evolution platform to generate gene therapy product candidates designed to provide durable efficacy by inducing sustained expression of a therapeutic protein. We have also acquired certain other gene therapy product candidates through our acquisition of Annapurna Therapeutics SAS (Annapurna), a privately-held French gene therapy company, on May 11, 2016. Our core capabilities include clinical development and in-house manufacturing expertise, specifically in process development, assay development, and novel vector development, and we are led by a team with significant drug development and gene therapy expertise.

We are focused on advancing our three lead gene therapy programs to address unmet needs in wet age-related macular degeneration (wAMD) and in rare diseases alpha-1 antitrypsin (A1AT) deficiency and hereditary angioedema (HAE). For wAMD, we are advancing a new anti-VEGF gene therapy candidate, ADVM-022 (AAV.7m8-aflibercept). This therapy utilizes a proprietary vector and is administered intravitreally for this indication. Preclinical data demonstrate that ADVM-022 has the potential to minimize the treatment burden of frequent injections and maximize visual outcomes in patients living with this disease.

At 2016 scientific meetings, we presented preclinical proof-of-concept data of ADVM-022 anti-angiogenic effect in a laser-induced choroidal neovascularization (CNV) model in non-human primates, the industry standard for testing new wAMD therapies. The data from a single injection of ADVM-022 showed efficacy that was comparable to the anti-VEGF standard of care, the positive control in the CNV model. We held a pre-IND meeting with the U.S. Food and Drug Administration (FDA) in the first quarter of 2017 and are preparing to file an IND.

Before focusing on our new therapy for wAMD, we were developing AVA-101 in a Phase 2a clinical trial in 32 patients with wAMD. In June 2015, we announced top-line results, and although we did not observe any serious safety issues, we also did not observe evidence of a complete and/or durable anti-VEGF response in the majority of subjects treated with AVA-101 as administered (via surgical sub-retinal delivery) in the Phase 2a study. As a result, in July 2016, we announced our decision to discontinue development of AVA-101.

With our pipeline of gene therapies for rare diseases, we are advancing ADVM-043 (formerly known as ANN-001) for the treatment of A1AT deficiency. ADVM-043 is a product candidate designed to be a single-administration treatment. This therapy has the potential to induce stable, long-term A1AT expression at therapeutic levels, as seen in preclinical proof-of-concept studies. ADVM-043 has an open IND with the FDA, and we met with the agency in 2017 to review our development plan. We are upgrading ADVM-043’s manufacturing process to a commercial-grade baculovirus-based process and are transferring this process to a contract manufacturing organization to produce clinical materials for our trials. We plan to begin patient enrollment in a Phase 1/2 trial in the fourth quarter of 2017.

We are also advancing ADVM-053 (formerly known as ANN-002) to treat HAE. We are working to transfer our manufacturing process to a contract manufacturing organization to produce clinical materials for our future ADVM-053 studies. We held a pre-IND meeting with the FDA in the first quarter of 2017 and are preparing to file an IND.

Our earlier-stage research programs include gene therapies targeting cardiomyopathy associated with Friedreich’s ataxia and severe allergy.

Our partnered programs include vectors we are developing under collaboration agreements. Under an agreement with Editas Medicine, we are leveraging our AAV-vectors for use with Editas’ leading CRISPR-based genome editing technologies to treat up to five inherited retinal diseases. Our agreement with Regeneron provides for development of up to eight distinct ocular therapeutic targets, four of which are already identified, including AVA-311 for the treatment of juvenile X-Linked Retinoschisis (XLRS).

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Financial Overview

Summary

We have not generated positive cash flow or net income from operations since our inception and, as of June 30, 2017, we had an accumulated deficit of $225.4 million, primarily as a result of research and development, general and administrative expenses, impairment of goodwill and intangible assets, and restructuring charges. We expect to incur substantial expenses and increasing losses from operations in the foreseeable future as we continue our research and development efforts, advance our product candidates through preclinical and clinical development, manufacture clinical study materials, seek regulatory approval and prepare for, and if approved, proceed to commercialization. We are at an early stage of development and may never be successful in developing or commercializing our product candidates.

While we may in the future generate revenue from a variety of sources, including license fees, milestone and research and development payments in connection with strategic partnerships, and potentially revenue from approved product sales, we have not yet generated any revenue from approved therapeutic product candidates.

We entered into our first research, collaboration and license revenue generating agreement with Regeneron in May 2014. We entered into the collaboration, option and license agreement with Editas in August 2016 that also is a revenue agreement as discussed in Note 6, Significant Agreements, of the notes to condensed consolidated financial statements included in this Form 10-Q. We have no clinical or commercial manufacturing facilities, and all of our clinical manufacturing activities are contracted out to third parties. Additionally, we plan to use third-party clinical research organizations (CROs) to carry out our clinical development and we do not yet have a sales organization.

We expect to incur substantial and increasing expenditures in the foreseeable future for the development and potential commercialization of our product candidates. We will need substantial additional funding in the future to support our operating activities as we advance our product candidates through preclinical and clinical development, seek regulatory approval and prepare for and, if approved, proceed to commercialization. Adequate funding may not be available to us on acceptable terms, or at all. If we are unable to raise capital, or to do so on acceptable terms, when needed, or to form additional collaboration partnerships to support our efforts, we could be forced to delay, reduce or eliminate our research and development programs or potential commercialization efforts.

As of June 30, 2017, we had $197.4 million in cash, cash equivalents and short-term investments. We believe that we have sufficient funds to continue our operations through the end of 2019.

Revenue

To date we have not generated any revenue from the sale of our products. In May 2014, we entered into a research, collaboration and license agreement with Regeneron. Under the terms of the agreement, we received initial payments of $8.0 million that included payment for research license fees, prepaid collaboration research costs and the right of first negotiation for a potential license to develop and commercialize AVA-101. As the agreement provides for multiple deliverables, we account for this agreement as a multiple elements revenue arrangement. If deliverables do not appear to have a standalone fair value, they were combined with other deliverables into a unit of accounting with standalone fair value. We allocated the $8.0 million received to the fair values of the two units of accounting identified in the arrangement. We expect to recognize $6.5 million for research licenses and related research and development services ratably over the associated period of performance, which is the maximum research period of eight years. As there is no discernible pattern of performance and/or objectively measurable performance measures do not exist, we will recognize revenue on a straight-line basis over the eight-year performance period. The remaining $1.5 million allocated to the second unit of accounting for the time-limited right of first negotiation for AVA-101 was deferred. On November 2, 2015, Regeneron notified the management that it was not exercising this right of first negotiation and we recognized the entire $1.5 million as revenue in 2015. On February 23, 2017, Regeneron notified us that pursuant to the terms of the research, collaboration and license agreement, it is extending the research term of the license and development agreement for an additional three years, through May 1, 2020.  

The portion of the upfront payment that was applied to the original research budget was fully used in the fourth quarter of 2015, and Adverum and Regeneron, through a joint review committee, are to agree annually on an updated research and development services budget through the research period. We invoice Regeneron quarterly for services, if any, performed in the prior quarter. These additional research fees are added to the research licenses and related research and development services unit of accounting, recorded as deferred revenue and recognized to revenue over the remaining maximum research term.

Under our research, collaboration and license agreement with Regeneron, we are required to have a mutually agreed-on research plan with Regeneron in order to invoice Regeneron for services performed. We do not currently have a research plan in place, and, consequently, we are not currently receiving any reimbursements from Regeneron.

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In August 2016, we entered into a collaboration, option and license agreement with Editas. Under the terms of the agreement, we received initial payments of $1.0 million that included $0.5 million for research services. As the agreement provides for multiple deliverables, we accounted for this agreement as a multiple elements revenue arrangement. At the inception of the agreement, identified deliverables include research services, manufacturing of viral vectors for research, participation in the joint research committee and exclusivity during the option period. These deliverables did not appear to have a standalone value and were combined into one unit of accounting. Options for each indication to license our AAV vector are considered substantive options and do not include significant incremental discounts. Therefore, they are not considered as deliverables under the agreement. We allocated the $1.0 million received to a single unit of accounting identified in the arrangement. We expect to recognize $1.0 million ratably over the associated period of performance, which is the maximum research period of three years. As there is no discernible pattern of performance and/or objectively measurable performance measures do not exist, we will recognize revenue on a straight-line basis.

As of June 30, 2017, we had total deferred revenue of $8.0 million. The Company recognized $0.5 million and $0.3 million of revenue during the three months ended June 30, 2017 and 2016, respectively, and $0.9 million and $0.6 million of revenue during the six months ended June 30, 2017 and 2016, respectively.

Our ability to generate product revenue and become profitable depends upon our ability to successfully develop and commercialize our product candidates. Because of the numerous risks and uncertainties associated with product development, we are unable to predict the amount or timing of product revenue. Even if we are able to generate revenue from the sale of our products, we may be unable to continue our operations at planned levels and be forced to reduce our operations.

Research and Development Expenses

Conducting a significant amount of research and development is central to our business model. Research and development expenses include certain payroll and personnel expenses, stock-based compensation expense, laboratory supplies, consulting costs, external contract research and development expenses, including expenses incurred under agreements with CROs, the cost of acquiring, developing and manufacturing clinical study materials and overhead expenses, including rent, equipment depreciation, insurance and utilities.

Research and development costs are expensed as incurred. Advance payments for goods or services for future research and development activities are deferred and expensed as the goods are delivered or the related services are performed.

We estimate preclinical study and clinical trial expenses based on the services performed pursuant to contracts with research institutions and CROs that conduct and manage preclinical studies and clinical trials on our behalf. In accruing service fees, we estimate the time period over which services will be performed and the level of effort to be expended in each period. We estimate the amounts incurred through communications with third party service providers and our estimates of accrued expenses as of each balance sheet date are based on information available at the time. If the actual timing of the performance of services or the level of effort varies from the estimate, we will adjust the accrual accordingly.

At this time, we cannot reasonably estimate the nature, timing or aggregate costs of the efforts that will be necessary to complete the development of any of our product candidates. The successful development and commercialization of a product candidate is highly uncertain, and clinical development timelines, the probability of success, and development and commercialization costs can differ materially from expectations.

We have received refundable tax credits from the Australian and French tax authorities in connection with certain research costs incurred by our subsidiary conducting research in Australia and France. These refunds do not depend on our taxable income or tax position and therefore we do not account for them under an income tax accounting model. We recognize such refunds as government grants in the period when qualified expenses are incurred as a reduction of research expenses. We have recorded the reimbursement from the Australian and French tax authorities as a reduction of research and development expense in the consolidated statements of operations and comprehensive loss for the applicable period. During the six months ended June 30, 2017 and 2016, tax credits received were immaterial.

General and Administrative Expenses

General and administrative expenses consist principally of personnel-related costs, stock-based compensation, professional fees for legal, consulting, audit and tax services, rent and other general operating expenses not otherwise included in research and development expenses. Our general and administrative expenses may increase in future periods if and to the extent we elect to increase our investment in infrastructure to support continued research and development activities and potential commercialization of our product candidates. We will continue to evaluate the need for such investment in conjunction with our ongoing consideration of our pipeline of product candidates. We anticipate increased expenses related to audit, legal and regulatory functions, as well as director and officer insurance premiums and investor relations costs associated with being a public reporting company.

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Other Income (Expense), Net

Other income (expense), net is comprised mainly of interest income on our cash equivalents and investments in marketable securities.

Critical Accounting Policies and Significant Judgments and Estimates

Our management’s discussion and analysis of financial condition and results of operations are based upon our unaudited condensed consolidated financial statements, which have been prepared in accordance with U.S. generally accepted accounting principles (U.S. GAAP).  The preparation of these condensed consolidated financial statements requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses. On an on-going basis, we evaluate our critical accounting policies and estimates.  We base our estimates on historical experience and on various other assumptions that we believe to be reasonable in the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources.  Actual results may differ from these estimates under different assumptions and conditions.  Our significant accounting policies are more fully described in Note 2 to our audited consolidated financial statements contained in our Annual Report on Form 10-K (Annual Report) as filed with the SEC, on March 9, 2017.

Results of Operations

Comparison of the Three and Six Months Ended June 30, 2017 and 2016 (dollars in in thousands)

	Three Months Ended June 30,									Six Months Ended June 30,
	2017			2016			Change			2017			2016			Change
Collaboration revenue	$	463		$	307		$	156		$	925		$	572		$	353
Operating expenses:
Research and development		8,492			7,955			537			17,553			15,410			2,143
General and administrative		4,064			5,114			(1,050	)		12,053			13,432			(1,379	)
Goodwill impairment charge		—			49,120			(49,120	)		—			49,120			(49,120	)
Total operating expenses		12,556			62,189			(49,633	)		29,606			77,962			(48,356	)
Operating loss		(12,093	)		(61,882	)		49,789			(28,681	)		(77,390	)		48,709
Other income, net		663			222			441			1,152			338			814
Net loss	$	(11,430	)	$	(61,660	)	$	50,230		$	(27,529	)	$	(77,052	)	$	49,523

Revenue

Collaboration revenue increased by $0.2 million and $0.4 million for the three and six months ended June 30, 2017 as compared to the same periods last year, primarily due to amortization of additional billings related to our collaboration agreements with Regeneron and Editas.

Research and Development Expense

Research and development expenses increased by $0.5 million and $2.1 million for the three and six months ended June 30, 2017, respectively, as compared to the same periods last year, primarily due to an overall increase in research and development activity. For the three months ended June 30, 2017, the increase was primarily due to higher professional fees related to development programs acquired in the Annapurna acquisition. For the six months ended June 30, 2017, the increase was primarily due to $1.6 million of higher material production and outside service costs related to toxicology lot production and $1.1 million of higher professional fees, lab expenses and depreciation expense associated with lab equipment to support our ongoing research and development activity, partially offset by lower stock-based compensation expense mainly attributable to a one-time charge of stock-based compensation expense related to accelerated vesting of one of our executive employees’ stock awards during the six months ended June 30, 2016.

For the periods presented, substantially all of our research and development expense related to Adverum development activities for our A1AT and wAMD programs and our other potential product candidates. Upon completion of the Annapurna acquisition in May 2016, we began incurring expenses related to Annapurna’s four rare disease development programs. We expect that research and development expenses will increase in future periods as we continue to invest in our three lead gene therapy programs and earlier-stage research programs.

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General and Administrative Expense

General and administrative expenses decreased by $1.1 million and $1.4 million for the three and six months ended June 30, 2017, respectively, as compared to the same periods last year. For the three months ended June 30, 2017, the decrease was primarily due to lower professional fees mainly attributable to the Annapurna acquisition activity. For the six months ended June 30, 2017, the decrease was primarily due to $1.6 million of lower compensation expense mainly attributable to one-time charges of stock-based compensation expense related to accelerated vesting of our executive employees’ stock awards and $2.8 million of lower consulting and professional fees mainly attributable to the Annapurna acquisition activity, partially offset by $2.0 million of estimated termination costs associated with our master service agreement with Cornell University and $1.0 million litigation expenses related to the settlement of federal and state securities class actions.

We expect general and administrative expenses will increase in future periods to support continued research and development initiatives and potential commercialization of our product candidates. We will continue to assess such expenses as we advance our three lead gene therapy programs and earlier-stage research programs.

Goodwill Impairment Charge

As we recorded goodwill and IPR&D intangible assets upon the acquisition of Annapurna, we are required to test goodwill and indefinite-lived intangible assets for impairment on an annual basis or more frequently if indicators of impairment exist. We operate as one reporting unit and goodwill was recorded to this reporting unit. We fully impaired our goodwill from the Annapurna acquisition and recorded a goodwill impairment charge of $49.1 million for the three and six months ended June 30, 2016. There were no impairment charges during the three and six months ended June 30, 2017.

Other Income, Net

Other income, net increased by $0.4 million and $0.8 million for the three and six months ended June 30, 2017, respectively, as compared to the same periods last year, primarily due to higher interest income as we increased our investments in marketable securities.

Liquidity and Capital Resources and Plan of Operations

We have not generated positive cash flow or net income from operations since our inception and, as of June 30, 2017, we had an accumulated deficit of $225.4 million, primarily as a result of research and development and general and administration expenses. As of June 30, 2017, we had $197.4 million in cash, cash equivalents and short-term investments. We believe that our existing cash and cash equivalents and short-term investments as of June 30, 2017 will be sufficient to fund our operations through the end of 2019.

We expect to incur substantial expenditures in the foreseeable future for the development and potential commercialization of our product candidates and ongoing internal research and development programs. At this time, we cannot reasonably estimate the nature, timing or aggregate amount of such costs. However, in order to complete our planned preclinical trials and any future clinical trials, and to complete the process of obtaining regulatory approval for our product candidates, as well as to build the sales, marketing and distribution infrastructure that we believe will be necessary to commercialize our product candidates, if approved, we will require substantial additional funding in the future.

If and when we seek additional funding, we will do so through equity or debt financings, collaborative or other arrangements with corporate sources or through other sources of financing. Adequate additional funding may not be available to us on acceptable terms or at all. Our failure to raise capital in the future could have a negative impact on our financial condition and our ability to pursue our business strategies. In order to complete development and commercialization of any of our product candidates, we anticipate that we will need to raise substantial additional capital, the requirements of which will depend on many factors, including:

• the initiation, progress, timing, costs and results of preclinical studies and clinical trials for our product candidates;

• the outcome, timing of and costs involved in, seeking and obtaining approvals from the FDA and other regulatory authorities, including the potential for the FDA and other regulatory authorities to require that we perform more studies than those that we currently expect;

• the ability of our product candidates to progress through clinical development activities successfully;

• our need to expand our research and development activities;

• the rate of progress and cost of our commercialization of our products;

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• the cost of preparing to manufacture our products on a larger scale;

• the costs of commercialization activities including product sales, marketing, manufacturing and distribution;

• the degree and rate of market acceptance of any products launched by us or future partners;

• the costs of filing, prosecuting, defending and enforcing any patent claims and other intellectual property rights;

• our need to implement additional infrastructure and internal systems;

• our ability to hire additional personnel;

• our ability to enter into additional collaboration, licensing, commercialization or other arrangements and the terms and timing of such arrangements, and;

• the emergence of competing technologies or other adverse market developments.

If we are unable to raise additional funds when needed, we may be required to delay, reduce, or terminate some or all of our development programs and clinical trials. We may also be required to sell or license other technologies or clinical product candidates or programs that we would prefer to develop and commercialize ourselves.

Cash Flows

	Six Months Ended
	June 30,
	2017			2016
	(in thousands)
Net cash used in operating activities	$	(23,238	)	$	(20,377	)
Net cash provided by (used in) investing activities		(159,520	)		40,061
Net cash provided by financing activities		342			349
Effect of foreign currency exchange rate		(231	)		(79	)
Net increase (decrease) in cash and cash equivalents	$	(182,647	)	$	19,954

Cash Used in Operating Activities

During the six months ended June 30, 2017, net cash used in operating activities was $23.2 million, primarily as a result of the net loss of $27.5 million and $1.1 million of net decrease in operating assets and liabilities, partially offset by $5.4 million of non-cash charges mainly related to stock-based compensation expense and depreciation and amortization expense.

During the six months ended June 30, 2016, net cash used in operating activities was $20.4 million, primarily as a result of the net loss of $77.1 million, partially offset by $56.7 million of non-cash charges related to goodwill impairment charge, stock-based compensation expense and depreciation and amortization.

Cash Provided by (Used in) Investing Activities

Net cash provided by investing activities for the six months ended June 30, 2017, was $159.5 million, primarily due to 172.8 million of purchases of marketable securities and $0.7 million of purchases of property and equipment, partially offset by $14.0 million of maturities of marketable securities.

Net cash provided by investing activities for the six months ended June 30, 2016 was $40.1 million, primarily a result of $37.7 million from the maturities of marketable securities and $3.4 million of cash acquired in a business combination, partially offset by $1.1 million of purchases of property and equipment.

Purchases of property and equipment primarily consisted of the acquisition of laboratory equipment to support our research and development activities.

Cash Provided by Financing Activities

The net cash provided by financing activities of $0.3 million for both the six months ended June 30, 2017 and 2016 was a result of the proceeds from exercises of stock options.

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Contractual Obligations and Commitments

We have lease obligations consisting of an operating lease for our operating facility that expires in 2020. Additionally, we have contractual obligations to vendors.

The lease agreement provides for an escalation of rent payments each year and will expire on May 8, 2020. We may extend the lease term for up to four years.

In December 2016, we informed Cornell University, or Cornell, that we decided to terminate our master services agreement, or MSA, with Cornell effective January 6, 2017. Subsequently, Cornell informed us that it disputes the validity of our termination of the MSA. Although we intend to defend the validity of our termination of the MSA, we recorded $2.0 million of estimated costs associated with the termination of the MSA, which is recorded within accrued expenses and other current liabilities in our condensed consolidated balance sheet as of June 30, 2017 and within general and administrative expenses in our condensed consolidated statement of operations for the six months ended June 30, 2017.

We are obligated to make future payments to third parties under in-license agreements, including sublicense fees, royalties and payments that become due and payable on the achievement of certain development and commercialization milestones. As the amount and timing of sublicense fees and the achievement and timing of these milestones are not probable and estimable, such commitments have not been included on our balance sheet or in the contractual obligations tables above.

Off-Balance Sheet Arrangements

We do not have any off-balance sheet arrangements.

Item 3. Quantitative and Qualitative Disclosures about Market Risk

There have not been any material changes to our exposure to market risk during the six months ended June 30, 2017.  For additional information regarding market risk, refer to the Qualitative and Quantitative Disclosures About Market Risk section of our Annual Report on Form 10-K.

Item 4. Controls and Procedures

Evaluation of disclosure controls and procedures. Management, including our Principal Executive Officer and Chief Financial Officer, evaluated the effectiveness of our disclosure controls and procedures, as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act, as of June 30, 2017. The evaluation of our disclosure controls and procedures included a review of our processes and implementation and the effect on the information generated for use in this Quarterly Report on Form 10-Q. In the course of this evaluation, we sought to identify any material weaknesses in our disclosure controls and procedures to determine whether we had identified any acts of fraud involving personnel who have a significant role in our disclosure controls and procedures, and to confirm that necessary corrective action, including process improvements, was taken. This type of evaluation is done quarterly so that our conclusions concerning the effectiveness of these controls can be reported in our periodic reports filed with the SEC. The overall goals of these evaluation activities are to monitor our disclosure controls and procedures and to make modifications as necessary. We intend to maintain these disclosure controls and procedures, modifying them as circumstances warrant.

Based on that evaluation, the Principal Executive Officer and Chief Financial Officer concluded that, as of June 30, 2017, the Company’s disclosure controls and procedures were effective to provide reasonable assurance that information required to be disclosed by us in the reports that we file or submit under the Exchange Act is (i) recorded, processed, summarized and reported as and when required and (ii) accumulated and communicated to our management, including the Principal Executive Officer and Chief Financial Officer, as appropriate to allow timely discussion regarding required disclosure.

Changes in internal control over financial reporting. There have been no changes in our internal control over financial reporting during the three and six months ended June 30, 2017 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

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Inherent Limitations on Controls and Procedures

Our management, including the Principal Executive Officer and the Chief Financial Officer, does not expect that our disclosure controls and procedures and our internal controls will prevent all error and all fraud. A control system, no matter how well designed and operated, can only provide reasonable assurances that the objectives of the control system are met. The design of a control system reflects resource constraints; the benefits of controls must be considered relative to their costs. Because there are inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, within the Company have been or will be detected. As these inherent limitations are known features of the financial reporting process, it is possible to design into the process safeguards to reduce, though not eliminate, these risks. These inherent limitations include the realities that judgments in decision-making can be faulty and that breakdowns occur because of simple error or mistake. Controls can be circumvented by the individual acts of some persons, by collusion of two or more people, or by management override of the control. The design of any system of controls is based in part upon certain assumptions about the likelihood of future events. While our disclosure controls and procedures are designed to provide reasonable assurance of achieving their objectives, there can be no assurance that any design will succeed in achieving its stated goals under all future conditions. Over time, controls may become inadequate because of changes in conditions or deterioration in the degree of compliance with the policies or procedures. Because of the inherent limitations in a cost-effective control system, misstatements due to error or fraud may occur and not be detected.

We intend to review and evaluate the design and effectiveness of our disclosure controls and procedures on an ongoing basis, to improve our controls and procedures over time and to correct any deficiencies that we may discover in the future. While our Principal Executive Officer and Chief Financial Officer have concluded that, as of June 30, 2017, the design of our disclosure controls and procedures, as defined in Rule 13a-15(e) under the Exchange Act, was effective, future events affecting our business may cause us to significantly modify our disclosure controls and procedures.

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PART II – OTHER INFORMATION

Item 1. Legal Proceedings

In July 2015, three securities class action lawsuits were filed against us and certain of our officers in the United States District Court for the Northern District of California, each on behalf of a purported class of persons and entities who purchased or otherwise acquired our publicly traded securities between July 31, 2014 and June 15, 2015. The lawsuits assert claims under the Exchange Act and Securities Act and allege that the defendants made materially false and misleading statements and omitted allegedly material information related to, among other things, the Phase 2a clinical trial for AVA-101 and the prospects of AVA-101. The complaints seek unspecified damages, attorneys’ fees and other costs.

In December 2015, a securities class action lawsuit was filed against us, our board of directors, underwriters of our January 13, 2015, follow-on public stock offering, and two of our institutional stockholders, in the Superior Court of the State of California for the County of San Mateo. The complaint alleges that, in connection with our follow-on stock offering, the defendants violated the Securities Act in essentially the same manner alleged by the consolidated federal action: by allegedly making materially false and misleading statements and by allegedly omitting material information related to the Phase 2a clinical trial for AVA-101 and the prospects of AVA-101. The complaint seeks unspecified compensatory and rescissory damages, attorneys’ fees and other costs. The plaintiff has dismissed the two institutional stockholder defendants.

On March 16, 2017, the Company reached an agreement to settle the asserted actions. The proposed aggregate amount of the settlement is $13 million, of which $1 million would be contributed by the Company to cover its indemnification obligations to the underwriters, and the remainder would be contributed by the Company’s insurers. The settlement is subject to definitive documentation, shareholder notice and court approval. The Company and the defendants have denied and continue to deny each and all of the claims alleged in the actions, and the settlement does not assign or reflect any admission of fault, wrongdoing or liability as to any defendant. If final court approval is not obtained with respect to the settlement or the settlement otherwise does not become effective and litigation resumes, adverse outcomes in the actions could result in substantial damages.

Item 1A. Risk Factors

Investing in our common stock involves a high degree of risk. Before deciding to invest in our common stock, you should carefully consider each of the risk factors described in “Part I - Item 1A. Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2016 and our Quarterly Report on Form 10-Q for the period ended March 31, 2017. Those risks and the risks described in this Quarterly Report on Form 10-Q, including in the section entitled “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” could materially harm our business, financial condition, operating results, cash flow and prospects. If that occurs, the trading price of our common stock could decline, and you may lose all or part of your investment.

There have been no material changes to the Risk Factors described under “Part I - Item 1A. Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2016, except as set forth in our Quarterly Report on Form 10-Q for the period ended March 31, 2017, filed with the Securities and Exchange Commission on May 9, 2017.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds

Unregistered Sales of Equity Securities

None.

Use of Proceeds

On August 5, 2014, we closed our IPO and issued 6,900,000 shares of our common stock at an initial offering price of $17.00 per share. The offer and sale of all of the shares in the IPO were registered under the Securities Act pursuant to a registration statement on Form S-1, as amended (File Nos. 333-197133 and 333-197739), which was declared effective by the SEC on July 30, 2014. The joint book-running managers for the IPO were Jefferies LLC, Cowen and Company, LLC and Piper Jaffray & Co. The aggregate offering price to the public for the shares sold in the IPO was $117.3 million. We received net proceeds from the IPO of approximately $106.5 million, after deducting underwriting discounts and commissions of approximately $8.2 million and expenses of approximately $2.6 million payable by us. None of the expenses associated with the IPO were paid to directors, officers, persons owning 10% or more of any class of equity securities, or to their associates, or to our affiliates.

The remainder of the information required by this item regarding the use of our initial public offering proceeds has been omitted pursuant to SEC rules because such information has not changed since the date of our last periodic report.

29

Item 3. Defaults Upon Senior Securities

None.

Item 4. Mine Safety Disclosures

Not applicable.

Item 5. Other Information

None.

Item 6. Exhibits

See the Exhibit Index on the page immediately preceding the exhibits for a list of exhibits filed as part of this Quarterly Report on Form 10-Q, which Exhibit Index is incorporated herein by reference.

30

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

Date: August 8, 2017	ADVERUM BIOTECHNOLOGIES, INC.
	By:	/s/ Amber Salzman
		Amber Salzman
		President and Chief Executive Officer

By:	/s/ Leone Patterson
	Leone Patterson
	Chief Financial Officer (Principal Financial and Accounting Officer)

31

EXHIBIT INDEX

EXHIBIT NUMBER	DESCRIPTION
10.1	Offer Letter, dated June 15, 2017, by and between Adverum Biotechnologies, Inc. and Athena Countouriotis, M.D. (filed as Exhibit 10.1 to the Company’s Current Report on Form 8-K filed on June 20, 2017, and incorporated herein by reference).
10.2	Change in Control and Severance Agreement, dated June 15, 2017, by and between Adverum Biotechnologies, Inc. and Athena Countouriotis, M.D. (filed as Exhibit 10.1 to the Company’s Current Report on Form 8-K filed on June 20, 2017, and incorporated herein by reference).
31.1	Certification of Principal Executive Officer, as required Under Rule 13a-14(a) and 15d-14(a) of the Securities Exchange Act of 1934, as amended.
31.2	Certification of Chief Financial Officer, as required Under Rule 13a-14(a) and 15d-14(a) of the Securities Exchange Act of 1934, as amended.
32.1	Certification of Principal Executive Officer and Chief Financial Officer, as required Under Rule 13a-14(b) of the Securities Exchange Act of 1934, as amended, and 18 U.S.C. §1350.
101	The following materials from Registrant’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2017, formatted in eXtensible Business Reporting Language (XBRL) includes: (i) Condensed Consolidated Balance Sheets at June 30, 2017 (unaudited) and December 31, 2016, (ii) Condensed Consolidated Statements of Operations and Comprehensive Loss (unaudited) for the three and six months ended June 30, 2017 and 2016, (iii) Condensed Consolidated Statements of Cash Flows (unaudited) for the six months ended June 30, 2017 and 2016, and (iv) Notes to the Condensed Consolidated Financial Statements.

32

EX-31.1

Exhibit 31.1

CERTIFICATION OF THE PRINCIPAL EXECUTIVE OFFICER

PURSUANT TO

SECURITIES EXCHANGE ACT RULES 13A-14(A) AND 15D-14(A)

I, Amber Salzman, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Adverum Biotechnologies, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the registrant and have:

a. Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b. Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c. Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d. Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting;

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: August 8, 2017

 /s/ Amber Salzman

Amber Salzman

President and Chief Executive Officer

EX-31.2

Exhibit 31.2

CERTIFICATION OF THE CHIEF FINANCIAL OFFICER

PURSUANT TO

SECURITIES EXCHANGE ACT RULES 13A-14(A) AND 15D-14(A)

I, Leone Patterson, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Adverum Biotechnologies, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the registrant and have:

a. Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b. Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c. Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d. Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting;

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: August 8, 2017

 /s/ Leone Patterson

Leone Patterson

Chief Financial Officer

(principal financial and accounting officer)

EX-32.1

Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Adverum Biotechnologies, Inc. (the “Company”) on Form 10-Q for the fiscal quarter ended June 30, 2017, as filed with the Securities and Exchange Commission (the “Report”), Amber Salzman, President and Chief Executive Officer of the Company, and Leone Patterson, Senior Vice President and Chief Financial Officer of the Company, respectively, do each hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

• The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

• The information in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: August 8, 2017

 /s/ Amber Salzman

Amber Salzman

President and Chief Executive Officer

 /s/ Leone Patterson

Leone Patterson

Chief Financial Officer

(principal financial and accounting officer)

XML

Document and Entity Information - shares	6 Months Ended
	Jun. 30, 2017	Jul. 31, 2017
Document And Entity Information [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Jun. 30, 2017
Document Fiscal Year Focus	2017
Document Fiscal Period Focus	Q2
Trading Symbol	ADVM
Entity Registrant Name	Adverum Biotechnologies, Inc.
Entity Central Index Key	0001501756
Current Fiscal Year End Date	--12-31
Entity Filer Category	Accelerated Filer
Entity Common Stock, Shares Outstanding		43,286,786

XML

Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
Current assets:
Cash and cash equivalents	$ 39,523	$ 222,170
Short-term investments	157,895
Receivable from collaborative partner		886
Prepaid expenses and other current assets	2,223	2,218
Total current assets	199,641	225,274
Property and equipment, net	3,798	4,169
Deposit and other long-term assets	140	140
Intangible assets	5,000	5,000
Total assets	208,579	234,583
Current liabilities:
Accounts payable	1,125	1,474
Restructuring liabilities		25
Accrued expenses and other current liabilities	5,226	6,451
Deferred rent, current portion	112	96
Deferred revenue, current portion	1,850	1,850
Total current liabilities	8,313	9,896
Long-term liabilities:
Deferred rent, net of current portion	293	352
Deferred revenue, net of current portion	6,174	7,099
Deferred tax liability	1,250	1,250
Other noncurrent liabilities	369	386
Total liabilities	16,399	18,983
Commitments and contingencies (Note 10)
Stockholders’ equity:
Preferred stock, $0.0001 par value, 5,000,000 shares authorized; no shares issued and outstanding
Common stock, $0.0001 par value, 300,000,000 shares authorized at June 30, 2017 and December 31, 2016; 43,201,786 and 41,805,009 shares issued and outstanding at June 30, 2017 and December 31, 2016, respectively	5	4
Additional paid-in capital	418,022	413,518
Accumulated other comprehensive loss	(403)	(7)
Accumulated deficit	(225,444)	(197,915)
Total stockholders’ equity	192,180	215,600
Total liabilities and stockholders’ equity	$ 208,579	$ 234,583

XML

Condensed Consolidated Balance Sheets (Parenthetical) (Unaudited) - $ / shares	Jun. 30, 2017	Dec. 31, 2016
Statement Of Financial Position [Abstract]
Preferred stock, par value	$ 0.0001	$ 0.0001
Preferred stock, shares authorized	5,000,000	5,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value	$ 0.0001	$ 0.0001
Common stock, shares authorized	300,000,000	300,000,000
Common stock, shares issued	43,201,786	41,805,009
Common stock, shares outstanding	43,201,786	41,805,009

XML

Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Income Statement [Abstract]
Collaboration revenue	$ 463	$ 307	$ 925	$ 572
Operating expenses:
Research and development	8,492	7,955	17,553	15,410
General and administrative	4,064	5,114	12,053	13,432
Goodwill impairment charge		49,120		49,120
Total operating expenses	12,556	62,189	29,606	77,962
Operating loss	(12,093)	(61,882)	(28,681)	(77,390)
Other income (expense), net
Other income (expense), net	663	222	1,152	338
Total other income (expense), net	663	222	1,152	338
Net loss	(11,430)	(61,660)	(27,529)	(77,052)
Other comprehensive loss:
Net unrealized (loss) gain on marketable securities	(49)		(137)	6
Foreign currency translation adjustment	(141)	(4)	(259)	10
Comprehensive loss	$ (11,620)	$ (61,664)	$ (27,925)	$ (77,036)
Net loss per share attributable to common stockholders-basic and diluted	$ (0.27)	$ (1.76)	$ (0.65)	$ (2.50)
Weighted-average common shares outstanding-basic and diluted	43,009	35,044	42,579	30,825

XML

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016
Cash flows from operating activities:
Net loss	$ (27,529)	$ (77,052)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,056	663
Stock-based compensation expense	4,139	6,903
Goodwill impairment charge		49,120
Amortization of premium and accrued interest on marketable securities	203
Non-cash research and development expense	24
Changes in operating assets and liabilities:
Receivable from collaborative partner	886	(580)
Prepaid expenses and other current assets	576	1,069
Accounts payable	(334)	646
Accrued expenses and other current liabilities	(1,266)	(1,706)
Restructuring liabilities	(25)	(988)
Deferred revenue	(925)	1,575
Deferred rent	(43)	(27)
Net cash used in operating activities	(23,238)	(20,377)
Cash flows from investing activities:
Purchases of investments	(172,788)
Maturities of investments	14,000	37,738
Purchases of property and equipment	(732)	(1,126)
Cash acquired in business acquisition		3,449
Net cash provided by (used in) investing activities	(159,520)	40,061
Cash flows from financing activities:
Proceeds from issuance of common stock pursuant to option exercises	342	349
Net cash provided by financing activities	342	349
Effect of foreign currency exchange rate on cash and cash equivalents	(231)	(79)
Net increase (decrease) in cash and cash equivalents	(182,647)	19,954
Cash and cash equivalents at beginning of period	222,170	221,348
Cash and cash equivalents at end of period	39,523	241,302
Supplemental schedule of noncash investing and financing information
Issuance of common stock and exchange of stock options for business combination		64,845
Fixed assets in accounts payable, accrued expenses and other current liabilities	$ 124	$ 153

XML

Organization and Basis of Presentation

6 Months Ended

Jun. 30, 2017

Accounting Policies [Abstract]

Organization and Basis of Presentation

1. Organization and Basis of Presentation

Adverum Biotechnologies, Inc. (the “Company”, “we” or “us”) was incorporated in Delaware on July 17, 2006 as Avalanche Biotechnologies, Inc. and changed its name to Adverum Biotechnologies, Inc. on May 11, 2016. The Company is headquartered in Menlo Park, California. The Company is a gene therapy company advancing novel medicines that may offer life-changing benefits to patients living with serious rare and ocular diseases. Since the Company’s inception, it has devoted its efforts principally to performing research and development activities, including conducting preclinical studies and, early clinical trials, filing patent applications, obtaining regulatory agreements, hiring personnel, and raising capital to support these activities.

The Company has not generated any revenue from the sale of products since its inception. The Company has experienced net losses since its inception and had an accumulated deficit of $225.4 million as of June 30, 2017. The Company expects to incur losses and have negative net cash flows from operating activities as it engages in further research and development activities. The Company believes that it has sufficient funds to continue its operations through the end of 2019.

On May 11, 2016, the Company completed the acquisition of all the outstanding shares of Annapurna Therapeutics SAS, a French simplified joint stock company (“Annapurna”). As a result, Annapurna is now a wholly owned subsidiary of the Company.

Upon completion of the acquisition of Annapurna, the Company changed its name to “Adverum Biotechnologies, Inc.”. The Company’s shares of common stock listed on The NASDAQ Global Market, previously trading through the close of business on Wednesday, May 11, 2016 under the ticker symbol “AAVL,” commenced trading on The NASDAQ Global Market under the ticker symbol “ADVM” on Thursday, May 12, 2016.

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United States of America (“U.S. GAAP”) and follow the requirements of the Securities and Exchange Commission (“SEC”) for interim reporting. As permitted under those rules, certain footnotes or other financial information that are normally required by U.S. GAAP can be condensed or omitted. These unaudited condensed consolidated financial statements have been prepared on the same basis as the Company’s annual consolidated financial statements and, in the opinion of management, reflect all adjustments, consisting only of normal recurring adjustments, which are necessary for a fair statement of the Company’s consolidated financial information. The results of operations for the three and six months ended June 30, 2017, are not necessarily indicative of the results to be expected for the full year or any other future period. The balance sheet as of December 31, 2016 has been derived from audited consolidated financial statements at that date but does not include all of the information required by U.S. GAAP for complete consolidated financial statements.

The accompanying unaudited condensed consolidated financial statements and related financial information should be read in conjunction with the audited consolidated financial statements and the related notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016 filed with the SEC.

XML

Summary of Significant Accounting Policies

6 Months Ended

Jun. 30, 2017

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

2. Summary of Significant Accounting Policies

The accounting policies followed in the preparation of the interim condensed consolidated financial statements are consistent in all material respects with those presented in Note 2 to the consolidated financial statements included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016.

Recently-Issued and Not Yet Adopted Accounting Pronouncements —In May 2014, the FASB issued ASU No. 2014-09, Revenue from Contracts with Customers (Topic 606), which supersedes the revenue recognition requirements in ASC 605, Revenue Recognition. This ASU is based on the principle that revenue is recognized to depict the transfer of goods or services to customers in an amount that reflects the consideration to which the entity expects to be entitled in exchange for those goods or services. ASU 2014-09 defines a five step process to achieve this core principle and, in doing so, it is possible more judgment and estimates may be required within the revenue recognition process than required under existing GAAP including identifying performance obligations in the contract, estimating the amount of variable consideration to include in the transaction price and allocating the transaction price to each separate performance obligation. ASU 2014-09 is required to be adopted, using either of two methods: (i) retrospective to each prior reporting period presented with the option to elect certain practical expedients as defined within ASU 2014-09; or (ii) retrospective with the cumulative effect of initially applying ASU 2014-09 recognized at the date of initial application and providing certain additional disclosures. In July 2015, the FASB voted to approve a one-year deferral of the effective date to December 15, 2017 for interim and annual reporting periods beginning after that date and permitted early adoption of the standard, but not before the original effective date of December 15, 2016. The FASB issued supplemental adoption guidance and clarification to ASU 2014-09 in March 2016, April 2016, May 2016 and December 2016 within ASU 2016-08 Revenue From Contracts With Customers: Principal vs. Agent Considerations, ASU 2016-10 Revenue From Contracts with Customers: Identifying Performance Obligations and Licensing, ASU 2016-12 Revenue from Contracts with Customers: Narrow-Scope Improvements and Practical Expedients and ASU 2016-20 Technical Corrections and Improvement to Topic 606 – Revenue from Contracts with Customers, respectively. The ASU will be effective for the Company in the first quarter of 2018. Preliminarily, the Company intends to adopt the new standard in the first quarter of 2018 using the retrospective approach noted in (ii) above. The Company is currently evaluating the impact of the adoption of this standard on its condensed consolidated financial statements and related disclosures.

In January 2016, the FASB issued ASU No. 2016-01, Recognition and Measurement of Financial Assets and Financial Liabilities, which amends the current guidance on the classification and measurement of financial instruments. Although this ASU retains many current requirements, it significantly revises an entity’s accounting related to (i) the classification and measurement of investments in equity securities and (ii) the presentation of certain fair value changes for financial liabilities measured at fair value. This ASU also amends certain disclosure requirements associated with the fair value of financial instruments. The new standard is effective for fiscal years and interim periods within those fiscal years beginning after December 15, 2017, with early adoption permitted for certain changes. This ASU will be effective for the Company in the first quarter of 2018 and must be adopted using a modified retrospective approach, with certain exceptions. The adoption of this standard is not expected to have a significant impact on the Company’s condensed consolidated financial statements and related disclosures.

In February 2016, the FASB issued ASU No. 2016-2, Leases, which amends the current guidance on leasing activities to provide more transparency and comparability, and requires that all leases be recognized by lessees on their balance sheet as a right-of-use asset and corresponding lease liability, which are currently accounted for as operating leases. The new standard is effective for fiscal years and interim periods within those fiscal years beginning after December 15, 2018, with early adoption permitted. This ASU will be effective for the Company in the first quarter of 2019 and must be adopted using a modified retrospective transition approach. The company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of this standard on its condensed consolidated financial statements and related disclosures.

In June 2016, the FASB issued ASU No. 2016-13 Measurement of Credit Losses on Financial Instruments. This ASU requires measurement and recognition of expected credit losses for financial assets held. The new standard is effective for fiscal years beginning after December 15, 2020 and interim periods beginning after December 15, 2021 with early adoption permitted beginning in the first quarter of 2019. This ASU will be effective for the Company in the first quarter of 2021 and must be adopted using a modified retrospective approach, with certain exceptions. The Company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of this standard on its condensed consolidated financial statements and related disclosures.

In August 2016, the FASB issued ASU No. 2016-15, Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and Cash Payments, which clarifies the presentation and classification of certain cash receipts and cash payments in the statement of cash flows. This ASU is effective for annual reporting periods beginning after December 15, 2017, and interim periods within that reporting period. Early adoption is permitted. This ASU will be effective for the Company in the first quarter of 2018. The Company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of this standard on its condensed consolidated financial statements and related disclosures.

In November 2016, the FASB issued ASU No. 2016-18, Statement of Cash Flows (Topic 230): Restricted Cash, which provides amendments to current guidance to address the classification and presentation of changes in restricted cash in the statement of cash flows. This ASU is effective for annual reporting periods beginning after December 15, 2017, and interim periods within that reporting period. Early adoption is permitted. This ASU will be effective for the Company in the first quarter of 2018. The Company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of these standards on its condensed consolidated financial statements and related disclosures.

In May 2017, the FASB issued ASU No. 2017-09, Scope of Modification Accounting, which provides amendments to the current guidance for modification accounting. This ASU clarifies that an entity should account for the effects of a modification unless all the following criteria are met: (1) the fair value of the modified award is the same as the fair value of the original award immediately before the original award is modified, (2) the vesting conditions of the modified award are the same as the vesting conditions of the original award immediately before the original award is modified, and (3) the classification of the modified award as an equity instrument or a liability instrument is the same as the classification of the original award immediately before the original award is modified. This ASU is effective for annual reporting periods beginning after December 15, 2017, and interim periods within that reporting period. Early adoption is permitted. This ASU will be effective for the Company in the first quarter of 2018. The Company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of these standards on its condensed consolidated financial statements and related disclosures.

The Company has reviewed other recent accounting pronouncements and concluded they are either not applicable to the business or no material effect is expected on the consolidated financial statements as a result of future adoption.

XML

Acquisition of Annapurna

6 Months Ended

Jun. 30, 2017

Business Combinations [Abstract]

Acquisition of Annapurna

3. Acquisition of Annapurna

(a) Purchase Price Allocation

On May 11, 2016, the Company completed the acquisition of all outstanding equity interests of Annapurna. Annapurna was a privately held French limited liability company with two wholly-owned subsidiaries, Annapurna, Inc. in the U.S. and Annapurna Therapeutics Limited in Ireland. Annapurna is a biopharmaceutical company focused on discovering and developing novel gene therapy products for people living with severe rare diseases. The primary reasons for the acquisition were to expand the technology platforms within the Company’s research and development portfolio and to apply the Company’s resources and expertise in gene vectors development to advance Annapurna’s programs through development and clinical trials. Annapurna’s results of operations and fair value of assets acquired and liabilities assumed are included in the Company’s condensed consolidated financial statements from the date of acquisition.

The purchase price consideration was $64.8 million, which was based on the Company’s common stock closing price on NASDAQ on the acquisition closing date of $4.14 per share. A total of 14,087,246 shares of the Company’s common stock were issued to shareholders of Annapurna in exchange for all common and preferred stock outstanding at the closing date. Annapurna stockholders did not receive any fractional shares of the Company’s common stock in connection with the acquisition. Instead of receiving any fractional shares, each Annapurna stockholder was paid an amount in cash (without interest) equal to such fraction amount multiplied by the average 10 business days sale price of the Company’s common stock on NASDAQ from the acquisition date. Annapurna Series O preferred shares issued to founders were canceled prior to the acquisition date and were not included in the purchase price consideration. Vesting of certain of Annapurna’s options and unvested common stock shares was accelerated at the closing date. The fair value of awards related to the accelerated vesting of options and shares of $0.9 million was excluded from the purchase price consideration and included in the Company’s operating expenses post acquisition.

A portion of the purchase price was attributed to the exchange of Annapurna’s options and other rights to purchase capital stock outstanding at the acquisition closing date for corresponding common stock options of the Company at an exchange ratio of 9.54655.

The Company reserved 3,673,940 shares for the future exercise of the Company’s stock options. The total fair value of assumed Annapurna stock options and stock-based awards was estimated at $14.7 million on the acquisition date, using the Black-Scholes pricing model, assuming no dividends, expected volatilities of 80% and 89%, risk-free interest rates of 1.4% and 1.1%, and expected lives of six and ten years for employees and non-employees awards, respectively. Of the total fair value, $7.4 million was attributed as pre-combination service and included as part of the total purchase price consideration. The post-combination attribution of $7.2 million is recognized as compensation expense over the remaining requisite service period. The Company included $0.9 million in stock-based compensation expense related to the vesting of exchanged stock options and day-one post combination compensation expenses related to the accelerated vesting of options and shares in its condensed consolidated statement of operations during the three months ended June 30, 2016.

Total purchase price consideration was estimated as follows (in thousands):

Fair value of common shares issued	$	58,321
Fair value of the Company's common share options    exchanged for Annapurna stock options and other awards    attributable to pre-combination services		7,422
Less: value of common stock and options accelerated    vesting at the closing date		(898	)
Total purchase price consideration	$	64,845

The transaction was accounted for using the acquisition method based on ASC 805, Business Combinations, with Adverum identified as the acquirer, based onthe existence of a controlling financial interest of the combined entities. Under the acquisition method, assets acquired and liabilities assumed were recorded at their estimated fair values as of May 11, 2016. Goodwill, as well as intangible assets that do not qualify for separate recognition, is measured as of the acquisition date as the excess of consideration transferred, which is also measured at fair value, and the net of the fair values of the assets acquired and the liabilities assumed as of the acquisition closing date. Goodwill represented expected synergies of two combined companies. Acquisition costs of $0.6 million and $2.5 million for the three and six months ended June 30, 2016, respectively, were expensed as incurred and recorded as general and administrative expenses in the Company’s consolidated statement of operations.

The allocation of total purchase price consideration is as follows (in thousands):

Cash	$	3,449
Prepaid expenses and other assets		865
Property and equipment		185
Acquired intangible assets		16,200
Goodwill		49,514
Accounts payable		(1,118	)
Accrued liabilities		(1,848	)
Other noncurrent liabilities		(377	)
Deferred tax liabilities		(2,025	)
Total purchase price allocation	$	64,845

The identifiable intangible assets acquired consist of IPR&D assets related to products in development, as summarized in the table below (in thousands):

IPR&D - Alpha-1 antitrypsin deficiency	$	11,700
IPR&D - Hereditary angioedema		4,500
Total acquired intangible assets	$	16,200

The fair value of each IPR&D asset is estimated using the income approach and calculated using cash flow projections adjusted for inherent risks regarding regulatory approval, promotion, and distribution, discounted at a rate of approximately 11.0%. The Company acquired two additional intangible assets relating to the Friedreich’s Ataxia (FA) and severe allergy programs, but the fair value of each of these assets was determined to be nominal and is not included in the total acquired intangible assets. All IPR&D intangible assets acquired are currently classified as indefinite-lived and are not currently being amortized. During the year ended December 31, 2016, the Company recorded $11.2 million of IPR&D impairment charge related to these intangible assets.

Goodwill, which represents the excess of the purchase price over the fair values assigned to the net assets acquired, was estimated in the amount of $49.5 million on the acquisition date. The full amount of the preliminary value of goodwill has been assigned to the entire Company, since management has determined that the Company has only one reporting unit. The goodwill is not deductible for tax purposes. During the three months ended June 30, 2016, goodwill was fully impaired.

The pro forma financial information combines the results of operations of Adverum and Annapurna as though the businesses had been combined as of the beginning of fiscal 2016. The pro forma financial information is presented for informational purposes only, and is not indicative of the results of operations that would have been achieved in the current or any future periods. The following table presents the unaudited pro forma results for the three and six months ended June 30, 2016 (in thousands, except per share data).

	Three Months Ended June 30,			Six Months Ended June 30,
	2016			2016
Pro forma information
Collaboration revenue	$	307		$	572
Net loss	$	(62,572	)	$	(80,846	)
Basic and diluted loss per share	$	(1.52	)	$	(1.97	)

Pro-forma adjustments included the following:

• Actual acquisition-related transaction costs of $0.6 million and $2.5 million for the three and six months ended June 30, 2016, respectively were excluded from pro forma results above as these expenses were incurred prior to the closing of the acquisition.  

• Stock-based compensation expense related to accelerated vesting associated with the acquisition of $0.9 million was excluded from the pro forma results above.

• Stock-based compensation expense related to options granted to executives upon the acquisition closing of $0.1 million and $0.2 million for the three and six months ended June 30, 2016, respectively ,was included in pro forma results above.

• Interest expense related to convertible notes and changes in fair value of preferred stock warrants of $0.5 million and $1.0 million for the three and six months ended June 30, 2016, respectively, were excluded from the pro-forma results above, as the convertible notes and warrants were settled prior to the acquisition closing.

• $0.4 million bonuses paid in connection with the closing of the acquisition in May 2016 were excluded from the pro forma results above.

The unaudited condensed pro forma information does not include any anticipated synergies that may be achievable subsequent to the date of acquisition.

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Cash Equivalents and Short-Term Investments

6 Months Ended

Jun. 30, 2017

Cash And Cash Equivalents [Abstract]

Cash Equivalents and Short-Term Investments

4. Cash Equivalents and Short-Term Investments

The following is a summary of the Company’s available-for-sale securities as of June 30, 2017 (in thousands):  

	June 30, 2017
	Amortized Cost Basis			Unrealized Gains		Unrealized Loses			Estimated Fair Value
Money market funds	$	3,003		$	—	$	—		$	3,003
Certificates of deposit		11,967			—		—			11,967
Commercial paper		50,947			—		—			50,947
U.S. government agency		63,262			1		(76	)		63,187
Corporate bonds		66,142			—		(62	)		66,080
Total cash equivalents and    short-term investments		195,321			1		(138	)		195,184
Less: cash equivalents		(37,289	)		—		—			(37,289	)
Total short-term investments	$	158,032		$	1	$	(138	)	$	157,895

The following table is a summary of the cost and estimated fair value of the Company’s available-for-sale securities based on stated effective maturities as of June 30, 2017 (in thousands):

	June 30, 2017
	Amortized Cost Basis		Estimated Fair Value
Mature within one year	$	160,946	$	160,870
Mature after one year to three years		34,375		34,314
Total cash equivalents and short-term    investments	$	195,321	$	195,184

As of December 31, 2016, all of the Company’s investments were held in money market funds and were treated as cash equivalents. Management determined that the gross unrealized losses of $0.1 million on the Company’s available-for-sale securities as of June 30, 2017 were temporary in nature. Therefore, none of the Company’s available-for-sale securities were other-than-temporarily impaired as of June 30, 2017.

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Fair Value Measurements and Fair Value of Financial Instruments

6 Months Ended

Jun. 30, 2017

Fair Value Disclosures [Abstract]

Fair Value Measurements and Fair Value of Financial Instruments

5. Fair Value Measurements and Fair Value of Financial Instruments

The authoritative guidance on fair value measurements establishes a three-tier fair value hierarchy for disclosure of fair value measurements as follows:

Level 1: Quoted prices in active markets for identical assets or liabilities.

Level 2: Observable inputs other than Level 1 prices, such as quoted prices for similar assets or liabilities, quoted prices in markets that are not active, or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

Level 3: Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

Assets and liabilities measured at fair value are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires management to make judgments and consider factors specific to the asset or liability.

The fair value of Level 1 securities are determined using quoted prices in active markets for identical assets. Level 1 securities consist of highly liquid money market funds. Financial assets and liabilities are considered Level 2 when their fair values are determined using inputs that are observable in the market or can be derived principally from or corroborated by observable market data such as pricing for similar securities, recently executed transactions, cash flow models with yield curves, and benchmark securities. In addition, Level 2 financial instruments are valued using comparisons to like-kind financial instruments and models that use readily observable market data as their basis. U.S. government and agency securities, commercial paper, corporate bonds and certificate of deposit are valued primarily using market prices of comparable securities, bid/ask quotes, interest rate yields and prepayment spreads and are included in Level 2.

In certain cases where there is limited activity or less transparency around inputs to valuation, securities are classified as Level 3 within the valuation hierarchy. Level 3 liabilities that were measured at estimated fair value on a recurring basis consist of a financing arrangement entered into during the year ended December 31, 2016.

During the periods presented, the Company has not changed the manner in which it values liabilities that are measured at estimated fair value using Level 3 inputs. There were no transfers within the hierarchy during the three and six months ended June 30, 2017.

The following table summarizes, for assets recorded at fair value on a recurring basis, the respective fair value and the classification by level of input within the fair value hierarchy as described above (in thousands):

			Quoted Prices		Significant Other		Significant
	Total		In Active Markets		Observable Inputs		Unobservable Inputs
	Carrying Value		(Level 1)		(Level 2)		(Level 3)
June 30, 2017
Assets:
Money market funds	$	3,003	$	3,003	$	—	$	—
Certificates of deposit		11,967		—		11,967		—
Commercial paper		50,947		—		50,947		—
U.S. government agency		63,187		—		63,187		—
Corporate bonds		66,080		—		66,080		—
Total cash equivalents and short    term investments	$	195,184	$	3,003	$	192,181	$	—
Other noncurrent liability:
Financing arrangement	$	74	$	—	$	—	$	74
December 31, 2016
Assets:
Money market funds	$	215,916	$	215,916	$	—	$	—
Total cash equivalents	$	215,916	$	215,916	$	—	$	—
Other noncurrent liability:
Financing arrangement	$	74	$	—	$	—	$	74

Non-financial assets such as intangible assets, property, plant, and equipment are evaluated for impairment and adjusted to their fair value using Level 3 inputs, only when impairment is recognized. Fair values are considered Level 3 when management makes significant assumptions in developing a discounted cash flow model based upon a number of considerations including projections of revenues, earnings and a discount rate.

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Significant Agreements

6 Months Ended

Jun. 30, 2017

Research And Development [Abstract]

Significant Agreements

6. Significant Agreements

University of California— In May 2010, the Company entered into a license agreement with the Regents of University of California (“Regents”), as amended in September 2013. Under the license agreement, the Regents have granted to the Company an exclusive (even as to the Regents) license, with the right to grant sublicenses, under the Regents’ undivided interest in patent rights covering a method of using recombinant gene delivery vectors for treating or preventing diseases of the eye, to develop, make, have made, use offer for sale, import, export and sell products covered by such patent rights in all fields of use in the United States. The licensed patent rights are jointly owned by the Regents and Chiron Corporation, but the Company’s license extends only to the Regents’ interest in such patent rights.

Under the license agreement, the Company is required to diligently proceed with the development, manufacture and sale of licensed products, which includes obligations to meet certain development-stage milestones within specified periods of time, and to market the resulting licensed products in sufficient quantity to meet market demand. The Company has the right and option to extend the date by which it must meet any milestone by six-months up to two times by paying an extension fee for each such extension.

The Company has paid the Regents a license fee of $100,000. The Company is also obligated to make milestone payments totaling up to $900,000 upon reaching certain stages of development of the licensed products for one indication, and totaling up to $500,000 for each subsequent indication for which licensed products are developed, for up to a maximum of two additional indications. Through June 30, 2017, none of these goals had been achieved, and no milestones were payable. The Company must pay the Regents a low single-digit royalty on net sales of the licensed products by the Company or its sublicensees, subject to a minimum annual royalty payment of $50,000 beginning in the calendar year after the first commercial sale of a licensed product, until the patent rights upon which such royalties are based expire or are held invalid, which is currently expected to occur in 2020, subject to any potential patent term extensions. The Company is obligated to reimburse the Regents for expenses associated with the prosecution and maintenance of the licensed patents. Finally, the Company is obligated to pay the Regents a mid-teen percentage of non-royalty licensing revenue that the Company receives from sublicensees.

The Company’s license agreement with the Regents continues in effect for the life of the last-to-expire patent. The Company may terminate this agreement without cause at any time upon 30 days’ prior written notice to the Regents. The Regents may terminate this agreement for a breach by the Company that remains uncured for 60 days, if the Company becomes insolvent, if the Company directly or through a third party files a claim that a licensed patent right is invalid or unenforceable or if the Company fails to meet or extend the date for meeting certain diligence milestones.

Regeneron—In May 2014, the Company entered into a research collaboration and license agreement with Regeneron to discover, develop and commercialize novel gene therapy products for the treatment of ophthalmologic diseases. The collaboration covers up to eight distinct therapeutic targets (“collaboration targets”). The Company and Regeneron collaborate during the initial research period of three years that can be extended by Regeneron for up to an additional five years. During the research period, Regeneron has the option to obtain an exclusive worldwide license for a collaboration target’s further development by giving written notice to the Company and paying $2.0 million per target. If Regeneron exercises its option, it will be responsible for all further development and commercialization of the target. The Company is then eligible to receive contingent payments of up to $80.0 million upon achievement of certain development and regulatory milestones for product candidates directed toward each collaboration target, for a combined total of up to $640.0 million in potential milestone payments for product candidates directed toward all eight collaboration targets, plus a royalty in the low- to mid-single-digits on worldwide net sales of collaboration products.

For any two collaboration targets, the Company has an option to share up to 35% of the worldwide product candidate development costs and profits. If the Company exercises this option, the Company will not be eligible for milestone and royalty payments as discussed above but rather the Company will share development costs and profits with Regeneron.

The agreement will expire with respect to each collaboration target upon the earlier of the (a) expiration of the research term if the option right has not been triggered by the end of the research term or (b) expiration of the option right if the option right has not been exercised by Regeneron. If the option right has been exercised, the agreement in connection with each collaboration target will expire upon expiration of all payment obligations by Regeneron. In addition, the agreement, or Regeneron’s rights to any target development under the agreement, may terminate early under the following situations:

• Regeneron may terminate the agreement for convenience at any time on a target by target basis or in totality upon a 30-day notice.

• Each party can terminate the agreement if another party commits a material breach or material default in performance of its obligations and such breach or default is not cured within 60 days.

• The agreement is automatically terminated upon initiation of any bankruptcy proceedings, reorganization or dissolution of either party.

• The Company can terminate the agreement upon 30-day notice if Regeneron challenges the validity, scope or enforceability of any Company patent.

On February 23, 2017, Regeneron notified Adverum that, pursuant to the terms of the research collaboration and license agreement, it extended the research term of the collaboration for an additional three years, through May 1, 2020.

Under the Company’s research, collaboration and license agreement with Regeneron, the Company is required to have a mutually agreed-on research plan with Regeneron in order to invoice Regeneron for services performed. The Company does not currently have a research plan in place, and, consequently, we are not currently receiving any reimbursements from Regeneron.

Editas—In August 2016, the Company entered into a collaboration, option and license agreement with Editas Medicine, Inc. (“Editas”) pursuant to which the Company and Editas will collaborate on certain studies using adeno-associated viral (“AAV”) vectors in connection with Editas’ genome editing technology and the Company will grant to Editas an exclusive option to obtain certain exclusive rights to use the Company’s proprietary vectors in up to five ophthalmic indications (“Indications”). The Company received a $1.0 million non-refundable upfront payment during the year ended December 31, 2016, with $0.5 million of such payment to be credited against Editas’ obligation to fund research and development costs. Under the terms of the agreement, both the Company and Editas will be subject to exclusivity obligations.

Editas may exercise the option, with respect to a designated initial Indication, until the first anniversary of the effective date of the agreement. With respect to the four other Indications, Editas may exercise the option until the third anniversary of the effective date, provided that the option will expire on the second anniversary of the effective date if Editas has not exercised the option with respect to the initial Indication or any other Indication by such date. Upon each exercise of the option, Editas will pay the Company a $1.0 million fee per Indication. If Editas elects to develop a product using certain of the Company’s proprietary vectors, the Company will be eligible to receive up to $15.5 million in development and commercialization milestone payments for such product, and tiered royalties between the mid-single digits and low teens on net sales of such product, subject to certain adjustments.

Unless earlier terminated, the agreement will be in effect until the later of the expiration of the option exercise period or the expiration of the royalty term of the last product. At any time after the option is first exercised, Editas may terminate the agreement for convenience in its entirety or on an indication-by indication or country-by-country basis, upon prior written notice to the Company. The Company may also terminate the agreement if Editas challenges the Company’s patents relating to its proprietary vectors and does not withdraw such challenge within a defined period of time. In addition, either party may terminate the agreement with written notice upon a bankruptcy of the other party or upon an uncured material breach by the other party.

Cornell University—The Company had been a party to a master service agreement (“MSA”) with Cornell University (“Cornell”) originally established in August 2014 and amended in December 2015. In December 2016, the Company informed Cornell that the Company decided to terminate the MSA for material breach, effective January 6, 2017. Subsequently, Cornell informed the Company that it disputes the validity of the Company’s termination of the MSA. Although the Company intends to defend the validity of its termination of the MSA, the Company recorded $2.0 million of estimated costs associated with the termination of the MSA during the six months ended June 30, 2017. This MSA included services relating to the Company’s gene therapy programs ADVM-043, ADVM-053 and severe allergy. The Company’s three licensing agreements with Cornell for these programs remain unchanged.

The decision to terminate the MSA was due to Cornell’s failure to deliver therapeutic material of ADVM-043 suitable for use in human patients. As a result of this decision, the Company has contracted with a large-scale contract manufacturing organization that complies with current good manufacturing practice industry standards and can produce product quantities for both the Company’s planned clinical trials and potential commercial supply. This is part of the Company’s planned upgrade of the manufacturing process for ADVM-043, implementing its proprietary, highly-scalable baculovirus-based production system, in advance of the Company’s plans to begin patient enrollment in a Phase 1/2 clinical trial for ADVM-043 in the fourth quarter of 2017.

Under the MSA, Cornell provided assistance in regulatory affairs, overall project management, and parameter development. The MSA, as amended, provided for Annapurna to pay Cornell $13.3 million ratably over 4 years for these services as services were performed.

In December 2015, Annapurna entered into three licensing agreements with Cornell, pursuant to which Annapurna will advance its gene therapy programs ADVM-043, ADVM-053, and severe allergy, which originally were initiated at the Department of Genetic Medicine at Weill Cornell.

A1AT Deficiency License Agreement: Under this agreement, Annapurna holds an exclusive license to certain technology related to alpha-1 antitrypsin (A1AT) deficiency and rights to an Investigational New Drug (IND) application to initiate clinical studies of gene therapy for A1AT.

HAE License Agreement: Under this agreement, Annapurna holds an exclusive license to certain technology related to hereditary angioedema (HAE) and a non-exclusive license to certain other intellectual property related to the HAE program.

Allergy License Agreement: Under this agreement, Annapurna holds an exclusive license to certain patents related to allergens and a non-exclusive license to certain other technology related to allergens.

Across these three license agreements, Cornell is entitled to receive aggregate annual maintenance fees ranging from $30,000 to $300,000 per year, up to $16.0 million in aggregate milestone payments and royalties on sales in the low single-digits, subject to adjustments and minimum thresholds.

Annapurna may terminate any of these license agreements for convenience upon ninety days written notice. Cornell may terminate any of the license agreements for material breach if such breach is not cured within a specified number of days. Cornell may also terminate the HAE License Agreement and/or the Allergy License Agreement if Annapurna commences any action and files a written claim asserting that any portion of the licensed patent rights is invalid or unenforceable.

Dr. Crystal, Chairman of Genetic Medicine, the Bruce Webster Professor of Internal Medicine and a Professor of Genetic Medicine and of Medicine at Weill Cornell, served as a consultant to Annapurna since inception and continues to provide services to the Company for the annual compensation of $0.3 million. Dr. Crystal also owns common shares of the Company and he does not have significant influence on the Company’s operations.

REGENXBIO—A1AT Deficiency/Allergy License Agreement: In October 2015, Annapurna entered into an exclusive worldwide license to certain intellectual property in order to make, have made, use, import, sell and offer for sale certain licensed products for the treatment ofA1AT deficiency. Under this agreement, Annapurna has an option to be granted an exclusive worldwide license to certain intellectual property related to the treatment of severe allergies, which option expired in October 2016. Under this license agreement, REGENXBIO, Inc. (“REGENXBIO”) is eligible to receive annual maintenance fees, up to approximately $20.0 million in combined milestone payments and royalties in the mid-to-high single digits.

Unless earlier terminated, this license agreement will be in effect on a country-by-country, licensed product-by-licensed product basis until the expiration, lapse, abandonment, or invalidation of the last claim of the licensed intellectual property to expire, lapse, or become abandoned or unenforceable for the applicable licensed product. Annapurna may terminate this license agreement for any reason upon six months’ prior written notice. REGENXBIO may terminate this license agreement if Annapurna is a specified number of days late in paying money due under the license agreement, or if Annapurna, its affiliates, or any sublicensees become insolvent or, effective immediately, if they commence any action against REGENEXBIO or its licensors to declare or render any claim of the licensed patent rights invalid or unenforceable. Either party may terminate this license agreement for material breach if such breach is not cured within a specified number of days.

In April 2017, the Company notified REGENXBIO that Annapurna exercised its right to terminate the license agreement for any reason upon six months’ prior written notice. The termination will be effective in October 2017.

Friedreich’s Ataxia License Agreement: In April 2014, Annapurna entered into an exclusive worldwide license to certain intellectual property related to the Friedreich’s Ataxia (“FA”) program to make, have made, use, import, sell and offer for sale licensed products using AAVrh10 for FA where the vector is administered by any route except directly to the central nervous system (“FA Systemic”). Under the terms of this license agreement, Annapurna also had an option to obtain a non-exclusive worldwide license to make, have made, use, import, sell and offer for sale licensed products using a single vector for each of FA where the vector is administered directly to the central nervous system (“FA CNS”) and FA Systemic. Under this license agreement, REGENXBIO is eligible to receive annual maintenance fees, up to $13.85 million in combined milestone fees and royalties in the mid-to-high single digits. The option to obtain a non-exclusive license to FA Systemic expired in April 2015 and the option to obtain a non-exclusive license for FA CNS expired in April 2016. Annapurna is obligated to achieve certain development milestones with respect to each licensed disease indication, including the filing of an Investigational New Drug application (“IND”) for each licensed disease indication within a specified time period, which Annapurna may extend for additional time for a specified number of extensions upon the payment of a fee.

Unless earlier terminated, this license agreement expires upon the expiration, lapse, abandonment, or invalidation of the last claim of the licensed intellectual property to expire, lapse, or become abandoned or unenforceable in all the countries of the world. Annapurna Therapeutics Limited may terminate this license agreement upon six months’ prior written notice. REGENXBIO may terminate this license agreement if Annapurna Therapeutics Limited is a specified number of days late in paying money due under the license agreement, or if Annapurna Therapeutics Limited, its affiliates, or any sublicensees become insolvent or, effective immediately, if they commence any action against REGENXBIO or its licensors to declare or render any claim of the licensed patent rights invalid or unenforceable. Either party may terminate this license agreement for material breach if such breach is not cured within a specified number of days.

During the six months ended June 30, 2017, expenses associated with the REGENXBIO agreements were $0.2 million.

Inserm Transfert—In July 2014, Annapurna entered into an agreement with Inserm Transfert (Inserm) whereby Annapurna holds an exclusive license to certain patents to develop, make, have made, use, import, offer for sale and sell or otherwise distribute products for the treatment of Friedreich’s ataxia and a non-exclusive license to certain other intellectual property related to the FA program. The agreement was amended in October 2015 to increase the scope of the intellectual property under the licenses. Under this agreement, Inserm is entitled to receive certain de minimis license payments, certain development milestone payments of up to approximately €2.0 million in the aggregate and royalties on sales in the low single-digits, subject to adjustments. No milestone payments were probable to achieve and none were recorded as of June 30, 2017.

Unless earlier terminated, this agreement will be in effect on a country-by-country, licensed product-by-licensed product basis until the later of the expiration of the last claim of the licensed intellectual property which cover the manufacture, use or sale of such product in such country or 10 years after the first commercial sale of such product in such country in which such product is sold. Upon a country-by-country and product-by-product basis, Annapurna will have a fully paid up, perpetual, irrevocable license with respect to such product in such country under the licensed intellectual property following expiration of this agreement with respect to such product in the applicable country. Annapurna may terminate this agreement upon 60 days’ prior written notice. Inserm may terminate this license agreement if Annapurna becomes the subject of a voluntary or involuntary petition in bankruptcy or fails to meet development milestones and such failure is not cured within a specified number of days. Inserm may also terminate the license granted to Annapurna in a given country if Annapurna (i) before regulatory approval of a product in any country, has ceased conducting any development of products in all countries for 12 consecutive months or (ii) after regulatory approval of a product in a given country, has ceased marketing such product in such country for 12 consecutive months.

Pursuant to the terms of the agreement with Inserm, the Company’s acquisition of Annapurna triggered a one-time payment to Inserm of €250,000, which was recorded to research and development expense in the Company’s consolidated statement of operations during the year ended December 31, 2016.

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Property and Equipment, Net

6 Months Ended

Jun. 30, 2017

Property Plant And Equipment [Abstract]

Property and Equipment, Net

7. Property and Equipment, Net

Property and equipment, net consists of the following (in thousands):

	June 30, 2017			December31,2016
Computer equipment and software	$	447		$	300
Laboratory equipment		4,838			4,285
Furniture and fixtures		552			552
Leasehold improvements		1,541			1,522
Construction in progress		64			104
Total property and equipment		7,442			6,763
Less accumulated depreciation and amortization		(3,644	)		(2,594	)
Property and equipment, net	$	3,798		$	4,169

Depreciation and amortization expense related to property and equipment for the three months ended June 30, 2017 and 2016 was $0.6 million and $0.3 million, respectively. Depreciation and amortization expense related to property and equipment for the six months ended June 30, 2017 and 2016 was $1.1 million and $0.7 million, respectively.

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Accrued Expenses and Other Current Liabilities

6 Months Ended

Jun. 30, 2017

Payables And Accruals [Abstract]

Accrued Expenses and Other Current Liabilities

8. Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consist of the following (in thousands):

	June 30, 2017		December31, 2016
Employees’ compensation expenses	$	1,363	$	2,570
Accrued preclinical costs		676		1,683
Accrued clinical and process development costs		424		1,142
Accrued professional services		501		894
Accrued contract settlement		2,000		—
Other		262		162
Total accrued expenses and other current liabilities	$	5,226	$	6,451

During the six months ended June 30, 2017, the Company accrued approximately $2.0 million of estimated costs associated with the termination of its MSA with Cornell University (see Note 6, “Significant Agreements”).

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Other Non-Current Liabilities

6 Months Ended

Jun. 30, 2017

Other Liabilities Disclosure [Abstract]

Other Non-Current Liabilities

9. Other non-current liabilities

In August 2015, Banque Publique d’Investissement (“BPI France”) granted Annapurna a €0.5 million interest free conditional advance. Payments are scheduled in equal quarterly amounts of €25,000 from September 30, 2017 to June 30, 2022. This payment schedule will be modified if the Company will receive revenue from license or product sales before advances are paid in full. The Company calculated 7% imputed interest expense on these advances that was recorded as a discount at the issuance date. The discount is amortized as an interest expense over the life of the advances. As of June 30, 2017 the carrying value of this interest-free conditional advance, which approximates its fair value, was $0.4 million, of which $0.3 million is recorded within other non-current liabilities and $0.1 million within accrued expenses and other current liabilities in the Company’s condensed consolidated balance sheets. Interest expense for this interest-free conditional advance was immaterial for the three and six months ended June 30, 2017.

In July 2016, the Company entered into a sponsored research agreement with The Alpha-1 Project, Inc. (“TAP”) to fund the Company’s A1AT research activities of up to $0.3 million, of which $0.1 million was received during the year ended December 31, 2016 (“TAP financing arrangement”). The Company may repay up to 4.5 times the received amount if and when certain product approval and sales milestones are achieved. As of June 30, 2017, the estimated fair value of the TAP financing arrangement was $0.1 million, which was recorded within other noncurrent liabilities in the Company’s condensed consolidated balance sheets.

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Commitments and Contingencies

6 Months Ended

Jun. 30, 2017

Commitments And Contingencies Disclosure [Abstract]

Commitments and Contingencies

10. Commitments and Contingencies

Facility Lease Agreement

The Company leases its office building under a non-cancelable lease agreement, which expires on May 8, 2020. The Company may extend this lease for up to four years. The lease agreement provides for an escalation of rent payments each year. The Company records rent expense on a straight-line basis over the term of the lease.

Rent expense recognized under the operating lease, including additional rent charges for utilities, parking, maintenance, and real estate taxes was $1.0 million and $1.0 million for the six months ended June 30, 2017 and 2016, respectively.

Collaborations and License Agreements

The Company is a party to various agreements, principally relating to licensed technology that requires payment of annual maintenance fees and future payments relating to milestones or royalties on future sales of specified products. The Company expenses the annual maintenance fees on a straight-line basis and accrues the aggregate balances until invoiced or paid. Through June 30, 2017, none of the goals had been achieved under the license agreements and no cash milestones were accrued or payable. Since the achievement of these milestones is not fixed and determinable, such commitments have not been included in the Company’s condensed consolidated balance sheets.

Guarantees and Indemnifications

In the normal course of business, the Company enters into contracts and agreements that contain a variety of representations and warranties and provide for indemnification for certain liabilities. The exposure under these agreements is unknown because it involves claims that may be made against the Company in the future but have not yet been made. To date, the Company has not paid any claims or been required to defend any action related to its indemnification obligations. However, the Company may record charges in the future as a result of these indemnification obligations. The Company also has indemnification obligations to its directors and executive officers for specified events or occurrences, subject to some limits, while they are serving at the Company’s request in such capacities. There have been no claims to date and the Company believes the fair value of these indemnification agreements is minimal. Accordingly, the Company has not recorded any liabilities for these agreements as of June 30, 2017.

Legal Proceedings

From time to time, the Company may become involved in litigation and other legal actions. The Company estimates the range of liability related to any pending litigation where the amount and range of loss can be estimated. The Company records its best estimate of a loss when the loss is considered probable. Where a liability is probable and there is a range of estimated loss with no best estimate in the range, the Company records a charge equal to at least the minimum estimated liability for a loss contingency when both of the following conditions are met: (i) information available prior to issuance of the financial statements indicates that it is probable that a liability had been incurred at the date of the financial statements and (ii) the range of loss can be reasonably estimated.

In July 2015, three securities class action lawsuits were filed against the Company and certain of its officers in the United States District Court for the Northern District of California, each on behalf of a purported class of persons and entities who purchased or otherwise acquired the Company’s publicly traded securities between July 31, 2014 and June 15, 2015. The lawsuits assert claims under the Exchange Act and Securities Act and allege that the defendants made materially false and misleading statements and omitted allegedly material information related to, among other things, the Phase 2a clinical trial for AVA-101 and the prospects of AVA-101. The complaints seek unspecified damages, attorneys’ fees and other costs.

In December 2015, a putative securities class action lawsuit was filed against the Company, the Company’s board of directors, underwriters of the Company’s January 13, 2015, follow-on public stock offering, and two of the Company’s institutional stockholders, in the Superior Court of the State of California for the County of San Mateo. The complaint alleges that, in connection with the Company’s follow-on stock offering, the defendants violated the Securities Act of 1933, as amended, by allegedly making materially false and misleading statements and by allegedly omitting material information related to the Phase 2a clinical trial for AVA-101 and the prospects of AVA-101. The complaint seeks unspecified compensatory and rescissory damages, attorneys’ fees and other costs. The plaintiff has dismissed the two institutional stockholder defendants.

On March 16, 2017, the Company reached an agreement to settle the asserted actions. The proposed aggregate amount of the settlement is $13.0 million, of which $1.0 million would be contributed by the Company to cover its indemnification obligations to the underwriters, and the remainder would be contributed by the Company’s insurers. The settlement is subject to definitive documentation, shareholder notice and court approval. The Company and the defendants have denied and continue to deny each and all of the claims alleged in the actions, and the settlement does not assign or reflect any admission of fault, wrongdoing or liability as to any defendant. If final court approval is not obtained with respect to the settlement or the settlement otherwise does not become effective and litigation resumes, adverse outcomes in the actions could result in substantial damages. The Company recorded $1.0 million as general and administrative expense during the three months ended March 31, 2017, when the amount and time of settlement became estimable and probable.

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Stock Plans

6 Months Ended

Jun. 30, 2017

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Stock Plans

11. Stock Plans

The Company’s  2014 Equity Incentive Award Plan (2014 Plan) permits the issuance of stock options (options), restricted stock units (RSUs) and other types of awards to employees, directors, and consultants.

As of June 30, 2017, a total of 14,834,856 shares of common stock were authorized for issuance and 1,662,588 shares were available for future grants under the 2014 Plan.

In July 2014, the Company’s board of directors and its stockholders approved the establishment of the 2014 Employee Stock Purchase Plan (2014 ESPP).  During the three and six months ended June 30, 2017 and 2016, 35,954 shares and 32,425 shares, respectively, were issued under the 2014 ESPP.  A total of 1,000,783 shares of common stock were reserved for issuance under the 2014 ESPP and were available for issuance under the 2014 ESPP as of June 30, 2017.

The following table summarizes option activity under our stock plans and related information:

						Weighted-
	Number			Weighted-		Average Remaining		Aggregate
	of Options			Average Exercise		Contractual Life		Intrinsic Value (a)
	(in thousands)			Price		(In years)		(in thousands)
Balance at December 31, 2016		7,449		$	4.46
Options granted		1,716			2.81
Options exercised		(1,235	)		0.21
Options cancelled		(262	)		12.24
Balance at June 30, 2017		7,668		$	4.51		8.3	$	7,037
Vested and expected to vest as of June 30, 2017		7,668		$	4.51		8.3	$	7,037
Exercisable as of June 30, 2017		3,404		$	4.52		7.5	$	5,045

^(a) The aggregate intrinsic value is calculated as the difference between the option exercise price and the closing price of common stock of $2.50 per share as of June 30, 2017.

The options granted during 2016, include the Company’s stock options for 3,673,940 common stock shares issued in exchange for Annapurna stock options at $0.21 exercise price per share.

The weighted-average fair values of options granted during the six months ended June 30, 2017 and 2016 were $1.96 and $1.62, respectively. The total intrinsic value of options exercised during the six months ended June 30, 2017 and 2016 were $3.2 million and $6.3 million, respectively.

The Company has recorded aggregate stock-based compensation expense related to the issuance of stock awards to employees and nonemployees in the condensed consolidated statement of operations and comprehensive loss as follows (in thousands):

	Three Months Ended				Six Months Ended
	June 30,				June 30,
	2017		2016		2017		2016
Research and development	$	1,395	$	1,912	$	2,637	$	4,140
General and administrative		848		914		1,502		2,770
Total share-based compensation	$	2,243	$	2,826	$	4,139	$	6,910

During the three and six months ended June 30, 2016, respectively, stock-based compensation expense included additional charges of $0.3 million, which was recorded within general and administrative expense, and $2.5 million, of which $1.4 million was recorded within research and development expense and $1.1 million within general and administrative expense, in the Company’s condensed consolidated statements of operations and comprehensive loss, related to stock modifications in connection with the separation agreements for two of the Company’s executive officers.

As of June 30, 2017, unrecognized compensation cost related to unvested employee options was $12.5 million, which is expected to be recognized over a weighted-average remaining period of 2.6 years.

Restricted Stock Units

Restricted stock units, or RSUs, are share awards that entitle the holder to receive freely tradable shares of our common stock upon vesting. The fair value of RSUs is based upon the closing sales price of our common stock on the grant date. RSUs granted to employees generally vest over a two to four year period.

The following table summarizes the RSUs activity under our stock plans and related information:

				Weighted-Average		Weighted-Average
	Number of			Grant-Date		Remaining
	Units (in thousands)			Fair Value (in dollars)		Contractual Term (in years)
Outstanding at December 31, 2016		1,049		$	5.47		1.7
Granted		1,966			2.72
Vested and released		(191	)		5.28
Forfeited		(331	)		3.69
Outstanding at June 30, 2017		2,493		$	3.56		1.9

The total fair value of RSUs that vested for the six months ended June 30, 2017 and 2016 was $1.0 million and $2.2 million, respectively. As of June 30, 2017, unrecognized compensation cost related to unvested RSUs was $7.3 million, which is expected to be recognized over a weighted-average remaining period of 3.2 years.

Stock Options Granted to Employees

The fair value of each option issued to employees was estimated at the date of grant using the Black-Scholes valuation model with the following weighted-average assumptions:

	Three Months Ended						Six Months Ended
	June 30,						June 30,
	2017			2016			2017			2016
Option grants:
Expected volatility		81	%		81	%		81	%		81	%
Expected term (in years)		5.7			5.9			6.0			5.9
Expected dividend yield		—			—			—			—
Risk-free interest rate		1.9	%		1.3	%		1.9	%		1.3	%

Stock Options Granted to Non-Employees

Stock-based compensation related to options granted to non-employees is measured and recognized as the options are earned. The Company believes that the estimated fair value of the options is more readily measurable than the fair value of the services rendered. The following weighted-average assumptions were used in estimating non-employees’ stock-based compensation expenses:

	Three Months Ended						Six Months Ended
	June 30,						June 30,
	2017			2016			2017			2016
Option grants:
Expected volatility		82	%		84	%		82	%		83	%
Expected term (in years)		9.0			8.0			9.0			7.5
Expected dividend yield					—						—
Risk-free interest rate		2.2	%		1.6	%		2.3	%		1.6	%

As of June 30, 2017, unrecognized stock-based compensation expense related to non-employees’ options was $0.6 million, which was expected to be recognized over a weighted-average remaining period of 1.9 years.

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401(k) Savings Plan

6 Months Ended

Jun. 30, 2017

Postemployment Benefits [Abstract]

401(k) Savings Plan

12. 401(k) Savings Plan

The Company established a defined-contribution savings plan under Section 401(k) of the Code (the 401(k) Plan). The 401(k) Plan covers all employees who meet defined minimum age and service requirements, and allows participants to defer a portion of their annual compensation on a pretax basis. For the six months ended June 30, 2017 and 2016, the Company contributed $0.2 million and $0.2 million to the 401(k) Plan, respectively.

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Net Loss per Share

6 Months Ended

Jun. 30, 2017

Earnings Per Share [Abstract]

Net Loss per Share

13. Net Loss per Share

Basic net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock outstanding for the period. Diluted net loss per share attributable is computed by giving effect to all potential dilutive common stock equivalents outstanding for the period. Diluted net loss per share is the same as basic net loss per share for all periods presented, since the effects of potentially dilutive securities are antidilutive.

We have excluded warrants and equity awards to purchase approximately 10.3 million and 9.9 million shares of our common stock that were outstanding as of June 30, 2017 and 2016, respectively, in the computation of diluted net loss per share attributable to common stockholders because their effect was antidilutive.

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Summary of Significant Accounting Policies (Policies)

6 Months Ended

Jun. 30, 2017

Accounting Policies [Abstract]

Recently-Issued and Not Yet Adopted Accounting Pronouncements

Recently-Issued and Not Yet Adopted Accounting Pronouncements —In May 2014, the FASB issued ASU No. 2014-09, Revenue from Contracts with Customers (Topic 606), which supersedes the revenue recognition requirements in ASC 605, Revenue Recognition. This ASU is based on the principle that revenue is recognized to depict the transfer of goods or services to customers in an amount that reflects the consideration to which the entity expects to be entitled in exchange for those goods or services. ASU 2014-09 defines a five step process to achieve this core principle and, in doing so, it is possible more judgment and estimates may be required within the revenue recognition process than required under existing GAAP including identifying performance obligations in the contract, estimating the amount of variable consideration to include in the transaction price and allocating the transaction price to each separate performance obligation. ASU 2014-09 is required to be adopted, using either of two methods: (i) retrospective to each prior reporting period presented with the option to elect certain practical expedients as defined within ASU 2014-09; or (ii) retrospective with the cumulative effect of initially applying ASU 2014-09 recognized at the date of initial application and providing certain additional disclosures. In July 2015, the FASB voted to approve a one-year deferral of the effective date to December 15, 2017 for interim and annual reporting periods beginning after that date and permitted early adoption of the standard, but not before the original effective date of December 15, 2016. The FASB issued supplemental adoption guidance and clarification to ASU 2014-09 in March 2016, April 2016, May 2016 and December 2016 within ASU 2016-08 Revenue From Contracts With Customers: Principal vs. Agent Considerations, ASU 2016-10 Revenue From Contracts with Customers: Identifying Performance Obligations and Licensing, ASU 2016-12 Revenue from Contracts with Customers: Narrow-Scope Improvements and Practical Expedients and ASU 2016-20 Technical Corrections and Improvement to Topic 606 – Revenue from Contracts with Customers, respectively. The ASU will be effective for the Company in the first quarter of 2018. Preliminarily, the Company intends to adopt the new standard in the first quarter of 2018 using the retrospective approach noted in (ii) above. The Company is currently evaluating the impact of the adoption of this standard on its condensed consolidated financial statements and related disclosures.

In January 2016, the FASB issued ASU No. 2016-01, Recognition and Measurement of Financial Assets and Financial Liabilities, which amends the current guidance on the classification and measurement of financial instruments. Although this ASU retains many current requirements, it significantly revises an entity’s accounting related to (i) the classification and measurement of investments in equity securities and (ii) the presentation of certain fair value changes for financial liabilities measured at fair value. This ASU also amends certain disclosure requirements associated with the fair value of financial instruments. The new standard is effective for fiscal years and interim periods within those fiscal years beginning after December 15, 2017, with early adoption permitted for certain changes. This ASU will be effective for the Company in the first quarter of 2018 and must be adopted using a modified retrospective approach, with certain exceptions. The adoption of this standard is not expected to have a significant impact on the Company’s condensed consolidated financial statements and related disclosures.

In February 2016, the FASB issued ASU No. 2016-2, Leases, which amends the current guidance on leasing activities to provide more transparency and comparability, and requires that all leases be recognized by lessees on their balance sheet as a right-of-use asset and corresponding lease liability, which are currently accounted for as operating leases. The new standard is effective for fiscal years and interim periods within those fiscal years beginning after December 15, 2018, with early adoption permitted. This ASU will be effective for the Company in the first quarter of 2019 and must be adopted using a modified retrospective transition approach. The company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of this standard on its condensed consolidated financial statements and related disclosures.

In June 2016, the FASB issued ASU No. 2016-13 Measurement of Credit Losses on Financial Instruments. This ASU requires measurement and recognition of expected credit losses for financial assets held. The new standard is effective for fiscal years beginning after December 15, 2020 and interim periods beginning after December 15, 2021 with early adoption permitted beginning in the first quarter of 2019. This ASU will be effective for the Company in the first quarter of 2021 and must be adopted using a modified retrospective approach, with certain exceptions. The Company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of this standard on its condensed consolidated financial statements and related disclosures.

In August 2016, the FASB issued ASU No. 2016-15, Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and Cash Payments, which clarifies the presentation and classification of certain cash receipts and cash payments in the statement of cash flows. This ASU is effective for annual reporting periods beginning after December 15, 2017, and interim periods within that reporting period. Early adoption is permitted. This ASU will be effective for the Company in the first quarter of 2018. The Company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of this standard on its condensed consolidated financial statements and related disclosures.

In November 2016, the FASB issued ASU No. 2016-18, Statement of Cash Flows (Topic 230): Restricted Cash, which provides amendments to current guidance to address the classification and presentation of changes in restricted cash in the statement of cash flows. This ASU is effective for annual reporting periods beginning after December 15, 2017, and interim periods within that reporting period. Early adoption is permitted. This ASU will be effective for the Company in the first quarter of 2018. The Company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of these standards on its condensed consolidated financial statements and related disclosures.

In May 2017, the FASB issued ASU No. 2017-09, Scope of Modification Accounting, which provides amendments to the current guidance for modification accounting. This ASU clarifies that an entity should account for the effects of a modification unless all the following criteria are met: (1) the fair value of the modified award is the same as the fair value of the original award immediately before the original award is modified, (2) the vesting conditions of the modified award are the same as the vesting conditions of the original award immediately before the original award is modified, and (3) the classification of the modified award as an equity instrument or a liability instrument is the same as the classification of the original award immediately before the original award is modified. This ASU is effective for annual reporting periods beginning after December 15, 2017, and interim periods within that reporting period. Early adoption is permitted. This ASU will be effective for the Company in the first quarter of 2018. The Company has not yet determined whether it will elect early adoption and is currently evaluating the impact of the adoption of these standards on its condensed consolidated financial statements and related disclosures.

The Company has reviewed other recent accounting pronouncements and concluded they are either not applicable to the business or no material effect is expected on the consolidated financial statements as a result of future adoption.

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Acquisition of Annapurna (Tables)

6 Months Ended

Jun. 30, 2017

Business Combinations [Abstract]

Summary of Total Purchase Price Consideration Estimated

Total purchase price consideration was estimated as follows (in thousands):

Fair value of common shares issued	$	58,321
Fair value of the Company's common share options    exchanged for Annapurna stock options and other awards    attributable to pre-combination services		7,422
Less: value of common stock and options accelerated    vesting at the closing date		(898	)
Total purchase price consideration	$	64,845

Components of Allocation of Total Purchase Price Consideration

The allocation of total purchase price consideration is as follows (in thousands):

Cash	$	3,449
Prepaid expenses and other assets		865
Property and equipment		185
Acquired intangible assets		16,200
Goodwill		49,514
Accounts payable		(1,118	)
Accrued liabilities		(1,848	)
Other noncurrent liabilities		(377	)
Deferred tax liabilities		(2,025	)
Total purchase price allocation	$	64,845

Summary of Identifiable Intangible Assets Acquired

The identifiable intangible assets acquired consist of IPR&D assets related to products in development, as summarized in the table below (in thousands):

IPR&D - Alpha-1 antitrypsin deficiency	$	11,700
IPR&D - Hereditary angioedema		4,500
Total acquired intangible assets	$	16,200

Schedule of Pro Forma Financial Information

The following table presents the unaudited pro forma results for the three and six months ended June 30, 2016 (in thousands, except per share data).

	Three Months Ended June 30,			Six Months Ended June 30,
	2016			2016
Pro forma information
Collaboration revenue	$	307		$	572
Net loss	$	(62,572	)	$	(80,846	)
Basic and diluted loss per share	$	(1.52	)	$	(1.97	)

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Cash Equivalents and Short-Term Investments (Tables)

6 Months Ended

Jun. 30, 2017

Cash And Cash Equivalents [Abstract]

Summary of Available-for-Sale Securities

The following is a summary of the Company’s available-for-sale securities as of June 30, 2017 (in thousands):  

	June 30, 2017
	Amortized Cost Basis			Unrealized Gains		Unrealized Loses			Estimated Fair Value
Money market funds	$	3,003		$	—	$	—		$	3,003
Certificates of deposit		11,967			—		—			11,967
Commercial paper		50,947			—		—			50,947
U.S. government agency		63,262			1		(76	)		63,187
Corporate bonds		66,142			—		(62	)		66,080
Total cash equivalents and    short-term investments		195,321			1		(138	)		195,184
Less: cash equivalents		(37,289	)		—		—			(37,289	)
Total short-term investments	$	158,032		$	1	$	(138	)	$	157,895

Summary of Cost and Estimated Fair Value of Available-for-Sale Securities Based on Stated Effective Maturities

The following table is a summary of the cost and estimated fair value of the Company’s available-for-sale securities based on stated effective maturities as of June 30, 2017 (in thousands):

	June 30, 2017
	Amortized Cost Basis		Estimated Fair Value
Mature within one year	$	160,946	$	160,870
Mature after one year to three years		34,375		34,314
Total cash equivalents and short-term    investments	$	195,321	$	195,184

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Fair Value Measurements and Fair Value of Financial Instruments (Tables)

6 Months Ended

Jun. 30, 2017

Fair Value Disclosures [Abstract]

Financial Assets Measured and Recognized at Fair Value on Recurring Basis

The following table summarizes, for assets recorded at fair value on a recurring basis, the respective fair value and the classification by level of input within the fair value hierarchy as described above (in thousands):

			Quoted Prices		Significant Other		Significant
	Total		In Active Markets		Observable Inputs		Unobservable Inputs
	Carrying Value		(Level 1)		(Level 2)		(Level 3)
June 30, 2017
Assets:
Money market funds	$	3,003	$	3,003	$	—	$	—
Certificates of deposit		11,967		—		11,967		—
Commercial paper		50,947		—		50,947		—
U.S. government agency		63,187		—		63,187		—
Corporate bonds		66,080		—		66,080		—
Total cash equivalents and short    term investments	$	195,184	$	3,003	$	192,181	$	—
Other noncurrent liability:
Financing arrangement	$	74	$	—	$	—	$	74
December 31, 2016
Assets:
Money market funds	$	215,916	$	215,916	$	—	$	—
Total cash equivalents	$	215,916	$	215,916	$	—	$	—
Other noncurrent liability:
Financing arrangement	$	74	$	—	$	—	$	74

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Property and Equipment, Net (Tables)

6 Months Ended

Jun. 30, 2017

Property Plant And Equipment [Abstract]

Schedule of Property and Equipment, Net

Property and equipment, net consists of the following (in thousands):

	June 30, 2017			December31,2016
Computer equipment and software	$	447		$	300
Laboratory equipment		4,838			4,285
Furniture and fixtures		552			552
Leasehold improvements		1,541			1,522
Construction in progress		64			104
Total property and equipment		7,442			6,763
Less accumulated depreciation and amortization		(3,644	)		(2,594	)
Property and equipment, net	$	3,798		$	4,169

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Accrued Expenses and Other Current Liabilities (Tables)

6 Months Ended

Jun. 30, 2017

Payables And Accruals [Abstract]

Schedule of Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consist of the following (in thousands):

	June 30, 2017		December31, 2016
Employees’ compensation expenses	$	1,363	$	2,570
Accrued preclinical costs		676		1,683
Accrued clinical and process development costs		424		1,142
Accrued professional services		501		894
Accrued contract settlement		2,000		—
Other		262		162
Total accrued expenses and other current liabilities	$	5,226	$	6,451

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Stock Plans (Tables)

6 Months Ended

Jun. 30, 2017

Stock-Based Compensation Expense Related to Issuance of Stock Awards to Employees and Nonemployees

The Company has recorded aggregate stock-based compensation expense related to the issuance of stock awards to employees and nonemployees in the condensed consolidated statement of operations and comprehensive loss as follows (in thousands):

	Three Months Ended				Six Months Ended
	June 30,				June 30,
	2017		2016		2017		2016
Research and development	$	1,395	$	1,912	$	2,637	$	4,140
General and administrative		848		914		1,502		2,770
Total share-based compensation	$	2,243	$	2,826	$	4,139	$	6,910

Summary of Restricted Stock Units Activity

The following table summarizes the RSUs activity under our stock plans and related information:

				Weighted-Average		Weighted-Average
	Number of			Grant-Date		Remaining
	Units (in thousands)			Fair Value (in dollars)		Contractual Term (in years)
Outstanding at December 31, 2016		1,049		$	5.47		1.7
Granted		1,966			2.72
Vested and released		(191	)		5.28
Forfeited		(331	)		3.69
Outstanding at June 30, 2017		2,493		$	3.56		1.9

Schedule of Fair Value of Option Issued to Employees Valuation Assumptions

The fair value of each option issued to employees was estimated at the date of grant using the Black-Scholes valuation model with the following weighted-average assumptions:

	Three Months Ended						Six Months Ended
	June 30,						June 30,
	2017			2016			2017			2016
Option grants:
Expected volatility		81	%		81	%		81	%		81	%
Expected term (in years)		5.7			5.9			6.0			5.9
Expected dividend yield		—			—			—			—
Risk-free interest rate		1.9	%		1.3	%		1.9	%		1.3	%

Non Employee Stock Option [Member]

Schedule of Non-Employees Stock Purchase Plan Valuation Assumptions

The following weighted-average assumptions were used in estimating non-employees’ stock-based compensation expenses:

	Three Months Ended						Six Months Ended
	June 30,						June 30,
	2017			2016			2017			2016
Option grants:
Expected volatility		82	%		84	%		82	%		83	%
Expected term (in years)		9.0			8.0			9.0			7.5
Expected dividend yield					—						—
Risk-free interest rate		2.2	%		1.6	%		2.3	%		1.6	%

2006 and 2014 Equity Incentive Plan [Member]

Summary of Stock Options Activity

The following table summarizes option activity under our stock plans and related information:

						Weighted-
	Number			Weighted-		Average Remaining		Aggregate
	of Options			Average Exercise		Contractual Life		Intrinsic Value (a)
	(in thousands)			Price		(In years)		(in thousands)
Balance at December 31, 2016		7,449		$	4.46
Options granted		1,716			2.81
Options exercised		(1,235	)		0.21
Options cancelled		(262	)		12.24
Balance at June 30, 2017		7,668		$	4.51		8.3	$	7,037
Vested and expected to vest as of June 30, 2017		7,668		$	4.51		8.3	$	7,037
Exercisable as of June 30, 2017		3,404		$	4.52		7.5	$	5,045

^(a) The aggregate intrinsic value is calculated as the difference between the option exercise price and the closing price of common stock of $2.50 per share as of June 30, 2017.

XML

Organization and Basis of Presentation - Additional Information (Detail) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2017	Dec. 31, 2016
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Date of incorporation	Jul. 17, 2006
Change of entity name date	May 11, 2016
Accumulated deficit	$ (225,444)	$ (197,915)

XML

Acquisition of Annapurna - Additional Information (Detail) $ / shares in Units, $ in Thousands		1 Months Ended	3 Months Ended		6 Months Ended		12 Months Ended
	May 11, 2016 USD ($) Segment $ / shares shares	May 31, 2016 USD ($)	Jun. 30, 2017	Jun. 30, 2016 USD ($)	Jun. 30, 2017	Jun. 30, 2016 USD ($)	Dec. 31, 2016 USD ($)
Business Acquisition [Line Items]
Total purchase price consideration						$ 64,845
Stock Options [Member]
Business Acquisition [Line Items]
Expected volatility			81.00%	81.00%	81.00%	81.00%
Risk-free interest rate			1.90%	1.30%	1.90%	1.30%
Expected term (in years)			5 years 8 months 12 days	5 years 10 months 25 days	6 years	5 years 10 months 25 days
Non Employee Stock Option [Member]
Business Acquisition [Line Items]
Expected volatility			82.00%	84.00%	82.00%	83.00%
Risk-free interest rate			2.20%	1.60%	2.30%	1.60%
Expected term (in years)			9 years	8 years	9 years	7 years 6 months
Annapurna Therapeutics SAS [Member]
Business Acquisition [Line Items]
Date of acquisition					May 11, 2016
Total purchase price consideration	$ 64,845
Fair value of awards related to accelerated vesting of options and shares	$ 900
Common stock exchange ratio			9.54655		9.54655
Goodwill, description					Goodwill represented expected synergies of two combined companies.
Acquisition costs				$ 600		$ 2,500
Fair value, discounted rate	11.00%
Goodwill	$ 49,514
Number of reporting unit | Segment	1
Interest expense related to convertible notes and changes in fair value of preferred stock warrants				500		1,000
Bonuses paid		$ 400
Annapurna Therapeutics SAS [Member] | IPR&D [Member]
Business Acquisition [Line Items]
Impairment of intangible assets							$ 11,200
Annapurna Therapeutics SAS [Member] | Stock Options [Member]
Business Acquisition [Line Items]
Shares reserved for future exercise of stock options | shares	3,673,940
Fair value of estimated stock options and stock-based awards at acquisition	$ 14,700
Dividends	0.00%
Expected volatility	80.00%
Risk-free interest rate	1.40%
Expected term (in years)	6 years
Fair value of stock options attributed as pre-combination service and included as part of acquisition consideration	$ 7,400
Fair value of stock options post-combination attribution recognized as compensation expense	$ 7,200
Stock-based compensation expense related to vesting of stock options				900
Annapurna Therapeutics SAS [Member] | Stock Options [Member] | Executives [Member]
Business Acquisition [Line Items]
Stock-based compensation expense related to vesting of stock options				$ 100		$ 200
Annapurna Therapeutics SAS [Member] | Non Employee Stock Option [Member]
Business Acquisition [Line Items]
Dividends	0.00%
Expected volatility	89.00%
Risk-free interest rate	1.10%
Expected term (in years)	10 years
Annapurna Therapeutics SAS [Member] | Common Shares [Member]
Business Acquisition [Line Items]
Number of shares issued to acquired an entity | shares	14,087,246
Share price of common stock on date of acquisition | $ / shares	$ 4.14

XML

Acquisition of Annapurna - Summary of Total Purchase Price Consideration Estimated (Detail) - USD ($) $ in Thousands		6 Months Ended
	May 11, 2016	Jun. 30, 2016
Business Acquisition [Line Items]
Total purchase price consideration		$ 64,845
Annapurna Therapeutics SAS [Member]
Business Acquisition [Line Items]
Less: value of common stock and options accelerated vesting at the closing date	$ (898)
Total purchase price consideration	64,845
Annapurna Therapeutics SAS [Member] | Common Shares [Member]
Business Acquisition [Line Items]
Fair value of common shares issued/common share options exchanged	58,321
Annapurna Therapeutics SAS [Member] | Common Shares [Member] | Stock Options [Member]
Business Acquisition [Line Items]
Fair value of common shares issued/common share options exchanged	$ 7,422

XML

Acquisition of Annapurna - Components of Allocation of Total Purchase Price Consideration (Detail) - Annapurna Therapeutics SAS [Member] $ in Thousands	May 11, 2016 USD ($)
Business Acquisition [Line Items]
Cash	$ 3,449
Prepaid expenses and other assets	865
Property and equipment	185
Acquired intangible assets	16,200
Goodwill	49,514
Accounts payable	(1,118)
Accrued liabilities	(1,848)
Other noncurrent liabilities	(377)
Deferred tax liabilities	(2,025)
Total purchase price allocation	$ 64,845

XML

Acquisition of Annapurna - Summary of Identifiable Intangible Assets Acquired (Detail) - Annapurna Therapeutics SAS [Member] $ in Thousands	May 11, 2016 USD ($)
Acquired Indefinite Lived Intangible Assets [Line Items]
Acquired intangible assets	$ 16,200
IPR&D [Member]
Acquired Indefinite Lived Intangible Assets [Line Items]
Acquired intangible assets	16,200
IPR&D [Member] | Alpha-1 Antitrypsin Deficiency [Member]
Acquired Indefinite Lived Intangible Assets [Line Items]
Acquired intangible assets	11,700
IPR&D [Member] | Hereditary Angioedema [Member]
Acquired Indefinite Lived Intangible Assets [Line Items]
Acquired intangible assets	$ 4,500

XML

Acquisition of Annapurna - Schedule of Pro Forma Financial Information (Detail) - Annapurna Therapeutics SAS [Member] - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended	6 Months Ended
	Jun. 30, 2016	Jun. 30, 2016
Pro forma information
Collaboration revenue	$ 307	$ 572
Net loss	$ (62,572)	$ (80,846)
Basic and diluted loss per share	$ (1.52)	$ (1.97)

XML

Cash Equivalents and Short-Term Investments - Summary of Available-for-Sale Securities (Detail) $ in Thousands	Jun. 30, 2017 USD ($)
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost Basis	$ 158,032
Unrealized Gains	1
Unrealized Loses	(138)
Estimated Fair Value	157,895
Less: Cash Equivalents, Amortized Cost Basis	(37,289)
Less: Cash Equivalents, Unrealized Gains	0
Less: Cash Equivalents, Estimated Fair Value	(37,289)
Money Market Funds [Member]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost Basis	3,003
Estimated Fair Value	3,003
Certificates of Deposit [Member]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost Basis	11,967
Estimated Fair Value	11,967
Commercial Paper [Member]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost Basis	50,947
Estimated Fair Value	50,947
U.S. Government Agency [Member]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost Basis	63,262
Unrealized Gains	1
Unrealized Loses	(76)
Estimated Fair Value	63,187
Corporate Bonds [Member]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost Basis	66,142
Unrealized Loses	(62)
Estimated Fair Value	66,080
Total Cash Equivalents and Short-term Investments [Member]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost Basis	195,321
Unrealized Gains	1
Unrealized Loses	(138)
Estimated Fair Value	$ 195,184

XML

Cash Equivalents and Short-Term Investments - Summary of Cost and Estimated Fair Value of Available-for-Sale Securities Based on Stated Effective Maturities (Detail) $ in Thousands	Jun. 30, 2017 USD ($)
Investments Debt And Equity Securities [Abstract]
Amortized Cost Basis, Mature within one year	$ 160,946
Amortized Cost Basis, Mature after one year to three years	34,375
Amortized Cost Basis, Total cash equivalents and short-term investments	195,321
Estimated Fair Value, Mature within one year	160,870
Estimated Fair Value, Mature after one year to three years	34,314
Estimated Fair Value, Total cash equivalents and short-term investments	$ 195,184

XML

Cash Equivalents and Short-Term Investments - Additional Information (Detail)	Jun. 30, 2017 USD ($)
Available For Sale Securities [Abstract]
Gross unrealized losses on available-for-sale-securities temporary	$ 100,000
Available-for-sale securities other-than-temporarily impaired	$ 0

XML

Fair Value Measurements and Fair Value of Financial Instruments - Additional Information (Detail) - USD ($)	3 Months Ended	6 Months Ended
	Jun. 30, 2017	Jun. 30, 2017
Fair Value Disclosures [Abstract]
Liabilities transferred within Level 3	$ 0	$ 0

XML

Fair Value Measurements and Fair Value of Financial Instruments - Financial Assets Measured and Recognized at Fair Value on Recurring Basis (Detail) - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
Assets:
Assets	$ 195,184	$ 215,916
Corporate Bonds [Member]
Assets:
Assets	66,080
Financing Arrangement [Member]
Other noncurrent liability:
Other noncurrent liability	74	74
Money Market Funds [Member]
Assets:
Assets	3,003	215,916
Commercial Paper [Member]
Assets:
Assets	50,947
Certificates of Deposit [Member]
Assets:
Assets	11,967
US Government Agency [Member]
Assets:
Assets	63,187
Quoted Prices in Active Markets (Level 1) [Member]
Assets:
Assets	3,003	215,916
Quoted Prices in Active Markets (Level 1) [Member] | Money Market Funds [Member]
Assets:
Assets	3,003	215,916
Significant Other Observable Inputs (Level 2) [Member]
Assets:
Assets	192,181
Significant Other Observable Inputs (Level 2) [Member] | Corporate Bonds [Member]
Assets:
Assets	66,080
Significant Other Observable Inputs (Level 2) [Member] | Commercial Paper [Member]
Assets:
Assets	50,947
Significant Other Observable Inputs (Level 2) [Member] | Certificates of Deposit [Member]
Assets:
Assets	11,967
Significant Other Observable Inputs (Level 2) [Member] | US Government Agency [Member]
Assets:
Assets	63,187
Significant Unobservable Inputs (Level 3) [Member] | Financing Arrangement [Member]
Other noncurrent liability:
Other noncurrent liability	$ 74	$ 74

XML

Significant Agreements - Additional Information (Detail)		1 Months Ended									6 Months Ended	12 Months Ended
	Feb. 23, 2017	Apr. 30, 2017	Dec. 31, 2016 Agreement	Aug. 31, 2016 USD ($)	Dec. 31, 2015 USD ($) Agreement	Oct. 31, 2015 USD ($)	Oct. 31, 2015 EUR (€)	May 31, 2014 USD ($) Target	Apr. 30, 2014 USD ($)	May 31, 2010 USD ($)	Jun. 30, 2017 USD ($)	Dec. 31, 2016 USD ($)	Dec. 31, 2016 EUR (€)
Regeneron Corporation [Member]
License Agreement [Line Items]
Agreement termination scenario description											Regeneron may terminate the agreement for convenience at any time on a target by target basis or in totality upon a 30-day notice.Each party can terminate the agreement if another party commits a material breach or material default in performance of its obligations and such breach or default is not cured within 60 days.The agreement is automatically terminated upon initiation of any bankruptcy proceedings, reorganization or dissolution of either party.The Company can terminate the agreement upon 30-day notice if Regeneron challenges the validity, scope or enforceability of any Company patent.
Potential target of collaborations | Target								8
Initial collaboration term								3 years
Additional collaboration term								5 years
Collaboration fee for exclusive worldwide license per target								$ 2,000,000
Potential milestone earnings								640,000,000
Reimbursement of research and development expense											35.00%
Collaboration agreement extension period	3 years
Collaboration agreement expiration date	May 01, 2020
Regeneron Corporation [Member] | Development and Regulatory Milestone [Member]
License Agreement [Line Items]
Potential milestone earnings								$ 80,000,000
University of California [Member]
License Agreement [Line Items]
Right and option to extend date to meet milestone, period										6 months
Right and option to extend date to meet milestone, description											The Company has the right and option to extend the date by which it must meet any milestone by six-months up to two times by paying an extension fee for each such extension.
License fee paid										$ 100,000
Aggregate amount of milestone payments for one indication										900,000
Additional milestone payments recognized											$ 0
Non-royalty licensing revenue, description											mid-teen percentage
Agreement termination scenario description											The Company may terminate this agreement without cause at any time upon 30 days’ prior written notice to the Regents. The Regents may terminate this agreement for a breach by the Company that remains uncured for 60 days, if the Company becomes insolvent, if the Company directly or through a third party files a claim that a licensed patent right is invalid or unenforceable or if the Company fails to meet or extend the date for meeting certain diligence milestones.
License agreement termination notice period											30 days
University of California [Member] | Maximum [Member]
License Agreement [Line Items]
Additional milestone payments for up to two additional indications										500,000
University of California [Member] | Minimum [Member]
License Agreement [Line Items]
Annual royalty payment										$ 50,000
Editas Medicine Inc [Member]
License Agreement [Line Items]
Non-refundable upfront payment received												$ 1,000,000
Non-refundable upfront payment, obligation to fund research and development costs												$ 500,000
Collaboration, option and license agreement fee receivable per indication				$ 1,000,000
Range of tiered royalties receivable on net sales											between the mid-single digits and low teens
Editas Medicine Inc [Member] | Maximum [Member]
License Agreement [Line Items]
Potential milestone earnings				$ 15,500,000
Cornell University [Member]
License Agreement [Line Items]
Agreement termination scenario description											Annapurna may terminate any of these license agreements for convenience upon ninety days written notice. Cornell may terminate any of the license agreements for material breach if such breach is not cured within a specified number of days. Cornell may also terminate the HAE License Agreement and/or the Allergy License Agreement if Annapurna commences any action and files a written claim asserting that any portion of the licensed patent rights is invalid or unenforceable.
License agreement termination notice period											90 days
Number of license agreements | Agreement			3		3
Service fees payable					$ 13,300,000
Service fees, payable period					4 years
Aggregate milestone payments and royalties on sales											$ 16,000,000
Cornell University [Member] | Consultant [Member]
License Agreement [Line Items]
Annual compensation											300,000
Cornell University [Member] | Master Service Agreement [Member]
License Agreement [Line Items]
Estimated costs associated with the termination											2,000,000
Agreement termination effective date			Jan. 06, 2017
Cornell University [Member] | Maximum [Member]
License Agreement [Line Items]
Annual maintenance fee payable											300,000
Cornell University [Member] | Minimum [Member]
License Agreement [Line Items]
Annual maintenance fee payable											$ 30,000
REGENXBIO [Member]
License Agreement [Line Items]
Agreement termination scenario description											Annapurna Therapeutics Limited may terminate this license agreement upon six months’ prior written notice. REGENXBIO may terminate this license agreement if Annapurna Therapeutics Limited is a specified number of days late in paying money due under the license agreement, or if Annapurna Therapeutics Limited, its affiliates, or any sublicensees become insolvent or, effective immediately, if they commence any action against REGENXBIO or its licensors to declare or render any claim of the licensed patent rights invalid or unenforceable. Either party may terminate this license agreement for material breach if such breach is not cured within a specified number of days.
License agreement termination notice period											6 months
Expenses associated with license agreement											$ 200,000
REGENXBIO [Member] | A1AT Deficiency/Allergy License Agreement [Member]
License Agreement [Line Items]
Agreement termination scenario description											Annapurna may terminate this license agreement for any reason upon six months’ prior written notice. REGENXBIO may terminate this license agreement if Annapurna is a specified number of days late in paying money due under the license agreement, or if Annapurna, its affiliates, or any sublicensees become insolvent or, effective immediately, if they commence any action against REGENEXBIO or its licensors to declare or render any claim of the licensed patent rights invalid or unenforceable. Either party may terminate this license agreement for material breach if such breach is not cured within a specified number of days.
License agreement termination notice period											6 months
Aggregate milestone payments and royalties on sales						$ 20,000,000
License agreement termination effective date		2017-10
REGENXBIO [Member] | Friedreich's Ataxia License Agreement [Member]
License Agreement [Line Items]
Aggregate milestone payments and royalties on sales									$ 13,850,000
Inserm Transfert [Member]
License Agreement [Line Items]
Additional milestone payments recognized											$ 0
Agreement termination scenario description											Annapurna may terminate this agreement upon 60 days’ prior written notice. Inserm may terminate this license agreement if Annapurna becomes the subject of a voluntary or involuntary petition in bankruptcy or fails to meet development milestones and such failure is not cured within a specified number of days. Inserm may also terminate the license granted to Annapurna in a given country if Annapurna (i) before regulatory approval of a product in any country, has ceased conducting any development of products in all countries for 12 consecutive months or (ii) after regulatory approval of a product in a given country, has ceased marketing such product in such country for 12 consecutive months.
License agreement termination notice period											60 days
Aggregate milestone payments and royalties on sales | €							€ 2,000,000
Inserm Transfert [Member] | Research and Development Expense [Member]
License Agreement [Line Items]
One-time payment due to termination of license agreement | €													€ 250,000

XML

Property and Equipment, Net - Schedule of Property and Equipment, Net (Detail) - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
Property, Plant and Equipment [Line Items]
Total property and equipment	$ 7,442	$ 6,763
Less accumulated depreciation and amortization	(3,644)	(2,594)
Property and equipment, net	3,798	4,169
Computer Equipment and Software [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment	447	300
Laboratory Equipment [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment	4,838	4,285
Furniture and Fixtures [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment	552	552
Leasehold Improvements [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment	1,541	1,522
Construction in Progress [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment	$ 64	$ 104

XML

Property and Equipment, Net - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Property Plant And Equipment [Abstract]
Depreciation and amortization expense	$ 600	$ 300	$ 1,056	$ 663

XML

Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
Accrued Expenses And Other Current Liabilities [Abstract]
Employees’ compensation expenses	$ 1,363	$ 2,570
Accrued preclinical costs	676	1,683
Accrued clinical and process development costs	424	1,142
Accrued professional services	501	894
Accrued contract settlement	2,000
Other	262	162
Total accrued expenses and other current liabilities	$ 5,226	$ 6,451

XML

Accrued Expenses and Other Current Liabilities - Additional Information (Detail) $ in Millions	6 Months Ended
	Jun. 30, 2017 USD ($)
Cornell University [Member] | Master Service Agreement [Member]
Accrued Expenses And Other Current Liabilities [Line Items]
Estimated costs associated with the termination	$ 2.0

XML

Other Non-Current Liabilities - Additional Information (Detail)	1 Months Ended	6 Months Ended	12 Months Ended
	Jul. 31, 2016 USD ($)	Jun. 30, 2017 EUR (€)	Dec. 31, 2016 USD ($)	Jun. 30, 2017 USD ($)	Aug. 31, 2015 EUR (€)
Line Of Credit Facility [Line Items]
Financing arrangement included in other noncurrent liabilities			$ 386,000	$ 369,000
The Alpha-1 Project, Inc. [Member]
Line Of Credit Facility [Line Items]
Proceeds from financing arrangement			$ 100,000
Financing arrangement included in other noncurrent liabilities				$ 100,000
The Alpha-1 Project, Inc. [Member] | Maximum [Member]
Line Of Credit Facility [Line Items]
Potential milestone earnings	$ 300,000
Expected percentage of milestone repayments	450.00%
BPI France [Member]
Line Of Credit Facility [Line Items]
Interest free conditional advance, maximum borrowing capacity | €					€ 500,000
Interest free conditional advance, frequency of payments		Quarterly
Interest free conditional advance, periodic payment | €		€ 25,000
Interest free conditional advance, beginning date of periodic payment		Sep. 30, 2017
Interest free conditional advance, ending date of periodic payment		Jun. 30, 2022
Interest free conditional advance, imputed interest rate				7.00%
Interest free conditional advance				$ 400,000
BPI France [Member] | Other Noncurrent Liabilities [Member]
Line Of Credit Facility [Line Items]
Interest free conditional advance				300,000
BPI France [Member] | Accrued Expenses and Other Current Liabilities [Member]
Line Of Credit Facility [Line Items]
Interest free conditional advance				$ 100,000

XML

Commitments and Contingencies - Additional Information (Detail)		1 Months Ended		3 Months Ended			6 Months Ended
	Mar. 16, 2017 USD ($)	Dec. 31, 2015 Claim	Jul. 31, 2015 Claim	Jun. 30, 2017 USD ($)	Mar. 31, 2017 USD ($)	Jun. 30, 2016 USD ($)	Jun. 30, 2017 USD ($) Claim	Jun. 30, 2016 USD ($)
Other Commitments [Line Items]
Lease renewal term							4 years
Lease expiration date							May 08, 2020
Rent expense							$ 1,000,000	$ 1,000,000
Accrued royalties				$ 0			0
Claims paid to date related to indemnification issues							$ 0
Number of claims to date | Claim		1	3				0
Accruals or expenses related to indemnification issues							$ 0
Proposed aggregate amount of settlement	$ 13,000,000
General and administrative expense				$ 4,064,000		$ 5,114,000	$ 12,053,000	$ 13,432,000
Indemnification Obligations [Member]
Other Commitments [Line Items]
Proposed aggregate amount of settlement	$ 1,000,000
General and administrative expense					$ 1,000,000

XML

Stock Plans - Additional Information (Detail) $ / shares in Units, $ in Millions	3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 30, 2017 USD ($) shares	Jun. 30, 2016 USD ($) shares	Jun. 30, 2017 USD ($) $ / shares shares	Jun. 30, 2016 USD ($) Executive $ / shares shares	Dec. 31, 2016 $ / shares shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted-average fair values of options granted | $ / shares			$ 1.96	$ 1.62
Total intrinsic value of options exercised			$ 3.2	$ 6.3
Stock-based compensation expense for modifications				$ 2.5
Number of executive officers affected by modifications of stock-based compensation awards | Executive				2
Unrecognized compensation cost related to unvested employee options	$ 12.5		$ 12.5
Unrecognized stock-based compensation, weighted-average remaining period			2 years 7 months 6 days
Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized stock-based compensation, weighted-average remaining period			3 years 2 months 12 days
Total fair values of RSUs vested			$ 1.0	$ 2.2
Unrecognized compensation cost	7.3		7.3
Non Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost related to unvested employee options	$ 0.6		$ 0.6
Unrecognized stock-based compensation, weighted-average remaining period			1 year 10 months 24 days
Minimum [Member] | Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units granted to employees vesting period			2 years
Maximum [Member] | Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units granted to employees vesting period			4 years
Research and Development [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense for modifications				1.4
General and Administrative [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense for modifications		$ 0.3		$ 1.1
Annapurna Therapeutics SAS [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of stock options granted | shares					3,673,940
Stock options exercise price granted | $ / shares					$ 0.21
2014 Equity Incentive Award Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock shares authorized for issuance | shares	14,834,856		14,834,856
Shares available for future grants | shares	1,662,588		1,662,588
2014 Employee Stock Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares available for future grants | shares	1,000,783		1,000,783
Common stock, shares issued | shares	35,954	32,425	35,954	32,425
Common stock shares available for future grant | shares	1,000,783		1,000,783

XML

Stock Plans - Summary of Stock Options Activity (Detail) - 2006 Equity Incentive Plan [Member] $ / shares in Units, $ in Thousands	6 Months Ended
	Jun. 30, 2017 USD ($) $ / shares shares
Share-based Compensation Arrangement by Share-based Payment Award, Number of Options [Roll Forward]
Number of Options, Beginning Balance | shares	7,449,000
Number of Options, Options granted | shares	1,716,000
Number of Options, Options exercised | shares	(1,235,000)
Number of Options, Options cancelled | shares	(262,000)
Number of Options, Ending Balance | shares	7,668,000
Number of Options, Vested and expected to vest | shares	7,668,000
Number of Options, Exercisable | shares	3,404,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Weighted-Average Exercise Price, Beginning Balance | $ / shares	$ 4.46
Weighted-Average Exercise Price, Options granted | $ / shares	2.81
Weighted-Average Exercise Price, Options exercised | $ / shares	0.21
Weighted-Average Exercise Price, Options cancelled | $ / shares	12.24
Weighted-Average Exercise Price, Ending Balance | $ / shares	4.51
Weighted-Average Exercise Price, Vested and expected to vest | $ / shares	4.51
Weighted-Average Exercise Price, Exercisable | $ / shares	$ 4.52
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Weighted-Average Remaining Contractual Life (In years)	8 years 3 months 19 days
Weighted-Average Remaining Contractual Life (In years), Vested and expected to vest	8 years 3 months 19 days
Weighted-Average Remaining Contractual Life (In years), Exercisable	7 years 6 months
Aggregate Intrinsic Value, Options outstanding | $	$ 7,037
Aggregate Intrinsic Value, Vested and expected to vest | $	7,037
Aggregate Intrinsic Value, Exercisable | $	$ 5,045

XML

Stock Plans - Summary of Stock Options Activity (Parenthetical) (Detail)	6 Months Ended
	Jun. 30, 2017 $ / shares
Equity [Abstract]
Aggregate intrinsic value of option per share	$ 2.50

XML

Stock Plans - Stock-Based Compensation Expense Related to Issuance of Stock Awards to Employees and Nonemployees (Detail) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total share-based compensation	$ 2,243	$ 2,826	$ 4,139	$ 6,910
Research and Development [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total share-based compensation	1,395	1,912	2,637	4,140
General and Administrative [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total share-based compensation	$ 848	$ 914	$ 1,502	$ 2,770

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Stock Plans - Summary of Restricted Stock Units Activity (Detail) - Restricted Stock Units [Member] - $ / shares	6 Months Ended	12 Months Ended
	Jun. 30, 2017	Dec. 31, 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Units, Beginning Balance	1,049,000
Number of Units, Granted	1,966,000
Number of Units, Vested and released	(191,000)
Number of Units, Forfeited	(331,000)
Number of Units, Ending Balance	2,493,000	1,049,000
Weighted-Average Grant-Date Fair Value, Beginning Balance	$ 5.47
Weighted-Average Grant-Date Fair Value, Granted	2.72
Weighted-Average Grant-Date Fair Value, Vested and released	5.28
Weighted-Average Grant-Date Fair Value, Forfeited	3.69
Weighted-Average Grant-Date Fair Value, Ending Balance	$ 3.56	$ 5.47
Weighted-Average Remaining Contractual Term (In years)	1 year 10 months 25 days	1 year 8 months 12 days

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Stock Plans - Schedule of Employees Stock Purchase Plan Valuation Assumptions (Detail)	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected volatility	81.00%	81.00%	81.00%	81.00%
Expected term (in years)	5 years 8 months 12 days	5 years 10 months 25 days	6 years	5 years 10 months 25 days
Risk-free interest rate	1.90%	1.30%	1.90%	1.30%
Non Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected volatility	82.00%	84.00%	82.00%	83.00%
Expected term (in years)	9 years	8 years	9 years	7 years 6 months
Risk-free interest rate	2.20%	1.60%	2.30%	1.60%

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401(k) Savings Plan - Additional Information (Detail) - USD ($) $ in Millions	6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016
Compensation And Retirement Disclosure [Abstract]
Contribution by company	$ 0.2	$ 0.2

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Net Loss per Share - Additional Information (Detail) - shares shares in Millions	6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016
Earnings Per Share [Abstract]
Antidilutive common stock equivalents excluded from calculation of diluted net loss per share	10.3	9.9