Balance sheet components - Schedule of property and equipment (Details) - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Property and equipment
Total property and equipment, gross	$ 134,731	$ 179,296
Accumulated depreciation	(69,285)	(70,573)
Total property and equipment, net	65,446	108,723
Leasehold improvements
Property and equipment
Total property and equipment, gross	56,392	73,095
Laboratory equipment
Property and equipment
Total property and equipment, gross	50,465	67,261
Computer equipment
Property and equipment
Total property and equipment, gross	11,147	13,511
Furniture and fixtures
Property and equipment
Total property and equipment, gross	996	1,427
Construction-in-progress
Property and equipment
Total property and equipment, gross	7,621	21,006
Other
Property and equipment
Total property and equipment, gross	$ 8,110	$ 2,996