EX-99.1 2 a991pressreleaseforearning.htm EX-99.1 Document

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Invitae Reports Fourth Quarter and Full Year 2022 Financial Results; Provides Company Updates

– Entered into a ~$336 million transaction for the 2024 convertible notes, effectively addressing ~96% of the amount outstanding (see separate press release to follow) –
– Repaid its 2024 senior secured term loan in full, improving its balance sheet –
– Company maintains cash runway through the end of 2024 –
– Annual revenue grew by 12.1%; Continued to improve on key financial metrics –
– Major initiatives under strategic realignment largely completed –
– Guiding to low double digit pro forma revenue growth and continued expansion of non-GAAP gross margin in 2023, decreasing cash burn by over 45% from 2022 –
– Conference call and webcast today at 4:30 p.m. Eastern Time / 1:30 p.m. Pacific Time –

SAN FRANCISCO – February 28, 2023 – Invitae (NYSE: NVTA), a leading medical genetics company, today announced financial and operating results for the fourth quarter and year ended December 31, 2022.

“2022 was a transformative year for Invitae as we shifted our focus to drive more profitable growth, and we are pleased that the major initiatives under our strategic realignment are now largely completed,” said Ken Knight, president and chief executive officer of Invitae. “Our talented teams made great progress, and continued their work in service of patients and customers while delivering on the financial objectives aligned to our new path. These continued improvements in our financial metrics reflect our new priorities and operating discipline. In light of that execution, we separately announced today significant developments in addressing approximately 96% of our near-term debt obligations. Our investors have agreed to extend the maturities of our 2024 convertible notes into 2028, along with equitizing a portion of the debt and adding capital, demonstrating their confidence in Invitae’s future. We have also repaid our term loan in full and further improved our balance sheet. Overall, we are looking forward to 2023, as we continue to drive operational excellence, along with setting the stage for our long-term growth opportunities for years to come.

Full Year and Fourth Quarter 2022 Financial Results

Generated revenue of $516.3 million in 2022, a 12.1% increase from $460.4 million in 2021. Fourth quarter 2022 revenue of $122.5 million, versus $126.1 million a year ago, reflecting the impact of exited businesses and geographies announced earlier in the year.
GAAP gross profit was $99.1 million in 2022, including $29.6 million in the fourth quarter. Non-GAAP gross profit was $219.7 million in 2022, including $58.5 million in the fourth quarter.
GAAP gross margin was 19.2% in 2022, as compared with 24.3% in 2021, and 24.2% in the fourth quarter of 2022, versus 23.8% in the fourth quarter of 2021. Non-GAAP gross margin was 42.5% in 2022, as compared with 36.6% in 2021. Non-GAAP gross margin was 47.8% in the fourth quarter of 2022, compared to 36.5% in the fourth quarter of 2021.
Cash, cash equivalents, restricted cash and marketable securities were $557.1 million as of December 31, 2022, compared to $596.0 million as of September 30, 2022 and $1.06 billion as of December 31, 2021.



Cash burn in 2022 was $509.6 million, compared to a cash burn of $849.2 million in 2021. 2022 cash burn included outflows of $53.3 million ($38.4 million related to realignment and $14.9 million acquisition-related payments), as well as an inflow of $44.5 million related to the selected assets sale of the RUO kitted solutions.
Cash burn in the fourth quarter was $41.8 million and included an outflow of $9.3 million related to realignment and $0.1 million of acquisition-related payments, as well as an inflow of $44.5 million related to the selected assets sale of the RUO kitted solutions. Excluding these items, cash burn would have been $77.0 million. This represents a continued improving trend since the fourth quarter of 2021 driven by our strategic realignment and cost reduction plans.
Total active healthcare provider accounts totaled 20,929 as of December 31, 2022, an increase of approximately 13% year-over-year.
Active pharmaceutical and commercial partnerships grew to 238, an increase of approximately 34% year-over-year, reflecting growing adoption of our product and services to pharmaceutical, health systems and other partners.
Revenue per patient was $475 in 2022, a decrease of approximately 3% from $491 in 2021. Revenue per patient was $511 in the fourth quarter of 2022, compared to $505 in the third quarter of 2022, and $476 in the fourth quarter of 2021, primarily as a result of our realignment efforts.
Total patient population as of December 31, 2022 is more than 3.6 million with over 62% available for data sharing.

Total GAAP operating expense, which excludes cost of revenue, for the fourth quarter of 2022 was $124.5 million, which includes items related to the strategic realignment. As a result, GAAP operating expense as a percentage of revenue was 102%, compared to 194% in the fourth quarter of 2021. Non-GAAP operating expense was $135.6 million for the fourth quarter of 2022. Non-GAAP operating expense as a percentage of revenue was 111%, compared to 171% in the fourth quarter of 2021.

Net loss for the fourth quarter of 2022 was $99.8 million, or a $0.41 net loss per share, compared to net loss of $205.1 million, or net loss per share of $0.90, for the fourth quarter of 2021. Non-GAAP net loss for the fourth quarter of 2022 was $82.0 million, or a $0.34 non-GAAP net loss per share, compared to a net loss of $184.7 million, or an $0.81 non-GAAP net loss per share, for the fourth quarter of 2021.

Financial Guidance
On a pro forma basis, the company exited fourth quarter 2022 at an annualized revenue of approximately $450 million for its remaining business. Management is expecting 2023 revenue to be over $500 million, representing low double-digit year-over-year growth compared to 2022 pro forma revenue.

Thanks to realignment initiatives, non-GAAP gross margin for 2023 is expected to be between 48-50%, compared to 42.5% in 2022. Cash burn is expected to be in the range of $250-275 million in 2023, a more than 45% reduction from 2022.

Webcast and Conference Call Details
Management will host a conference call and webcast today at 4:30 p.m. Eastern Time / 1:30 p.m. Pacific Time to discuss financial results and recent developments. To access the conference call, please register at the link below:

https://www.netroadshow.com/events/login?show=d75171b5&confId=46549

Upon registering, each participant will be provided with call details and access codes.

The live webcast of the call and slide deck may be accessed here or by visiting the investors section of the company's website at ir.invitae.com. A replay of the webcast will be available shortly after the conclusion of the call and will be archived on the company's website.




About Invitae
Invitae (NYSE: NVTA) is a leading medical genetics company trusted by millions of patients and their providers to deliver timely genetic information using digital technology. We aim to provide accurate and actionable answers to strengthen medical decision-making for individuals and their families. Invitae's genetics experts apply a rigorous approach to data and research, serving as the foundation of their mission to bring comprehensive genetic information into mainstream medicine to improve healthcare for billions of people.

To learn more, visit invitae.com and follow for updates on Twitter, Instagram, Facebook and LinkedIn @Invitae.

Safe Harbor Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to the company’s mission; the expected impact, benefits, and timing of the company’s strategic business realignment or various aspects thereof; the company’s expectations regarding future financial and operating results, and the drivers of future financial results; the company’s roadmap for 2023 and long-term growth; and the company’s expectations regarding the exchange and equitization of existing notes, extension of debt maturity and repayment of senior secured loans. Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially and reported results should not be considered as an indication of future performance. These risks and uncertainties include, but are not limited to: the ability of the company to successfully execute its strategic business realignment and achieve the intended benefits thereof on the expected timeframe or at all; unforeseen or greater than expected costs associated with the strategic business realignment; the risk that the disruption that may result from the realignment may harm the company’s business, market share or its relationship with customers or potential customers; satisfaction of closing conditions related to the debt exchange and equitization transaction; the impact of COVID-19 on the company, and the effectiveness of the efforts it has taken or may take in the future in response thereto; the impact of inflation and the current economic environment on the company’s business; the company's ability to grow its business in a cost-efficient manner; the company's history of losses; the company’s ability to maintain important customer relationships; the company’s ability to compete; the company's failure to manage growth effectively; the company's need to scale its infrastructure in advance of demand for its tests and to increase demand for its tests; the risk that the company may not obtain or maintain sufficient levels of reimbursement for its tests; the applicability of clinical results to actual outcomes; risks associated with litigation; the company's ability to use rapidly changing genetic data to interpret test results accurately and consistently; laws and regulations applicable to the company's business; and the other risks set forth in the reports filed by the company with the SEC, including its Quarterly Report on Form 10-Q for the quarter ended September 30, 2022. These forward-looking statements speak only as of the date hereof, and Invitae Corporation disclaims any obligation to update these forward-looking statements.

Non-GAAP Financial Measures
To supplement the company's consolidated financial statements prepared in accordance with generally accepted accounting principles in the United States (GAAP), the company is providing several non-GAAP measures. These non-GAAP financial measures exclude certain items that are required by GAAP. In addition, these non-GAAP measures are not based on any standardized methodology prescribed by GAAP and are not necessarily comparable to similarly-titled measures presented by other companies. Management believes these non-GAAP financial measures are useful to investors in evaluating the company’s ongoing operating results and trends. Management uses such non-GAAP information to manage the company’s business and monitor its performance.

Other companies, including companies in the same industry, may not use the same non-GAAP measures or may calculate these metrics in a different manner than management or may use other financial measures to evaluate their performance, all of which could reduce the usefulness of these non-GAAP



measures as comparative measures. Because of these limitations, the company's non-GAAP financial measures should not be considered in isolation from, or as a substitute for, financial information prepared in accordance with GAAP. Investors are encouraged to review the non-GAAP reconciliations provided in the tables below and on the company’s website.

In addition, this press release includes the company’s non-GAAP gross margin guidance, a non-GAAP measure used to describe the company’s expected performance. The company has not presented a reconciliation of this non-GAAP measure to the company’s gross margin, the most comparable GAAP financial measure, because the reconciliation could not be prepared without unreasonable effort. The information necessary to prepare the reconciliation is not available on a forward-looking basis and cannot be accurately predicted. The unavailable information could have a significant impact on the calculation of the comparable GAAP financial measure.



INVITAE CORPORATION
Consolidated Balance Sheets
(in thousands)
December 31,
20222021
Assets  
Current assets:  
Cash and cash equivalents$257,489 $923,250 
Marketable securities289,611 122,121 
Accounts receivable96,148 66,227 
Inventory30,386 33,516 
Prepaid expenses and other current assets19,496 33,691 
Total current assets693,130 1,178,805 
Property and equipment, net108,723 114,714 
Operating lease assets106,563 121,169 
Restricted cash10,030 10,275 
Intangible assets, net1,012,549 1,187,994 
Goodwill— 2,283,059 
Other assets23,121 23,551 
Total assets$1,954,116 $4,919,567 
Liabilities and stockholders’ equity
Current liabilities:
Accounts payable$13,984 $21,127 
Accrued liabilities74,388 106,453 
Operating lease obligations14,600 12,359 
Finance lease obligations5,121 4,156 
Total current liabilities108,093 144,095 
Operating lease obligations, net of current portion134,386 124,369 
Finance lease obligations, net of current portion3,780 5,683 
Debt122,333 113,391 
Convertible senior notes, net1,470,783 1,464,138 
Deferred tax liability8,130 51,696 
Other long-term liabilities4,775 37,797 
Total liabilities1,852,280 1,941,169 
Stockholders’ equity:
Common stock
25 23 
Accumulated other comprehensive loss(80)(7)
Additional paid-in capital4,931,032 4,701,230 
Accumulated deficit(4,829,141)(1,722,848)
Total stockholders’ equity101,836 2,978,398 
Total liabilities and stockholders’ equity$1,954,116 $4,919,567 






INVITAE CORPORATION
Consolidated Statements of Operations
(in thousands, except per share data)
 Three Months Ended December 31,Year Ended December 31,
 2022202120222021
Revenue:  
Test revenue$119,042 $121,624 $500,560 $444,072 
Other revenue3,412 4,497 15,743 16,377 
Total revenue122,454 126,121 516,303 460,449 
Operating expenses:
Cost of revenue92,844 96,106 417,256 348,669 
Research and development71,529 131,764 402,088 416,087 
Selling and marketing46,795 62,205 218,881 225,910 
General and administrative43,243 50,430 192,314 248,070 
Goodwill and IPR&D impairment— — 2,313,047 — 
Restructuring and other costs10,292 — 140,331 — 
Gain on sale of RUO kit assets(47,354)— (47,354)— 
Change in fair value of contingent consideration— 190 (1,850)(386,646)
Total operating expenses217,349 340,695 3,634,713 852,090 
Loss from operations(94,895)(214,574)(3,118,410)(391,641)
Other income (expense), net:
Change in fair value of acquisition-related liabilities240 16,017 15,906 25,196 
Other income (expense), net4,083 (185)8,054 482 
Total other income, net4,323 15,832 23,960 25,678 
Interest expense(14,598)(14,031)(56,747)(49,900)
Net loss before taxes(105,170)(212,773)(3,151,197)(415,863)
Income tax benefit5,353 7,649 44,904 36,857 
Net loss$(99,817)$(205,124)$(3,106,293)$(379,006)
Net loss per share, basic and diluted$(0.41)$(0.90)$(13.18)$(1.80)
Shares used in computing net loss per share, basic and diluted243,948 226,849 235,676 210,946 




INVITAE CORPORATION

Consolidated Statements of Cash Flows
(in thousands)
 Year Ended December 31,
 202220212020
Cash flows from operating activities: 
Net loss$(3,106,293)$(379,006)$(602,170)
Adjustments to reconcile net loss to net cash used in operating activities:
Goodwill and IPR&D impairment2,313,047 — — 
Impairments and losses on disposals of long-lived assets60,507 — — 
Gain on sale of RUO kit assets(47,354)— — 
Depreciation and amortization142,071 80,472 39,050 
Stock-based compensation199,304 180,075 158,747 
Amortization of debt discount and issuance costs15,587 14,226 17,204 
Remeasurements of liabilities associated with business combinations(17,756)(411,842)92,348 
Benefit from income taxes(44,904)(36,857)(112,100)
Post-combination expense for acceleration of unvested equity and deferred stock compensation8,428 9,530 91,021 
Amortization of premiums and discounts on investment securities(1,515)6,221 1,236 
Non-cash lease expense10,240 3,496 777 
Other1,018 1,487 (588)
Changes in operating assets and liabilities, net of businesses acquired:
Accounts receivable(29,921)(16,696)(2,814)
Inventory3,130 (1,486)(7,832)
Prepaid expenses and other current assets14,195 (14,563)(2,010)
Other assets3,124 (3,274)895 
Accounts payable(2,465)(9,258)10,186 
Accrued expenses and other long-term liabilities(13,404)17,660 17,548 
Net cash used in operating activities(492,961)(559,815)(298,502)
Cash flows from investing activities:
Purchases of marketable securities(892,361)(325,957)(280,258)
Proceeds from sales of marketable securities— — 12,832 
Proceeds from maturities of marketable securities726,313 425,293 277,487 
Acquisition of businesses, net of cash acquired— (247,396)(383,753)
Proceeds from sale of RUO kit assets44,554 — — 
Purchases of property and equipment(53,309)(54,720)(22,865)
Other— (1,300)(4,026)
Net cash used in investing activities(174,803)(204,080)(400,583)
Cash flows from financing activities:
Proceeds from public offerings of common stock, net9,658 434,263 263,688 
Proceeds from issuance of common stock8,157 23,767 284,203 
Proceeds from issuance of convertible senior notes, net— 1,116,427 — 
Proceeds from issuance of debt, net— — 129,214 
Finance lease principal payments(5,410)(3,759)(2,655)
Settlement of acquisition obligations(10,647)(4,758)(1,457)
Net cash provided by financing activities1,758 1,565,940 672,993 
Net (decrease) increase in cash, cash equivalents and restricted cash(666,006)802,045 (26,092)
Cash, cash equivalents and restricted cash at beginning of period933,525 131,480 157,572 
Cash, cash equivalents and restricted cash at end of period$267,519 $933,525 $131,480 




INVITAE CORPORATION

Reconciliation of GAAP to Non-GAAP Cost of Revenue
(in thousands)
(unaudited)
 Three Months Ended December 31,Year Ended December 31,
2022202120222021
Cost of revenue$92,844 $96,106 $417,256 $348,669 
Amortization of acquired intangible assets(26,950)(15,392)(100,568)(49,970)
Acquisition-related stock-based compensation(156)(141)(581)(2,461)
Acquisition-related post-combination expense— (479)(1,053)(1,058)
Change in fair value of acquisition-related assets— — — (3,148)
Restructuring-related retention bonuses(82)— (252)— 
Inventory and prepaid write-offs(1,712)— (18,179)— 
Non-GAAP cost of revenue$63,944 $80,094 $296,623 $292,032 


Reconciliation of GAAP to Non-GAAP Gross Profit
(in thousands)
(unaudited)
 Three Months Ended December 31,Year Ended December 31,
2022202120222021
Revenue$122,454 $126,121 $516,303 $460,449 
Cost of revenue92,844 96,106 417,256 348,669 
Gross profit29,610 30,015 99,047 111,780 
Amortization of acquired intangible assets26,950 15,392 100,568 49,970 
Acquisition-related stock-based compensation156 141 581 2,461 
Acquisition-related post-combination expense— 479 1,053 1,058 
Change in fair value of acquisition-related assets— — — 3,148 
Restructuring-related retention bonuses82 — 252 — 
Inventory and prepaid write-offs1,712 — 18,179 — 
Non-GAAP gross profit$58,510 $46,027 $219,680 $168,417 


Reconciliation of GAAP to Non-GAAP Research and Development Expense
(in thousands)
(unaudited)
 Three Months Ended December 31,Year Ended December 31,
2022202120222021
Research and development$71,529 $131,764 $402,088 $416,087 
Amortization of acquired intangible assets(91)(529)(1,429)(2,117)
Acquisition-related stock-based compensation(14,367)(23,703)(80,086)(44,406)
Acquisition-related post-combination expense(3,460)(2,607)(10,646)(6,056)
Restructuring-related retention bonuses(1,339)— (1,985)— 
Restructuring-related accelerated depreciation(2,607)— (5,918)— 
Non-GAAP research and development$49,665 $104,925 $302,024 $363,508 




INVITAE CORPORATION

Reconciliation of GAAP to Non-GAAP Selling and Marketing Expense
(in thousands)
(unaudited)
 Three Months Ended December 31,Year Ended December 31,
2022202120222021
Selling and marketing$46,795 $62,205 $218,881 $225,910 
Amortization of acquired intangible assets(1,595)(1,686)(6,451)(6,748)
Acquisition-related stock-based compensation(511)— (2,885)(2,696)
Acquisition-related post-combination expense— — — (38)
Restructuring-related retention bonuses(243)— (358)— 
Non-GAAP selling and marketing$44,446 $60,519 $209,187 $216,428 

Reconciliation of GAAP to Non-GAAP General and Administrative Expense
(in thousands)
(unaudited)
 Three Months Ended December 31,Year Ended December 31,
2022202120222021
General and administrative$43,243 $50,430 $192,314 $248,070 
Acquisition-related stock-based compensation(1,119)(32)(7,775)(21,293)
Acquisition-related post-combination expense— (165)— (35,628)
Restructuring-related retention bonuses(595)— (895)— 
Restructuring-related accelerated depreciation(71)— (182)— 
Non-GAAP general and administrative$41,458 $50,233 $183,462 $191,149 

Reconciliation of Operating Expenses to Non-GAAP Operating Expenses
(in thousands)
(unaudited)
 Three Months Ended December 31,Year Ended December 31,
2022202120222021
Research and development$71,529 $131,764 $402,088 $416,087 
Selling and marketing46,795 62,205 218,881 225,910 
General and administrative43,243 50,430 192,314 248,070 
Goodwill and IPR&D impairment— — 2,313,047 — 
Restructuring and other costs10,292 — 140,331 — 
Gain on sale of RUO kit assets(47,354)— (47,354)— 
Change in fair value of contingent consideration— 190 (1,850)(386,646)
Operating expenses124,505 244,589 3,217,457 503,421 
Goodwill and IPR&D impairment— — (2,313,047)— 
Restructuring and other costs(10,292)— (140,331)— 
Gain on sale of RUO kit assets47,354 — 47,354 — 
Change in fair value of contingent consideration— (190)1,850 386,646 
Amortization of acquired intangible assets(1,686)(2,215)(7,880)(8,865)
Acquisition-related stock-based compensation(15,997)(23,735)(90,746)(68,395)
Acquisition-related post-combination expense(3,460)(2,772)(10,646)(41,722)
Restructuring-related retention bonuses(2,177)— (3,238)— 
Restructuring-related accelerated depreciation(2,678)— (6,100)— 
Non-GAAP operating expenses$135,569 $215,677 $694,673 $771,085 



INVITAE CORPORATION

Reconciliation of Other Income, Net to Non-GAAP Other Income (Expense), Net
(in thousands)
(unaudited)
Three Months Ended December 31,Year Ended December 31,
 2022202120222021
Other income, net$4,323 $15,832 $23,960 $25,678 
Change in fair value of acquisition-related liabilities(240)(16,017)(15,906)(25,196)
Non-GAAP other income (expense), net$4,083 $(185)$8,054 $482 


Reconciliation of Net Loss to Non-GAAP Net Loss and Non-GAAP Net Loss Per Share
(in thousands, except per share data)
(unaudited)
 Three Months Ended December 31,Year Ended December 31,
2022202120222021
Net loss$(99,817)$(205,124)$(3,106,293)$(379,006)
Goodwill and IPR&D impairment— — 2,313,047 — 
Restructuring and other costs10,292 — 140,331 — 
Gain on sale of RUO kit assets(47,354)— (47,354)— 
Change in fair value of contingent consideration— 190 (1,850)(386,646)
Amortization of acquired intangible assets28,636 17,607 108,448 58,835 
Acquisition-related stock-based compensation16,153 23,876 91,327 70,856 
Acquisition-related post-combination expense3,460 3,251 11,699 42,780 
Change in fair value of acquisition-related assets and liabilities(240)(16,017)(15,906)(22,048)
Restructuring-related retention bonuses2,259 — 3,490 — 
Restructuring-related accelerated depreciation2,678 — 6,100 — 
Inventory and prepaid write-offs1,712 — 18,179 — 
Acquisition-related income tax benefit235 (8,480)(39,960)(39,087)
Non-GAAP net loss$(81,986)$(184,697)$(518,742)$(654,316)
Net loss per share, basic and diluted$(0.41)$(0.90)$(13.18)$(1.80)
Non-GAAP net loss per share, basic and diluted$(0.34)$(0.81)$(2.20)$(3.10)
Shares used in computing net loss per share, basic and diluted243,948 226,849 235,676 210,946 





INVITAE CORPORATION

Reconciliation of Net (Decrease) Increase in Cash, Cash Equivalents and Restricted Cash to Cash Burn
(in thousands)
(unaudited)
 Three Months EndedYear Ended
TABLE11March 31, 2022June 30, 2022September 30, 2022December 31, 2022December 31, 2022
Net cash used in operating activities$(147,543)$(134,689)$(128,702)$(82,027)$(492,961)
Net cash (used in) provided by investing activities(449,456)108,965 43,797 121,891 (174,803)
Net cash (used in) provided by financing activities(920)3,770 (1,691)599 1,758 
Net (decrease) increase in cash, cash equivalents and restricted cash(597,919)(21,954)(86,596)40,463 (666,006)
Adjustments:
Net changes in investments428,608 (125,087)(55,212)(82,261)166,048 
Proceeds from public offering of common stock, net— — (9,658)— (9,658)
Cash burn$(169,311)$(147,041)$(151,466)$(41,798)$(509,616)
• Cash burn for the three months ended June 30, 2022 includes $0.7 million of acquisition-related payments.
• Cash burn for the three months ended September 30, 2022 includes $29.1 million of restructuring-related cash payments and $14.1 million of acquisition-related payments.
• Cash burn for the three months ended December 31, 2022 includes $44.5 million of proceeds from the sale of RUO kit assets, $9.3 million of restructuring-related cash payments and $0.1 million of acquisition-related payments.

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Contacts for Invitae:

Investor Relations
Hoki Luk
ir@invitae.com

Public Relations
Amy Hadsock
pr@invitae.com