Exhibit 5.1

Yigal Arnon (1929-2014) Dror Vigdor Amalia Meshi Amnon Lorch Hagai Shmueli Barry Levenfeld David H. Schapiro Hagit Bavly Orna Sasson Barak Tal Shiri Shaham Doron Tamir Daniel Abarbanel David Osborne Gil Oren Ronit Amir Yaniv Orly Tsioni Mordehai Baicz Barak Platt Benjamin Horef Yoran Gill Asaf Eylon Daniel Marcovici Adrian Daniels Yuval Shalheveth Jacob Ben Chitrit Peter Sugarman Ben Sandler Boaz Fiel Joeri Kreisberg Simon Weintraub Ruth Loven Yarom Romem Adam Spruch Yuval Bargil Eliran Furman Eran Lempert Ofir Levy
Daniel Green Hanital Belinson Yoheved Novogroder
Oren Roth
Dror Varsano Odelia Sidi Shira Lahat Micki Shapira Eran Zach Ido Chitman Aner Hefetz David Akrish Nir Rosner Assaf Mesica Liron Hacohen Guy Fuhrer Ezra Gross David Roness Eli Greenbaum Lee Maor
Nimrod Vromen Guy Sagiv Shani Rapoport Lior Gelbard Keren Tal Naftali Nir Yael Hoefler Sagi Schiff Netanella Treistman Daniel Damboritz Yulia Lazbin Joshua Lieberman Eyal Aichel Roy Masuri
Avi Anouchi Sivan Gilron Dotan Tomer Bar-Nathan Edan Regev Gitit Ramot-Adler Guy Kortany Goor Koren
Roey Sasson Nir Rodnizky Michal Sagmon Hila Rot
Eran Kadosh Neta Goshen Chen Lanir Daphna Livneh Tamar Gilboa
Adi Samuel Alona Toledano
Elad Offek Yuval Shamir Lihi Katzenelson
Inbar Hakimian-Nahari Shahar Uziely Yehudit Biton Omri Schnaider Rinat Michael Adi Attar Daniella Milner Amos Oseasohn Ofir Paz Adi Daniel Dafna Shaham Miriam Friedmann Roni Osborne Shir Eshkol Noam Shochat Noa Slavin
Michael Horowitz Guy Fatal
Shani Lorch Itamar Cohen
Shai Margalit Yonatan Whitefield Moshe Lankry
Nir Kamhi Shira Teger Rachel Lerman Ravid Saar Sophie Blackston Elad Morgenstern
Ron Ashkenazi Sara Haber Carmel Nudler Shmuel Brill Ben Nachshon Yehonatan Cohen David Shmulevitz Tair Cherbakovsky Ophir Dagan Guy Ziv-Shalom Lior Cohen Goldstein Liad Kalderon Nataly Damary Shiran Glitman Dani Weissberg Lareine Khoury Nohar Hadar Nitzan Kahana Tali Har-Oz Tal Alon Ohad  Sarusi Mor Ido Nechemia Englman Tomer Tako
Natalie Korenfeld Moshe Pasker Mazi Ohayon Nitzan Fisher-Conforti Victoria Savu Derora Tropp Hila Amiel Chaim Cohen Michal Mor Daniel Siso Maytal Spivak Avraham Schoen Elan Loshinsky Ariel Even Josh Hauser Eitan Cohen Itai Guttel Dror Kanarik Sarig Royi Heilig Maor Alev Tamar Drori Vered Glaubach Yair Taitelbaum Gabi Priel Regina Pevzner
Sophy Litvin Igal Lavi Maor Layani Areen Nashef David Chesterman Ido Zahavi Guy Yarom Danielle Berkowicz Inbar Rosenthal Hadar Stein Dan Shimon Avital Salzman Rotem Cohen Idan Adar Shahar Iluz Itay Ashkenazi Roei Brizel Ido Sella Evyatar Latz Hadil Nassif Khawand
Maayan Malka Rublin Ran Aziel Dima Trostianesky Stav Orenstein Avia Ickovics Liron Soffer ___________________ Gidon Weinstock Of Counsel Roy Keidar Of Counsel Tamar Tavory Of Counsel Paul H. Baris (1934-2010) Rami Kook Nira Kuritzky Eran Ilan

Tel Aviv | January 21, 2021

BioLineRx Ltd.

2 Hamayan Street

Modi’in Technology Park

Modi’in 7177871

Israel

Dear Sir and Madam:

We have acted as Israeli counsel to BiolineRX, Ltd., (the “Company”)  in connection with (i) the issuance and sale of an aggregate of 14,375,000  American Depositary Shares (the “Public Offering Securities”), each representing fifteen ordinary shares, NIS 0.10 par value per share, of the Company (which includes 1,875,000 American Depository Shares issued pursuant to the exercise by the Underwriter (as defined below) of its option to purchase additional American Depository Shares)  pursuant to the terms of an Amended and Restated Underwriting Agreement dated January 19, 2021 (the “Underwriting Agreement”) by and between the Company and H.C. Wainwright & Co., LLC (the “Underwriter”).  The Public Offering Securities will be issued pursuant to a registration statement on Form F-3 (Registration Statement No. 333-251857) (the “Registration Statement”) filed with the Securities and Exchange Commission (the “Commission”) under the Securities Act of 1933, as amended (the “Securities Act”), and the prospectus supplement dated January 19, 2021, filed with the Commission pursuant to Rule 424(b) of the Rules and Regulations of the Securities Act.

As counsel to the Company in Israel, we have examined copies of the Articles of Association of the Company currently in effect, of the Company and such corporate records, instruments, and other documents relating to the Company and such matters of law as we have considered necessary or appropriate for the purpose of rendering this opinion. In such examination, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, and the conformity to authentic originals of all documents submitted to us as copies.

Based on the foregoing, we advise you that in our opinion the ordinary shares underlying the Public Offering Securities to be sold to the Underwriters as described in the Registration Statement and the Prospectus Supplement, have been duly authorized and have been, or upon delivery of the Public Offering Securities and payment therefor in accordance with the Underwriting Agreement, will be, validly issued, fully paid and non-assessable.

We are members of the Israeli bar, and the opinions expressed herein are limited to questions arising under the laws of the State of Israel, and we disclaim any opinion whatsoever with respect to matters governed by the laws of any other jurisdiction.

We hereby consent to the use of this opinion as Exhibit 5.1 to the Company’s Report on Form 6-K to be filed with the Commission on January 21, 2021, which will be incorporated by reference in the Registration Statement, and to the reference to us under the caption “Legal Matters” in the prospectus included in the Registration Statement.  In giving such consent, we do not hereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Commission thereunder.

Sincerely,

/s/Yigal Arnon & Co.

Yigal Arnon & Co.

1 Azrieli Center, Tel Aviv, 6702101 | Phone: +972-3-6087777  | Fax: +972-3-6087724

31 Hillel Street, Jerusalem, 9458131 | Phone: +972-2-6239239  | Fax: +972-2-6239233

www.arnon.co.il | info@arnon.co.il

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