Exhibit 5.1

Yigal Arnon (1929-2014) Dror Vigdor Amalia Meshi Amnon Lorch Hagai Shmueli Barry Levenfeld David H. Schapiro Hagit Bavly Orna Sasson Barak Tal Shiri Shaham Doron Tamir Daniel Abarbanel David Osborne Gil Oren Ronit Amir Orly Tsioni Mordehai Baicz Barak Platt Benjamin Horef Yoran Gill Asaf Eylon Daniel Marcovici Adrian Daniels Yuval Shalheveth Jacob Ben Chitrit Peter Sugarman Ben Sandler Boaz Fiel Joeri Kreisberg Simon WeintraubRuth Loven Yarom Romem Adam Spruch Yuval Bargil Eliran Furman Eran Lempert Ofir LevyDaniel Green Hanital Belinson Yoheved NovogroderOren RothDror Varsano Odelia Sidi Shira Lahat Ido Chitman Aner Hefetz David Akrish Nir Rosner Assaf Mesica Liron Hacohen Guy Fuhrer Ezra Gross David Roness Eli Greenbaum Lee MaorNimrod Vromen Guy Sagiv Micha Tollman Shani Rapoport Lior GelbardKeren Tal Naftali NirMichal Sagmon Hila Roth Neta Goshen Roy Masuri Daphna Livneh Tamar Gilboa Yael Hoefler Sagi Schiff Lilach Grimberg Adi Samuel Netanella Treistman Daniel Damboritz Shlomi Schneider Alona ToledanoElad Offek Yuval Shamir Dana Heller Yulia Lazbin Joshua LiebermanLiat Pillersdorf Orly RottenbergAvi Anouchi Shay FahimaSivan Gilron Dotan Tomer Bar-NathanEvan SchendlerLihi KatzenelsonEyal AichelShahar Uziely Edan RegevYehudit Biton Gitit Ramot-AdlerOmri Schnaider Rinat MichaelAdi AttarIvor Krumholtz Daniella MilnerHarel Sinai Amos Oseasohn Guy Kortany Goor KorenAdi DanielMiriam Friedmann Itamar Lippner Roni Osborne Ortal Zanzuri Reut SassonRoey Sasson Shir Eshkol Nir Rodnizky Noa SlavinGuy FatalShani Lorch Ira Evental Itamar CohenShai Margalit Ofir SchwartzMeital SingerYonatan Whitefield Moshe LankryShira Teger Rachel Lerman Ravid SaarDebbie Shalit Sophie Blackston Eti Elbaz Elad MorgensternRon Ashkenazi Dafna Raz Sara HaberIlan Akouka Shlomit Bukaya Yehonatan Cohen David Shmulevitz Tair Cherbakovsky Ophir DaganYael Meretyk Hanan Nataly DamaryShiran Glitman Michael RosenblitDani Weissberg Lareine Khoury Nohar Hadar Shirley Youseri Nitzan Kahana Yahel KaplanTali Har-Oz Liad Kalderon Natalie Korenfeld Moshe Pasker Mazi Ohayon Nitzan Fisher-ConfortiVictoria SavuDerora Tropp Amos ShiffmanHila AmielMaytal Spivak Avraham Schoen Or Lev Or Karabaki Elan Loshinsky Eyal Sharf Ron Shaham Ariel Even Daniel GazitJosh Hauser Ron JacobyEitan Cohen Itai Guttel                                                                  Rebecca Hazan Of CounselRoy Keidar Of Counsel                                          Paul H. Baris (1934-2010) Rami Kook Nira Kuritzky Eran Ilan

Tel Aviv | December 26, 2018

BioLineRx Ltd.

2 Hamayan Street

Modi’in Technology Park

Modi’in 7177871

Israel

Re: BioLineRx Ltd. — 957,549 American Depositary Shares Representing 957,549 Ordinary Shares

Dear Sir and Madam:

We have acted as Israeli counsel to BioLineRx, Ltd., (the “Company”) in connection with the issuance to Kreos Capital V (Expert Fund) L.P., of a warrant (the “Warrant”) to purchase up to an aggregate of 957,549 American Depositary Shares (the “ADSs”), each representing one ordinary share, NIS 0.10 par value per share of the Company (the “Ordinary Shares”), which Warrant was issued on October 2, 2018.  The ADSs issuable upon exercise of the Warrant are being registered under a registration statement on Form F-3 (Registration Statement No. 333-_________) (the “Registration Statement”) filed with the Securities and Exchange Commission (the “Commission”) under the Securities Act of 1933, as amended (the “Securities Act”), and any related prospectus or prospectuses, if any.

As counsel to the Company in Israel, we have examined copies of the Memorandum of Association and the Articles of Association, as amended, of the Company and such corporate records, instruments, and other documents relating to the Company and such matters of law as we have considered necessary or appropriate for the purpose of rendering this opinion. In such examination, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, and the conformity to authentic originals of all documents submitted to us as copies.

  1 Azrieli Center, Tel Aviv, 6702101 | Phone: +972-3-6087777  | Fax: +972-3-6087724 31 Hillel Street, Jerusalem, 9458131 | Phone: +972-2-6239239  | Fax: +972-2-6239233 www.arnon.co.il | info@arnon.co.il

Based on the foregoing, we advise you that in our opinion, the Warrant was duly issued, and the Ordinary Shares underlying the ADSs are duly authorized, legally issued, fully-paid and non-assessable.

We are members of the Israeli bar, and the opinions expressed herein are limited to questions arising under the laws of the State of Israel, and we disclaim any opinion whatsoever with respect to matters governed by the laws of any other jurisdiction.

Mayer Brown LLP may rely upon this opinion for the purpose of rendering their opinion dated December  [—], 2018, with respect to certain matters concerning the ADSs.

We hereby consent to the use of this opinion as Exhibit 5.1 to the Registration Statement, and to the reference to us under the caption “Legal Matters” in the prospectus included in the Registration Statement.  In giving such consent, we do not hereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Commission.

Sincerely,

/s/ Yigal Arnon & Co.

Yigal Arnon & Co.

  1 Azrieli Center, Tel Aviv, 6702101 | Phone: +972-3-6087777  | Fax: +972-3-6087724 31 Hillel Street, Jerusalem, 9458131 | Phone: +972-2-6239239  | Fax: +972-2-6239233 www.arnon.co.il | info@arnon.co.il

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