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Note 5 - Stockholders' Equity (Tables)
 9 Months Ended
Sep. 30, 2019
Notes Tables  
Share-based Payment Arrangement, Option, Activity [Table Text Block]
   
Number of
Options
    
Weighted
Average
Exercise
Price
    
Weighted
Average
Remaining
Contractual
Term
(in years)
    
Aggregate
Intrinsic
Value
  
Outstanding, December 31, 2018
    
1,206,709
     $
17.93
      
7.0
     $
-
  
Granted
    
714,350
     $
5.76
      
 
      
 
  
Exercised, cancelled or forfeited
    
(176,380
)
   $
8.70
      
 
      
 
  
Outstanding, September 30, 2019
    
1,744,679
     $
13.88
      
7.1
     $
150,450
  
                                 
Exercisable, September 30, 2019
    
991,662
     $
20.15
      
5.5
     $
49,349