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Note 6 - Stockholders' Equity (Tables)
 9 Months Ended
Sep. 30, 2018
Notes Tables  
Share-based Compensation, Stock Options, Activity [Table Text Block]
   
Number of
Options
    
Weighted
Average
Exercise
Price
    
Weighted
Average
Remaining
Contractual
Term
(in years)
    
Aggregate
Intrinsic
Value
  
Outstanding, December 31, 2017
    
1,166,709
     $
18.54
      
7.8
     $
90,097
  
Granted
    
85,000
     $
3.46
      
 
      
 
  
Exercised, cancelled or forfeited
    
(45,000
)
   $
6.55
      
 
      
 
  
Outstanding, September 30, 2018
    
1,206,709
     $
17.93
      
7.2
     $
66,675
  
                                 
Exercisable, September 30, 2018
    
1,009,459
     $
20.39
      
6.8
     $
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