INCOME TAXES (Details - Deferred tax assets) - USD ($)	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets:
Net operating loss carryforward	$ 4,082,474	$ 4,261,552
Operating lease obligation	1,079,312	1,016,847
Stock-based compensation	621,460	650,737
Tax credits	526,549	491,261
Capital loss carryforward and other	0	270,551
Other carryforwards	3,603	0
Accrued bonuses	285,336	0
Deferred tax assets, gross	6,598,734	6,690,948
Deferred tax liabilities:
Intangible assets	(651,767)	(548,149)
Fixed assets	(111,255)	(435,218)
Right-of-use assets	(1,079,507)	(1,014,606)
Deferred tax liabilities	(1,842,529)	(1,997,973)
Less valuation allowance	(4,756,205)	(4,692,975)
Deferred tax asset, net	$ 0	$ 0