0001496201-24-000010.txt : 20240814
0001496201-24-000010.hdr.sgml : 20240814
20240814153611
ACCESSION NUMBER: 0001496201-24-000010
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20240630
FILED AS OF DATE: 20240814
DATE AS OF CHANGE: 20240814
EFFECTIVENESS DATE: 20240814
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
ORGANIZATION NAME:
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 241206962
BUSINESS ADDRESS:
STREET 1: 4 ITZHAK SADE BUILDING A
STREET 2: 29TH FLOOR
CITY: TEL AVIV
STATE: L3
ZIP: 6777520
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 4 ITZHAK SADE BUILDING A
STREET 2: 29TH FLOOR
CITY: TEL AVIV
STATE: L3
ZIP: 6777520
13F-HR
1
primary_doc.xml
X0202
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
06-30-2024
06-30-2024
SPHERA FUNDS MANAGEMENT LTD.
4 ITZHAK SADE BUILDING A
29TH FLOOR
TEL AVIV
L3
6777520
13F HOLDINGS REPORT
028-15863
000312614
802-120694
Y
Investment discretion with regard to a portion of the securities reported herein exercised by Sphera Portfolio Management Ltd, which is wholly owned by Sphera Funds Management Ltd. Per guidance received from the Division of Investment Management, since Sphera Portfolio Management Ltd does not meet the Section 13(f) securities threshold, its holdings are aggregated with those reported for Sphera Funds Management Ltd. Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 90% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint the members of the board of directors of the General Partner (the "Board of Directors"), and therefore may be deemed to control the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, Sphera Portfolio Management, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, Sphera Portfolio Management, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S..
Oshrat Levi
Chief Financial Officer
972 3 6845617
Oshrat Levi
Tel Aviv
L3
08-14-2024
2
119
733237722
false
1
0001599854
028-15865
000172608
802-127045
Sphera Global Healthcare Management LP
2
028-15864
Sphera Global Healthcare GP Ltd.
INFORMATION TABLE
2
sphera13f.xml
4D MOLECULAR THERAPEUTICS IN
COM
35104E100
5090621
242526
SH
DFND
1,2
242526
0
0
89BIO INC
COM
282559103
4217641
526547
SH
DFND
1,2
526547
0
0
ABBVIE INC
COM
00287Y109
6517760
38000
SH
DFND
1,2
38000
0
0
ACADIA PHARMACEUTICALS INC
COM
004225108
5322509
327539
SH
DFND
1,2
327539
0
0
ADC THERAPEUTICS SA
SHS
H0036K147
2166329
685547
SH
DFND
1,2
685547
0
0
AKERO THERAPEUTICS INC
COM
00973Y108
3322405
141620
SH
DFND
1,2
141620
0
0
ALECTOR INC
COM
014442107
2769400
610000
SH
DFND
1,2
610000
0
0
ALUMIS INC
COM
022307102
1662500
125000
SH
DFND
1,2
125000
0
0
AMAZON COM INC
COM
023135106
19601734
101432
SH
DFND
101432
0
0
AMYLYX PHARMACEUTICALS INC
COM
03237H101
68495
36050
SH
DFND
1,2
36050
0
0
ANALOG DEVICES INC
COM
032654105
2967380
13000
SH
DFND
13000
0
0
APPLE INC
COM
037833100
12953130
61500
SH
DFND
61500
0
0
APPLIED MATLS INC
COM
038222105
5806298
24604
SH
DFND
24604
0
0
APPLIED THERAPEUTICS INC
COM
03828A101
3148832
674268
SH
DFND
1,2
674268
0
0
APREA THERAPEUTICS INC
COM NEW
03836J201
1098900
270000
SH
DFND
1,2
270000
0
0
ARBE ROBOTICS LTD
ORDINARY SHARES
M1R95N100
82445
43165
SH
DFND
43165
0
0
ARGENX SE
SPONSORED ADR
04016X101
669142
1556
SH
DFND
1,2
1556
0
0
ARROWHEAD PHARMACEUTICALS IN
COM
04280A100
1252068
48175
SH
DFND
1,2
48175
0
0
ASML HOLDING N V
N Y REGISTRY SHS
N07059210
10126050
9901
SH
DFND
9901
0
0
ASTRAZENECA PLC
SPONSORED ADR
046353108
14822779
190060
SH
DFND
1,2
190060
0
0
ASTRIA THERAPEUTICS INC
COM
04635X102
1481862
162842
SH
DFND
1,2
162842
0
0
BIOGEN INC
COM
09062X103
10991050
47412
SH
DFND
1,2
47412
0
0
BRIDGEBIO PHARMA INC
COM
10806X102
23052073
910070
SH
DFND
1,2
910070
0
0
BRIDGEBIO PHARMA INC
COM
10806X102
5182518
204600
SH
Call
DFND
1,2
0
0
0
BROADCOM INC
COM
11135F101
3108306
19360
SH
DFND
19360
0
0
CAMTEK LTD
ORD
M20791105
242966
1940
SH
DFND
1940
0
0
CARGO THERAPEUTICS INC
COM
14179K101
2553409
155506
SH
DFND
1,2
155506
0
0
CARTESIAN THERAPEUTICS INC
COM NEW
816212302
677141
25070
SH
DFND
1,2
25070
0
0
CATALYST PHARMACEUTICALS INC
COM
14888U101
4461120
288000
SH
DFND
1,2
288000
0
0
CELLDEX THERAPEUTICS INC NEW
COM NEW
15117B202
11445898
309265
SH
DFND
1,2
309265
0
0
COMPUGEN LTD
ORD
M25722105
1241922
739239
SH
DFND
1,2
739239
0
0
CYBIN INC
COM
23256X100
6932558
25581395
SH
DFND
1,2
25581395
0
0
CYTOKINETICS INC
COM NEW
23282W605
20855182
384924
SH
DFND
1,2
384924
0
0
DAY ONE BIOPHARMACEUTICALS I
COM
23954D109
4790300
347627
SH
DFND
1,2
347627
0
0
DISC MEDICINE INC
COM
254604101
2616043
58044
SH
DFND
1,2
58044
0
0
ELEDON PHARMACEUTICALS INC
COM
28617K101
3424135
1297021
SH
DFND
1,2
1297021
0
0
ELEVATION ONCOLOGY INC
COM
28623U101
891000
330000
SH
DFND
1,2
330000
0
0
ELI LILLY & CO
COM
532457108
11941962
13190
SH
DFND
1,2
13190
0
0
ELIEM THERAPEUTICS INC
COM
28658R106
1529923
215179
SH
DFND
1,2
215179
0
0
ENLIGHT RENEWABLE ENERGY LTD
SHS
M4056D110
2735565
169280
SH
DFND
169280
0
0
ENPHASE ENERGY INC
COM
29355A107
5662730
56792
SH
DFND
56792
0
0
FULCRUM THERAPEUTICS INC
COM
359616109
365800
59000
SH
Put
DFND
1,2
59000
0
0
GLOBAL E ONLINE LTD
SHS
M5216V106
2425883
66884
SH
DFND
66884
0
0
GOSSAMER BIO INC
COM
38341P102
200121
222134
SH
DFND
1,2
222134
0
0
GSK PLC
SPONSORED ADR
37733W204
3850000
100000
SH
DFND
1,2
100000
0
0
ICL GROUP LTD
SHS
M53213100
458979
107238
SH
DFND
107238
0
0
IMMATICS N.V
*W EXP 07/01/202
N44445117
277000
100000
SH
DFND
1,2
100000
0
0
IMMATICS N.V
SHS
N44445109
8495510
731111
SH
DFND
1,2
731111
0
0
INOZYME PHARMA INC
COM
45790W108
6523749
1462724
SH
DFND
1,2
1462724
0
0
INSMED INC
COM PAR $.01
457669307
1111463
16589
SH
DFND
1,2
16589
0
0
INTELLIA THERAPEUTICS INC
COM
45826J105
3120197
139419
SH
DFND
1,2
139419
0
0
INVESCO QQQ TR
UNIT SER 1
46090E103
10971619
22900
SH
Call
DFND
0
0
0
IONIS PHARMACEUTICALS INC
COM
462222100
6683743
140238
SH
DFND
1,2
140238
0
0
JASPER THERAPEUTICS INC
COM NEW
471871202
10310953
454227
SH
DFND
1,2
454227
0
0
JFROG LTD
ORD SHS
M6191J100
4426432
117881
SH
DFND
117881
0
0
JOHNSON & JOHNSON
COM
478160104
10206499
69831
SH
DFND
1,2
69831
0
0
KEZAR LIFE SCIENCES INC
COM
49372L100
1231006
2051676
SH
DFND
1,2
2051676
0
0
KLA CORP
COM NEW
482480100
2720883
3300
SH
DFND
3300
0
0
KURA ONCOLOGY INC
COM
50127T109
12576907
610826
SH
DFND
1,2
610826
0
0
KYVERNA THERAPEUTICS INC
COM
501976104
1770218
236029
SH
DFND
1,2
236029
0
0
L3HARRIS TECHNOLOGIES INC
COM
502431109
2245800
10000
SH
DFND
10000
0
0
LAM RESEARCH CORP
COM
512807108
3939945
3700
SH
DFND
3700
0
0
LARIMAR THERAPEUTICS INC
COM
517125100
2265400
312469
SH
DFND
1,2
312469
0
0
LAVA THERAPEUTICS NV
SHS
N51517105
661648
367582
SH
DFND
1,2
367582
0
0
MARVELL TECHNOLOGY INC
COM
573874104
1398000
20000
SH
DFND
20000
0
0
MERCK & CO INC
COM
58933Y105
7378480
59600
SH
DFND
1,2
59600
0
0
MERUS N V
COM
N5749R100
8735445
147633
SH
DFND
1,2
147633
0
0
META PLATFORMS INC
CL A
30303M102
16860613
33439
SH
DFND
33439
0
0
MICRON TECHNOLOGY INC
COM
595112103
4866610
37000
SH
DFND
37000
0
0
MICROSOFT CORP
COM
594918104
14716723
32927
SH
DFND
32927
0
0
MINERALYS THERAPEUTICS INC
COM
603170101
5180198
442752
SH
DFND
1,2
442752
0
0
MONTE ROSA THERAPEUTICS INC
COM
61225M102
1402500
375000
SH
DFND
1,2
375000
0
0
NICE LTD
SPONSORED ADR
653656108
14008848
81461
SH
DFND
81461
0
0
NICE LTD
SPONSORED ADR
653656108
5520237
32100
SH
Call
DFND
0
0
0
NOVARTIS AG
SPONSORED ADR
66987V109
5323000
50000
SH
DFND
1,2
50000
0
0
NOVO-NORDISK A S
ADR
670100205
11145139
78080
SH
DFND
1,2
78080
0
0
NUTRIEN LTD
COM
67077M108
2073564
40730
SH
DFND
40730
0
0
NVIDIA CORPORATION
COM
67066G104
2470800
20000
SH
DFND
20000
0
0
OUTLOOK THERAPEUTICS INC
COM
69012T305
4217139
571428
SH
DFND
1,2
571428
0
0
PALO ALTO NETWORKS INC
COM
697435105
6102180
18000
SH
DFND
18000
0
0
PERION NETWORK LTD
SHS NEW
M78673114
1958985
234609
SH
DFND
234609
0
0
PERSPECTIVE THERAPEUTICS INC
COM NEW
46489V302
7845483
786909
SH
DFND
1,2
786909
0
0
PFIZER INC
COM
717081103
2518200
90000
SH
DFND
1,2
90000
0
0
PHARVARIS N V
COM
N69605108
7581382
403265
SH
DFND
1,2
403265
0
0
PLIANT THERAPEUTICS INC
COM
729139105
2779456
258554
SH
DFND
1,2
258554
0
0
PRAXIS PRECISION MEDICINES I
COM NEW
74006W207
11722417
283424
SH
DFND
1,2
283424
0
0
PRAXIS PRECISION MEDICINES I
COM NEW
74006W207
3102000
75000
SH
Call
DFND
1,2
0
0
0
PRIME MEDICINE INC
COM
74168J101
654959
127424
SH
DFND
1,2
127424
0
0
PROMIS NEUROSCIENCES INC
COM NEW
74346M406
2721320
1814213
SH
DFND
1,2
1814213
0
0
PTC THERAPEUTICS INC
COM
69366J200
2884244
94318
SH
DFND
1,2
94318
0
0
QUALCOMM INC
COM
747525103
3749564
18825
SH
DFND
18825
0
0
REZOLUTE INC
COM NEW
76200L309
7344396
1707999
SH
DFND
1,2
1707999
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
4455267
206933
SH
DFND
1,2
206933
0
0
SALESFORCE INC
COM
79466L302
8638560
33600
SH
DFND
33600
0
0
SANOFI
SPONSORED ADR
80105N105
21810468
449515
SH
DFND
1,2
449515
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
13218122
83659
SH
DFND
1,2
83659
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
2370000
15000
SH
Call
DFND
1,2
0
0
0
SAVARA INC
COM
805111101
3879629
962687
SH
DFND
1,2
962687
0
0
SENTINELONE INC
CL A
81730H109
5974074
283804
SH
DFND
283804
0
0
SHL TELEMEDICINE LTD
SPONSORED ADS
78423T200
3223438
632456
SH
DFND
632456
0
0
SKYE BIOSCIENCE INC
COM NEW
83086J200
10399479
1298312
SH
DFND
1,2
1298312
0
0
SPRINGWORKS THERAPEUTICS INC
COM
85205L107
2647033
70269
SH
DFND
1,2
70269
0
0
SYNDAX PHARMACEUTICALS INC
COM
87164F105
16876625
822047
SH
DFND
1,2
822047
0
0
TABOOLA.COM LTD
ORD SHS
M8744T106
2295801
667384
SH
DFND
667384
0
0
TAIWAN SEMICONDUCTOR MFG LTD
SPONSORED ADS
874039100
982027
5650
SH
DFND
5650
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
6093750
375000
SH
DFND
1,2
375000
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
6734260
414416
SH
DFND
414416
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
53119625
3268900
SH
Call
DFND
0
0
0
TOWER SEMICONDUCTOR LTD
SHS NEW
M87915274
5880776
149600
SH
DFND
149600
0
0
ULTRAGENYX PHARMACEUTICAL IN
COM
90400D108
12076495
293832
SH
DFND
1,2
293832
0
0
UPWORK INC
COM
91688F104
1257750
117000
SH
DFND
117000
0
0
VANECK ETF TRUST
SEMICONDUCTR ETF
92189F676
39052862
149800
SH
Put
DFND
149800
0
0
VARONIS SYS INC
COM
922280102
767520
16000
SH
DFND
16000
0
0
VENTYX BIOSCIENCES INC
COM
92332V107
2339450
1012749
SH
DFND
1,2
1012749
0
0
VIGIL NEUROSCIENCE INC
COM
92673K108
6768664
1692166
SH
DFND
1,2
1692166
0
0
VIR BIOTECHNOLOGY INC
COM
92764N102
1442254
162051
SH
DFND
1,2
162051
0
0
VISTAGEN THERAPEUTICS INC
COM
92840H400
2813754
808550
SH
DFND
1,2
808550
0
0
WEREWOLF THERAPEUTICS INC
COM
95075A107
1529416
626810
SH
DFND
1,2
626810
0
0
WIX COM LTD
SHS
M98068105
4004905
25177
SH
DFND
25177
0
0