The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103   4,564,889 408,674 SH   DFND 1,2 408,674 0 0
ABBVIE INC COM 00287Y109   7,128,620 46,000 SH   DFND 1,2 46,000 0 0
ADVANCED MICRO DEVICES INC COM 007903107   7,427,548 50,387 SH   DFND   50,387 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   6,934,784 36,230 SH   DFND 1,2 36,230 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   3,828,200 20,000 SH Call DFND 1,2 0 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   4,476,069 234,841 SH   DFND 1,2 234,841 0 0
AMAZON COM INC COM 023135106   8,459,411 55,676 SH   DFND   55,676 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   2,703,328 183,650 SH   DFND 1,2 183,650 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   1,472,000 100,000 SH Call DFND 1,2 0 0 0
APOGEE THERAPEUTICS INC COM 03770N101   838,200 30,000 SH   DFND 1,2 30,000 0 0
ARBE ROBOTICS LTD ORDINARY SHARES M1R95N100   94,100 43,165 SH   DFND   43,165 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100   4,433,909 144,899 SH   DFND 1,2 144,899 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   12,127,041 180,060 SH   DFND 1,2 180,060 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   8,840,794 1,151,145 SH   DFND 1,2 1,151,145 0 0
BIOGEN INC COM 09062X103   11,992,954 46,346 SH   DFND 1,2 46,346 0 0
BRIDGEBIO PHARMA INC COM 10806X102   11,390,234 282,146 SH   DFND 1,2 282,146 0 0
BROADCOM INC COM 11135F101   2,009,250 1,800 SH   DFND   1,800 0 0
CARGO THERAPEUTICS INC COM 14179K101   1,736,250 75,000 SH   DFND 1,2 75,000 0 0
CARTESIAN THERAPEUTICS INC COM 816212104   518,523 752,137 SH   DFND 1,2 752,137 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   12,518,441 315,644 SH   DFND 1,2 315,644 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   4,588,662 115,700 SH Call DFND 1,2 0 0 0
COGENT BIOSCIENCES INC COM 19240Q201   1,524,102 259,201 SH   DFND 1,2 259,201 0 0
COMPUGEN LTD ORD M25722105   1,523,093 769,239 SH   DFND 1,2 769,239 0 0
CYTOKINETICS INC COM NEW 23282W605   18,686,732 223,820 SH   DFND 1,2 223,820 0 0
CYTOKINETICS INC COM NEW 23282W605   2,988,942 35,800 SH Call DFND 1,2 0 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   7,489,800 513,000 SH   DFND 1,2 513,000 0 0
ELEVATION ONCOLOGY INC COM 28623U101   483,300 900,000 SH   DFND 1,2 900,000 0 0
ELI LILLY & CO COM 532457108   8,271,635 14,190 SH   DFND 1,2 14,190 0 0
ENLIGHT RENEWABLE ENERGY LTD SHS M4056D110   3,240,019 169,280 SH   DFND   169,280 0 0
ENPHASE ENERGY INC COM 29355A107   4,598,472 34,800 SH   DFND   34,800 0 0
ENPHASE ENERGY INC COM 29355A107   4,241,694 32,100 SH Call DFND   0 0 0
FIVE9 INC COM 338307101   1,180,350 15,000 SH   DFND   15,000 0 0
FREELINE THERAPEUTICS HLDGS SPONSORED ADS 35655L206   104,755 16,445 SH   DFND 1,2 16,445 0 0
FUSION PHARMACEUTICALS INC COM 36118A100   10,432,991 1,085,639 SH   DFND 1,2 1,085,639 0 0
GILEAD SCIENCES INC COM 375558103   1,620,200 20,000 SH   DFND 1,2 20,000 0 0
GLOBAL E ONLINE LTD SHS M5216V106   10,691,936 269,794 SH   DFND   269,794 0 0
GOSSAMER BIO INC COM 38341P102   1,221,007 1,338,090 SH   DFND 1,2 1,338,090 0 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103   5,049,477 502,936 SH   DFND 1,2 502,936 0 0
GSK PLC SPONSORED ADR 37733W204   3,706,000 100,000 SH   DFND 1,2 100,000 0 0
ICL GROUP LTD SHS M53213100   2,104,200 420,000 SH   DFND   420,000 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117   292,000 100,000 SH   DFND 1,2 0 0 0
IMMATICS N.V SHS N44445109   6,540,299 621,111 SH   DFND 1,2 621,111 0 0
INCYTE CORP COM 45337C102   5,623,221 89,556 SH   DFND 1,2 89,556 0 0
INHIBRX INC COM 45720L107   8,608,938 226,551 SH   DFND 1,2 226,551 0 0
INOZYME PHARMA INC COM 45790W108   6,657,984 1,562,907 SH   DFND 1,2 1,562,907 0 0
JASPER THERAPEUTICS INC COM 471871103   5,626,063 713,063 SH   DFND 1,2 713,063 0 0
JFROG LTD ORD SHS M6191J100   3,803,812 109,905 SH   DFND   109,905 0 0
JOHNSON & JOHNSON COM 478160104   12,512,711 79,831 SH   DFND 1,2 79,831 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   1,943,758 2,051,676 SH   DFND 1,2 2,051,676 0 0
KURA ONCOLOGY INC COM 50127T109   10,113,267 703,287 SH   DFND 1,2 703,287 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   6,424,728 27,767 SH   DFND 1,2 27,767 0 0
MEDIWOUND LTD SHS NEW M68830112   498,124 48,980 SH   DFND 1,2 48,980 0 0
MERCK & CO INC COM 58933Y105   13,474,872 123,600 SH   DFND 1,2 123,600 0 0
MERUS N V COM N5749R100   6,334,158 230,333 SH   DFND 1,2 230,333 0 0
META PLATFORMS INC CL A 30303M102   12,141,890 34,303 SH   DFND   34,303 0 0
MICROSOFT CORP COM 594918104   8,967,802 23,848 SH   DFND   23,848 0 0
MINERALYS THERAPEUTICS INC COM 603170101   6,394,883 743,591 SH   DFND 1,2 743,591 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102   274,087 48,511 SH   DFND 1,2 48,511 0 0
MORPHIC HLDG INC COM 61775R105   431,814 14,952 SH   DFND 1,2 14,952 0 0
NICE LTD SPONSORED ADR 653656108   13,510,418 67,718 SH   DFND   67,718 0 0
NOVA LTD COM M7516K103   18,135,480 132,000 SH   DFND   132,000 0 0
NOVARTIS AG SPONSORED ADR 66987V109   6,058,070 60,000 SH   DFND 1,2 60,000 0 0
NOVO-NORDISK A S ADR 670100205   9,629,126 93,080 SH   DFND 1,2 93,080 0 0
ORIC PHARMACEUTICALS INC COM 68622P109   1,166,560 126,800 SH   DFND 1,2 126,800 0 0
PALO ALTO NETWORKS INC COM 697435105   4,890,585 16,585 SH   DFND   16,585 0 0
PERSPECTIVE THERAPEUTICS INC COM 46489V104   10,320 25,671 SH   DFND 1,2 25,671 0 0
PFIZER INC COM 717081103   2,591,100 90,000 SH   DFND 1,2 90,000 0 0
PHARVARIS N V COM N69605108   6,872,250 245,000 SH   DFND 1,2 245,000 0 0
PLIANT THERAPEUTICS INC COM 729139105   3,505,263 193,554 SH   DFND 1,2 193,554 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W108   7,329,808 328,986 SH   DFND 1,2 328,986 0 0
PRIME MEDICINE INC COM 74168J101   655,463 73,980 SH   DFND 1,2 73,980 0 0
PROMIS NEUROSCIENCES INC COM NEW 74346M406   2,109,148 1,834,042 SH   DFND 1,2 1,834,042 0 0
PROTHENA CORP PLC SHS G72800108   2,478,388 68,200 SH Call DFND 1,2 0 0 0
PTC THERAPEUTICS INC COM 69366J200   3,762,629 136,525 SH   DFND 1,2 136,525 0 0
REPLIMUNE GROUP INC COM 76029N106   135,689 16,096 SH   DFND 1,2 16,096 0 0
REZOLUTE INC COM NEW 76200L309   989,235 996,710 SH   DFND 1,2 996,710 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603   1,780,783 1,228,126 SH   DFND 1,2 1,228,126 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   5,717,767 190,783 SH   DFND 1,2 190,783 0 0
SANOFI SPONSORED ADR 80105N105   24,840,881 499,515 SH   DFND 1,2 499,515 0 0
SAREPTA THERAPEUTICS INC COM 803607100   1,205,375 12,500 SH   DFND 1,2 12,500 0 0
SAREPTA THERAPEUTICS INC COM 803607100   2,545,752 26,400 SH Call DFND 1,2 0 0 0
SENTINELONE INC CL A 81730H109   5,856,190 213,418 SH   DFND   213,418 0 0
SHL TELEMEDICINE LTD SPONSORED ADS 78423T200   5,043,837 632,456 SH   DFND   632,456 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104   4,492,800 48,000 SH   DFND   48,000 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104   2,508,480 26,800 SH Call DFND   0 0 0
SPDR SER TR S&P BIOTECH 78464A870   44,645,000 500,000 SH Put DFND 1,2 500,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   6,214,855 170,270 SH   DFND 1,2 170,270 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   16,703,752 772,964 SH   DFND 1,2 772,964 0 0
TABOOLA.COM LTD ORD SHS M8744T106   7,469,025 1,724,948 SH   DFND   1,724,948 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   20,557,404 1,969,100 SH   DFND   1,969,100 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   5,220,000 500,000 SH   DFND 1,2 500,000 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   13,404,959 1,284,000 SH Call DFND   0 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274   16,123,716 528,300 SH   DFND   528,300 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   9,613,924 201,044 SH   DFND 1,2 201,044 0 0
UPWORK INC COM 91688F104   3,758,898 252,784 SH   DFND   252,784 0 0
VENTYX BIOSCIENCES INC COM 92332V107   444,600 180,000 SH   DFND 1,2 180,000 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   1,808,706 535,120 SH   DFND 1,2 535,120 0 0
VISTAGEN THERAPEUTICS INC COM 92840H400   4,155,947 808,550 SH   DFND 1,2 808,550 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107   2,419,487 626,810 SH   DFND 1,2 626,810 0 0
WIX COM LTD SHS M98068105   7,070,821 57,477 SH   DFND   57,477 0 0