The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
89BIO INC | COM | 282559103 | 4,564,889 | 408,674 | SH | DFND | 1,2 | 408,674 | 0 | 0 | ||
ABBVIE INC | COM | 00287Y109 | 7,128,620 | 46,000 | SH | DFND | 1,2 | 46,000 | 0 | 0 | ||
ADVANCED MICRO DEVICES INC | COM | 007903107 | 7,427,548 | 50,387 | SH | DFND | 50,387 | 0 | 0 | |||
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 6,934,784 | 36,230 | SH | DFND | 1,2 | 36,230 | 0 | 0 | ||
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 3,828,200 | 20,000 | SH | Call | DFND | 1,2 | 0 | 0 | 0 | |
ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 4,476,069 | 234,841 | SH | DFND | 1,2 | 234,841 | 0 | 0 | ||
AMAZON COM INC | COM | 023135106 | 8,459,411 | 55,676 | SH | DFND | 55,676 | 0 | 0 | |||
AMYLYX PHARMACEUTICALS INC | COM | 03237H101 | 2,703,328 | 183,650 | SH | DFND | 1,2 | 183,650 | 0 | 0 | ||
AMYLYX PHARMACEUTICALS INC | COM | 03237H101 | 1,472,000 | 100,000 | SH | Call | DFND | 1,2 | 0 | 0 | 0 | |
APOGEE THERAPEUTICS INC | COM | 03770N101 | 838,200 | 30,000 | SH | DFND | 1,2 | 30,000 | 0 | 0 | ||
ARBE ROBOTICS LTD | ORDINARY SHARES | M1R95N100 | 94,100 | 43,165 | SH | DFND | 43,165 | 0 | 0 | |||
ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 | 4,433,909 | 144,899 | SH | DFND | 1,2 | 144,899 | 0 | 0 | ||
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 12,127,041 | 180,060 | SH | DFND | 1,2 | 180,060 | 0 | 0 | ||
ASTRIA THERAPEUTICS INC | COM | 04635X102 | 8,840,794 | 1,151,145 | SH | DFND | 1,2 | 1,151,145 | 0 | 0 | ||
BIOGEN INC | COM | 09062X103 | 11,992,954 | 46,346 | SH | DFND | 1,2 | 46,346 | 0 | 0 | ||
BRIDGEBIO PHARMA INC | COM | 10806X102 | 11,390,234 | 282,146 | SH | DFND | 1,2 | 282,146 | 0 | 0 | ||
BROADCOM INC | COM | 11135F101 | 2,009,250 | 1,800 | SH | DFND | 1,800 | 0 | 0 | |||
CARGO THERAPEUTICS INC | COM | 14179K101 | 1,736,250 | 75,000 | SH | DFND | 1,2 | 75,000 | 0 | 0 | ||
CARTESIAN THERAPEUTICS INC | COM | 816212104 | 518,523 | 752,137 | SH | DFND | 1,2 | 752,137 | 0 | 0 | ||
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 12,518,441 | 315,644 | SH | DFND | 1,2 | 315,644 | 0 | 0 | ||
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 4,588,662 | 115,700 | SH | Call | DFND | 1,2 | 0 | 0 | 0 | |
COGENT BIOSCIENCES INC | COM | 19240Q201 | 1,524,102 | 259,201 | SH | DFND | 1,2 | 259,201 | 0 | 0 | ||
COMPUGEN LTD | ORD | M25722105 | 1,523,093 | 769,239 | SH | DFND | 1,2 | 769,239 | 0 | 0 | ||
CYTOKINETICS INC | COM NEW | 23282W605 | 18,686,732 | 223,820 | SH | DFND | 1,2 | 223,820 | 0 | 0 | ||
CYTOKINETICS INC | COM NEW | 23282W605 | 2,988,942 | 35,800 | SH | Call | DFND | 1,2 | 0 | 0 | 0 | |
DAY ONE BIOPHARMACEUTICALS I | COM | 23954D109 | 7,489,800 | 513,000 | SH | DFND | 1,2 | 513,000 | 0 | 0 | ||
ELEVATION ONCOLOGY INC | COM | 28623U101 | 483,300 | 900,000 | SH | DFND | 1,2 | 900,000 | 0 | 0 | ||
ELI LILLY & CO | COM | 532457108 | 8,271,635 | 14,190 | SH | DFND | 1,2 | 14,190 | 0 | 0 | ||
ENLIGHT RENEWABLE ENERGY LTD | SHS | M4056D110 | 3,240,019 | 169,280 | SH | DFND | 169,280 | 0 | 0 | |||
ENPHASE ENERGY INC | COM | 29355A107 | 4,598,472 | 34,800 | SH | DFND | 34,800 | 0 | 0 | |||
ENPHASE ENERGY INC | COM | 29355A107 | 4,241,694 | 32,100 | SH | Call | DFND | 0 | 0 | 0 | ||
FIVE9 INC | COM | 338307101 | 1,180,350 | 15,000 | SH | DFND | 15,000 | 0 | 0 | |||
FREELINE THERAPEUTICS HLDGS | SPONSORED ADS | 35655L206 | 104,755 | 16,445 | SH | DFND | 1,2 | 16,445 | 0 | 0 | ||
FUSION PHARMACEUTICALS INC | COM | 36118A100 | 10,432,991 | 1,085,639 | SH | DFND | 1,2 | 1,085,639 | 0 | 0 | ||
GILEAD SCIENCES INC | COM | 375558103 | 1,620,200 | 20,000 | SH | DFND | 1,2 | 20,000 | 0 | 0 | ||
GLOBAL E ONLINE LTD | SHS | M5216V106 | 10,691,936 | 269,794 | SH | DFND | 269,794 | 0 | 0 | |||
GOSSAMER BIO INC | COM | 38341P102 | 1,221,007 | 1,338,090 | SH | DFND | 1,2 | 1,338,090 | 0 | 0 | ||
GRACELL BIOTECHNOLOGIES INC | SPONSORED ADS | 38406L103 | 5,049,477 | 502,936 | SH | DFND | 1,2 | 502,936 | 0 | 0 | ||
GSK PLC | SPONSORED ADR | 37733W204 | 3,706,000 | 100,000 | SH | DFND | 1,2 | 100,000 | 0 | 0 | ||
ICL GROUP LTD | SHS | M53213100 | 2,104,200 | 420,000 | SH | DFND | 420,000 | 0 | 0 | |||
IMMATICS N.V | *W EXP 07/01/202 | N44445117 | 292,000 | 100,000 | SH | DFND | 1,2 | 0 | 0 | 0 | ||
IMMATICS N.V | SHS | N44445109 | 6,540,299 | 621,111 | SH | DFND | 1,2 | 621,111 | 0 | 0 | ||
INCYTE CORP | COM | 45337C102 | 5,623,221 | 89,556 | SH | DFND | 1,2 | 89,556 | 0 | 0 | ||
INHIBRX INC | COM | 45720L107 | 8,608,938 | 226,551 | SH | DFND | 1,2 | 226,551 | 0 | 0 | ||
INOZYME PHARMA INC | COM | 45790W108 | 6,657,984 | 1,562,907 | SH | DFND | 1,2 | 1,562,907 | 0 | 0 | ||
JASPER THERAPEUTICS INC | COM | 471871103 | 5,626,063 | 713,063 | SH | DFND | 1,2 | 713,063 | 0 | 0 | ||
JFROG LTD | ORD SHS | M6191J100 | 3,803,812 | 109,905 | SH | DFND | 109,905 | 0 | 0 | |||
JOHNSON & JOHNSON | COM | 478160104 | 12,512,711 | 79,831 | SH | DFND | 1,2 | 79,831 | 0 | 0 | ||
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 1,943,758 | 2,051,676 | SH | DFND | 1,2 | 2,051,676 | 0 | 0 | ||
KURA ONCOLOGY INC | COM | 50127T109 | 10,113,267 | 703,287 | SH | DFND | 1,2 | 703,287 | 0 | 0 | ||
MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 6,424,728 | 27,767 | SH | DFND | 1,2 | 27,767 | 0 | 0 | ||
MEDIWOUND LTD | SHS NEW | M68830112 | 498,124 | 48,980 | SH | DFND | 1,2 | 48,980 | 0 | 0 | ||
MERCK & CO INC | COM | 58933Y105 | 13,474,872 | 123,600 | SH | DFND | 1,2 | 123,600 | 0 | 0 | ||
MERUS N V | COM | N5749R100 | 6,334,158 | 230,333 | SH | DFND | 1,2 | 230,333 | 0 | 0 | ||
META PLATFORMS INC | CL A | 30303M102 | 12,141,890 | 34,303 | SH | DFND | 34,303 | 0 | 0 | |||
MICROSOFT CORP | COM | 594918104 | 8,967,802 | 23,848 | SH | DFND | 23,848 | 0 | 0 | |||
MINERALYS THERAPEUTICS INC | COM | 603170101 | 6,394,883 | 743,591 | SH | DFND | 1,2 | 743,591 | 0 | 0 | ||
MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 274,087 | 48,511 | SH | DFND | 1,2 | 48,511 | 0 | 0 | ||
MORPHIC HLDG INC | COM | 61775R105 | 431,814 | 14,952 | SH | DFND | 1,2 | 14,952 | 0 | 0 | ||
NICE LTD | SPONSORED ADR | 653656108 | 13,510,418 | 67,718 | SH | DFND | 67,718 | 0 | 0 | |||
NOVA LTD | COM | M7516K103 | 18,135,480 | 132,000 | SH | DFND | 132,000 | 0 | 0 | |||
NOVARTIS AG | SPONSORED ADR | 66987V109 | 6,058,070 | 60,000 | SH | DFND | 1,2 | 60,000 | 0 | 0 | ||
NOVO-NORDISK A S | ADR | 670100205 | 9,629,126 | 93,080 | SH | DFND | 1,2 | 93,080 | 0 | 0 | ||
ORIC PHARMACEUTICALS INC | COM | 68622P109 | 1,166,560 | 126,800 | SH | DFND | 1,2 | 126,800 | 0 | 0 | ||
PALO ALTO NETWORKS INC | COM | 697435105 | 4,890,585 | 16,585 | SH | DFND | 16,585 | 0 | 0 | |||
PERSPECTIVE THERAPEUTICS INC | COM | 46489V104 | 10,320 | 25,671 | SH | DFND | 1,2 | 25,671 | 0 | 0 | ||
PFIZER INC | COM | 717081103 | 2,591,100 | 90,000 | SH | DFND | 1,2 | 90,000 | 0 | 0 | ||
PHARVARIS N V | COM | N69605108 | 6,872,250 | 245,000 | SH | DFND | 1,2 | 245,000 | 0 | 0 | ||
PLIANT THERAPEUTICS INC | COM | 729139105 | 3,505,263 | 193,554 | SH | DFND | 1,2 | 193,554 | 0 | 0 | ||
PRAXIS PRECISION MEDICINES I | COM NEW | 74006W108 | 7,329,808 | 328,986 | SH | DFND | 1,2 | 328,986 | 0 | 0 | ||
PRIME MEDICINE INC | COM | 74168J101 | 655,463 | 73,980 | SH | DFND | 1,2 | 73,980 | 0 | 0 | ||
PROMIS NEUROSCIENCES INC | COM NEW | 74346M406 | 2,109,148 | 1,834,042 | SH | DFND | 1,2 | 1,834,042 | 0 | 0 | ||
PROTHENA CORP PLC | SHS | G72800108 | 2,478,388 | 68,200 | SH | Call | DFND | 1,2 | 0 | 0 | 0 | |
PTC THERAPEUTICS INC | COM | 69366J200 | 3,762,629 | 136,525 | SH | DFND | 1,2 | 136,525 | 0 | 0 | ||
REPLIMUNE GROUP INC | COM | 76029N106 | 135,689 | 16,096 | SH | DFND | 1,2 | 16,096 | 0 | 0 | ||
REZOLUTE INC | COM NEW | 76200L309 | 989,235 | 996,710 | SH | DFND | 1,2 | 996,710 | 0 | 0 | ||
RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 1,780,783 | 1,228,126 | SH | DFND | 1,2 | 1,228,126 | 0 | 0 | ||
ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 5,717,767 | 190,783 | SH | DFND | 1,2 | 190,783 | 0 | 0 | ||
SANOFI | SPONSORED ADR | 80105N105 | 24,840,881 | 499,515 | SH | DFND | 1,2 | 499,515 | 0 | 0 | ||
SAREPTA THERAPEUTICS INC | COM | 803607100 | 1,205,375 | 12,500 | SH | DFND | 1,2 | 12,500 | 0 | 0 | ||
SAREPTA THERAPEUTICS INC | COM | 803607100 | 2,545,752 | 26,400 | SH | Call | DFND | 1,2 | 0 | 0 | 0 | |
SENTINELONE INC | CL A | 81730H109 | 5,856,190 | 213,418 | SH | DFND | 213,418 | 0 | 0 | |||
SHL TELEMEDICINE LTD | SPONSORED ADS | 78423T200 | 5,043,837 | 632,456 | SH | DFND | 632,456 | 0 | 0 | |||
SOLAREDGE TECHNOLOGIES INC | COM | 83417M104 | 4,492,800 | 48,000 | SH | DFND | 48,000 | 0 | 0 | |||
SOLAREDGE TECHNOLOGIES INC | COM | 83417M104 | 2,508,480 | 26,800 | SH | Call | DFND | 0 | 0 | 0 | ||
SPDR SER TR | S&P BIOTECH | 78464A870 | 44,645,000 | 500,000 | SH | Put | DFND | 1,2 | 500,000 | 0 | 0 | |
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 6,214,855 | 170,270 | SH | DFND | 1,2 | 170,270 | 0 | 0 | ||
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 16,703,752 | 772,964 | SH | DFND | 1,2 | 772,964 | 0 | 0 | ||
TABOOLA.COM LTD | ORD SHS | M8744T106 | 7,469,025 | 1,724,948 | SH | DFND | 1,724,948 | 0 | 0 | |||
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 20,557,404 | 1,969,100 | SH | DFND | 1,969,100 | 0 | 0 | |||
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 5,220,000 | 500,000 | SH | DFND | 1,2 | 500,000 | 0 | 0 | ||
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 13,404,959 | 1,284,000 | SH | Call | DFND | 0 | 0 | 0 | ||
TOWER SEMICONDUCTOR LTD | SHS NEW | M87915274 | 16,123,716 | 528,300 | SH | DFND | 528,300 | 0 | 0 | |||
ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 9,613,924 | 201,044 | SH | DFND | 1,2 | 201,044 | 0 | 0 | ||
UPWORK INC | COM | 91688F104 | 3,758,898 | 252,784 | SH | DFND | 252,784 | 0 | 0 | |||
VENTYX BIOSCIENCES INC | COM | 92332V107 | 444,600 | 180,000 | SH | DFND | 1,2 | 180,000 | 0 | 0 | ||
VIGIL NEUROSCIENCE INC | COM | 92673K108 | 1,808,706 | 535,120 | SH | DFND | 1,2 | 535,120 | 0 | 0 | ||
VISTAGEN THERAPEUTICS INC | COM | 92840H400 | 4,155,947 | 808,550 | SH | DFND | 1,2 | 808,550 | 0 | 0 | ||
WEREWOLF THERAPEUTICS INC | COM | 95075A107 | 2,419,487 | 626,810 | SH | DFND | 1,2 | 626,810 | 0 | 0 | ||
WIX COM LTD | SHS | M98068105 | 7,070,821 | 57,477 | SH | DFND | 57,477 | 0 | 0 |