0001496201-24-000005.txt : 20240215
0001496201-24-000005.hdr.sgml : 20240215
20240215074032
ACCESSION NUMBER: 0001496201-24-000005
CONFORMED SUBMISSION TYPE: 13F-HR/A
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20231231
FILED AS OF DATE: 20240215
DATE AS OF CHANGE: 20240215
EFFECTIVENESS DATE: 20240215
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
ORGANIZATION NAME:
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR/A
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 24642118
BUSINESS ADDRESS:
STREET 1: 4 ITZHAK SADE BUILDING A
STREET 2: 29TH FLOOR
CITY: TEL AVIV
STATE: L3
ZIP: 6777520
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 4 ITZHAK SADE BUILDING A
STREET 2: 29TH FLOOR
CITY: TEL AVIV
STATE: L3
ZIP: 6777520
13F-HR/A
1
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12-31-2023
12-31-2023
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1
RESTATEMENT
SPHERA FUNDS MANAGEMENT LTD.
4 ITZHAK SADE BUILDING A
29TH FLOOR
TEL AVIV
L3
6777520
13F HOLDINGS REPORT
028-15863
000031261
802-120694
Y
Investment discretion with regard to a portion of the securities reported herein exercised by Sphera Portfolio Management Ltd, which is wholly owned by Sphera Funds Management Ltd. Per guidance received from the Division of Investment Management, since Sphera Portfolio Management Ltd does not meet the Section 13(f) securities threshold, its holdings are aggregated with those reported for Sphera Funds Management Ltd. Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 90% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint the members of the board of directors of the General Partner (the "Board of Directors"), and therefore may be deemed to control the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, Sphera Portfolio Management, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, Sphera Portfolio Management, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Neomi Elpeleg
Chief Financial Officer
972 3 6845564
Neomi Elpeleg
Tel Aviv
L3
02-15-2024
2
100
621338814
false
1
0001599854
028-15865
000017260
802-127045
Sphera Global Healthcare Management LP
2
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
INFORMATION TABLE
2
spheraq413f.xml
89BIO INC
COM
282559103
4564889
408674
SH
DFND
1,2
408674
0
0
ABBVIE INC
COM
00287Y109
7128620
46000
SH
DFND
1,2
46000
0
0
ADVANCED MICRO DEVICES INC
COM
007903107
7427548
50387
SH
DFND
50387
0
0
ALNYLAM PHARMACEUTICALS INC
COM
02043Q107
6934784
36230
SH
DFND
1,2
36230
0
0
ALNYLAM PHARMACEUTICALS INC
COM
02043Q107
3828200
20000
SH
Call
DFND
1,2
0
0
0
ALPINE IMMUNE SCIENCES INC
COM
02083G100
4476069
234841
SH
DFND
1,2
234841
0
0
AMAZON COM INC
COM
023135106
8459411
55676
SH
DFND
55676
0
0
AMYLYX PHARMACEUTICALS INC
COM
03237H101
2703328
183650
SH
DFND
1,2
183650
0
0
AMYLYX PHARMACEUTICALS INC
COM
03237H101
1472000
100000
SH
Call
DFND
1,2
0
0
0
APOGEE THERAPEUTICS INC
COM
03770N101
838200
30000
SH
DFND
1,2
30000
0
0
ARBE ROBOTICS LTD
ORDINARY SHARES
M1R95N100
94100
43165
SH
DFND
43165
0
0
ARROWHEAD PHARMACEUTICALS IN
COM
04280A100
4433909
144899
SH
DFND
1,2
144899
0
0
ASTRAZENECA PLC
SPONSORED ADR
046353108
12127041
180060
SH
DFND
1,2
180060
0
0
ASTRIA THERAPEUTICS INC
COM
04635X102
8840794
1151145
SH
DFND
1,2
1151145
0
0
BIOGEN INC
COM
09062X103
11992954
46346
SH
DFND
1,2
46346
0
0
BRIDGEBIO PHARMA INC
COM
10806X102
11390234
282146
SH
DFND
1,2
282146
0
0
BROADCOM INC
COM
11135F101
2009250
1800
SH
DFND
1800
0
0
CARGO THERAPEUTICS INC
COM
14179K101
1736250
75000
SH
DFND
1,2
75000
0
0
CARTESIAN THERAPEUTICS INC
COM
816212104
518523
752137
SH
DFND
1,2
752137
0
0
CELLDEX THERAPEUTICS INC NEW
COM NEW
15117B202
12518441
315644
SH
DFND
1,2
315644
0
0
CELLDEX THERAPEUTICS INC NEW
COM NEW
15117B202
4588662
115700
SH
Call
DFND
1,2
0
0
0
COGENT BIOSCIENCES INC
COM
19240Q201
1524102
259201
SH
DFND
1,2
259201
0
0
COMPUGEN LTD
ORD
M25722105
1523093
769239
SH
DFND
1,2
769239
0
0
CYTOKINETICS INC
COM NEW
23282W605
18686732
223820
SH
DFND
1,2
223820
0
0
CYTOKINETICS INC
COM NEW
23282W605
2988942
35800
SH
Call
DFND
1,2
0
0
0
DAY ONE BIOPHARMACEUTICALS I
COM
23954D109
7489800
513000
SH
DFND
1,2
513000
0
0
ELEVATION ONCOLOGY INC
COM
28623U101
483300
900000
SH
DFND
1,2
900000
0
0
ELI LILLY & CO
COM
532457108
8271635
14190
SH
DFND
1,2
14190
0
0
ENLIGHT RENEWABLE ENERGY LTD
SHS
M4056D110
3240019
169280
SH
DFND
169280
0
0
ENPHASE ENERGY INC
COM
29355A107
4598472
34800
SH
DFND
34800
0
0
ENPHASE ENERGY INC
COM
29355A107
4241694
32100
SH
Call
DFND
0
0
0
FIVE9 INC
COM
338307101
1180350
15000
SH
DFND
15000
0
0
FREELINE THERAPEUTICS HLDGS
SPONSORED ADS
35655L206
104755
16445
SH
DFND
1,2
16445
0
0
FUSION PHARMACEUTICALS INC
COM
36118A100
10432991
1085639
SH
DFND
1,2
1085639
0
0
GILEAD SCIENCES INC
COM
375558103
1620200
20000
SH
DFND
1,2
20000
0
0
GLOBAL E ONLINE LTD
SHS
M5216V106
10691936
269794
SH
DFND
269794
0
0
GOSSAMER BIO INC
COM
38341P102
1221007
1338090
SH
DFND
1,2
1338090
0
0
GRACELL BIOTECHNOLOGIES INC
SPONSORED ADS
38406L103
5049477
502936
SH
DFND
1,2
502936
0
0
GSK PLC
SPONSORED ADR
37733W204
3706000
100000
SH
DFND
1,2
100000
0
0
ICL GROUP LTD
SHS
M53213100
2104200
420000
SH
DFND
420000
0
0
IMMATICS N.V
*W EXP 07/01/202
N44445117
292000
100000
SH
DFND
1,2
0
0
0
IMMATICS N.V
SHS
N44445109
6540299
621111
SH
DFND
1,2
621111
0
0
INCYTE CORP
COM
45337C102
5623221
89556
SH
DFND
1,2
89556
0
0
INHIBRX INC
COM
45720L107
8608938
226551
SH
DFND
1,2
226551
0
0
INOZYME PHARMA INC
COM
45790W108
6657984
1562907
SH
DFND
1,2
1562907
0
0
JASPER THERAPEUTICS INC
COM
471871103
5626063
713063
SH
DFND
1,2
713063
0
0
JFROG LTD
ORD SHS
M6191J100
3803812
109905
SH
DFND
109905
0
0
JOHNSON & JOHNSON
COM
478160104
12512711
79831
SH
DFND
1,2
79831
0
0
KEZAR LIFE SCIENCES INC
COM
49372L100
1943758
2051676
SH
DFND
1,2
2051676
0
0
KURA ONCOLOGY INC
COM
50127T109
10113267
703287
SH
DFND
1,2
703287
0
0
MADRIGAL PHARMACEUTICALS INC
COM
558868105
6424728
27767
SH
DFND
1,2
27767
0
0
MEDIWOUND LTD
SHS NEW
M68830112
498124
48980
SH
DFND
1,2
48980
0
0
MERCK & CO INC
COM
58933Y105
13474872
123600
SH
DFND
1,2
123600
0
0
MERUS N V
COM
N5749R100
6334158
230333
SH
DFND
1,2
230333
0
0
META PLATFORMS INC
CL A
30303M102
12141890
34303
SH
DFND
34303
0
0
MICROSOFT CORP
COM
594918104
8967802
23848
SH
DFND
23848
0
0
MINERALYS THERAPEUTICS INC
COM
603170101
6394883
743591
SH
DFND
1,2
743591
0
0
MONTE ROSA THERAPEUTICS INC
COM
61225M102
274087
48511
SH
DFND
1,2
48511
0
0
MORPHIC HLDG INC
COM
61775R105
431814
14952
SH
DFND
1,2
14952
0
0
NICE LTD
SPONSORED ADR
653656108
13510418
67718
SH
DFND
67718
0
0
NOVA LTD
COM
M7516K103
18135480
132000
SH
DFND
132000
0
0
NOVARTIS AG
SPONSORED ADR
66987V109
6058070
60000
SH
DFND
1,2
60000
0
0
NOVO-NORDISK A S
ADR
670100205
9629126
93080
SH
DFND
1,2
93080
0
0
ORIC PHARMACEUTICALS INC
COM
68622P109
1166560
126800
SH
DFND
1,2
126800
0
0
PALO ALTO NETWORKS INC
COM
697435105
4890585
16585
SH
DFND
16585
0
0
PERSPECTIVE THERAPEUTICS INC
COM
46489V104
10320
25671
SH
DFND
1,2
25671
0
0
PFIZER INC
COM
717081103
2591100
90000
SH
DFND
1,2
90000
0
0
PHARVARIS N V
COM
N69605108
6872250
245000
SH
DFND
1,2
245000
0
0
PLIANT THERAPEUTICS INC
COM
729139105
3505263
193554
SH
DFND
1,2
193554
0
0
PRAXIS PRECISION MEDICINES I
COM NEW
74006W108
7329808
328986
SH
DFND
1,2
328986
0
0
PRIME MEDICINE INC
COM
74168J101
655463
73980
SH
DFND
1,2
73980
0
0
PROMIS NEUROSCIENCES INC
COM NEW
74346M406
2109148
1834042
SH
DFND
1,2
1834042
0
0
PROTHENA CORP PLC
SHS
G72800108
2478388
68200
SH
Call
DFND
1,2
0
0
0
PTC THERAPEUTICS INC
COM
69366J200
3762629
136525
SH
DFND
1,2
136525
0
0
REPLIMUNE GROUP INC
COM
76029N106
135689
16096
SH
DFND
1,2
16096
0
0
REZOLUTE INC
COM NEW
76200L309
989235
996710
SH
DFND
1,2
996710
0
0
RIGEL PHARMACEUTICALS INC
COM NEW
766559603
1780783
1228126
SH
DFND
1,2
1228126
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
5717767
190783
SH
DFND
1,2
190783
0
0
SANOFI
SPONSORED ADR
80105N105
24840881
499515
SH
DFND
1,2
499515
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
1205375
12500
SH
DFND
1,2
12500
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
2545752
26400
SH
Call
DFND
1,2
0
0
0
SENTINELONE INC
CL A
81730H109
5856190
213418
SH
DFND
213418
0
0
SHL TELEMEDICINE LTD
SPONSORED ADS
78423T200
5043837
632456
SH
DFND
632456
0
0
SOLAREDGE TECHNOLOGIES INC
COM
83417M104
4492800
48000
SH
DFND
48000
0
0
SOLAREDGE TECHNOLOGIES INC
COM
83417M104
2508480
26800
SH
Call
DFND
0
0
0
SPDR SER TR
S&P BIOTECH
78464A870
44645000
500000
SH
Put
DFND
1,2
500000
0
0
SPRINGWORKS THERAPEUTICS INC
COM
85205L107
6214855
170270
SH
DFND
1,2
170270
0
0
SYNDAX PHARMACEUTICALS INC
COM
87164F105
16703752
772964
SH
DFND
1,2
772964
0
0
TABOOLA.COM LTD
ORD SHS
M8744T106
7469025
1724948
SH
DFND
1724948
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
20557404
1969100
SH
DFND
1969100
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
5220000
500000
SH
DFND
1,2
500000
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
13404959
1284000
SH
Call
DFND
0
0
0
TOWER SEMICONDUCTOR LTD
SHS NEW
M87915274
16123716
528300
SH
DFND
528300
0
0
ULTRAGENYX PHARMACEUTICAL IN
COM
90400D108
9613924
201044
SH
DFND
1,2
201044
0
0
UPWORK INC
COM
91688F104
3758898
252784
SH
DFND
252784
0
0
VENTYX BIOSCIENCES INC
COM
92332V107
444600
180000
SH
DFND
1,2
180000
0
0
VIGIL NEUROSCIENCE INC
COM
92673K108
1808706
535120
SH
DFND
1,2
535120
0
0
VISTAGEN THERAPEUTICS INC
COM
92840H400
4155947
808550
SH
DFND
1,2
808550
0
0
WEREWOLF THERAPEUTICS INC
COM
95075A107
2419487
626810
SH
DFND
1,2
626810
0
0
WIX COM LTD
SHS
M98068105
7070821
57477
SH
DFND
57477
0
0