The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103   4,930,007 319,301 SH   DFND 1,2 319,301 0 0
ABBVIE INC COM 00287Y109   6,856,760 46,000 SH   DFND 1,2 46,000 0 0
ADVANCED MICRO DEVICES INC COM 007903107   4,968,262 48,320 SH   DFND   48,320 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   6,393,487 36,101 SH   DFND 1,2 36,101 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   2,061,000 180,000 SH   DFND 1,2 180,000 0 0
AMAZON COM INC COM 023135106   12,114,536 95,300 SH   DFND   95,300 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   3,545,732 193,650 SH   DFND 1,2 193,650 0 0
APOGEE THERAPEUTICS INC COM 03770N101   639,000 30,000 SH   DFND 1,2 30,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   19,304,263 285,060 SH   DFND 1,2 285,060 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   4,331,269 580,599 SH   DFND 1,2 580,599 0 0
BIOGEN INC COM 09062X103   6,642,680 25,846 SH   DFND 1,2 25,846 0 0
BRIDGEBIO PHARMA INC COM 10806X102   9,111,811 345,537 SH   DFND 1,2 345,537 0 0
CALLIDITAS THERAPEUTICS AB SPONSERED ADS 13124Q106   216,618 11,863 SH   DFND 1,2 11,863 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   4,953,600 180,000 SH   DFND 1,2 180,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   2,752,000 100,000 SH Call DFND 1,2 0 0 0
COGENT BIOSCIENCES INC COM 19240Q201   4,095,000 420,000 SH   DFND 1,2 420,000 0 0
COMPUGEN LTD ORD M25722105   1,226,892 1,319,239 SH   DFND 1,2 1,319,239 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105   2,510,700 15,000 SH   DFND   15,000 0 0
CYTOKINETICS INC COM NEW 23282W605   6,891,666 233,933 SH   DFND 1,2 233,933 0 0
CYTOKINETICS INC COM NEW 23282W605   1,914,900 65,000 SH Call DFND 1,2 0 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   6,503,100 530,000 SH   DFND 1,2 530,000 0 0
DISC MEDICINE INC COM 254604101   5,233,478 111,398 SH   DFND 1,2 111,398 0 0
ELEVATION ONCOLOGY INC COM 28623U101   596,340 900,000 SH   DFND 1,2 900,000 0 0
ELI LILLY & CO COM 532457108   7,621,875 14,190 SH   DFND 1,2 14,190 0 0
ENPHASE ENERGY INC NOTE 3/0 29355AAK3   17,329,862 20,900,000 SH   DFND   20,900,000 0 0
FUSION PHARMACEUTICALS INC COM 36118A100   3,521,071 1,354,258 SH   DFND 1,2 1,354,258 0 0
GILEAD SCIENCES INC COM 375558103   2,997,600 40,000 SH   DFND 1,2 40,000 0 0
GOSSAMER BIO INC COM 38341P102   1,609,443 1,932,568 SH   DFND 1,2 1,932,568 0 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103   4,410,711 1,531,497 SH   DFND 1,2 1,531,497 0 0
GSK PLC SPONSORED ADR 37733W204   3,625,000 100,000 SH   DFND 1,2 100,000 0 0
ICL GROUP LTD SHS M53213100   2,608,500 470,000 SH   DFND   470,000 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117   354,000 100,000 SH   DFND 1,2 0 0 0
IMMATICS N.V SHS N44445109   7,146,863 617,173 SH   DFND 1,2 617,173 0 0
INHIBRX INC COM 45720L107   4,704,408 256,371 SH   DFND 1,2 256,371 0 0
INOZYME PHARMA INC COM 45790W108   5,186,609 1,234,907 SH   DFND 1,2 1,234,907 0 0
INVESCO QQQ TR PUT 46090E953   48,903,854 136,500 SH Put DFND   136,500 0 0
JASPER THERAPEUTICS INC COM 471871103   3,980,994 5,687,134 SH   DFND 1,2 5,687,134 0 0
JOHNSON & JOHNSON COM 478160104   14,769,928 94,831 SH   DFND 1,2 94,831 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   2,441,494 2,051,676 SH   DFND 1,2 2,051,676 0 0
KURA ONCOLOGY INC COM 50127T109   6,413,977 703,287 SH   DFND 1,2 703,287 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   7,428,617 50,867 SH   DFND 1,2 50,867 0 0
MEDIWOUND LTD SHS NEW M68830112   521,144 48,980 SH   DFND 1,2 48,980 0 0
MEDIWOUND LTD SHS NEW M68830112   633,647 59,553 SH   DFND   59,553 0 0
MERCK & CO INC COM 58933Y105   12,724,620 123,600 SH   DFND 1,2 123,600 0 0
MERUS N V COM N5749R100   5,973,592 253,333 SH   DFND 1,2 253,333 0 0
META PLATFORMS INC CL A 30303M102   4,569,196 15,220 SH   DFND   15,220 0 0
MICROSOFT CORP COM 594918104   10,875,062 34,442 SH   DFND   34,442 0 0
MINERALYS THERAPEUTICS INC COM 603170101   4,330,854 455,400 SH   DFND 1,2 455,400 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   3,611,374 114,284 SH   DFND 1,2 114,284 0 0
MORPHIC HLDG INC COM 61775R105   2,061,900 90,000 SH   DFND 1,2 90,000 0 0
NICE LTD SPONSORED ADR 653656108   6,371,940 37,482 SH   DFND   37,482 0 0
NICE LTD SPONSORED ADR 653656108   17,850,000 105,000 SH Call DFND   0 0 0
NOVARTIS AG SPONSORED ADR 66987V109   6,111,600 60,000 SH   DFND 1,2 60,000 0 0
NOVO-NORDISK A S ADR 670100205   8,464,695 93,080 SH   DFND 1,2 93,080 0 0
PALO ALTO NETWORKS INC COM 697435105   6,742,260 28,759 SH   DFND   28,759 0 0
PFIZER INC COM 717081103   2,985,300 90,000 SH   DFND 1,2 90,000 0 0
PLIANT THERAPEUTICS INC COM 729139105   2,707,364 156,134 SH   DFND 1,2 156,134 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109   6,354,122 952,642 SH   DFND 1,2 952,642 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108   8,294,042 4,850,317 SH   DFND 1,2 4,850,317 0 0
PROMIS NEUROSCIENCES INC COM NEW 74346M406   3,686,424 1,834,042 SH   DFND 1,2 1,834,042 0 0
PTC THERAPEUTICS INC COM 69366J200   4,895,666 218,459 SH   DFND 1,2 218,459 0 0
REPLIMUNE GROUP INC COM 76029N106   3,165,624 185,016 SH   DFND 1,2 185,016 0 0
REZOLUTE INC COM NEW 76200L309   1,315,657 996,710 SH   DFND 1,2 996,710 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603   1,326,376 1,228,126 SH   DFND 1,2 1,228,126 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   4,283,230 209,040 SH   DFND 1,2 209,040 0 0
SANOFI SPONSORED ADR 80105N105   26,793,985 499,515 SH   DFND 1,2 499,515 0 0
SAREPTA THERAPEUTICS INC COM 803607100   6,061,000 50,000 SH   DFND 1,2 50,000 0 0
SELECTA BIOSCIENCES INC COM 816212104   797,265 752,137 SH   DFND 1,2 752,137 0 0
SHL TELEMEDICINE LTD SPONSORED ADS 78423T200   6,956,523 632,256 SH   DFND   632,256 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104   6,928,785 53,500 SH Call DFND   0 0 0
SPDR SER TR S&P BIOTECH 78464A870   3,651,000 50,000 SH   DFND 1,2 50,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   7,396,342 319,911 SH   DFND 1,2 319,911 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   11,224,846 773,061 SH   DFND 1,2 773,061 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   6,120,000 600,000 SH   DFND 1,2 600,000 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   51,140,759 5,013,800 SH Call DFND   0 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274   11,532,737 469,574 SH   DFND   469,574 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   9,238,163 259,135 SH   DFND 1,2 259,135 0 0
UNIQURE NV SHS N90064101   998,005 148,734 SH   DFND 1,2 148,734 0 0
VERA THERAPEUTICS INC CL A 92337R101   1,439,550 105,000 SH   DFND 1,2 105,000 0 0
VISTAGEN THERAPEUTICS INC COM 92840H400   524,000 100,000 SH   DFND 1,2 100,000 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107   1,341,373 626,810 SH   DFND 1,2 626,810 0 0
XENON PHARMACEUTICALS INC COM 98420N105   1,330,839 38,959 SH   DFND 1,2 38,959 0 0
XENON PHARMACEUTICALS INC COM 98420N105   2,814,784 82,400 SH Put DFND 1,2 82,400 0 0