0001496201-23-000012.txt : 20231114
0001496201-23-000012.hdr.sgml : 20231114
20231114155420
ACCESSION NUMBER: 0001496201-23-000012
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20230930
FILED AS OF DATE: 20231114
DATE AS OF CHANGE: 20231114
EFFECTIVENESS DATE: 20231114
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 231405390
BUSINESS ADDRESS:
STREET 1: 4 ITZHAK SADE BUILDING A
STREET 2: 29TH FLOOR
CITY: TEL AVIV
STATE: L3
ZIP: 6777520
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 4 ITZHAK SADE BUILDING A
STREET 2: 29TH FLOOR
CITY: TEL AVIV
STATE: L3
ZIP: 6777520
13F-HR
1
primary_doc.xml
X0202
13F-HR
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false
false
false
0001496201
XXXXXXXX
09-30-2023
09-30-2023
SPHERA FUNDS MANAGEMENT LTD.
4 ITZHAK SADE BUILDING A
29TH FLOOR
TEL AVIV
L3
6777520
13F HOLDINGS REPORT
028-15863
000312614
802-120694
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Global Healthcare Management L.P. (the "Management Company"). The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 90% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint the members of the board of directors of the General Partner (the "Board of Directors"), and therefore may be deemed to control the General Partner and Management Company. This Form 13F shall not be construed as an admission by SFML, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Neomi Elpeleg
Chief Financial Officer
972 3 6845564
Neomi Elpeleg
Tel Aviv
L3
11-14-2023
2
83
548993552
false
1
0001599854
028-15865
000172608
802-127045
Sphera Global Healthcare Management LP
2
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
INFORMATION TABLE
2
sphera13f.xml
89BIO INC
COM
282559103
4930007
319301
SH
DFND
1,2
319301
0
0
ABBVIE INC
COM
00287Y109
6856760
46000
SH
DFND
1,2
46000
0
0
ADVANCED MICRO DEVICES INC
COM
007903107
4968262
48320
SH
DFND
48320
0
0
ALNYLAM PHARMACEUTICALS INC
COM
02043Q107
6393487
36101
SH
DFND
1,2
36101
0
0
ALPINE IMMUNE SCIENCES INC
COM
02083G100
2061000
180000
SH
DFND
1,2
180000
0
0
AMAZON COM INC
COM
023135106
12114536
95300
SH
DFND
95300
0
0
AMYLYX PHARMACEUTICALS INC
COM
03237H101
3545732
193650
SH
DFND
1,2
193650
0
0
APOGEE THERAPEUTICS INC
COM
03770N101
639000
30000
SH
DFND
1,2
30000
0
0
ASTRAZENECA PLC
SPONSORED ADR
046353108
19304263
285060
SH
DFND
1,2
285060
0
0
ASTRIA THERAPEUTICS INC
COM
04635X102
4331269
580599
SH
DFND
1,2
580599
0
0
BIOGEN INC
COM
09062X103
6642680
25846
SH
DFND
1,2
25846
0
0
BRIDGEBIO PHARMA INC
COM
10806X102
9111811
345537
SH
DFND
1,2
345537
0
0
CALLIDITAS THERAPEUTICS AB
SPONSERED ADS
13124Q106
216618
11863
SH
DFND
1,2
11863
0
0
CELLDEX THERAPEUTICS INC NEW
COM NEW
15117B202
4953600
180000
SH
DFND
1,2
180000
0
0
CELLDEX THERAPEUTICS INC NEW
COM NEW
15117B202
2752000
100000
SH
Call
DFND
1,2
0
0
0
COGENT BIOSCIENCES INC
COM
19240Q201
4095000
420000
SH
DFND
1,2
420000
0
0
COMPUGEN LTD
ORD
M25722105
1226892
1319239
SH
DFND
1,2
1319239
0
0
CROWDSTRIKE HLDGS INC
CL A
22788C105
2510700
15000
SH
DFND
15000
0
0
CYTOKINETICS INC
COM NEW
23282W605
6891666
233933
SH
DFND
1,2
233933
0
0
CYTOKINETICS INC
COM NEW
23282W605
1914900
65000
SH
Call
DFND
1,2
0
0
0
DAY ONE BIOPHARMACEUTICALS I
COM
23954D109
6503100
530000
SH
DFND
1,2
530000
0
0
DISC MEDICINE INC
COM
254604101
5233478
111398
SH
DFND
1,2
111398
0
0
ELEVATION ONCOLOGY INC
COM
28623U101
596340
900000
SH
DFND
1,2
900000
0
0
ELI LILLY & CO
COM
532457108
7621875
14190
SH
DFND
1,2
14190
0
0
ENPHASE ENERGY INC
NOTE 3/0
29355AAK3
17329862
20900000
SH
DFND
20900000
0
0
FUSION PHARMACEUTICALS INC
COM
36118A100
3521071
1354258
SH
DFND
1,2
1354258
0
0
GILEAD SCIENCES INC
COM
375558103
2997600
40000
SH
DFND
1,2
40000
0
0
GOSSAMER BIO INC
COM
38341P102
1609443
1932568
SH
DFND
1,2
1932568
0
0
GRACELL BIOTECHNOLOGIES INC
SPONSORED ADS
38406L103
4410711
1531497
SH
DFND
1,2
1531497
0
0
GSK PLC
SPONSORED ADR
37733W204
3625000
100000
SH
DFND
1,2
100000
0
0
ICL GROUP LTD
SHS
M53213100
2608500
470000
SH
DFND
470000
0
0
IMMATICS N.V
*W EXP 07/01/202
N44445117
354000
100000
SH
DFND
1,2
0
0
0
IMMATICS N.V
SHS
N44445109
7146863
617173
SH
DFND
1,2
617173
0
0
INHIBRX INC
COM
45720L107
4704408
256371
SH
DFND
1,2
256371
0
0
INOZYME PHARMA INC
COM
45790W108
5186609
1234907
SH
DFND
1,2
1234907
0
0
INVESCO QQQ TR
PUT
46090E953
48903854
136500
SH
Put
DFND
136500
0
0
JASPER THERAPEUTICS INC
COM
471871103
3980994
5687134
SH
DFND
1,2
5687134
0
0
JOHNSON & JOHNSON
COM
478160104
14769928
94831
SH
DFND
1,2
94831
0
0
KEZAR LIFE SCIENCES INC
COM
49372L100
2441494
2051676
SH
DFND
1,2
2051676
0
0
KURA ONCOLOGY INC
COM
50127T109
6413977
703287
SH
DFND
1,2
703287
0
0
MADRIGAL PHARMACEUTICALS INC
COM
558868105
7428617
50867
SH
DFND
1,2
50867
0
0
MEDIWOUND LTD
SHS NEW
M68830112
521144
48980
SH
DFND
1,2
48980
0
0
MEDIWOUND LTD
SHS NEW
M68830112
633647
59553
SH
DFND
59553
0
0
MERCK & CO INC
COM
58933Y105
12724620
123600
SH
DFND
1,2
123600
0
0
MERUS N V
COM
N5749R100
5973592
253333
SH
DFND
1,2
253333
0
0
META PLATFORMS INC
CL A
30303M102
4569196
15220
SH
DFND
15220
0
0
MICROSOFT CORP
COM
594918104
10875062
34442
SH
DFND
34442
0
0
MINERALYS THERAPEUTICS INC
COM
603170101
4330854
455400
SH
DFND
1,2
455400
0
0
MIRUM PHARMACEUTICALS INC
COM
604749101
3611374
114284
SH
DFND
1,2
114284
0
0
MORPHIC HLDG INC
COM
61775R105
2061900
90000
SH
DFND
1,2
90000
0
0
NICE LTD
SPONSORED ADR
653656108
6371940
37482
SH
DFND
37482
0
0
NICE LTD
SPONSORED ADR
653656108
17850000
105000
SH
Call
DFND
0
0
0
NOVARTIS AG
SPONSORED ADR
66987V109
6111600
60000
SH
DFND
1,2
60000
0
0
NOVO-NORDISK A S
ADR
670100205
8464695
93080
SH
DFND
1,2
93080
0
0
PALO ALTO NETWORKS INC
COM
697435105
6742260
28759
SH
DFND
28759
0
0
PFIZER INC
COM
717081103
2985300
90000
SH
DFND
1,2
90000
0
0
PLIANT THERAPEUTICS INC
COM
729139105
2707364
156134
SH
DFND
1,2
156134
0
0
POINT BIOPHARMA GLOBAL INC
COM
730541109
6354122
952642
SH
DFND
1,2
952642
0
0
PRAXIS PRECISION MEDICINES I
COM
74006W108
8294042
4850317
SH
DFND
1,2
4850317
0
0
PROMIS NEUROSCIENCES INC
COM NEW
74346M406
3686424
1834042
SH
DFND
1,2
1834042
0
0
PTC THERAPEUTICS INC
COM
69366J200
4895666
218459
SH
DFND
1,2
218459
0
0
REPLIMUNE GROUP INC
COM
76029N106
3165624
185016
SH
DFND
1,2
185016
0
0
REZOLUTE INC
COM NEW
76200L309
1315657
996710
SH
DFND
1,2
996710
0
0
RIGEL PHARMACEUTICALS INC
COM NEW
766559603
1326376
1228126
SH
DFND
1,2
1228126
0
0
ROCKET PHARMACEUTICALS INC
COM
77313F106
4283230
209040
SH
DFND
1,2
209040
0
0
SANOFI
SPONSORED ADR
80105N105
26793985
499515
SH
DFND
1,2
499515
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
6061000
50000
SH
DFND
1,2
50000
0
0
SELECTA BIOSCIENCES INC
COM
816212104
797265
752137
SH
DFND
1,2
752137
0
0
SHL TELEMEDICINE LTD
SPONSORED ADS
78423T200
6956523
632256
SH
DFND
632256
0
0
SOLAREDGE TECHNOLOGIES INC
COM
83417M104
6928785
53500
SH
Call
DFND
0
0
0
SPDR SER TR
S&P BIOTECH
78464A870
3651000
50000
SH
DFND
1,2
50000
0
0
SPRINGWORKS THERAPEUTICS INC
COM
85205L107
7396342
319911
SH
DFND
1,2
319911
0
0
SYNDAX PHARMACEUTICALS INC
COM
87164F105
11224846
773061
SH
DFND
1,2
773061
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
6120000
600000
SH
DFND
1,2
600000
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
51140759
5013800
SH
Call
DFND
0
0
0
TOWER SEMICONDUCTOR LTD
SHS NEW
M87915274
11532737
469574
SH
DFND
469574
0
0
ULTRAGENYX PHARMACEUTICAL IN
COM
90400D108
9238163
259135
SH
DFND
1,2
259135
0
0
UNIQURE NV
SHS
N90064101
998005
148734
SH
DFND
1,2
148734
0
0
VERA THERAPEUTICS INC
CL A
92337R101
1439550
105000
SH
DFND
1,2
105000
0
0
VISTAGEN THERAPEUTICS INC
COM
92840H400
524000
100000
SH
DFND
1,2
100000
0
0
WEREWOLF THERAPEUTICS INC
COM
95075A107
1341373
626810
SH
DFND
1,2
626810
0
0
XENON PHARMACEUTICALS INC
COM
98420N105
1330839
38959
SH
DFND
1,2
38959
0
0
XENON PHARMACEUTICALS INC
COM
98420N105
2814784
82400
SH
Put
DFND
1,2
82400
0
0