0001496201-22-000007.txt : 20220815
0001496201-22-000007.hdr.sgml : 20220815
20220815153235
ACCESSION NUMBER: 0001496201-22-000007
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20220630
FILED AS OF DATE: 20220815
DATE AS OF CHANGE: 20220815
EFFECTIVENESS DATE: 20220815
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPHERA FUNDS MANAGEMENT LTD.
CENTRAL INDEX KEY: 0001496201
IRS NUMBER: 000000000
STATE OF INCORPORATION: L3
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15863
FILM NUMBER: 221165299
BUSINESS ADDRESS:
STREET 1: 4 ITZHAK SADE BUILDING A
STREET 2: 29TH FLOOR
CITY: TEL AVIV
STATE: L3
ZIP: 6777504
BUSINESS PHONE: 972-3-6845535
MAIL ADDRESS:
STREET 1: 4 ITZHAK SADE BUILDING A
STREET 2: 29TH FLOOR
CITY: TEL AVIV
STATE: L3
ZIP: 6777504
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001496201
XXXXXXXX
06-30-2022
06-30-2022
SPHERA FUNDS MANAGEMENT LTD.
4 ITZHAK SADE BUILDING A
29TH FLOOR
TEL AVIV
L3
6777504
13F HOLDINGS REPORT
028-15863
Y
Investment discretion with regard to a portion of the securities reported herein is exercised by Sphera Healthcare US Inc (the "Management Company"). The Management Company is wholly owned by Sphera Global Healthcare Management L.P. ("SGHM") which is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd. (the "General Partner"), the shares of which are owned 90% by Sphera Funds Management Ltd. ("SFML"). SFML is entitled to appoint the members of the board of directors of the General Partner (the "Board of Directors"), and therefore may be deemed to control the General Partner and the Management Company. This Form 13F shall not be construed as an admission by SFML, SGHM, the General Partner, or the Management Company that it is the beneficial owner of any of the securities covered by this Form 13F, and each of SFML, the General Partner, SGHM, and the Management Company disclaim beneficial ownership of any such securities. Per informal guidance received from the Division of Investment Management, section 13(f) securities that are dual listed on a U.S. stock exchange and the Tel Aviv Stock Exchange were included in this Form 13F only if they were purchased in the U.S.
Israel Mor
Partner
972 3 6845535
Israel Mor
Tel Aviv
L3
08-15-2022
3
57
934859
false
1
0001599854
028-15865
Sphera Global Healthcare Management LP
2
0001599855
028-15864
Sphera Global Healthcare GP Ltd.
3
0001891596
028-21415
Sphera Healthcare US Inc.
INFORMATION TABLE
2
spheraq2.xml
89BIO INC
COM
282559103
1449
450000
SH
DFND
1,2,3
450000
0
0
ABBVIE INC
COM
00287Y109
33448
218385
SH
DFND
1,2,3
218385
0
0
ADVANCED MICRO DEVICES INC
COM
007903107
1206
15773
SH
DFND
15773
0
0
AIRBNB INC
COM CL A
009066101
2468
27700
SH
DFND
27700
0
0
ALNYLAM PHARMACEUTICALS INC
CALL
02043Q107
10939
75000
SH
Call
DFND
1,2,3
0
0
75000
ALTIMMUNE INC
COM NEW
02155H200
16297
1392884
SH
DFND
1,2,3
1392884
0
0
AMICUS THERAPEUTICS INC
COM
03152W109
8088
753037
SH
DFND
1,2,3
753037
0
0
ARBE ROBOTICS LTD
ORDINARY SHARES
M1R95N100
237
43165
SH
DFND
43165
0
0
ASTRAZENECA PLC
SPONSORED ADR
046353108
52764
798610
SH
DFND
1,2,3
798610
0
0
C4 THERAPEUTICS INC
COM STK
12529R107
5321
705736
SH
DFND
1,2,3
705736
0
0
CHINOOK THERAPEUTICS INC
COM
16961L106
11259
643731
SH
DFND
1,2,3
643731
0
0
CONCERT PHARMACEUTICALS INC
COM
206022105
2860
679400
SH
DFND
1,2,3
679400
0
0
CRINETICS PHARMACEUTICALS IN
COM
22663K107
10944
586820
SH
DFND
1,2,3
586820
0
0
FIVE9 INC
COM
338307101
12848
140968
SH
DFND
140968
0
0
FIVERR INTL LTD
NOTE 11/0
33835LAA3
3786
4951000
SH
DFND
4951000
0
0
GENERAC HLDGS INC
COM
368736104
486
2310
SH
DFND
2310
0
0
IMMATICS N.V
*W EXP 07/01/202
N44445117
204
100000
SH
DFND
1,2,3
100000
0
0
IMMATICS N.V
SHS
N44445109
6365
730712
SH
DFND
1,2,3
730712
0
0
INOZYME PHARMA INC
COM
45790W108
5560
1165600
SH
DFND
1,2,3
1165600
0
0
INVESCO QQQ TR
UNIT SER 1
46090E103
2294
8186
SH
DFND
8186
0
0
INVESCO QQQ TR
CALL
46090E103
278262
992800
SH
Call
DFND
0
0
992800
IVERIC BIO INC
COM
46583P102
9259
962470
SH
DFND
1,2,3
962470
0
0
IVERIC BIO INC
CALL
46583P102
1924
200000
SH
Call
DFND
1,2,3
0
0
200000
JOHNSON & JOHNSON
COM
478160104
49073
276451
SH
DFND
1,2,3
276451
0
0
KEROS THERAPEUTICS INC
COM
492327101
1879
67997
SH
DFND
1,2,3
67997
0
0
KEZAR LIFE SCIENCES INC
COM
49372L100
2478
299654
SH
DFND
1,2,3
299654
0
0
KINNATE BIOPHARMA INC
COM
49705R105
1156
91673
SH
DFND
1,2,3
91673
0
0
KURA ONCOLOGY INC
COM
50127T109
9066
494595
SH
DFND
1,2,3
494595
0
0
LILLY ELI & CO
COM
532457108
42879
132250
SH
DFND
1,2,3
132250
0
0
MAGIC SOFTWARE ENTERPRISES L
ORD
559166103
1445
81293
SH
DFND
81293
0
0
MERCK & CO INC
COM
58933Y105
25983
285000
SH
DFND
1,2,3
285000
0
0
MERUS N V
COM
N5749R100
9263
409161
SH
DFND
1,2,3
409161
0
0
META PLATFORMS INC
CL A
30303M102
8063
50000
SH
DFND
50000
0
0
NICE LTD
SPONSORED ADR
653656108
10678
55482
SH
DFND
55482
0
0
NICE SYS INC
NOTE 1.250% 1/1
65366HAB9
588
250000
SH
DFND
250000
0
0
NOVO-NORDISK A S
ADR
670100205
29132
261440
SH
DFND
1,2,3
261440
0
0
NVIDIA CORPORATION
COM
67066G104
1711
11288
SH
DFND
11288
0
0
ONCORUS INC
COM
68236R103
681
540258
SH
DFND
1,2,3
540258
0
0
OTONOMO TECHNOLOGIES LTD
ORDINARY SHARES
M7571L103
431
391863
SH
DFND
391863
0
0
PMV PHARMACEUTICALS INC
COM
69353Y103
2676
187800
SH
DFND
1,2,3
187800
0
0
RELMADA THERAPEUTICS INC
COM
75955J402
8865
466830
SH
DFND
1,2,3
466830
0
0
REZOLUTE INC
COM NEW
76200L309
3734
1155897
SH
DFND
1,2,3
1155897
0
0
RIGEL PHARMACEUTICALS INC
COM NEW
766559603
2853
2525000
SH
DFND
1,2,3
2525000
0
0
SANOFI
SPONSORED ADR
80105N105
42336
846215
SH
DFND
1,2,3
846215
0
0
SPDR S&P 500 ETF TR
CALL
78462F103
75261
199500
SH
Call
DFND
0
0
199500
SPDR SER TR
S&P BIOTECH
78464A870
32512
437748
SH
DFND
1,2,3
437748
0
0
SPDR SER TR
CALL
78464A870
14854
200000
SH
Call
DFND
1,2,3
0
0
200000
SPRINGWORKS THERAPEUTICS INC
COM
85205L107
13213
536664
SH
DFND
1,2,3
536664
0
0
SYNDAX PHARMACEUTICALS INC
COM
87164F105
21921
1139329
SH
DFND
1,2,3
1139329
0
0
TEVA PHARMACEUTICAL INDS LTD
SPONSORED ADS
881624209
8632
1147878
SH
DFND
1147878
0
0
TEVA PHARMACEUTICAL INDS LTD
CALL
881624209
25430
3381600
SH
Call
DFND
0
0
3381600
VINCERX PHARMA INC
COM NEW
92731L106
93
70467
SH
DFND
1,2,3
70467
0
0
VISA INC
COM CL A
92826C839
2481
12600
SH
DFND
12600
0
0
VISTAGEN THERAPEUTICS INC
COM NEW
92840H202
2896
3291135
SH
DFND
1,2,3
3291135
0
0
VISTAGEN THERAPEUTICS INC
CALL
92840H202
1320
1500000
SH
Call
DFND
1,2,3
0
0
1500000
WEREWOLF THERAPEUTICS INC
COM
95075A107
2442
597003
SH
DFND
1,2,3
597003
0
0
WIX COM LTD
NOTE 8/1
92940WAD1
566
700000
SH
DFND
700000
0
0