0001493152-23-016865.txt : 20230515 0001493152-23-016865.hdr.sgml : 20230515 20230515062625 ACCESSION NUMBER: 0001493152-23-016865 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20230331 FILED AS OF DATE: 20230515 DATE AS OF CHANGE: 20230515 EFFECTIVENESS DATE: 20230515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: RTW INVESTMENTS, LP CENTRAL INDEX KEY: 0001493215 IRS NUMBER: 000000000 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-16670 FILM NUMBER: 23918245 BUSINESS ADDRESS: STREET 1: 40 10TH AVENUE STREET 2: 7TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 646-597-6980 MAIL ADDRESS: STREET 1: 40 10TH AVENUE STREET 2: 7TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: RTW INVESTMENTS, LLC DATE OF NAME CHANGE: 20100602 13F-HR 1 primary_doc.xml X0202 13F-HR LIVE false true false 0001493215 XXXXXXXX 03-31-2023 03-31-2023 false RTW INVESTMENTS, LP

40 10TH AVENUE 7Th FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-16670 000153232 801-78183 N Roderick Wong 646-597-6980 /s/ Roderick Wong New York NY 05-15-2023 3 60 4802152628 1 0001493219 028-16671 RTW MASTER FUND, LTD. 2 0001776733 028-19525 RTW Innovation Master Fund Ltd. 3 0001785169 028-19571 RTW Venture Fund Ltd INFORMATION TABLE 2 infotable.xml 10X GENOMICS INC CL A COM 88025U109 51844866 929286 SH SOLE 1,2,3 929286 0 0 ACADIA PHARMACEUTICALS INC C COM 004225108 155130700 8242864 SH SOLE 1,2,3 8242864 0 0 ADICET BIO INC COM 007002108 24430879 4241472 SH SOLE 1,2,3 4241472 0 0 AKOYA BIOSCIENCES INC COM 00974H104 2686492 328422 SH SOLE 1,2,3 328422 0 0 ALLAKOS INC COM 01671P100 5903406 1326608 SH SOLE 1,2,3 1326608 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 337211076 1683362 SH SOLE 1,2,3 1683362 0 0 APYX MEDICAL CORPORATION COM 03837C106 9787044 3398279 SH SOLE 1,2,3 3398279 0 0 ARGENX SE SPONSORED ADR 04016X101 179656213 482195 SH SOLE 1,2,3 482195 0 0 ARYA SCIENCES ACQU CORP IV CL A G31659108 1324490 127970 SH SOLE 1,2,3 127970 0 0 AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 52596161 5741939 SH SOLE 1,2,3 5741939 0 0 AVIDITY BIOSCIENCES INC COM 05370A108 98043182 6387178 SH SOLE 1,2,3 6387178 0 0 AXONICS INC COM 05465P101 48284181 884974 SH SOLE 1,2,3 884974 0 0 AXSOME THERAPEUTICS INC COM 05464T104 233203136 3780855 SH SOLE 1,2,3 3780855 0 0 BRUKER CORP COM 116794108 93610043 1187342 SH SOLE 1,2,3 1187342 0 0 CASTLE BIOSCIENCES INC COM 14843C105 5873075 258498 SH SOLE 1,2,3 258498 0 0 CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 110970056 3084215 SH SOLE 1,2,3 3084215 0 0 CUTERA INC COM 232109108 43616598 1846596 SH SOLE 1,2,3 1846596 0 0 CYTOKINETICS INC COM NEW 23282W605 90586028 2574198 SH SOLE 1,2,3 2574198 0 0 DERMTECH INC COM 24984K105 10003550 2718356 SH SOLE 1,2,3 2718356 0 0 ESTABLISHMENT LABS HLDGS INC COM G31249108 161840208 2389138 SH SOLE 1,2,3 2389138 0 0 EXAGEN INC COM 30068X103 3380577 1391184 SH SOLE 1,2,3 1391184 0 0 FULCRUM THERAPEUTICS INC COM 359616109 15708741 5511839 SH SOLE 1,2,3 5511839 0 0 GH RESEARCH PLC ORDINARY SHARES G3855L106 17329966 2168957 SH SOLE 1,2,3 2168957 0 0 GUARDANT HEALTH INC COM 40131M109 10099991 430887 SH SOLE 1,2,3 430887 0 0 ILLUMINA INC COM 452327109 87496938 376250 SH SOLE 1,2,3 376250 0 0 IMMATICS N.V SHS N44445109 5830500 845000 SH SOLE 1,2,3 845000 0 0 IMMUNIC INC COM 4525EP101 6398744 4294459 SH SOLE 1,2,3 4294459 0 0 IMMUNOCORE HLDGS PLC ADS 45258D105 279333182 5649943 SH SOLE 1,2,3 5649943 0 0 JASPER THERAPEUTICS INC COM 471871103 4216954 2329809 SH SOLE 1,2,3 2329809 0 0 MASIMO CORP COM 574795100 277085518 1501493 SH SOLE 1,2,3 1501493 0 0 MILESTONE PHARMACEUTICALS IN COM 59935V107 12829042 3256102 SH SOLE 1,2,3 3256102 0 0 MINERALYS THERAPEUTICS INC COM 603170101 14440086 922100 SH SOLE 1,2,3 922100 0 0 MIRATI THERAPEUTICS INC COM 60468T105 135450979 3643114 SH SOLE 1,2,3 3643114 0 0 MIROMATRIX MED INC COM 60471P108 747973 445222 SH SOLE 1,2,3 445222 0 0 MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104 10695000 500000 SH SOLE 1,2,3 500000 0 0 NATERA INC COM 632307104 145006192 2611783 SH SOLE 1,2,3 2611783 0 0 OLINK HLDG AB SPONSORED ADS 680710100 14748408 654612 SH SOLE 1,2,3 654612 0 0 ORCHESTRA BIOMED HLDGS INC COM 68572M106 100169182 5118507 SH SOLE 1,2,3 5118507 0 0 OUTSET MED INC COM 690145107 14879307 808658 SH SOLE 1,2,3 808658 0 0 PENUMBRA INC COM 70975L107 187661764 673371 SH SOLE 1,2,3 673371 0 0 PMV PHARMACEUTICALS INC COM 69353Y103 14305697 2999098 SH SOLE 1,2,3 2999098 0 0 PROMETHEUS BIOSCIENCES INC COM 74349U108 351162201 3272104 SH SOLE 1,2,3 3272104 0 0 PROTAGONIST THERAPEUTICS INC COM 74366E102 105818377 4600799 SH SOLE 1,2,3 4600799 0 0 PTC THERAPEUTICS INC COM 69366J200 343599355 7093298 SH SOLE 1,2,3 7093298 0 0 RELMADA THERAPEUTICS INC COM 75955J402 4817947 2131835 SH SOLE 1,2,3 2131835 0 0 ROCKET PHARMACEUTICALS INC *W EXP 09/02/202 77313F114 38500 350000 SH SOLE 1,2,3 350000 0 0 ROCKET PHARMACEUTICALS INC COM 77313F106 302991534 17687772 SH SOLE 1,2,3 17687772 0 0 ROIVANT SCIENCES LTD SHS G76279101 11459051 1552717 SH SOLE 1,2,3 1552717 0 0 SCPHARMACEUTICALS INC COM 810648105 29911436 3297843 SH SOLE 1,2,3 3297843 0 0 SIGHT SCIENCES INC COM 82657M105 361224 41330 SH SOLE 1,2,3 41330 0 0 STOKE THERAPEUTICS INC COM 86150R107 36573348 4390558 SH SOLE 1,2,3 4390558 0 0 THIRD HARMONIC BIO INC COM 88427A107 2202910 534687 SH SOLE 1,2,3 534687 0 0 TARSUS PHARMACEUTICALS INC COM 87650L103 32029931 2548125 SH SOLE 1,2,3 2548125 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 167339808 290334 SH SOLE 1,2,3 290334 0 0 ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 171266940 4270996 SH SOLE 1,2,3 4270996 0 0 UROGEN PHARMA LTD COM M96088105 7922967 857464 SH SOLE 1,2,3 857464 0 0 VENTYX BIOSCIENCES INC COM 92332V107 46527514 1388881 SH SOLE 1,2,3 1388881 0 0 VERICEL CORP COM 92346J108 96517716 3291873 SH SOLE 1,2,3 3291873 0 0 VIKING THERAPEUTICS INC COM 92686J106 16650000 1000000 SH SOLE 1,2,3 1000000 0 0 YS BIOPHARMA CO LTD ORDINARY SHARES G9845F109 545744 341090 SH SOLE 1,2,3 341090 0 0