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Stock-Based Compensation - Schedule of Estimated Assumptions Used to Calculate Weighted-Average Grant Date Fair Value of Options Granted (Detail) - Stock Options [Member] - 2006 and 2014 Stock Option Plans and Inducement Plan [Member]
6 Months Ended
Jun. 30, 2023
Jun. 30, 2022
Share-Based Compensation    
Weighted-average risk-free interest rate 3.87% 2.18%
Expected volatility 118.00% 106.00%
Expected terms 6 years 6 years