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Stock-Based Compensation - Summary of Stock Option Activity (Detail) - 2006 and 2014 Stock Option Plans and Inducement Plan [Member] - Stock Options [Member] - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Share-Based Compensation    
Number of Shares Outstanding, beginning of the period 197,171  
Number of Shares, Granted 33,520  
Number of Shares, Forfeited (37,611)  
Number of Shares, Canceled (13,439)  
Number of Shares Outstanding, end of the period 179,641 197,171
Number of Shares, Exercisable 133,727  
Number of Shares, Vested or expected to vest 174,164  
Weighted-Average Exercise Price Per Share Outstanding, beginning of the period $ 143.96  
Weighted-Average Exercise Price Per Share, Granted 21.50  
Weighted-Average Exercise Price Per Share, Forfeited 38.70  
Weighted-Average Exercise Price Per Share, Canceled 117.93  
Weighted-Average Exercise Price Per Share Outstanding, end of the period 145.09 $ 143.96
Weighted-Average Exercise Price Per Share, Exercisable 179.55  
Weighted-Average Exercise Price Per Share, Vested or expected to vest $ 148.41  
Weighted-Average Remaining Contractual Term, Outstanding 5 years 11 months 4 days 7 years 1 month 2 days
Weighted-Average Remaining Contractual Term, Exercisable 5 years 2 months 4 days  
Weighted-Average Remaining Contractual Term, Vested or expected to vest 5 years 10 months 6 days  
Aggregate Intrinsic Value, Outstanding   $ 51