Condensed Consolidated Statements of Changes in Stockholder's Equity (Deficit) (Unaudited) - USD ($) $ in Thousands	Total	Common Stock [Member]	Additional Paid-In Capital [Member]	Accumulated Other Comprehensive Income/(Loss) [Member]	Accumulated Deficit [Member]
Beginning balance at Dec. 31, 2021	$ 198,662	$ 10	$ 1,857,430	$ (2,090)	$ (1,656,688)
Beginning balance, Shares at Dec. 31, 2021		97,524,000
Common Stock -follow-on-offering	380,120	$ 1	380,119
Common Stock -follow-on-offering, shares		8,564,000
Issuance of common stock upon exercise of stock options	4,000		4,000
Issuance of common stock upon exercise of stock options, shares		239,000
Vesting of restricted stock units, net of shares withheld for taxes	(2,416)		(2,416)
Vesting of restricted stock units, net of shares withheld for taxes. shares		113,000
Share-based compensation expense	20,773		20,773
Unrealized gain on available-for-sale investments	(52)			(52)
Net loss	(138,935)				(138,935)
Foreign currency gain	83			83
Ending balance at Mar. 31, 2022	462,235	$ 11	2,259,906	(2,059)	(1,795,623)
Ending balance, Shares at Mar. 31, 2022		106,440,000
Beginning balance at Dec. 31, 2022	169,872	$ 11	2,479,596	(875)	(2,308,860)
Beginning balance, Shares at Dec. 31, 2022		110,772,000
Issuance of common stock and pre-funded warrants in common stock offering	384,387	$ 1	384,386
Issuance of common stock and pre-funded warrants in common stock offering, shares		4,008,000
Issuance of common stock upon exercise of stock options	17,718		17,718
Issuance of common stock upon exercise of stock options, shares		951,000
Vesting of restricted stock units, net of shares withheld for taxes	(10,999)		(10,999)
Vesting of restricted stock units, net of shares withheld for taxes. shares		448,000
Share-based compensation expense	28,823		28,823
Net loss	(177,778)				(177,778)
Foreign currency gain	100			100
Ending balance at Mar. 31, 2023	$ 412,123	$ 12	$ 2,899,524	$ (775)	$ (2,486,638)
Ending balance, Shares at Mar. 31, 2023		116,179,000