Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Components of Loss From Continuing Operation Before Provision for Income Taxes

The components of loss from continuing operations before provision for income taxes are as follows (in thousands):

	Year Ended December 31,
	2022			2021			2020
United States	$	(82,815	)	$	(314,673	)	$	(118,839	)
Foreign		(568,688	)		(431,329	)		(224,190	)
Total	$	(651,503	)	$	(746,002	)	$	(343,029	)

Schedule of Provision for Income Tax Expense

Provision for income taxes for the years ended December 31, 2022, 2021, and 2020 are as follows (in thousands):

	Year Ended December 31, 2022		Year Ended December 31, 2021		Year Ended December 31, 2020
Current income tax expense:
U.S. Federal	$	—	$	—	$	—
U.S. State and Local		520		205		57
Foreign		149		147		1,788
Total current income tax expense		669		352		1,845
Deferred income tax expense:
U.S. Federal		—		—		—
U.S. State and Local		—		—		—
Foreign		—		—		—
Total deferred income tax expense		—		—		—
Total tax expense	$	669	$	352	$	1,845

Schedule of Reconciliation Between U.S. Federal Statutory Rate and Effective Tax rate

A reconciliation between the U.S. federal statutory tax rate and our effective tax rate is summarized as follows (in thousands):

	Year Ended December
	2022						2021						2020
	Amount			Percentage of income before income taxes			Amount			Percentage of income before income taxes			Amount			Percentage of income before income taxes
Statutory U.S. federal income tax	$	(136,816	)		21.0	%	$	(156,660	)		21.0	%	$	(72,036	)		21.0	%
Foreign tax rate differential		50,219			(7.7	)		38,677			(5.2	)		22,760			(6.6	)
State income taxes, net of federal benefit		9,051			(1.4	)		(14,145	)		1.9			(14,107	)		4.1
Change in valuation allowances		94,668			(14.5	)		133,668			(17.9	)		240,065			(69.9	)
Intellectual property transfer		—			—			—			—			(162,000	)		47.2
Tax credits		(19,966	)		3.0			(20,005	)		2.6			(11,696	)		3.4
Change in state apportionment		(35	)		—			—			—			93			—
Loss on debt conversion		6,626			1.0			19,548			(2.6	)		—			—
Permanent and other		(3,078	)		0.5			(731	)		0.1			(1,234	)		0.3
Effective income tax provision	$	669			(0.1	)	$	352			(0.1	)	$	1,845			(0.5	)

Schedule of Deferred Tax Assets and Liabilities

The following table presents the principal components of the Company’s deferred tax assets and liabilities (in thousands):

	December 31,
	2022			2021
Deferred tax assets:
Intangible assets	$	187,839		$	180,963
Share-based compensation		29,673			22,404
Deferred interest expense		—			3,925
Net operating loss carryforwards		228,985			167,160
Research and development credits		57,419			39,672
Orphan drug credits		30,160			23,678
Development derivative liability		79,374			91,183
Convertible debt		6,850			5,551
Lease liability		4,304			5,029
Accruals		16,272			5,100
Total deferred tax assets		640,876			544,665
Deferred tax liabilities:
Fixed assets		(91	)		(69	)
Right-of-use asset		(4,032	)		(4,874	)
481(a) adjustment		(233	)		(937	)
Total deferred tax liabilities		(4,356	)		(5,880	)
Net deferred tax assets before allowance:		636,520			538,785
Less valuation allowance		(636,520	)		(538,785	)
Net deferred tax assets	$	—		$	—