Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the registration statements (Nos. 333-253864, 333-262982, 333-265696, 333-266533, 333-268131, and 333-236297) on Form S-8 and in the registration statement (No. 333-253865) on Form S-3 of our reports dated February 28, 2023, with respect to the consolidated financial statements of Schrödinger, Inc. and the effectiveness of internal control over financial reporting.

/s/ KPMG LLP

Portland, Oregon
February 28, 2023