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Note 3 - Summary of Accounting Policies (Details Textual) - USD ($)
9 Months Ended
Jan. 01, 2021
Sep. 30, 2021
Jun. 30, 2021
Mar. 31, 2021
Dec. 31, 2020
Sep. 30, 2020
Jun. 30, 2020
Mar. 31, 2020
Dec. 31, 2019
Stockholders' Equity Attributable to Parent, Ending Balance   $ 141,347,826 $ 144,071,902 $ 139,701,399 $ 27,167,932 $ 9,871,077 $ 8,374,306 $ 10,896,337 $ 13,156,005
Retained Earnings [Member]                  
Stockholders' Equity Attributable to Parent, Ending Balance   $ (124,402,093) $ (119,204,948) $ (112,165,700) (111,898,992) $ (104,415,673) $ (100,924,602) $ (97,018,460) $ (94,071,040)
Cumulative Effect, Period of Adoption, Adjustment [Member]                  
Stockholders' Equity Attributable to Parent, Ending Balance         13,003,075        
Cumulative Effect, Period of Adoption, Adjustment [Member] | Retained Earnings [Member]                  
Stockholders' Equity Attributable to Parent, Ending Balance         $ 3,271,361        
Accounting Standards Update 2020-06 [Member] | Cumulative Effect, Period of Adoption, Adjustment [Member]                  
Stockholders' Equity Attributable to Parent, Ending Balance $ 13,003,075                
Reclassification of Warrant Financing Expenses 938,794                
Fair Value Adjustment of Warrants 2,332,567                
Accounting Standards Update 2020-06 [Member] | Cumulative Effect, Period of Adoption, Adjustment [Member] | Retained Earnings [Member]                  
Stockholders' Equity Attributable to Parent, Ending Balance $ 3,271,361                
Minimum [Member]                  
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Vesting Term (Year)   1 year              
Maximum [Member]                  
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Vesting Term (Year)   4 years              
Share-based Payment Arrangement, Option [Member]                  
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period (Year)   10 years