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Note 14 - Stock Based Compensation - Stock Option Activity (Details) - The 2010 Stock Option and Incentive Plan [Member]
12 Months Ended
Dec. 31, 2018
$ / shares
shares
Outstanding, shares (in shares) | shares 172,510
Outstanding, Weighted average exercise price per share (in dollars per share) | $ / shares $ 49.27
Granted, shares (in shares) | shares 611,668
Granted, Weighted average exercise price per share (in dollars per share) | $ / shares $ 2.39
Forfeited, shares (in shares) | shares (795)
Forfeited, Weighted average exercise price per share (in dollars per share) | $ / shares $ 562.55
Outstanding, shares (in shares) | shares 783,383
Outstanding, Weighted average exercise price per share (in dollars per share) | $ / shares $ 12.14
Outstanding, weighted average contractual life remaining in years (Year) 9 years 62 days
Exercisable, shares (in shares) | shares 317,042
Exercisable, Weighted average exercise price per share (in dollars per share) | $ / shares $ 24.39
Exercisable, weighted average contractual life remaining in years (Year) 8 years 354 days
Vested and expected to vest, shares (in shares) | shares 783,383
Vested and expected to vest, Weighted average exercise price per share (in dollars per share) | $ / shares $ 12.14
Vested and expected to vest, weighted average contractual life remaining in years (Year) 9 years 62 days