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Related-Party Transactions (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Sep. 30, 2023
Sep. 30, 2022
Related-Party Transactions        
Research and development $ 19,551 $ 15,557 $ 54,710 $ 38,536
Penn        
Related-Party Transactions        
Research and development $ 300 $ 1,000 $ 600 $ 1,400