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Related Party Transactions (Details) - Director affiliate
3 Months Ended 6 Months Ended
Jun. 30, 2018
USD ($)
Jun. 30, 2017
USD ($)
Jun. 30, 2018
USD ($)
option
Jun. 30, 2017
USD ($)
Protoden Intellectual Property        
Related Party Transaction [Line Items]        
Rent expense in related party transaction     $ 25,000 $ 50,000
Annual fee under license agreement     $ 100,000  
Lease Facility In Winnipeg, Manitoba        
Related Party Transaction [Line Items]        
Lease term 5 years   5 years  
Renewal option | option     1  
Lease renewal term 5 years   5 years  
Rent expense in related party transaction $ 81,000 $ 80,000 $ 141,000 154,000
Lease Facility, Toronto, Ontario        
Related Party Transaction [Line Items]        
Rent expense in related party transaction $ 4,700 $ 4,500 $ 9,300 $ 8,900