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Share-Based Payments - Summary of Stock Option Activity (Detail)
6 Months Ended
Jun. 30, 2018
$ / shares
shares
Shares  
Outstanding at beginning of period (in shares) | shares 2,695,796
Granted (in shares) | shares 1,643,400
Exercised (in shares) | shares (55,259)
Cancelled or forfeited (in shares) | shares (256,111)
Outstanding at end of period (in shares) | shares 4,027,826
Exercisable at end of period (in shares) | shares 1,738,331
Vested and expected to vest at end of period (in shares) | shares 3,977,226
Weighted-Average Exercise Price  
Outstanding at beginning of period (in USD per share) | $ / shares $ 3.16
Granted (in USD per share) | $ / shares 1.82
Exercised (in USD per share) | $ / shares 0.53
Cancelled or forfeited (in USD per share) | $ / shares 2.95
Outstanding at end of period (in USD per share) | $ / shares 2.66
Exercisable at end of period (in USD per share) | $ / shares 3.53
Vested and expected to vest at end of period (in USD per share) | $ / shares $ 2.67