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Share-Based Payments (Tables)
3 Months Ended
Mar. 31, 2017
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Summary of Stock-Based Compensation Expense
Stock-based compensation expense by award type was as follows (in thousands): 
 
Three Months Ended
March 31,
 
2017
 
2016
Stock options
$
187

 
$
435

Restricted stock
51

 
54

Restricted stock units
3

 
92

Employee stock purchase plan
3

 
5

 
$
244

 
$
586


The Company allocated stock-based compensation expense as follows in the consolidated statements of operations and comprehensive loss (in thousands):
 
Three Months Ended
March 31,
 
2017
 
2016
Research and development expense
$
40

 
$
221

General and administrative expense
204

 
365

 
$
244

 
$
586

Summary of Stock Option Activity and Related Information
A summary of the stock option activity is presented below:
 
Shares
 
Weighted-Average
Exercise Price
Outstanding at December 31, 2016
2,024,468

 
$
4.41

Granted

 

Exercised
(140,400
)
 
0.28

Cancelled or forfeited
(166,887
)
 
9.85

Outstanding at March 31, 2017
1,717,181

 
$
4.22

Exercisable at March 31, 2017
863,767

 
$
4.93

Vested and expected to vest at March 31, 2017(1)
1,717,181

 
$
4.22

(1) 
Represents the number of vested options, plus the number of unvested options expected to vest. The Company adopted ASU 2016-09 as of January 1, 2017 and elected an accounting policy to record forfeitures as they occur.
Summary of Status and Changes of Unvested Restricted Stock
A summary of the restricted stock is presented below:
 
Restricted
Stock
 
Weighted-Average
Grant Date
Fair Value
Unvested at December 31, 2016
22,150

 
$
11.43

Vested
(4,430
)
 
11.43

Unvested at March 31, 2017
17,720

 
$
11.43

Schedule of Share-based Compensation, Restricted Stock and Restricted Stock Units Activity
A summary of the restricted stock units is presented below:
 
Restricted
Stock Units
 
Weighted-Average
Grant Date
Fair Value
Unvested at December 31, 2016
3,333

 
$
4.09

Vested
(3,333
)
 
4.09

Unvested at March 31, 2017

 
$