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Share-Based Payments - Estimation of Fair Value of Stock Option Granted using Black-Scholes Option-Pricing Model Assumptions - Non-employees (Details) - Non-Employee Stock Options
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Risk-free interest rate, minimum (as a percent) 1.08% 1.19% 1.67%
Risk-free interest rate, maximum (as a percent) 2.38% 2.26% 2.04%
Expected dividend yield (as a percent) 0.00% 0.00% 0.00%
Expected option life 10 years 10 years 10 years
Expected volatility, minimum (as a percent) 69.92% 67.24% 57.65%
Expected volatility, maximum (as a percent) 92.09% 92.40% 80.98%