Commitments and Contingencies - Narrative (Details) $ in Thousands	9 Months Ended
	Sep. 30, 2016 USD ($)
University of Zurich
Other Commitments [Line Items]
Percentage of royalty on net product sales	4.00%
Percentage requiring reduction in the amount of royalties owed	10.00%
Minimum percentage of royalty on net product sales	2.00%
University of Zurich | Clinical Development Milestone
Other Commitments [Line Items]
Amount payable upon achievement of first milestone	$ 750
Merck KGaA
Other Commitments [Line Items]
Period of expiration of first commercial sale of a licensed product	10 years
Maximum period of duration of non-payment of royalty of a licensed product	15 years