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Share-Based Payments (Tables)
9 Months Ended
Sep. 30, 2016
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Summary of Stock-Based Compensation Expense
Stock-based compensation expense by award type was as follows (in thousands): 
 
Three Months Ended
September 30,
 
Nine Months Ended
September 30,
 
2016
 
2015
 
2016
 
2015
Stock options
$
1,932

 
$
475

 
$
2,825

 
$
1,708

Restricted stock
50

 
55

 
155

 
88

Restricted stock units
156

 
99

 
354

 
99

Employee stock purchase plan
6

 

 
17

 

 
$
2,144

 
$
629

 
$
3,351

 
$
1,895

Summary of Stock Option Activity and Related Information
A summary of the stock option activity is presented below:

 
Shares
 
Weighted-Average
Exercise Price
Outstanding at December 31, 2015
1,803,574

 
$
6.28

Granted
1,747,495

 
1.69

Exercised
(341,526
)
 
0.49

Cancelled or forfeited
(494,787
)
 
3.30

Outstanding at September 30, 2016
2,714,756

 
$
4.60

Exercisable at September 30, 2016
1,606,002

 
$
5.18

Vested and expected to vest at September 30, 2016(1)
2,530,001

 
$
4.69

 
(1)
Represents the number of vested options, plus the number of unvested options expected to vest.
Summary of Status and Changes of Unvested Restricted Stock
A summary of the unvested restricted stock is presented below:
 
Restricted
Stock
 
Weighted-Average
Grant Date
Fair Value
Unvested at December 31, 2015
41,657

 
$
11.05

Vested
(15,077
)
 
10.38

Unvested at September 30, 2016
26,580

 
$
11.43

Schedule of Share-based Compensation, Restricted Stock and Restricted Stock Units Activity
A summary of the restricted stock units is presented below:
 
 
Restricted
Stock Units
 
Weighted-Average
Grant Date
Fair Value
Unvested at December 31, 2015
150,932

 
$
2.85

Vested
(131,166
)
 
2.83

Cancelled
(13,100
)
 
2.76

Unvested at September 30, 2016
6,666

 
$
3.43