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Share-Based Payments - Summary of Stock Option Activity and Related Information (Detail)
3 Months Ended
Mar. 31, 2016
$ / shares
shares
Shares  
Outstanding at beginning of period | shares 1,803,574
Granted | shares 916,776
Exercised | shares (118,110)
Cancelled or forfeited | shares (181,436)
Outstanding at end of period | shares 2,420,804
Exercisable at March 31, 2016 | shares 860,693
Vested and expected to vest at March 31, 2016 | shares 2,012,694
Weighted-Average Exercise Price  
Outstanding at beginning of period (in USD per share) | $ / shares $ 6.28
Granted (in USD per share) | $ / shares 0.28
Exercised (in USD per share) | $ / shares 0.06
Cancelled or forfeited (in USD per share) | $ / shares 2.85
Outstanding at end of period (in USD per share) | $ / shares 4.57
Exercisable at end of period (in USD per share) | $ / shares 5.88
Vested and expected to vest at end of period | $ / shares $ 5.14