UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

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¨ Preliminary Proxy Statement

¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

¨ Definitive Proxy Statement

x Definitive Additional Materials

¨ Soliciting Material under §240.14a-12

Eleven Biotherapeutics, Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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Important Notice Regarding the Availability of Proxy Materials for the Shareholder Meeting

to be held on June 16, 2015, for Eleven Biotherapeutics, Inc.

This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. To view the proxy statement and annual report, go to www.proxydocs.com/ebio. To submit your proxy while visiting this site, you will need the 12 digit control number in the box below.

Under United States Securities and Exchange

Commission rules, proxy materials do not have

to be delivered in paper. Proxy materials can

be distributed by making them available on the

Internet. We have chosen to use these procedures

for our 2015 Annual Meeting and need YOUR participation.

If you want to receive a paper or e-mail copy of

the proxy materials, you must request one. There

is no charge to you for requesting a copy. In

order to receive a paper package in time for this

year’s annual meeting, please make this request

on or before June 5, 2015.

  For a Convenient Way to VIEW Proxy Materials   —  and  —   VOTE Online go to: www.proxydocs.com/ebio  

Proxy Materials Available to View or Receive:

Annual Report on Form 10-K and Proxy Statement

Printed materials may be requested by one of the following methods:

You must use the 12 digit control number located in the shaded gray box below.		*  If requesting material by e-mail, please send a blank e-mail with the 12 digit control number (located below) in the subject line. No other requests, instructions or other inquiries should be included with your e-mail requesting material.

Eleven Biotherapeutics, Inc. Notice of Annual Meeting
	Date:	Tuesday, June 16, 2015
	Time:	10 A.M. (Eastern Time)
	Place:	WilmerHale LLP, 60 State Street, Boston, MA 02109
Board of Directors Recommends a Vote FOR each of the director nominees listed and FOR proposal 2.
1.      To elect three class I directors of our board of directors to serve until the 2018 Annual Meeting of Stockholders or until  their respective successors have been duly elected and qualified.
Nominees         (01)  David Berry
(02)  Barry Gertz
(03)  Cary Pfeffer
2.      To ratify the selection of Ernst & Young LLP as Eleven Biotherapeutics’ independent registered public accounting firm  for the fiscal year ending December 31, 2015.

Vote In-Person Instructions: While we encourage shareholders to vote by the means indicated above, a shareholder is entitled to vote in person at the Annual Meeting. If you wish to vote your shares at the Annual Meeting, please register with the Inspector of Elections at the desk marked “Shareholder Registration” at the entrance to receive a ballot. Proper photo ID is required. Ballots should be returned to the Inspector of Elections in order to be counted. Additionally, a shareholder who has submitted a proxy before the meeting, may revoke that proxy in person at the Annual Meeting.