<SEC-DOCUMENT>0001104659-23-005017-index.html : 20230119
<SEC-HEADER>0001104659-23-005017.hdr.sgml : 20230119
<ACCEPTANCE-DATETIME>20230119161858
ACCESSION NUMBER:		0001104659-23-005017
CONFORMED SUBMISSION TYPE:	424B3
PUBLIC DOCUMENT COUNT:		50
FILED AS OF DATE:		20230119
DATE AS OF CHANGE:		20230119

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sesen Bio, Inc.
		CENTRAL INDEX KEY:			0001485003
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				262025616
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-267891
		FILM NUMBER:		23537638

	BUSINESS ADDRESS:	
		STREET 1:		245 FIRST STREET
		STREET 2:		SUITE 1800
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142
		BUSINESS PHONE:		617-444-8550

	MAIL ADDRESS:	
		STREET 1:		245 FIRST STREET
		STREET 2:		SUITE 1800
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Eleven Biotherapeutics, Inc.
		DATE OF NAME CHANGE:	20100223
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B3
<SEQUENCE>1
<FILENAME>tm2227887-17_424b3.htm
<DESCRIPTION>424B3
<TEXT>
Document 1 - file: tm2227887-17_424b3.htm
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>2 <FILENAME>lg_sesenbio-4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 2 - file: lg_sesenbio-4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>3 <FILENAME>lg_carismatherapeutics-4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 3 - file: lg_carismatherapeutics-4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>4 <FILENAME>lg_mackenziepartners-bw.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 4 - file: lg_mackenziepartners-bw.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>5 <FILENAME>tm2227887d8-tbl_pipelin4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 5 - file: tm2227887d8-tbl_pipelin4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>6 <FILENAME>tm2227887d8-tbl_oncolog4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 6 - file: tm2227887d8-tbl_oncolog4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>7 <FILENAME>tm2227887d8-fc_problem4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 7 - file: tm2227887d8-fc_problem4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>8 <FILENAME>tm2227887d1-pht_tumor4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 8 - file: tm2227887d1-pht_tumor4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>9 <FILENAME>tm2227887d1-lc_human4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 9 - file: tm2227887d1-lc_human4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>10 <FILENAME>tm2227887d4-lc_contrl4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 10 - file: tm2227887d4-lc_contrl4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>11 <FILENAME>tm2227887d4-lc_reprogra4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 11 - file: tm2227887d4-lc_reprogra4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>12 <FILENAME>tm2227887d1-pht_macrop4clr.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 12 - file: tm2227887d1-pht_macrop4clr.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>13 <FILENAME>tm2227887d1-tbl_exvivo4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 13 - file: tm2227887d1-tbl_exvivo4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>14 <FILENAME>tm2227887d4-tbl_pipelin4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 14 - file: tm2227887d4-tbl_pipelin4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>15 <FILENAME>tm2227887d1-pht_key4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 15 - file: tm2227887d1-pht_key4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>16 <FILENAME>tm2227887d1-org_clinic4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 16 - file: tm2227887d1-org_clinic4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>17 <FILENAME>tm2227887d4-bc_adverse4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 17 - file: tm2227887d4-bc_adverse4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>18 <FILENAME>tm2227887d4-lc_rapidly4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 18 - file: tm2227887d4-lc_rapidly4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>19 <FILENAME>tm2227887d1-bc_single4clr.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 19 - file: tm2227887d1-bc_single4clr.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>20 <FILENAME>tm2227887d4-bc_mostpreva4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 20 - file: tm2227887d4-bc_mostpreva4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>21 <FILENAME>tm2227887d4-bc_frequen4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 21 - file: tm2227887d4-bc_frequen4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>22 <FILENAME>tm2227887d4-tbl_selct4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 22 - file: tm2227887d4-tbl_selct4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>23 <FILENAME>tm2227887d4-lc_pt4comp4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 23 - file: tm2227887d4-lc_pt4comp4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>24 <FILENAME>tm2227887d1-lc_asses4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 24 - file: tm2227887d1-lc_asses4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>25 <FILENAME>tm2227887d1-lc_itcar4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 25 - file: tm2227887d1-lc_itcar4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>26 <FILENAME>tm2227887d1-pht_profnd4clr.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 26 - file: tm2227887d1-pht_profnd4clr.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>27 <FILENAME>tm2227887d1-bc_119ct4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 27 - file: tm2227887d1-bc_119ct4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>28 <FILENAME>tm2227887d4-lc_ct1119a5494c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 28 - file: tm2227887d4-lc_ct1119a5494c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>29 <FILENAME>tm2227887d1-lc_carmno4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 29 - file: tm2227887d1-lc_carmno4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>30 <FILENAME>tm2227887d1-bc_cyto4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 30 - file: tm2227887d1-bc_cyto4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>31 <FILENAME>tm2227887d1-lc_polar4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 31 - file: tm2227887d1-lc_polar4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>32 <FILENAME>tm2227887d4-lc_persis4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 32 - file: tm2227887d4-lc_persis4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>33 <FILENAME>tm2227887d4-lc_tumor4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 33 - file: tm2227887d4-lc_tumor4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>34 <FILENAME>tm2227887d4-fc_antibody4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 34 - file: tm2227887d4-fc_antibody4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>35 <FILENAME>tm2227887d1-lc_poten4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 35 - file: tm2227887d1-lc_poten4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>36 <FILENAME>tm2227887d1-pht_ipsc4clr.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 36 - file: tm2227887d1-pht_ipsc4clr.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>37 <FILENAME>tm2227887d1-bc_icar4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 37 - file: tm2227887d1-bc_icar4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>38 <FILENAME>tm2227887d4-lc_ipscmacs4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 38 - file: tm2227887d4-lc_ipscmacs4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>39 <FILENAME>tm2227887d1-pht_myloid4clr.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 39 - file: tm2227887d1-pht_myloid4clr.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>40 <FILENAME>tm2227887d4-lc_lnp4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 40 - file: tm2227887d4-lc_lnp4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>41 <FILENAME>tm2227887d4-lc_2lnp4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 41 - file: tm2227887d4-lc_2lnp4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>42 <FILENAME>tm2227887d4-lc_3lnp4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 42 - file: tm2227887d4-lc_3lnp4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>43 <FILENAME>tm2227887d4-lc_4lnp4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 43 - file: tm2227887d4-lc_4lnp4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>44 <FILENAME>tm2227887d4-lc_5lnp4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 44 - file: tm2227887d4-lc_5lnp4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>45 <FILENAME>tm2227887d4-lc_6lnp4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 45 - file: tm2227887d4-lc_6lnp4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>46 <FILENAME>tm2227887d1-pht_reprobw.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 46 - file: tm2227887d1-pht_reprobw.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>47 <FILENAME>tm2227887d1-lc_macro4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 47 - file: tm2227887d1-lc_macro4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>48 <FILENAME>tm2227887d4-fc_carm4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 48 - file: tm2227887d4-fc_carm4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>49 <FILENAME>lg_svbsecurities-4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 49 - file: lg_svbsecurities-4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>50 <FILENAME>ft_svbsecurities-4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 50 - file: ft_svbsecurities-4c.jpg
</DOCUMENT> </SEC-DOCUMENT>