INCOME TAXES (Tables)

9 Months Ended

12 Months Ended

Sep. 30, 2022

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Components of Pre-tax Income (Loss)

The following table sets forth the components of the Company’s loss before income taxes by country (in thousands):

	Nine Months Ended
	September 30,
	2022		2021
Country:
United States	$	(32,083)	$	(38,864)
Canada		15,898		21,311
Total loss before income taxes	$	(16,185)	$	(17,553)

The following table sets forth the components of the Company’s loss before income taxes by country (in thousands):

	Year Ended December 31,
	2021		2020		2019
Country
United States	$	(32,757)	$	(35,529)	$	(27,468)
Canada		24,148		14,577		(80,032)
Total Loss Before Income Taxes	$	(8,609)	$	(20,952)	$	(107,500)

Components of Income Tax Benefit (Provision)

The Company’s tax benefit (provision) is comprised of the following components (in thousands):

	Nine Months Ended
	September 30,
	2022		2021
Current tax benefit (provision)
Federal	$	—	$	8,559
State		—		—
Foreign		3,875		(286)
Total current benefit	$	3,875	$	8,273

The Company’s tax benefit (provision) is comprised of the following components (in thousands):

	Year Ended December 31,
	2021		2020		2019
Current Tax Provision
Federal	$	—	$	—	$	—
State		—		—		—
Foreign		(286)		(1,445)		—
Total current (provision)	$	(286)	$	(1,445)	$	—
Deferred tax provision
Federal	$	—	$	—	$	—
State		—		—		—
Foreign		8,559		—		—
Total deferred benefit (provision)	$	8,559	$	—	$	—
Total Tax Benefit (Provision)	$	8,273	$	(1,445)	$	—

Reconciliation of Expected Income Tax Expense

The following table sets forth a reconciliation of the statutory United States federal income tax rate to the Company’s effective income tax rate:

	Year ended December 31,
	2021		2020		2019
United States federal statutory income tax rate	21.0	%	21.0	%	21.0	%
Impact of foreign rate differential	(15.9)		(4.2)		4.4
State taxes, net of federal benefit	2.3		2.0		0.6
Stock option cancellations	(1.1)		(0.2)		—
Contingent consideration	178.2		14.4		(18.0)
General business credits and other credits	2.4		6.6		0.4
Permanent differences	(1.4)		0.2		—
Other	(13.8)		(2.1)		(0.5)
Foreign taxes	(3.3)		(6.9)		—
Change in valuation allowance	(72.3)		(37.7)		(7.9)
Effective Income Tax Rate	96.1	%	(6.9)	%	—	%

Schedule Components of Deferred Tax Liabilities

The Company’s deferred tax liability is comprised of the following:

	September 30, 2022		December 31, 2021
Deferred tax liabilities
IPR&D	$	—	$	(3,969)
Total deferred tax liabilities	$	—	$	(3,969)

The following table sets forth the tax effects of temporary differences that gave rise to significant portions of the Company’s deferred tax assets and liabilities (in thousands):

	December 31,
	2021		2020		2019
Deferred tax assets:
NOL carryforwards	$	63,381	$	57,935	$	50,727
R&D credit carryforwards		4,316		3,787		4,385
Accruals and other		4,058		3,811		2,464
Capitalized start-up costs		53		70		91
Other		41		28		57
Gross deferred tax assets		71,849		65,631		57,724
Deferred tax liabilities:
IPR&D		(3,969)		(12,528)		(12,528)
Gross deferred tax liabilities		(3,969)		(12,528)		(12,528)
Valuation allowance		(71,849)		(65,631)		(57,724)
Net Deferred Tax Liability	$	(3,969)	$	(12,528)	$	(12,528)

Schedule of Credit Carryforwards

The following table summarizes the Company’s NOL and R&D and other credit carryforwards in the United States and Canada as of December 31, 2021 (in millions):

			Expiration
	Amount		Beginning in	Through
United States:
Federal NOL carryforwards - indefinite	$	101.1	None	None
Federal NOL carryforwards	$	118.9	2030	2038
State NOL carryforwards	$	138.4	2030	2040
Federal R&D credit carryforwards	$	2.5	2027	2040
State R&D credit carryforwards	$	0.8	2027	2040
Canada:
Federal non-capital loss carryforwards	$	31.2	2035	2040
Federal scientific research and experimental development expense carryforwards	$	5.1	2032	2040
Federal and provincial investment tax credit carryforwards	$	1.2	2032	2040