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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Revenue:      
Total Revenue $ 77,798 $ 15,325 $ 413
Operating expenses:      
Selling, general and administrative 198,821 151,846 62,011
Research and development 116,255 125,795 102,861
Amortization 13,988 6,077 0
Total operating expenses 352,474 288,487 164,872
Loss from operations (274,676) (273,162) (164,459)
Interest income 337 4,322 5,532
Interest expense (6,273) (15,148) 0
Changes in fair value of derivative liability 61 (129) (199)
Other expense, net (759) (592) (303)
Loss before income taxes (281,310) (284,709) (159,429)
Income tax benefit 0 2,620 0
Net loss (281,310) (282,089) (159,429)
Unrealized gain (loss) (18) (3) 11
Comprehensive loss (281,328) (282,092) (159,418)
Basic net loss (281,310) (282,089) (159,429)
Diluted net loss $ (281,310) $ (282,089) $ (159,429)
Basic net loss per share (in dollars per share) $ (4.17) $ (4.86) $ (3.67)
Diluted net loss per share (in dollars per share) $ (4.17) $ (4.86) $ (3.67)
Basic weighted-average number of shares used in computing net loss per share (in shares) 67,507,818 58,009,162 43,460,804
Diluted weighted-average number of shares used in computing net loss per share (in shares) 67,507,818 58,009,162 43,460,804
Product Revenue      
Revenue:      
Total Revenue $ 70,820 $ 12,877 $ 0
Operating expenses:      
Cost of product revenue /service revenue (exclusive of amortization 23,125 4,758 0
Collaboration revenue      
Revenue:      
Total Revenue 5,655 2,031 413
Service revenue      
Revenue:      
Total Revenue 1,323 417 0
Operating expenses:      
Cost of product revenue /service revenue (exclusive of amortization $ 285 $ 11 $ 0