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Income Taxes - Narrative (Details) - USD ($)
3 Months Ended 12 Months Ended
Dec. 31, 2020
Dec. 31, 2020
Dec. 31, 2019
Income Tax Contingency [Line Items]      
Increase in valuation allowance   $ 43,100,000 $ 54,700,000
Liability for uncertain tax positions $ 0 0  
HintMD      
Income Tax Contingency [Line Items]      
Business combination, provisional information, initial accounting incomplete, adjustment, deferred tax liability (2,700,000)    
Orphan Drug Credit Carryforward      
Income Tax Contingency [Line Items]      
Tax credit carryforwards 11,200,000 11,200,000  
Federal      
Income Tax Contingency [Line Items]      
NOL carryforwards 997,300,000 997,300,000  
Federal | Tax Year 2017      
Income Tax Contingency [Line Items]      
NOL carryforwards 501,000,000.0 501,000,000.0  
Federal | Research and Development Tax Credits      
Income Tax Contingency [Line Items]      
Tax credit carryforwards 10,600,000 10,600,000  
California      
Income Tax Contingency [Line Items]      
NOL carryforwards 413,400,000 413,400,000  
California | Research and Development Tax Credits      
Income Tax Contingency [Line Items]      
Tax credit carryforwards 8,600,000 8,600,000  
Other States      
Income Tax Contingency [Line Items]      
NOL carryforwards $ 145,200,000 $ 145,200,000