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Fair Value Measurements - Schedule of Fair Value of Financial Instruments (Detail) - Recurring - USD ($)
$ in Thousands
Jun. 30, 2019
Dec. 31, 2018
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value $ 240,571 $ 171,776
Total liabilities measured at fair value 2,824 2,753
Money market funds    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 81,734 38,354
U.S. treasury securities    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 114,107 80,844
U.S. government agency obligations    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value   52,578
Commercial paper    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 44,730  
Derivative liability associated with the Medicis settlement    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total liabilities measured at fair value 2,824 2,753
Level 1    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 195,841 119,198
Total liabilities measured at fair value 0 0
Level 1 | Money market funds    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 81,734 38,354
Level 1 | U.S. treasury securities    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 114,107 80,844
Level 1 | U.S. government agency obligations    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value   0
Level 1 | Commercial paper    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 0  
Level 1 | Derivative liability associated with the Medicis settlement    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total liabilities measured at fair value 0 0
Level 2    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 44,730 52,578
Total liabilities measured at fair value 0 0
Level 2 | Money market funds    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 0 0
Level 2 | U.S. treasury securities    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 0 0
Level 2 | U.S. government agency obligations    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value   52,578
Level 2 | Commercial paper    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 44,730  
Level 2 | Derivative liability associated with the Medicis settlement    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total liabilities measured at fair value 0 0
Level 3    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 0 0
Total liabilities measured at fair value 2,824 2,753
Level 3 | Money market funds    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 0 0
Level 3 | U.S. treasury securities    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 0 0
Level 3 | U.S. government agency obligations    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value   0
Level 3 | Commercial paper    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total assets measured at fair value 0  
Level 3 | Derivative liability associated with the Medicis settlement    
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]    
Total liabilities measured at fair value $ 2,824 $ 2,753