10-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-K

(Mark One)

x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2015

or

o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from             to             .

Commission File Number: 001-35907

QUINTILES TRANSNATIONAL HOLDINGS INC.

(Exact name of registrant as specified in its charter) 

North Carolina	27-1341991
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification Number)

4820 Emperor Blvd., Durham, North Carolina 27703

(Address of principal executive offices and Zip Code)

(919) 998-2000

(Registrant’s telephone number, including area code)

Securities registered pursuant to Section 12(b) of the Act:

Title of Each Class:	Name of Each Exchange on which Registered
Common Stock, par value $0.01 per share	New York Stock Exchange

Securities registered pursuant to Section 12(g) of the Act: None

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.    Yes  x    No  o

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or section 15(d) of the Exchange Act.    Yes  o    No  x

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding twelve months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes  x    No  o

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).    Yes  x    No  o

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K.  x

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer	x	Accelerated filer	o
Non-accelerated filer	o  (Do not check if a smaller reporting company)	Smaller reporting company	o

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes  o    No  x

The aggregate market value of the voting and non-voting common stock held by non-affiliates of the registrant, based upon the closing sale price as reported on the New York Stock Exchange on June 30, 2015, the last business day of the registrant’s most recently completed second quarter, was approximately $5,835,192,138.

Indicate the number of shares outstanding of each of the issuer’s classes of Common Stock, as of the latest practicable date.

Class	Number of Shares Outstanding
Common Stock $0.01 par value	119,384,993 shares outstanding as of February 4, 2016

Portions of the registrant’s Proxy Statement for the 2016 Annual Meeting of Shareholders are incorporated herein by reference in Part III of this Annual Report on Form 10-K to the extent stated herein. Such proxy statement will be filed with the Securities and Exchange Commission within 120 days of the registrant’s fiscal year ended December 31, 2015.

QUINTILES TRANSNATIONAL HOLDINGS INC.

FORM 10-K

TABLE OF CONTENTS

Item		Page
	PART I
1.	Business	4
1A.	Risk Factors	18
1B.	Unresolved Staff Comments	34
2.	Properties	34
3.	Legal Proceedings	34
4.	Mine Safety Disclosures	34
	PART II
5.	Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities	35
6.	Selected Financial Data	38
7.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	40
7A.	Quantitative and Qualitative Disclosures About Market Risk	60
8.	Financial Statements and Supplementary Data	61
9.	Changes in and Disagreements with Accountants on Accounting and Financial Disclosure	103
9A.	Controls and Procedures	103
9B.	Other Information	103
	PART III
10.	Directors, Executive Officers and Corporate Governance	104
11.	Executive Compensation	104
12.	Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters	104
13.	Certain Relationships and Related Transactions and Director Independence	104
14.	Principal Accountant Fees and Services	104
	PART IV
15.	Exhibits and Financial Statement Schedules	104
	Signatures	106
	Exhibit Index	113

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In this document, unless otherwise stated or the context otherwise requires, references to “Quintiles,” “we,” “us,” “our,” or similar references mean Quintiles Transnational Holdings Inc. and its subsidiaries on a consolidated basis. References to “Quintiles Holdings” refer to Quintiles Transnational Holdings Inc. on an unconsolidated basis. References to “Quintiles Transnational” refer to Quintiles Transnational Corp., Quintiles Holdings’ wholly-owned subsidiary through which we conduct our operations.

FORWARD-LOOKING STATEMENTS

This Annual Report on Form 10-K contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, or the Securities Act, and Section 21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act. Such forward-looking statements reflect, among other things, our current expectations, our forecasts and our anticipated results of operations, all of which are subject to known and unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements, market trends, or industry results to differ materially from those expressed or implied by such forward-looking statements. Therefore, any statements contained herein that are not statements of historical fact may be forward-looking statements and should be evaluated as such. Without limiting the foregoing, the words “anticipates,” “believes,” “estimates,” “expects,” “intends,” “may,” “plans,” “projects,” “should,” “targets,” “will” and the negative thereof and similar words and expressions are intended to identify forward-looking statements. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including those described in Part I, Item 1A, “Risk Factors.” Unless legally required, we assume no obligation to update any such forward-looking information to reflect actual results or changes in the factors affecting such forward-looking information.

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PART I

Item 1. Business

Company Overview

We are the world’s largest provider of biopharmaceutical development services and commercial outsourcing services. We are positioned at the intersection of business services and healthcare and generated $4.3 billion of service revenues in 2015, conduct business in approximately 100 countries and have approximately 36,100 employees. We use the breadth and depth of our service offerings, our global footprint and our therapeutic, scientific and analytics expertise to help our biopharmaceutical customers, as well as other healthcare customers, to be more successful in an increasingly complex healthcare environment.

We were founded in 1982 by Dennis B. Gillings, CBE, Ph.D., who was a biostatistics professor at the University of North Carolina at Chapel Hill. Dr. Gillings and his cofounder pioneered the use of sophisticated statistical algorithms to improve the quality of data used to determine the efficacy of various drug therapies. We expanded internationally into Europe in 1987 and into Asia in 1993. In 1994, we completed an initial public offering, or IPO, and in 2003 we exited the public markets through a going private transaction. In May 2013, we returned to the public markets by completing an IPO on the New York Stock Exchange, or NYSE.

We are a leader in the development and commercialization of new pharmaceutical therapies. Our Product Development segment is the world’s largest contract research organization, or CRO, based upon the most recently available public information of reported service revenues, and is focused primarily on Phase II-IV clinical trials and associated laboratory and analytical activities. Our Integrated Healthcare Services segment includes one of the leading global commercial pharmaceutical sales and service organizations, in addition to healthcare business services for the broader healthcare sector, such as real world and late phase research, market access and consulting, health information analytics and technology consulting, and other healthcare solutions. Product Development contributed approximately 74% and Integrated Healthcare Services contributed approximately 26% to our 2015 service revenues. Additional information regarding our segments is presented in Note 20 to our audited consolidated financial statements included elsewhere in this Annual Report on Form 10-K.

Our global scale and capabilities enable us to work with the leading companies in the biopharmaceutical sector. During each of the last 13 years, we have worked with the 20 largest biopharmaceutical companies ranked by 2014 reported revenues. We have provided services in connection with the development or commercialization of 98 of the top 100 best-selling biopharmaceutical products and the top 50 best-selling biologic products, from 2014 as measured by reported sales.

In 2015, our service revenues were $4.3 billion and our net income attributable to our shareholders was $387.2 million. In addition, our 2015 net new business was $5.3 billion, and we ended the year with $12.0 billion in backlog. Our backlog at December 31, 2015 was diversified with 28% from top 10 biopharmaceutical companies, 23% with biopharmaceutical companies ranked as 11-20, 24% with biopharmaceutical companies ranked as 21-50, and 25% with biopharmaceutical companies outside the top 50, in each case, as ranked by 2014 sales. See Part I, Item 1, “Business—Net New Business Reporting and Backlog” for more detail. During each of the last eight years, we have had at least eight customers from whom we earned more than $100 million in service revenues. No single customer represented more than 10% of our 2015 revenues.

Our Markets

The market served by Product Development consists primarily of biopharmaceutical companies, including medical device and diagnostics companies, that outsource services associated with the development of pharmaceutical products, such as clinical trials. We estimate that total research and development spending was approximately $143 billion in 2015 of which biopharmaceutical spending on drug development was approximately $97 billion, and we estimate that our addressable market (clinical development spending excluding preclinical spending) was approximately $54 billion. The portion of this $54 billion that was outsourced in 2015, based on our estimates, was approximately $22 billion. We estimate, based on industry data, analysis, and our own estimates, that the potential market for Product Development’s services should experience a compound annual growth rate, or CAGR, of 6%-8% from 2015 through 2018 as a result of the increased outsourcing of research and development spending by biopharmaceutical companies in addition to increases over time in this overall spending as compared to 2014.

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Integrated Healthcare Services primarily addresses markets related to the use of approved biopharmaceutical products. We estimate that total spending related to approved drugs, including biopharmaceutical spending on commercialization of these drugs and expenditures by participants in the broader healthcare market on real-world research, healthcare technology implementation analytics, and evidence-based medicine, exceeded $101 billion in 2015. Integrated Healthcare Services links product development to healthcare delivery. This segment’s services include commercial services such as recruiting, training, deploying and managing a global sales force, channel management, patient engagement services, market access consulting, brand communication, advisory services, and health information analytics and technology consulting. In addition, Integrated Healthcare Services offers real-world late phase services such as observational studies, comparative effectiveness studies and product and disease registry services, which are intended to help increase the quality and cost-effectiveness of healthcare and payer provider solutions. We believe that a combination of cost pressure in healthcare systems around the world and the increasing focus on the value and efficacy of pharmaceutical therapy provide us many opportunities to grow our revenues and expand our service offerings by improving the cost-effectiveness of drug therapies.

We believe that we are well-positioned to benefit from current trends in the biopharmaceutical and healthcare industries that affect our markets, including:

Trends in Research and Development Spending. We estimate that research and development spending was approximately $143 billion in 2015 and will grow to approximately $155 billion in 2018, with drug development accounting for approximately 68% of total expenditures. Research and development spending trends are impacted as a result of several factors, including major biopharmaceutical companies’ efforts to replenish revenues lost from the so-called “patent cliff” of recent years, increased access to capital by the small and midcap biotechnology industry, and recent increases in pharmaceutical approvals by regulatory authorities. In 2015, there were approximately 5,084 drugs in the Phase I-III development pipeline, an increase of 36% since 2010, and there were 45 new molecular entities approvals by the United States Food and Drug Administration, or FDA, which was the highest number of approvals in any of the past 19 years. We believe that further research and development spending, combined with the continued need for cost efficiency across the healthcare landscape, will continue to create opportunities for biopharmaceutical services companies, particularly those with a global reach and broad service offerings, to help biopharmaceutical companies with their pre- and post-launch product development and commercialization needs.

Growth in Outsourcing. We estimate that clinical development spending outsourced to CROs in Phases I-IV in 2015 was approximately $22 billion and will grow to approximately $28 billion by 2018. We expect outsourced clinical development to CROs to grow 6%-8% annually during this period, and believe this annual growth will be driven largely by increased outsourcing penetration, with up to 2% of this growth coming from increased research and development expenditures over 2015 to 2018. In estimating these growth rates, we monitor the ability of biopharmaceutical companies, including biotechnology companies, to raise capital, as well as the potential impact from merger and acquisition activity between biopharmaceutical companies. We estimate that overall outsourcing penetration of the addressable market in 2015 was 41%. The market served by Integrated Healthcare Services is diverse, which makes it difficult to estimate the current amount of outsourced integrated healthcare services and the expected growth in such services. However, based on our knowledge of these markets we believe that, while the rate of outsourcing penetration varies by market within Integrated Healthcare Services, the current outsourcing penetration of the estimated $101 billion market is approximately 23%. As business models continue to evolve in the healthcare sector, we believe that the growth rate for outsourcing across the Integrated Healthcare Services markets will be similar to the growth in clinical development.

We believe that we are well positioned for the future evolution of the healthcare sector as increasing demand from governments and other payers around the world for quality, accountability and value for money drive biopharmaceutical companies, providers and other healthcare organizations to transform their value chain away from a vertically integrated model to one that is more focused on their core competencies. In particular, we believe that the following trends will result in increased outsourcing to global biopharmaceutical services companies:

· Maximizing Productivity and Lowering Costs. Declining research and development productivity, increased development costs and diminished returns on marketing and sales have negatively impacted biopharmaceutical companies. We believe that the need for biopharmaceutical companies to maximize productivity and lower costs in their product development and commercial operations will cause them to look to partners as they enter into outsourcing arrangements to improve efficiency, increase sales force utilization and effectiveness, improve clinical success rates and turn fixed costs into variable costs across their research and development and commercial operations.

· Managing Complexity. Biopharmaceutical companies face environments in which it has become increasingly difficult to operate. Improved standards of care in many therapeutic areas and the emergence of new types of therapies, such as biologics, genetically targeted therapies, gene and stem cell therapies, and other treatment modalities have led to more complex development and regulatory pathways, such as recently released guidelines in the United States and Europe for the development of “biosimilar” products. We believe that our global clinical development capabilities, including our expertise in biomarkers and genomics and our global laboratory network, position us well to help biopharmaceutical companies manage the complexities inherent in an environment where this type of expertise is important.

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· Providing Enhanced Value for Patients. As healthcare costs rise globally, governments and third-party payers have looked for ways both to control healthcare expenditures and increase the quality, safety and effectiveness of drug therapies. Governments and regulatory bodies have adopted, and may continue to adopt, healthcare legislation and regulations that may significantly impact the healthcare industry by demanding more value for money spent and financial accountability for patient outcomes. Such legislation and regulations may tie reimbursement to the demonstrated clinical efficacy of a therapy, require payers and providers to demonstrate efficacy in the delivery of healthcare services and require more evidence-based decisions, all of which we believe will increase the demand for innovative and cost-effective commercialization strategies and outcome research and data analytics services.

· Increased Importance of Product Development in Local Markets. Increasingly, regulators require clinical trials involving local populations as part of the process for approving new pharmaceutical products, especially in certain Asian and emerging markets. Understanding the epidemiological and physiological differences in different ethnic populations and being able to conduct clinical trials locally in certain geographies will be important to pharmaceutical product growth strategies, both for multinational and local/regional biopharmaceutical companies. We believe that our global clinical development capabilities and unmatched presence in Asia and other emerging markets make us a strong partner for biopharmaceutical companies managing the complexities of international drug development.

· Increasing Number of Phase II-IV Clinical Trials. Based on the current and expected composition of the global drug development pipeline, we believe that spending on Phase II-IV clinical trials will continue to increase. As the complexity and cost of Phase II-IV clinical trials grow, clinical trial sponsors will continue to seek to recruit patients on a global basis. We believe that this increased spending and the demand for global patient recruitment will favor the limited number of biopharmaceutical services companies that have both the capabilities to administer large, complex global clinical trials and relationships with thought-leading investigators and clinical trial sites. In addition, as these drugs come to market, we believe that biopharmaceutical companies will also seek to outsource an increasing amount of the commercial and other integrated healthcare services necessary to effectively launch and market these drugs.

· Increase in Strategic Collaborations. Larger CROs are able to provide a greater variety of services and therapeutic expertise to the biopharmaceutical community. Biopharmaceutical companies continue to enter into long-term strategic collaborations with global service providers. We believe that biopharmaceutical companies have historically preferred, and will continue to prefer, financially sound, global service providers with broad therapeutic and functional expertise such as our company when selecting strategic providers.

Our Strategy

We believe that we are positioned to be the partner of choice to biopharmaceutical companies worldwide and a key resource to other healthcare industry participants who are looking to improve operational, therapeutic and patient outcomes. We differentiate ourselves from others in our industry through our competitive strengths and strategies, which include:

Global Scale and Leadership. We offer global capabilities in the biopharmaceutical services industry, with a presence in all of the major biopharmaceutical markets, including the United States, Japan, and Europe in addition to Brazil, Russia, India and China, or the BRIC countries. Our extensive global footprint provides us substantial local expertise in multinational patient populations and regulatory schemes that allows us to effectively serve customers worldwide. We believe that our industry leading size, global scale and significant technology and process capabilities differentiate us by enabling us to effectively manage increasingly complex and global clinical trials with continuous clinical data monitoring and niche pools of patients from around the world. We have earned a reputation as an industry and thought leader, which is reflected in our financial and operational performance. We believe we have the largest share of the outsourced global clinical and commercialization markets. Our broad geographic diversification is represented by operations in approximately 100 countries. Based on our public competitors’ most recently available information of reported service revenues, we believe we are the market leader in the United States, Japan and Europe, the three largest biopharmaceutical markets in the world. In addition, as of December 31, 2015, we had approximately 36,100 employees with the majority located outside the United States, including significant numbers in Japan and Europe. For more information regarding the geographic scope of our business, see Note 19 to our audited consolidated financial statements included elsewhere in this Annual Report on Form 10-K. For more information regarding our employee base, see “Employees” below.

Broad, Deep and Diverse Relationships. We believe that the breadth and depth of our service offerings allow us to establish and develop relationships with key decision makers throughout our customers’ organizations. During each of the last 13 years, we have worked with the 20 largest biopharmaceutical companies, as measured by their respective 2014 reported revenues. In 2015, we had 13 customers from whom we earned at least $100 million in service revenues. We also work with over 550 small, mid-size and other biopharmaceutical companies outside the 20 largest by revenues. We also have broad, deep and diverse relationships with clinics, large hospitals and health systems through which we have access to thousands of investigators and other providers worldwide. We intend to leverage our strong relationships to assist our customers as they seek to reduce and variabilize their cost structures while increasing their probability of product success.

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Therapeutic and Scientific Expertise. We believe our deep scientific, therapeutic and domain expertise enables us to help customers solve the complex challenges inherent in drug development and commercialization. We also believe that the breadth of our expertise, from expert consulting to data-driven planning and design, enables us to help biopharmaceutical companies improve operational efficiency and outcomes. We have continued to invest in developing world-class scientific capabilities underpinned with a focus on delivering consistent, high-quality services to our customers throughout the world. We have a strong therapeutic focus on oncology, cardiovascular, central nervous system, diabetes and internal medicine as these five therapeutic areas represent more than 70% of the total biopharmaceutical product pipeline in 2015 and are generally highly complex and require significant scientific expertise and global scale. Our employees have substantial scientific, quantitative, analytical and applied technology skills and substantial expertise in numerous therapeutic areas, with over 3,000 Ph.D.s, medical doctors, statisticians and statistical programmers on our staff worldwide.

Integrated Services to Enable Better Decision-making in the Broader Healthcare Market. We believe that sustainable and growing revenue can be achieved through differentiation of services, coupled with deeper and broader relationships and a commitment to structuring flexible and innovative solutions to meet the diversified and changing needs of the healthcare industry. We use our extensive scope of services to design innovative and flexible solutions tailored for our customers’ needs in an increasingly complex environment. Our core market is product development, and we have deep and global expertise across the phases of this market from first-in-man clinical trials through post-marketing studies. Our services are designed to provide integrated solutions that address the complex challenges faced by a broad range of healthcare industry participants. We believe that our significant capabilities in analytics, clinical science and real-world data, combined with our broad commercial, consulting and post-launch expertise, will enable us to meet the research and analytical needs of healthcare industry participants from the development and commercialization organizations within traditional and emerging biopharmaceutical companies to the broader healthcare market, including the needs of payers and providers to measure the value of various treatments and patient outcomes.

Experienced, Highly Trained Management and Staff. Our senior management team includes executives with experience from inside and outside the biopharmaceutical and biopharmaceutical services industries who use their decades of experience to serve our customers and grow our company. Each of our executive officers has more than 25 years of experience in large, multinational organizations. Our management and staff are comprised of approximately 36,100 employees worldwide, of whom over 1,100 are medical doctors and approximately 1,050 possess a Ph.D. or equivalent. Our employees contribute to a company-wide culture focused on delivering services and information that meet or exceed the quality standards demanded by customers, doctors, patients and regulatory authorities. At this time, we have over 6,700 contract medical sales representatives, a sales force that is comparable in size to the sales forces of many large biopharmaceutical companies. We strive to maintain a culture that reinforces collaboration, motivation and innovation which is consistent with our core values and Code of Conduct: Doing the Right Thing.

Technology Solutions and Process/Data Capabilities. For over 33 years, we have been devoted to advancing state of the art technology, processes and analytics to optimize our service offerings and provide our customers with the information they need to quickly make critical decisions regarding the development and commercialization of their products. We have focused on investment in quality data, including de-identified electronic health records, or EHR. Because data are only as good as the analytics used to analyze them, we have also invested heavily in data analytics products, services and professionals. As part of this investment, we created our proprietary data integration tool, the Quintiles Infosario® platform, which is a suite of modules that integrates data from across multiple source systems to provide us and our customers with current, quality and comprehensive information regarding clinical trials, allowing decisions to be made quickly and efficiently. In addition, we have developed a planning and design platform and other software solutions to enable improvements to the drug development process and to demonstrate the value of biopharmaceutical products in the real world.

Our Services

We address the needs of the healthcare industry by providing product development and integrated healthcare services to help our customers navigate the complex healthcare environment and improve outcomes. The broad scope of our services allows us to help our customers rapidly assess the viability of a growing number of potential new therapies, cost-effectively accelerate development of the most promising ones, launch new products to the market quickly, and evaluate their impact and appropriate use on patients.

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We offer our services through two reportable segments: Product Development and Integrated Healthcare Services. The figure below displays the range of our services across both of our segments.

Product Development Services		Integrated Healthcare Services
Project Management & Clinical Monitoring:	Q2 Solutions:	Commercial Services:
•  Study Design & Operational Planning	•  Clinical Trial Laboratories	•  Contract Sales
•  Investigator/Site Recruitment	•  Genomic Laboratories	•  Market Entry / Market Exit
•  Site & Regulatory Start Up	•  Bioanalytical Laboratories	•  Integrated Channel Management
•  Patient Recruitment		•  Patient Engagement Services
•  Clinical Monitoring	Strategic Planning & Design:	•  Market Access & Commercialization Consulting
•  Project Management	•  Biomarkers, Genomics & Personalized Medicine	•  Brand & Scientific Communications
•  Late Phase Interventional	•  Model Based Drug Development
	•  Planning & Design	Real-World and Late Phase Research:
Clinical Trial Support Services:	•  Regulatory Affairs Services	•  Observational Studies
•  Clinical Data Management		•  Product and Disease Registries
•  Biostatistical Services	Advisory Services:	•  Comparative Effectiveness Studies
•  Cardiac Safety & ECG Laboratory Services	•  Product Development Strategy Consulting
•  Safety & Pharmacovigilance Operations	•  Regulatory & Compliance Consulting	Communication and Health
•  Phase I Clinical Pharmacology Units	•  Process & IT Implementation Consulting	Engagement Services:
		•  Digital Patient Services
		•  Brand and Scientific Communications
		Other Healthcare Solutions:
		•  Payer & Provider Solutions
		•  Advisory Services

Product Development

Product Development provides services and expertise that enable biopharmaceutical companies to outsource the clinical development process from first-in-man clinical trials to post-launch monitoring. Product Development is comprised of Clinical Solutions & Services and Consulting. Clinical Solutions & Services provides services necessary to develop biopharmaceutical products, including project management and clinical monitoring functions for conducting multi-site clinical trials (generally Phase II-IV) and clinical trial support services that can improve clinical trial decision-making and data management and strategic planning and design services that can improve decisions and performance. Consulting provides strategy and management consulting services based on deep life science expertise and advanced analytics as well as regulatory and compliance consulting services.

Clinical Solutions & Services

Project Management and Clinical Monitoring

Drawing upon our years of experience, our site databases, our site relationships and our highly trained staff, Clinical Solutions & Services enables the efficient conduct and coordination of multi-site clinical trials (generally Phase II-IV). Clinical Solutions & Services’ service offerings include protocol design, feasibility and operational planning, site start up, patient recruitment, project management and monitoring of the investigator sites and data from patient visits.

Study Design and Operational Planning. We assist our customers in preparing the study protocol, designing clinical report forms and identifying appropriate patients, sites and the optimal country mix to meet their objectives, among other key upfront decisions. The study protocol defines the medical hypotheses to be examined, the number of patients required to produce statistically valid results, the period of time over which they must be tracked, the frequency and dosage of drug administration and the study procedures.

Investigator/Site Recruitment. During clinical trials, the drug is administered to patients by physicians, referred to as investigators, at hospitals, clinics or other sites. The quality of a clinical trial is dependent on the quality of the investigators who perform the clinical trials. Through our global prime site and partner programs, we have established relationships with thousands of investigators who conduct our clinical trials worldwide. We provide our investigators the resources and tools they need to effectively conduct the clinical trials.

Site and Regulatory Start Up. The process of identifying, training and contracting with sites while also securing regulatory and ethics approval is a complex and time-consuming aspect of clinical trials. We have a dedicated unit that draws upon our experience from participating in clinical trials globally across multiple therapeutic areas for over 30 years. We utilize technology and analytics to simplify and streamline this process, reducing time to first patient in and laying the groundwork for successful clinical trial execution.

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Patient Recruitment. We assist our customers in recruiting patients for clinical trials through investigator relationships, media advertising, use of web-based techniques and other methods. We also help to ensure patients are retained for the duration of the clinical trials. We use informatics tools and media-based recruitment methods to identify, reach and recruit the appropriate patients. Our patient recruitment system includes informatics tools and media-based recruitment methods to provide broad pools of prescreened patients as well as an efficient enrollment process and a call center. Through our global patient recruitment programs, we have enrolled on average over 100,000 patients in Phase I-III clinical trials annually during the last seven years.

Clinical Monitoring. We deploy and manage clinical research associates, or CRAs, to work with and monitor sites to assure the quality of the data, which we gather according to Good Clinical Practice, or GCP, and International Conference on Harmonisation, or ICH, regulations and guidelines, and to meet the customers’ and regulatory authorities’ requirements according to the study protocol. CRAs also assist with site initiation, training, patient enrollment and retention. Regulatory authorities are encouraging the use of innovative approaches in clinical trial monitoring, and we have deployed targeted, data-driven, risk-based, monitoring techniques to improve monitoring efficiency and effectiveness, focusing on the areas most likely to impact the quality of the data and safety of the patients in their particular clinical trial.

Project Management. Our project managers help customers navigate the complexity of the clinical trial process and coordinate all of the various activities, data streams and timelines associated therewith. Aligned by therapeutic experience, our project managers highlight risks before they become issues, while managing budgets and timelines. As clinical trials become more complex, project managers are becoming increasingly important in ensuring clinical trials are completed successfully.

Clinical Trial Support Services

Each clinical trial requires a number of concurrent services and data streams. We offer a broad range of functional services and consultation to support clinical trials through specialized expertise that help customers efficiently collect, analyze and report the quality data and evidence they need to gain regulatory approval. Our clinical trial support services include:

Clinical Data Management. Our data management services provide support for the collection, organization, validation and analysis of clinical data. Data used can be captured via electronic data capture, or EDC, or from paper. These databases include customized databases to meet customer-specific formats, integrated databases to support regulatory submissions to numerous regulatory authorities around the world, including, for example, to the FDA to support new drug applications, or NDAs, new biological license applications, or BLAs, and premarket approval applications, or PMAs, for medical devices.

Biostatistical Services. We provide statistical analyses of scientific databases for all phases of the drug development process. Biostatistics is at the core of every clinical trial, and we have been pioneering the use of biostatistics since our founding in 1982. We have more than 850 biostatisticians and statistical programmers around the world, of whom approximately 60% have advanced degrees. We use biostatistics to assist our customers in speeding drug development, staying current with evolving best practices, navigating regulatory requirements and developing and qualifying biomarkers.

Cardiac Safety and ECG Laboratory Services. Our centralized electrocardiogram, or ECG, laboratory in India provides continuous global collection and analysis of ECGs by trained cardiologists as part of clinical trials. Our laboratory logs, tracks and analyzes ECGs from around the world, and stores and transmits reports in near real time. We believe that integrating our ECG laboratory capabilities into clinical trials helps customers identify and adjust to cardiac safety signals earlier in the drug development process.

Safety and Pharmacovigilance Operations. Conducting clinical trials requires a dedicated, separate process to collect, analyze and report safety events. We have extensive experience, scale and geographic coverage for case management services. Our safety management system combines our expertise, standard operating procedures and best practices derived from thousands of projects. Underpinned by our technology, we help customers efficiently manage fluctuating case loads, streamline global operations and compliance, and gain better insights into clinical trial operations. We customize our lifecycle safety suite of services to monitor drug safety, including managing case reports, performing safety risk profiling and improving operation efficiency, quality and regulatory compliance.

Phase I Clinical Pharmacology Services. Phase I clinical trials often involve testing a new drug on a limited number of healthy volunteers and patients. For such Phase I clinical trials, we own and operate clinical pharmacology units (Phase I clinics) where we perform the core clinical functions related to these clinical trials, with support from the specialized expertise and functions from other members of Clinical Solutions & Services. Our Phase I clinical trial capabilities include dose ranging, bioavailability/bioequivalence studies, PK/PD modeling, first administration to humans, multiple dose tolerance, dose effect relationship and metabolism studies.

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Q² Solutions

We provide our customers globally scaled end-to-end clinical trial laboratory and research services through our majority-owned joint venture with Quest Diagnostics Incorporated, or Quest, which was formed on July 1, 2015. The following clinical trial, genomic, and bioanalytical laboratory service offerings operate within the joint venture which is referred to as Q² Solutions:

Clinical Trial Laboratories. We support the laboratory testing and reporting needs inherent in all phases of clinical trials, offering globally harmonized safety and efficacy biomarker testing through the world’s largest, network of clinical trial laboratories with individual College of American Pathologists accreditations. Services include assay development and validation, the provision of protocol-specific clinical trial materials, customized lab report design, and specimen management and archival. We support clinical trials anywhere in the world through facilities in the United States, the United Kingdom, South Africa, India, China, Singapore and Japan, and a tightly coordinated network of affiliated laboratories in Argentina and Brazil. Our global processes and harmonization scheme are designed to help ensure the standardization of laboratory test results and integrated, comparable data collection, management and transfer, including providing direct electronic integration of laboratory data into safety and efficacy reports for NDA submissions.

Genomic Laboratory. We provide a broad range of solutions in support of our customers’ clinical trial and research efforts, including experiment design, sample analysis, nucleic acid isolation, gene expression profiling, genotyping, next generation sequencing and advanced bioinformatics. Our services include whole genome to focused set gene expression profiling and genotyping assays along with DNA and RNA sequencings services, sequence enrichment technologies and bioinformatics support. Our quality system is designed to adhere to Clinical and Laboratory Standards Institute guidelines, and our Clinical Laboratory Improvements Amendments, or CLIA, certified laboratory supports good laboratory practice, or GLP, compliance.

Bioanalytical Laboratories. We offer our customers a broad range of GLP and non-GLP bioanalytical testing to support pharmacokinetic/pharmacodynamic, or PK/PD, studies, and absorption, distribution, metabolism and elimination studies in the early phases of clinical testing.

Strategic Planning and Design

Through our strategic planning and design services, we offer consultation services to improve decisions and performance including portfolio, program and protocol planning and design, biomarker consultation, benefit-risk management, regulatory affairs, biostatistics, modeling and simulation, and personalized medicine.

Biomarkers, Genomics and Personalized Medicine. Personalized medicine is an emerging practice of medicine that uses information about a person’s genes, proteins and environment to prevent, diagnose and treat disease. We support biopharmaceutical companies with deep expertise in the complex and groundbreaking efforts in the area of biomarker and genomics research, testing and analysis with a comprehensive suite of services, including biomarker discovery and development, assay development and validation, genomics, digital pathology and consultation on the use of biomarkers to improve patient selection for clinical trials.

Model-Based Drug Development. We have extensive capabilities in the development and use of modeling and simulation techniques to improve decision-making through scenario analysis at key points in the drug development process. Services include population PK/PD modeling and simulation to identify the concentration-response relationship and best doses to pursue in later testing, and clinical trial simulation to test various clinical trial design options simulated on computers before performing the actual clinical trial.

Planning and Design. Our Center for Integrated Drug Development has developed an innovative approach to strategic clinical research planning with a design platform that includes a modeling and simulation process for scenario planning and risk assessment to support portfolio, program development and protocol planning.

Regulatory Affairs Services. We provide comprehensive medical and regulatory affairs services for our biopharmaceutical customers. Our medical services include medical oversight of clinical trials, review and interpretation of adverse experiences, medical writing of reports and clinical trial protocols and strategic planning of drug development programs. Regulatory services for product registration include regulatory strategy design, document preparation, publishing, consultation and liaison with various regulatory authorities.

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Advisory Services

We offer our customers consulting services based on our experience with the product life cycle. By operating at the intersection of three core capabilities—strategy, data and analytics—and by providing access to the deep domain expertise offered by our various service lines, we can develop pragmatic solutions that help biopharmaceutical companies anticipate and address their myriad of challenges and opportunities.

Product Development Strategy Consulting. Our expert consultants support biopharmaceutical customers to improve the effectiveness and efficiency of their product development operations. We provide objective, industry vetted recommendations to help customers bring safer, differentiated products to market faster and more cost effectively. We begin in the conceptualization phase of development with strategic market research to bring a commercially minded approach to clinical design. Through a combination of secondary data and clinical analytics, we support customers in making informed development decisions.

Regulatory and Compliance Consulting. We supply regulatory and compliance consulting services to the biopharmaceutical industry related to Good Manufacturing Practice, or GMP, GCP and GLP, global regulatory affairs, and quality systems engineering and validation. We assist customers in preparing for interactions with the FDA and foreign regulatory authorities or agencies, including inspections and resolution of enforcement actions, and complying with current GMP, and quality systems regulations, meeting process and software validation requirements and bringing new medical devices to market.

Process and IT Implementation Consulting. Realizing that strategy is only as good as how effectively it is implemented, we both design highly executable strategies and help implement them. Our consultants help customers optimize clinical and business processes to accelerate timelines and eliminate waste. Change management experts help implement new processes and organizational initiatives. Finally, we develop technology and information technology, or IT, strategies and help ensure their successful implementation.

Integrated Healthcare Services

Integrated Healthcare Services provides the healthcare industry with both broad geographic presence and commercial capabilities. Our customized commercialization services are designed to accelerate the commercial success of biopharmaceutical and other health-related products by promoting, delivering and proving value. When integrated with our product development services, our commercialization services enable solutions across the full lifecycle of a product.

Commercial Services

Contract Sales. Skilled primary care, specialty and multi-channel integrated sales teams provide our customers with a flexible resource that is able to respond quickly and effectively to the changing marketplace. We provide our customers with a variety of staffing options, including direct hire, flexible work arrangements, leave of absence and “strike force” arrangements (in which a team is deployed to a particular territory to capitalize on a market niche opportunity) in both full-time and flex-time solutions. We can supplement our sales forces with remote e-detailing capabilities. Our training and development services integrate traditional, distance-learning and web-based services. Our contract sales unit helps customers design or revamp their existing sales training programs to meet marketplace demands.

Market Entry/Market Exit. Market entry services help biopharmaceutical companies quickly and successfully launch products before or in lieu of establishing a long-term commercial infrastructure. Market exit services help biopharmaceutical companies manage the regulatory, quality and governance issues that arise when exiting unprofitable or less profitable markets. Market entry and market exit services are integrated solutions that can include assistance with regulatory compliance, market access, brand strategy, import and distribution logistics, and sales and marketing programs.

Integrated Multichannel Management. Integrated multichannel solutions leverage market-based analytics to help biopharmaceutical companies optimize channel mix (including sales force mix) so that the sales and marketing strategy for individual drugs can be effectively executed across multiple channels, including the use of sales representatives, e-detailing, video, mail, call center, webinars and online portals. Our integrated multichannel management services allow our customers to access key healthcare stakeholders and tailor the channels used to optimize results.

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Patient Engagement Services. Our health management services professionals offer customized clinical and educational solutions to bridge the gap between the clinical and commercial phases of product development and provide expertise across a broad range of pre-launch, launch and post-launch opportunities. We provide customers with solutions in a broad-based spectrum, from patient adherence programs to clinical trial educators that assist in recruitment, education and retention of patients in clinical trials. We assist biopharmaceutical companies in evaluating the therapy from the perspective of the patient, not just the prescriber, supporting patient compliance and product dosing compliance therapy adherence and patient retention, which we believe can increase commercial success. Our professionals assist in the process of developing patient-centric strategies and implementing them for or side by side with customers.

Market Access and Commercialization Consulting. Market access services support biopharmaceutical customers in the development and execution of a strategy for bringing products into the market based on value. Once a product proceeds from large scale clinical trials to commercialization, our consultants help customers create product positioning, pricing and formulary access and reimbursement strategies based on extensive primary research with providers, patients, payers and other decision-makers.

Real-World and Late Phase Research

Since 2011, our Real World and Late Phase Research group has provided clinical services for more than 415 patient registries and post-approval programs with expertise across approximately 100 countries and numerous therapeutic areas. We provide real-world and late phase research to monitor safety and evaluate benefit-risk, demonstrate effectiveness, gain market access and expand labeling and approved indications. Services offered include observational studies, product and disease registries, safety and surveillance, risk management and risk evaluation and mitigation strategies, comparative and cost effectiveness, expanded labeling, health economics and outcomes, patient-reported outcomes, quality of life, medical record review, and electronic medical record and EHR studies.

Communication and Health Engagement Services

Digital Patient Services. Our digital patient services are designed to find and mobilize patients into clinical research, observational studies and disease management programs, retain patients through engagement strategies, and generate evidence such as patient reported outcomes, laboratory data and device diagnostics directly from patients

Brand and Scientific Communications. Our communications group offers a range of pre-launch, launch and post-launch services, beginning in the early stages of product development and continuing until the product reaches peak penetration. Services include communications strategies and planning, product positioning and branding, opinion leader development, faculty training, symposia, promotional programs, sponsored publications, new media-based programs, patient education and clinical experience programs (either standalone or supporting their health management services). As early as Phase I and Phase II clinical trials, we can begin to develop and disseminate scientific information, and develop and present educational forums to help gain opinion leader support for a new drug.

Other Healthcare Solutions

We utilize our global integrated health service platform, together with our scientific and clinical expertise, to offer a range of specialized services to organizations and users across the care continuum, including governments, hospitals, physician offices and pharmacies. These services include comparative and cost-effectiveness research capabilities, clinical management analytics, decision support services, medication adherence and health outcome optimization services, and web-based systems for measuring quality improvement. Our July 2014 acquisition of Encore Health Resources, or Encore, enhanced our EHR expertise, which is becoming increasingly important as biopharmaceutical customers, payers, and providers focus on measuring outcomes based on real-world performance in terms of clinical effectiveness and value.

Our Customers and Marketing

We take a holistic customer-oriented view toward business development. Our integrated business development group is responsible for assessing our customers’ current and future needs and helping to define the right service offerings to be delivered at the right time. We conduct business development efforts across our service offerings and within many individual service offerings, and in order to foster accountability in key service offering areas, each offering area has a designated leader who drives the financial contribution for that offering area. This management structure directs the selling and business development personnel in each of our major locations in the United States and throughout Europe, Asia, Japan, Canada and Latin America, providing coverage to both multinational and regional/domestic biopharmaceutical companies. We maintain dedicated customer teams that deliver customized solutions from the full breadth and depth of our service offerings for the world’s leading biopharmaceutical companies, and continue to evolve our relationships with our mid-size, small, and other biopharmaceutical customers outside the 20 largest biopharmaceutical companies based on 2014 reported revenues.

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In 2015, we earned service revenues of over $100 million each in six countries in North America, Europe and Asia. Please refer to Note 19 to our audited consolidated financial statements included elsewhere in this Annual Report on Form 10-K for further details regarding our foreign and domestic operations in 2015, 2014 and 2013. For a discussion of risks attendant to our foreign operations, see “Risk Factors—Our business is subject to international economic, political and other risks that could negatively affect our results of operations and financial condition.”

Our service revenues were attributed to our segments as follows:

	Year Ended December 31,
	2015			2014			2013
Product Development		73.8	%		74.4	%		76.7	%
Integrated Healthcare Services		26.2			25.6			23.3
Total		100.0	%		100.0	%		100.0	%

Additional information regarding our segments is presented in Note 20 to our audited consolidated financial statements included elsewhere in this Annual Report on Form 10-K.

No single customer accounted for 10% or more of our consolidated service revenues in 2015, 2014 or 2013. In the past, we have derived, and may in the future derive, a significant portion of our service revenues from a relatively limited number of major projects or customers. As biopharmaceutical companies continue to outsource large projects and/or functions to fewer providers, this concentration of business could increase.

Our Competition

The market for our product development services is highly competitive, and we compete against traditional CROs, the in-house research and development departments of biopharmaceutical companies, universities and teaching hospitals. Among the traditional CROs, there are several-hundred small, limited-service providers, several medium-sized firms and only a few full-service companies with global capabilities. Consolidation among CROs likely will result in greater competition among the larger CROs for customers, clinical personnel and acquisition candidates. Product Development’s primary competitors include Pharmaceutical Product Development, Inc., PAREXEL International Corporation, ICON plc, inVentiv Health, Inc., or inVentiv, INC Research, PRA International, and Covance Inc., the drug development business of Laboratory Corporation of America Holdings, or LabCorp, among others. Competitive factors for product development services include:

· previous experience and relationships;

· medical and scientific experience in specific therapeutic areas;

· the quality of contract research;

· speed to completion;

· the ability to organize and manage large scale clinical trials on a global basis;

· the ability to manage large and complex medical databases;

· the ability to provide statistical, regulatory and consulting services;

· the ability to recruit investigators and patients expeditiously;

· the ability to deploy and integrate IT systems to improve the efficiency of contract research;

· risk and reward sharing;

· the ability to form strategic alliances;

· a global presence with strategically located facilities and breadth of service offerings;

· financial strength and stability; and

· price.

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Integrated Healthcare Services competes in the post-approval and commercialization arenas. In the post-approval arena our solutions compete against real-world and late phase research providers including boutique firms, divisions of biopharmaceutical companies and divisions of traditional CRO’s (noted above). Our commercial solutions compete against the in-house sales and marketing departments of biopharmaceutical companies, other contract pharmaceutical sales and service organizations and consulting firms. Integrated Healthcare Services’ primary commercial competitors in the United States include inVentiv, PDI, Inc., which sold its commercial services business to Publicis Healthcare Communications Groupduring the fourth quarter of 2015, and Publicis Selling Solutions. Outside of the United States, Integrated Healthcare Services commercial teams typically compete against single country or more regionally focused commercial service providers, such as United Drug plc, inVentiv, EPS Corporation and CMIC HOLDINGS Co., Ltd in Japan. The primary competitive factors affecting Integrated Healthcare Services are breadth of service offering and ability to deploy in an integrated manner, quality and track record, i.e. the proven ability to quickly assemble, train and manage large qualified commercial teams on a global footprint and price.

Notwithstanding these competitive factors, we believe that the synergies arising from integrating product development services with commercial services, supported by therapeutic and scientific expertise, global operations, data analysis and the ability to form long term strategic alliances with biopharmaceutical companies, differentiate us from our competitors.

Government Regulation

Many aspects of our businesses are regulated by federal and state laws, rules and regulations. Accordingly, we maintain a comprehensive compliance program and we believe we operate our business in substantial compliance with all existing legal requirements material to the operation of our businesses. There are, however, significant uncertainties involving the application of various legal requirements, the violation of which could result in, among other things, sanctions. See “Part I — Item 1A — Risk Factors” for additional detail.

Good Clinical Practice

GCP regulations and guidelines contain the industry standards for the conduct of clinical trials with respect to the integrity of the data and safety of the research subjects. The FDA, the European Medicines Agency, or EMA, Japan’s Ministry of Health, Labour and Welfare and many other regulatory authorities require that study results and data submitted to such authorities be based on clinical trials conducted in accordance with GCP provisions. Records for clinical trials must be maintained for specified periods for inspection by the FDA and other regulators. Significant non-compliance with GCP requirements can result in the disqualification by regulators of data collected during the clinical trial.

Our standard operating procedures related to clinical trials are written in accordance with regulations and guidelines appropriate to the region where they are used, thus helping to ensure compliance with GCP. FDA regulations and guidelines serve as a basis for our North American standard operating procedures. Within Europe, we perform our work subject to the EMA’s Note for Guidance “Good Clinical Practice for Trials on Medicinal Products in the European Community.” All clinical trials (other than those defined as non-interventional) to be submitted to the EMA must meet the requirements of the ICH’s GCP standards. Our offices in Asia and in Latin America have developed standard operating procedures in accordance with their local requirements and in harmony with our North American and European operations.

Regulation of Drugs, Biologics and Medical Devices

In the United States, pharmaceutical, biological and medical device products are subject to extensive regulation by the FDA. The Federal Food, Drug, and Cosmetic Act, or the FDC Act, the Public Health Service Act, or the PHS Act, and other federal and state statutes and regulations, govern, among other things, the research, development, testing, manufacture, storage, recordkeeping, approval, labeling, promotion and marketing, distribution, post-approval monitoring and reporting, sampling, and import and export of pharmaceutical, biological and medical device products. Failure to comply with applicable United States requirements may subject a company to a variety of administrative or judicial sanctions, such as FDA refusal to approve a pending NDA for a new drug, a BLA for a new biological product, or PMA or clearance for a new medical device, warning or untitled letters, product recalls, product seizures, total or partial suspension of production or distribution, injunctions, fines, civil penalties, and criminal prosecution.

Before a new drug or biologic may be marketed, it must undergo extensive testing and regulatory review to determine that it is safe and effective and be approved by the FDA or other regulatory authority. Even after approval, a new PMA or PMA supplement may be required in the event of a modification to the device, its labeling or its manufacturing process.

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Regulation of Patient Information

Our information management services relate to the diagnosis and treatment of disease and are, therefore, subject to substantial governmental regulation. In addition, the confidentiality of patient-specific information and the circumstances under which such patient-specific records may be released for inclusion in our databases or used in other aspects of our business is heavily regulated. Federal, state and foreign governments are contemplating or have proposed or adopted additional legislation governing the possession, use and dissemination of personal data, such as personal health information and personal financial data, as well as security breach notification rules for loss or theft of such data. Additional legislation or regulation of this type might, among other things, require us to implement new security measures and processes or bring within the legislation or regulation de-identified health or other personal data, each of which may require substantial expenditures or limit our ability to offer some of our services.

In particular, personal health-related information is recognized in many countries such as the United States, the European Union, or EU, and several countries in Asia, as a special, sensitive category of personal information, subject to additional mandatory protections. Violations of data protection regulations are subject to administrative penalties, civil money penalties and criminal prosecution, including corporate fines and personal liability.

In order to comply with these evolving laws and regulations, we may need to implement new data protection, privacy and data security measures, which may require us to make substantial expenditures or cause us to discontinue or limit the products and services we offer. In addition, if we violate applicable laws, regulations, contractual commitments or other duties relating to the use, privacy or security of health information, we could be subject to regulatory sanctions, civil liability or criminal prosecution or suffer reputational harm, and it may be necessary to modify our business practices.

Regulation of Promotion, Marketing and Distribution of Pharmaceutical Products and Medical Devices

Our integrated healthcare services are subject to detailed and comprehensive regulation in each geographic market in which we operate. Such regulation relates, among other things, to the distribution of drug samples, the marketing and promotion of approved products, the qualifications of sales representatives and the use of healthcare professionals in sales functions.

In the United States, our integrated healthcare services are subject to numerous federal and state laws pertaining to promotional activities involving pharmaceutical products and medical devices, such as the FDA’s regulations against “off-label promotion,” which require sales representatives to restrict promotion of the approved product they are detailing to the approved labeling for the product, and the Prescription Drug Marketing Act which imposes licensing, personnel record keeping, packaging, labeling, product handling and facility storage and security requirements. Other federal and state laws prohibit manufacturers, suppliers and providers from offering, giving or receiving kickbacks or other remuneration in connection with ordering or recommending the purchase or rental of healthcare items and services. The sale or distribution of pharmaceutical products and devices is also governed by the United States Federal Trade Commission Act and state consumer protection laws. We are subject to similar regulations currently in effect in the other countries where we offer integrated healthcare services.

We are also subject to various laws and regulations that may apply to certain drug and device promotional practices, including, among others, various aspects of the Medicare program. Violations of these laws and regulations may result in criminal and/or civil penalties, including possibly as an “aider and abettor.”

Regulation of Laboratories

Our United States laboratories are subject to licensing and regulation under federal, state and local laws relating to hazard communication and employee right-to-know regulations, and the safety and health of laboratory employees. Additionally, our United States laboratories are subject to applicable federal and state laws and regulations and licensing requirements relating to the handling, storage and disposal of hazardous waste, radioactive materials and laboratory specimens, including the regulations of the Environmental Protection Agency, the Nuclear Regulatory Commission, the Department of Transportation, the National Fire Protection Agency and the United States Drug Enforcement Administration, or DEA. The use of controlled substances in testing for drugs with a potential for abuse is regulated in the United States by the DEA and by similar regulatory bodies in other parts of the world. Our United States laboratories using controlled substances for testing purposes are licensed by the DEA. The regulations of the United States Department of Transportation, Public Health Service and Postal Service apply to the surface and air transportation of laboratory specimens. Our laboratories also are subject to International Air Transport Association regulations, which govern international shipments of laboratory specimens. Furthermore, when the materials are sent to a foreign country, the transportation of such materials becomes subject to the laws, rules and regulations of such foreign country. Our laboratories outside the United States are subject to applicable national laws governing matters such as licensing, the handling and disposal of medical specimens, hazardous waste and radioactive materials, as well as the health and safety of laboratory employees.

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In addition to its comprehensive regulation of safety in the workplace, the United States Occupational Safety and Health Administration has established extensive requirements relating to workplace safety for healthcare employers whose workers may be exposed to blood-borne pathogens such as HIV and the hepatitis B virus. Although we believe that we are currently in compliance in all material respects with such federal, state and local laws, failure to comply with such laws could subject us to denial of the right to conduct business, fines, criminal penalties and other enforcement actions.

Further, laboratories that analyze human blood or other biological samples for the diagnosis and treatment of clinical trial subjects must comply with CLIA, as well as requirements established by various states. The failure to meet these requirements may result in civil penalties and suspension or revocation of the CLIA certification.

Our Intellectual Property

We develop and use a number of proprietary methodologies, analytics, systems, technologies and other intellectual property in the conduct of our business. We rely upon a combination of confidentiality policies, nondisclosure agreements, invention assignments and other contractual arrangements to protect our trade secrets, and patent, copyright and trademark laws to protect other intellectual property rights. We have also registered or applied for trademarks and service marks in the United States and a number of foreign countries, and our trademark “Quintiles^®” is of material importance to us. Although the duration of trademark and service mark registrations varies from country to country, trademarks and service marks generally may be renewed indefinitely so long as they are in use and/or their registrations are properly maintained, and so long as they have not been found to have become generic. Although we believe the ownership of our patents, trademarks and service marks is an important factor in our business and that our success does depend in part on the ownership thereof, we rely primarily on the innovative skills, technical competence and marketing abilities of our employees. Other than our Quintiles^® trademark, we do not have any material patents, trademarks, service marks, licenses, franchises or concessions.

Net New Business Reporting and Backlog

Net new business is the value of services awarded during the period from projects under signed contracts, letters of intent and, in some cases, pre-contract commitments, which are supported by written communications and adjusted for contracts that were modified or canceled during the period. Net new business under sole provider arrangements is recorded over the life of the arrangement as projects are awarded. Consistent with our methodology for calculating net new business during a particular period, backlog represents, at a particular point in time, future service revenues from work not yet completed or performed under signed contracts, letters of intent and, in some cases, pre-contract commitments that are supported by written communications. Once work begins on a project, service revenues are recognized over the duration of the project. Historically, net new business and backlog denominated in foreign currencies were valued each month throughout the year using foreign exchange rates that were in effect at the beginning of each fiscal year. Beginning with the first quarter of 2015, net new business and backlog denominated in foreign currencies are valued each month using the actual average foreign exchange rates in effect during the month. The application of this new approach to value foreign currency denominated net new business and backlog would not have had a significant impact to any prior period’s reported amounts; therefore historical amounts have not been restated to reflect this change in methodology. Included within backlog at December 31, 2015 is approximately $8,188 million of backlog that we do not expect to generate revenue in the next 12 months.

Backlog was as follows:

	December 31,
	2015		2014
	(in millions)
Backlog	$	12,038	$	11,244

Net new business was as follows:

	Year Ended December 31,
	2015		2014		2013
	(in millions)
Product Development	$	4,121	$	4,374	$	3,772
Integrated Healthcare Services		1,198		1,228		1,127
Total	$	5,319	$	5,602	$	4,899

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We believe that backlog and net new business may not be consistent indicators of future revenues because they have been and likely will be affected by a number of factors, including the variable size and duration of projects, many of which are performed over several years, cancellations, and changes to the scope of work during the course of projects. Projects that have been delayed remain in backlog, but the timing of the revenue generated may differ from the timing originally expected. Additionally, projects may be terminated or delayed by the customer or delayed by regulatory authorities. In the event that a customer cancels a contract, we typically would be entitled to receive payment for all services performed up to the cancellation date and subsequent customer-authorized services related to terminating the canceled project. However, we typically do not have a contractual right to the full amount of the revenue reflected in our backlog or net new business contracts in the event of cancellation. For more details regarding risks related to our backlog, see “Risk Factors—The relationship of backlog to revenues varies over time.”

Employees

As of December 31, 2015, we had approximately 36,100 full-time equivalent employees in approximately 60 countries, comprised approximately of 12,800 in the Americas region, 10,900 in the Europe and Africa region and 12,400 in the Asia-Pacific region, with at least 500 employees in more than 10 countries around the world. As of December 31, 2015, Product Development and Integrated Healthcare Services had approximately 24,800 and 9,500 full-time equivalent employees, respectively. In addition, our centralized operations/corporate office had approximately 1,800 full-time equivalent employees.

The success of our business depends upon our ability to attract and retain qualified professional, scientific and technical staff. The level of competition among employers in the United States and overseas for skilled personnel, particularly those with Ph.D., M.D. or equivalent degrees or training, is high. We believe that our brand recognition and our multinational presence are an advantage in attracting qualified candidates. In addition, we believe that the wide range of clinical trials in which we participate allows us to offer broad experience to clinical researchers. None of our employees are covered by a collective bargaining agreement or are represented by a labor union. Employees in some of our non-United States locations are represented by works councils as required by local laws. We believe that our relations with our employees are good.

Available Information

Our website address is www.quintiles.com, and our investor relations website is located at http://investors.quintiles.com. Information on our website is not incorporated by reference herein. Copies of our annual reports on Form 10-K, quarterly reports on Form 10-Q, current reports on Form 8-K and our Proxy Statements for our annual meetings of shareholders, and any amendments to those reports, as well as Section 16 reports filed by our insiders, are available free of charge on our website as soon as reasonably practicable after we file the reports with, or furnish the reports to, the Securities and Exchange Commission, or the SEC. Our SEC filings are also available for reading and copying at the SEC’s Public Reference Room at 100 F Street, NE, Washington, D.C. 20549. Information on the operation of the Public Reference Room may be obtained by calling the SEC at 1-800-SEC-0330. In addition, the SEC maintains an Internet site (http://www.sec.gov) containing reports, proxy and information statements, and other information regarding issuers that file electronically with the SEC.

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Item 1A. Risk Factors

RISK FACTORS

We operate in a rapidly changing environment that involves a number of risks, some of which are beyond our control. You should consider carefully the risks and uncertainties described below together with the other information included in this Annual Report on Form 10-K, including our consolidated financial statements and related notes included elsewhere in this Annual Report on Form 10-K, in evaluating our company. The occurrence of any of the following risks may materially and adversely affect our business, financial condition, results of operations and future prospects.

Risks Relating to Our Business

The potential loss or delay of our large contracts or of multiple contracts could adversely affect our results.

Most of our customers can terminate our contracts upon 30 to 90 days notice. Our customers may delay, terminate or reduce the scope of our contracts for a variety of reasons beyond our control, including but not limited to:

· decisions to forego or terminate a particular clinical trial;

· lack of available financing, budgetary limits or changing priorities;

· actions by regulatory authorities;

· production problems resulting in shortages of the drug being tested;

· failure of products being tested to satisfy safety requirements or efficacy criteria;

· unexpected or undesired clinical results for products;

· insufficient patient enrollment in a clinical trial;

· insufficient investigator recruitment;

· shift of business to a competitor or internal resources;

· product withdrawal following market launch; or

· shut down of manufacturing facilities.

As a result, contract terminations, delays and alterations are a regular part of our business. In the event of termination, our contracts often provide for fees for winding down the project, but these fees may not be sufficient for us to maintain our margins, and termination may result in lower resource utilization rates. In addition, we may not realize the full benefits of our backlog of contractually committed services if our customers cancel, delay or reduce their commitments under our contracts with them, which may occur if, among other things, a customer decides to shift its business to a competitor or revoke our status as a preferred provider. Thus, the loss or delay of a large contract or the loss or delay of multiple contracts could adversely affect our service revenues and profitability. We believe the risk of loss or delay of multiple contracts potentially has greater effect where we are party to broader partnering arrangements with global biopharmaceutical companies.

Our financial results may be adversely affected if we underprice our contracts, overrun our cost estimates or fail to receive approval for or experience delays in documenting change orders.

Most of our contracts are either fee for service contracts or fixed-fee contracts. Our past financial results have been, and our future financial results may be, adversely impacted if we initially underprice our contracts or otherwise overrun our cost estimates and are unable to successfully negotiate a change order. Change orders typically occur when the scope of work we perform needs to be modified from that originally contemplated by our contract with the customer. Modifications can occur, for example, when there is a change in a key clinical trial assumption or parameter or a significant change in timing. Where we are not successful in converting out-of-scope work into change orders under our current contracts, we bear the cost of the additional work. Such underpricing, significant cost overruns or delay in documentation of change orders could have a material adverse effect on our business, results of operations, financial condition or cash flows.

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The relationship of backlog to revenues varies over time.

Backlog represents future service revenues from work not yet completed or performed under signed contracts, letters of intent and, in some cases, written pre-contract commitments. Once work begins on a project, revenue is recognized over the duration of the project. Projects may be terminated or delayed by the customer or delayed by regulatory authorities for reasons beyond our control. To the extent projects are delayed, the timing of our revenue could be affected. In the event that a customer cancels a contract, we typically would be entitled to receive payment for all services performed up to the cancellation date and subsequent customer-authorized services related to terminating the canceled project. Typically, however, we have no contractual right to the full amount of the revenue reflected in our backlog in the event of a contract cancellation. The duration of the projects included in our backlog, and the related revenue recognition, range from a few weeks to many years. Our backlog may not be indicative of our future revenues, and we may not realize all the anticipated future revenue reflected in our backlog. A number of factors may affect backlog, including:

· the size, complexity and duration of the projects;

· the cancellation or delay of projects; and

· change in the scope of work during the course of a project.

Our backlog at December 31, 2015 was $12,038 million compared to backlog of $11,244 million at December 31, 2014. Although an increase in backlog will generally result in an increase in revenues to be recognized over time (depending on the level of cancellations), an increase in backlog at a particular point in time does not necessarily correspond directly to an increase in revenues during a particular period. The extent to which contracts in backlog will result in revenue depends on many factors, including but not limited to delivery against projected schedules, the need for scope changes (change orders), contract cancellations and the nature, duration, size, complexity and phase of the contracts, each of which factors can vary significantly from time to time. Our $12,038 million of backlog at December 31, 2015 included approximately $8,188 million of backlog that we do not expect to generate revenue in 2016 as compared to our $11,244 million of backlog at December 31, 2014, which included approximately $7,593 million of backlog that we did not expect to generate revenue in 2015.

The rate at which our backlog converts to revenue may vary over time for a variety of reasons. The revenue recognition on larger, more global projects could be slower than on smaller, less global projects for a variety of reasons, including but not limited to an extended period of negotiation between the time the project is awarded to us and the actual execution of the contract, as well as an increased timeframe for obtaining the necessary regulatory approvals. Additionally, the increased complexity of clinical trials and the need to enroll precise patient populations could extend the length of clinical trials causing revenue to be recognized over a longer period of time. Further, delayed projects will remain in backlog, unless otherwise canceled by the customer, and will not generate revenue at the rate originally expected. Thus, the relationship of backlog to realized revenues may vary over time.

Our business depends on the continued effectiveness and availability of our information systems, including the information systems we use to provide our services to our customers, and failures of these systems may materially limit our operations.

Due to the global nature of our business and our reliance on information systems to provide our services, we intend to increase our use of web-enabled and other integrated information systems in delivering our services. We also provide access to similar information systems to certain of our customers in connection with the services we provide them. As the breadth and complexity of our information systems continue to grow, we will increasingly be exposed to the risks inherent in the development, integration and ongoing operation of evolving information systems, including:

· disruption, impairment or failure of data centers, telecommunications facilities or other key infrastructure platforms;

· security breaches of, cyber attacks on and other failures or malfunctions in our critical application systems or their associated hardware; and

· excessive costs, excessive delays or other deficiencies in systems development and deployment.

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The materialization of any of these risks may impede the processing of data, the delivery of databases and services, and the day-to-day management of our business and could result in the corruption, loss or unauthorized disclosure of proprietary, confidential or other data. While we have disaster recovery plans in place, they might not adequately protect us in the event of a system failure. Despite any precautions we take, damage from fire, floods, hurricanes, power loss, telecommunications failures, computer viruses, break-ins and similar events at our various computer facilities could result in interruptions in the flow of data to our servers and from our servers to our customers. Corruption or loss of data may result in the need to repeat a clinical trial at no cost to the customer, but at significant cost to us, the termination of a contract or damage to our reputation. Additionally, significant delays in system enhancements or inadequate performance of new or upgraded systems once completed could damage our reputation and harm our business. Finally, long-term disruptions in the infrastructure caused by events such as natural disasters, the outbreak of war, the escalation of hostilities and acts of terrorism, particularly involving cities in which we have offices, could adversely affect our businesses. Although we carry property and business interruption insurance, our coverage might not be adequate to compensate us for all losses that may occur.

Unauthorized disclosure of sensitive or confidential data, whether through systems failure or employee negligence, fraud or misappropriation, could damage our reputation and cause us to lose customers. Similarly, we have been and expect that we will continue to be subject to attempts to gain unauthorized access to or through our information systems or those we develop for our customers, whether by our employees or third parties, including a cyber attack by computer programmers and hackers who may develop and deploy viruses, worms or other malicious software programs. To date these attacks have not had a material impact on our operations or financial results. Nonetheless, successful attacks in the future could result in negative publicity, significant remediation costs, legal liability and damage to our reputation and could have a material adverse effect on our results of operations. In addition, our liability insurance might not be sufficient in type or amount to cover us against claims related to security breaches, cyber attacks and other related breaches.

We may be adversely affected by customer or therapeutic concentration.

Although we did not have any customer that represented 10% or more of our service revenues in 2015, 2014, or 2013, we derive the majority of our revenues from a number of large customers. If any large customer decreases or terminates its relationship with us, our business, results of operations or financial condition could be materially adversely affected.

Additionally, conducting multiple clinical trials for different customers in a single therapeutic class involving drugs with the same or similar chemical action has in the past and may in the future adversely affect our business if some or all of the clinical trials are canceled because of new scientific information or regulatory judgments that affect the drugs as a class or if industry consolidation results in the rationalization of drug development pipelines. Similarly, marketing and selling drugs for different biopharmaceutical companies with similar chemical actions subjects us to risk if new scientific information or regulatory judgment prejudices the drugs as a class, which may lead to compelled or voluntary prescription limitations or withdrawal of some or all of such drugs from the market.

Our business is subject to international economic, political and other risks that could negatively affect our results of operations and financial condition.

We have significant operations in foreign countries that may require complex arrangements to deliver services on global contracts for our customers. Additionally, we have established operations in locations remote from our most developed business centers. As a result, we are subject to heightened risks inherent in conducting business internationally, including the following:

· conducting a single clinical trial across multiple countries is complex, and issues in one country, such as a failure to comply with local regulations or restrictions, may affect the progress of the clinical trial in the other countries, for example, by limiting the amount of data necessary for a clinical trial to proceed, resulting in delays or potential cancellation of contracts, which in turn may result in loss of revenue;

· the United States or foreign countries could enact legislation or impose regulations or other restrictions, including unfavorable labor regulations, tax policies or economic sanctions, which could have an adverse effect on our ability to conduct business in or expatriate profits from the countries in which we operate;

· foreign countries are expanding or may expand their regulatory framework with respect to patient informed consent, protection and compensation in clinical trials, which could delay or inhibit our ability to conduct clinical trials in such jurisdictions;

· the regulatory or judicial authorities of foreign countries may not enforce legal rights and recognize business procedures in a manner in which we are accustomed or would reasonably expect;

· changes in political and economic conditions may lead to changes in the business environment in which we operate, as well as changes in foreign currency exchange rates;

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· potential violations of local laws or anti-bribery laws, such as the United States Foreign Corrupt Practices Act, or the FCPA, and the UK Bribery Act, may cause difficulty in staffing and managing foreign operations, as well as significant consequences to us if those laws are violated;

· customers in foreign jurisdictions may have longer payment cycles, and it may be more difficult to collect receivables in foreign jurisdictions; and

· natural disasters, pandemics or international conflict, including terrorist acts, could interrupt our services, endanger our personnel or cause project delays or loss of clinical trial materials or results.

These risks and uncertainties could negatively impact our ability to, among other things, perform large, global projects for our customers. Furthermore, our ability to deal with these issues could be affected by applicable United States laws and the need to protect our assets. Any such risks could have an adverse impact on our financial condition and results of operations.

Due to the global nature of our business, we may be exposed to liabilities under the United States Foreign Corrupt Practices Act and various non-United States anti-corruption laws, and any allegation or determination that we violated these laws could have a material adverse effect on our business.

We are required to comply with the FCPA and other United States and non-United States anti-corruption laws, which prohibit companies from engaging in bribery including corruptly or improperly offering, promising, or providing money or anything else of value to non-United States officials and certain other recipients. In addition, the FCPA imposes certain books, records, and accounting control obligations on public companies and other issuers. We operate in parts of the world in which corruption can be common and compliance with anti-bribery laws may conflict with local customs and practices. Our global operations face the risk of unauthorized payments or offers being made by employees, consultants, sales agents, and other business partners outside of our control or without our authorization. It is our policy to implement safeguards to prohibit these practices by our employees and business partners with respect to our operations. However, irrespective of these safeguards, or as a result of monitoring compliance with such safeguards, it is possible that we or certain other parties may discover or receive information at some point that certain employees, consultants, sales agents, or other business partners may have engaged in corrupt conduct for which we might be held responsible. Violations of the FCPA or other non-United States anti-corruption laws may result in restatements of, or irregularities in, our financial statements as well as severe criminal or civil sanctions, and we may be subject to other liabilities, which could negatively affect our business, operating results and financial condition. In some cases, companies that violate the FCPA may be debarred by the United States government and/or lose their United States export privileges. Changes in anti-corruption laws or enforcement priorities could also result in increased compliance requirements and related costs which could adversely affect our business, financial condition and results of operations. In addition, the United States or other governments may seek to hold us liable for successor liability FCPA violations or violations of other anti-corruption laws committed by companies in which we invest or that we acquired or will acquire.

If we are unable to successfully develop and market new services or enter new markets, our growth, results of operations or financial condition could be adversely affected.

A key element of our growth strategy is the successful development and marketing of new services or entering new markets that complement or expand our existing business. As we develop new services or enter new markets, including services targeted at participants in the broader healthcare industry, we may not have or adequately build the competencies necessary to perform such services satisfactorily, may not receive market acceptance for such services or may face increased competition. If we are unable to succeed in developing new services, entering new markets or attracting a customer base for our new services or in new markets, we will be unable to implement this element of our growth strategy, and our future business, reputation, results of operations and financial condition could be adversely affected.

Upgrading the information systems that support our operating processes and evolving the technology platform for our services pose risks to our business.

Continued efficient operation of our business requires that we implement standardized global business processes and evolve our information systems to enable this implementation. We have continued to undertake significant programs to optimize business processes with respect to our services. Our inability to effectively manage the implementation and adapt to new processes designed into these new or upgraded systems in a timely and cost-effective manner may result in disruption to our business and negatively affect our operations.

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We have entered into agreements with certain vendors to provide systems development and integration services that develop or license to us the IT platform for programs to optimize our business processes. If such vendors fail to perform as required or if there are substantial delays in developing, implementing and updating the IT platform, our customer delivery may be impaired, and we may have to make substantial further investments, internally or with third parties, to achieve our objectives. Additionally, our progress may be limited by parties with existing or claimed patents who seek to enjoin us from using preferred technology or seek license payments from us.

Meeting our objectives is dependent on a number of factors which may not take place as we anticipate, including obtaining adequate technology-enabled services, creating IT-enabled services that our customers will find desirable and implementing our business model with respect to these services. Also, increased IT-related expenditures may negatively impact our profitability.

If we fail to perform our services in accordance with contractual requirements, regulatory standards and ethical considerations, we could be subject to significant costs or liability and our reputation could be harmed.

We contract with biopharmaceutical companies to perform a wide range of services to assist them in bringing new drugs to market. Our services include monitoring clinical trials, data and laboratory analysis, EDC, patient recruitment and other related services. Such services are complex and subject to contractual requirements, regulatory standards and ethical considerations. For example, we must adhere to regulatory requirements such as the FDA and current GCP, GLP and GMP requirements. If we fail to perform our services in accordance with these requirements, regulatory agencies may take action against us for failure to comply with applicable regulations governing clinical trials or sales and marketing practices. Such actions may include sanctions, such as injunctions or failure of such regulatory authorities to grant marketing approval of products, delay, suspension or withdrawal of approvals, license revocation, product seizures or recalls, operational restrictions, civil or criminal penalties or prosecutions, damages or fines. Customers may also bring claims against us for breach of our contractual obligations and patients in the clinical trials and patients taking drugs approved on the basis of those clinical trials may bring personal injury claims against us for negligence. Any such action could have a material adverse effect on our results of operations, financial condition and reputation.

Such consequences could arise if, among other things, the following occur:

Improper performance of our services. The performance of clinical development services is complex and time-consuming. For example, we may make mistakes in conducting a clinical trial that could negatively impact or obviate the usefulness of the clinical trial or cause the results of the clinical trial to be reported improperly. If the clinical trial results are compromised, we could be subject to significant costs or liability, which could have an adverse impact on our ability to perform our services. As examples:

· non-compliance generally could result in the termination of ongoing clinical trials or sales and marketing projects or the disqualification of data for submission to regulatory authorities;

· compromise of data from a particular clinical trial, such as failure to verify that informed consent was obtained from patients, could require us to repeat the clinical trial under the terms of our contract at no further cost to our customer, but at a substantial cost to us; and

· breach of a contractual term could result in liability for damages or termination of the contract.

Large clinical trials can cost hundreds of millions of dollars, and while we endeavor to contractually limit our exposure to such risks, improper performance of our services could have an adverse effect on our financial condition, damage our reputation and result in the cancellation of current contracts by or failure to obtain future contracts from the affected customer or other customers.

Investigation of customers. From time to time, one or more of our customers are audited or investigated by regulatory authorities or enforcement agencies with respect to regulatory compliance of their clinical trials, programs or the marketing and sale of their drugs. In these situations, we have often provided services to our customers with respect to the clinical trials, programs or activities being audited or investigated, and we are called upon to respond to requests for information by the authorities and agencies. There is a risk that either our customers or regulatory authorities could claim that we performed our services improperly or that we are responsible for clinical trial or program compliance. If our customers or regulatory authorities make such claims against us and prove them, we could be subject to damages, fines or penalties. In addition, negative publicity regarding regulatory compliance of our customers’ clinical trials, programs or drugs could have an adverse effect on our business and reputation.

Insufficient customer funding to complete a clinical trial. As noted above, clinical trials can cost hundreds of millions of dollars. There is a risk that we may initiate a clinical trial for a customer, and then the customer becomes unwilling or unable to fund the completion of the clinical trial. In such a situation, notwithstanding the customer’s ability or willingness to pay for or otherwise facilitate the completion of the clinical trial, we may be ethically bound to complete or wind down the clinical trial at our own expense.

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Our research and development services could subject us to potential liability that may adversely affect our results of operations and financial condition.

Our business involves the testing of new drugs on patients in clinical trials and, if marketing approval is granted, the availability of these drugs to be prescribed to patients. Our involvement in the clinical trials and development process creates a risk of liability for personal injury to or death of patients, particularly those with life-threatening illnesses, resulting from adverse reactions to the drugs administered during testing or after product launch, respectively. For example, we have from time to time been sued and may be sued in the future by individuals alleging personal injury due to their participation in clinical trials and seeking damages from us under a variety of legal theories. Although we maintain the types and amounts of insurance we view as customary in the industries and countries in which we operate, if we are required to pay damages or incur defense costs in connection with any personal injury claim that is outside the scope of indemnification agreements we have with our customers, if any indemnification agreement is not performed in accordance with its terms or if our liability exceeds the amount of any applicable indemnification limits or available insurance coverage, our financial condition, results of operations and reputation could be materially and adversely affected. Currently, we maintain professional liability insurance, including products liability for completed operations coverage, with annual aggregate limits in excess of $50.0 million. In the future, we may not be able to get adequate insurance for these types of risks at reasonable rates.

We also contract with physicians to serve as investigators in conducting clinical trials. If the investigators commit errors or make omissions during a clinical trial that result in harm to clinical trial patients or after a clinical trial to a patient using the drug after it has received regulatory approval, claims for personal injury or products liability damages may result. Additionally, if the investigators engage in fraudulent behavior, clinical trial data may be compromised, which may require us to repeat the clinical trial or subject us to liability. We do not believe we are legally responsible for the medical care rendered by such third-party investigators, and we would vigorously defend any claims brought against us. However, it is possible we could be found liable for claims with respect to the actions of third-party investigators.

Some of our services involve direct interaction with clinical trial subjects or volunteers and operation of Phase I clinical facilities, which could create potential liability that may adversely affect our results of operations and financial condition.

We operate facilities where Phase I clinical trials are conducted, which ordinarily involve testing an investigational drug on a limited number of healthy individuals, typically 20 to 80 persons, to determine such drug’s basic safety. Failure to operate such a facility in accordance with applicable regulations could result in that facility being shut down, which could disrupt our operations. Additionally, we face risks associated with adverse events resulting from the administration of such drugs to healthy volunteers and the professional malpractice of medical care providers. Occasionally, physicians employed at our Phase I clinical facilities act as principal investigators in later-phase clinical trials at those same facilities. We also directly employ nurses and other trained employees who assist in implementing the testing involved in our clinical trials, such as drawing blood from healthy volunteers. Any professional malpractice or negligence by such investigators, nurses or other employees could potentially result in liability to us in the event of personal injury to or death of a healthy volunteer in clinical trials. This liability, particularly if it were to exceed the limits of any indemnification agreements and insurance coverage we may have, may adversely affect our financial condition, results of operations and reputation.

Our commercial services could result in liability to us if a drug causes harm to a patient. While we are generally indemnified and insured against such risks, we may still suffer financial losses.

When we market drugs under contract for a biopharmaceutical company, we could suffer liability for harm allegedly caused by those drugs, either as a result of a lawsuit against the biopharmaceutical company to which we are joined, a lawsuit naming us or any of our subsidiaries or an action launched by a regulatory body. While we are generally indemnified by the biopharmaceutical company for the action of the drugs we market on its behalf, and we carry insurance to cover harm caused by our negligence in performing services, it is possible that we could nonetheless incur financial losses, regulatory penalties or both. In particular, any claim could result in potential liability for us if the claim is outside the scope of the indemnification agreement we have with the biopharmaceutical company, the biopharmaceutical company does not abide by the indemnification agreement as required or the liability exceeds the amount of any applicable indemnification limits or available insurance coverage. Such a finding could have an adverse impact on our financial condition, results of operations and reputation. Furthermore, negative publicity associated with harm caused by drugs we helped to market could have an adverse effect on our business and reputation.

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Our insurance may not cover all of our indemnification obligations and other liabilities associated with our operations.

We maintain insurance designed to provide coverage for ordinary risks associated with our operations and our ordinary indemnification obligations with annual aggregate limits in excess of $50.0 million. The coverage provided by such insurance may not be adequate for all claims we may make or may be contested by our insurance carriers. If our insurance is not adequate or available to pay liabilities associated with our operations, or if we are unable to purchase adequate insurance at reasonable rates in the future, our profitability may be adversely impacted.

If we are unable to attract suitable investigators and patients for our clinical trials, our clinical development business might suffer.

The recruitment of investigators and patients for clinical trials is essential to our business. Investigators are typically located at hospitals, clinics or other sites and supervise the administration of the investigational drug to patients during the course of a clinical trial. Patients generally include people from the communities in which the clinical trials are conducted. Our clinical development business could be adversely affected if we are unable to attract suitable and willing investigators or patients for clinical trials on a consistent basis. For example, if we are unable to engage investigators to conduct clinical trials as planned or enroll sufficient patients in clinical trials, we might need to expend additional funds to obtain access to resources or else be compelled to delay or modify the clinical trial plans, which may result in additional costs to us.

If we lose the services of key personnel or are unable to recruit additional qualified personnel, our business could be adversely affected

Our success substantially depends on the collective performance, contributions and expertise of our personnel including senior management and key personnel, qualified professional, scientific and technical operating staff and qualified sales representatives for our contract sales services. There is significant and increasing competition for qualified personnel, particularly those with higher educational degrees, such as a medical degree, a Ph.D. or an equivalent degree, or relevant experience as a clinical research associate in the biopharmaceutical and biopharmaceutical services industries. Competition for qualified personnel in certain geographic regions, such as North America and Asia, is putting additional pressure on our business. In addition, the departure of our key employees, or our inability to continue to identify, attract and retain qualified personnel or replace any departed personnel in a timely fashion, may impact our ability to grow our business and compete effectively in our industry and may negatively affect our ability to meet financial and operational goals.

Exchange rate fluctuations may affect our results of operations and financial condition.

In 2015, approximately 32% of our service revenues were denominated in currencies other than the United States dollar. Because a large portion of our service revenues and expenses are denominated in currencies other than the United States dollar and our financial statements are reported in United States dollars, changes in foreign currency exchange rates could significantly affect our results of operations and financial condition. Exchange rate fluctuations between local currencies and the United States dollar create risk in several ways, including:

Foreign Currency Translation Risk. The revenue and expenses of our foreign operations are generally denominated in local currencies and translated into United States dollars for financial reporting purposes. Accordingly, exchange rate fluctuations will affect the translation of foreign results into United States dollars for purposes of reporting our consolidated results.

Foreign Currency Transaction Risk. We are subject to foreign currency transaction risk for fluctuations in exchange rates during the period of time between the consummation and cash settlement of a transaction. We earn revenue from our service contracts over a period of several months and, in some cases, over several years. Accordingly, exchange rate fluctuations during this period may affect our profitability with respect to such contracts.

We may limit these risks through exchange rate fluctuation provisions stated in our service contracts, or we may hedge our transaction risk with foreign currency exchange contracts or options. We have not, however, hedged 100% of our foreign currency transaction risk, and we may experience fluctuations in financial results from our operations outside the United States and foreign currency transaction risk associated with our service contracts.

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Disruptions in the credit and capital markets and unfavorable general economic conditions could negatively affect our business, results of operations and financial condition.

Disruptions in the credit and capital markets could have negative effects on our business that may be difficult to predict or anticipate, including the ability of our customers, vendors, contractors and financing sources to meet their contractual obligations. Although we are unable to quantify the impact it has had on us, we are aware of a limited number of instances during the past several years where cancellations, changes in scope and failure to pay timely were attributable, at least in part, to difficulty in our customers’ ability to obtain financing. In the future such actions by our customers could, if they involve a significant amount of business with us, have a material adverse effect on our results of operations.

Our effective income tax rate may fluctuate, which may adversely affect our operations, earnings and earnings per share.

Our effective income tax rate is influenced by our projected profitability in the various taxing jurisdictions in which we operate. Changes in the distribution of profits and losses among taxing jurisdictions may have a significant impact on our effective income tax rate, which in turn could have an adverse effect on our net income and earnings per share. Factors that may affect our effective income tax rate include, but are not limited to:

· the requirement to exclude from our quarterly worldwide effective income tax calculations losses in jurisdictions where no income tax benefit can be recognized;

· actual and projected full year pre-tax income;

· the repatriation of foreign earnings to the United States;

· changes in tax laws in various taxing jurisdictions;

· audits by taxing authorities; and

· the establishment of valuation allowances against deferred income tax assets if we determined that it is more likely than not that future income tax benefits will not be realized.

These changes may cause fluctuations in our effective income tax rate that could adversely affect our results of operations and cause fluctuations in our earnings and earnings per share.

We have only a limited ability to protect our intellectual property rights, and these rights are important to our success.

Our success depends, in part, upon our ability to develop, use and protect our proprietary methodologies, analytics, systems, technologies and other intellectual property. Existing laws of the various countries in which we provide services or solutions offer only limited protection of our intellectual property rights, and the protection in some countries may be very limited. We rely upon a combination of trade secrets, confidentiality policies, nondisclosure, invention assignment and other contractual arrangements, and patent, copyright and trademark laws, to protect our intellectual property rights. These laws are subject to change at any time and certain agreements may not be fully enforceable, which could further restrict our ability to protect our innovations. Our intellectual property rights may not prevent competitors from independently developing services similar to or duplicative of ours. Further, the steps we take in this regard might not be adequate to prevent or deter infringement or other misappropriation of our intellectual property by competitors, former employees or other third parties, and we might not be able to detect unauthorized use of, or take appropriate and timely steps to enforce, our intellectual property rights. Enforcing our rights might also require considerable time, money and oversight, and we may not be successful in enforcing our rights.

Depending on the circumstances, we might need to grant a specific customer greater rights in intellectual property developed in connection with a contract than we otherwise generally do. In certain situations, we might forego all rights to the use of intellectual property we create, which would limit our ability to reuse that intellectual property for other customers. Any limitation on our ability to provide a service or solution could cause us to lose revenue-generating opportunities and require us to incur additional expenses to develop or license new or modified solutions for future projects.

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Our relationships with existing or potential customers who are in competition with each other may adversely impact the degree to which other customers or potential customers use our services, which may adversely affect our results of operations.

The biopharmaceutical industry is highly competitive, with biopharmaceutical companies each seeking to persuade payers, providers and patients that their drug therapies are better and more cost-effective than competing therapies marketed or being developed by competing firms. In addition to the adverse competitive interests that biopharmaceutical companies have with each other, biopharmaceutical companies also have adverse interests with respect to drug selection and reimbursement with other participants in the healthcare industry, including payers and providers. Biopharmaceutical companies also compete to be first to market with new drug therapies. We regularly provide services to biopharmaceutical companies who compete with each other, and we sometimes provide services or funding to such customers regarding competing drugs in development. Our existing or future relationships with our biopharmaceutical customers may therefore deter other biopharmaceutical customers from using our services or may result in our customers seeking to place limits on our ability to serve other biopharmaceutical industry participants. In addition, our further expansion into the broader healthcare market may adversely impact our relationships with biopharmaceutical customers, and such customers may elect not to use our services, reduce the scope of services that we provide to them or seek to place restrictions on our ability to serve customers in the broader healthcare market with interests that are adverse to theirs. A loss of customers or reductions in the level of revenues from a customer could have a material adverse effect on our results of operations, business and prospects.

If we are unable to successfully identify, acquire and integrate existing businesses, services and technologies, our business, results of operations and financial condition could be adversely impacted.

We anticipate that a portion of our future growth may come from acquiring existing businesses, services or technologies. The success of any acquisition will depend upon, among other things, our ability to effectively integrate acquired personnel, operations, products and technologies into our business and to retain the key personnel and customers of our acquired businesses. In addition, we may be unable to identify suitable acquisition opportunities or obtain any necessary financing on commercially acceptable terms. We may also spend time and money investigating and negotiating with potential acquisition targets but not complete the transaction. Any future acquisition could involve other risks, including, among others, the assumption of additional liabilities and expenses, difficulties and expenses in connection with integrating the acquired companies and achieving the expected benefits, issuances of potentially dilutive securities or interest-bearing debt, loss of key employees of the acquired companies, transaction costs, diversion of management’s attention from other business concerns and, with respect to the acquisition of foreign companies, the inability to overcome differences in foreign business practices, language and customs. Our failure to identify potential acquisitions, complete targeted acquisitions and integrate completed acquisitions could have a material adverse effect on our business, financial condition and results of operations.

Investments in our customers’ businesses or drugs and our related commercial rights strategies could have a negative impact on our financial performance.

We may enter into arrangements with our customers or other drug companies in which we take on some of the risk of the potential success or failure of their businesses or drugs, including making strategic investments in our customers or other drug companies, providing financing to customers or other drug companies or acquiring an interest in the revenues from customers’ drugs or in entities developing a limited number of drugs. As of December 31, 2015, we had approximately $51.1 million of such arrangements, and we were also committed to invest an additional $32.7 million in private equity funds that seeks to enter into similar risk-based arrangements. Our financial results would be adversely affected if these investments or the underlying drugs result in losses or do not achieve the level of success that we anticipate and/or our return or payment from the drug investment or financing is less than our direct and indirect costs with respect to these arrangements.

Our results of operations may be adversely affected if we fail to realize the full value of our goodwill and intangible assets.

As of December 31, 2015, we had goodwill and net intangible assets of $1,087.8 million, which constituted approximately 27.7% of our total assets at the end of this period. We assess the realizability of our indefinite-lived intangible assets and goodwill annually and conduct an interim evaluation whenever events or changes in circumstances, such as operating losses or a significant decline in earnings associated with the acquired business or asset, indicate that these assets may be impaired. Our ability to realize the value of the goodwill and indefinite-lived intangible assets will depend on the future cash flows of the businesses we have acquired, which in turn depend in part on how well we have integrated these businesses into our own business. If we are not able to realize the value of the goodwill and indefinite-lived intangible assets, we may be required to incur material charges relating to the impairment of those assets. Such impairment charges could materially and adversely affect our operating results and financial condition.

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We face risks arising from the restructuring of our operations.

From time to time, we have adopted restructuring plans to improve our operating efficiency through various means such as reduction of overcapacity, elimination of non-billable support roles or other realignment of resources. For example, during 2015 and 2014 we recognized $30.8 million and $9.0 million, respectively, of restructuring charges, net of reversals for changes in estimates, related to restructuring plans. Restructuring presents significant potential risks of events occurring that could adversely affect us, including;

· actual or perceived disruption of service or reduction in service standards to customers;

· the failure to preserve supplier relationships and distribution, sales and other important relationships and to resolve conflicts that may arise;

· loss of sales as we reduce or eliminate staffing on non-core services;

· diversion of management attention from ongoing business activities; and

· the failure to maintain employee morale and retain key employees.

Because of these and other factors, we cannot predict whether we will realize the purpose and anticipated benefits of these measures and, if we do not, our business and results of operations may be adversely affected.

Additionally, there may be delays in implementing the restructuring activities or a failure to achieve the anticipated levels of cost savings and efficiency as a result of the restructuring activities, each of which could materially and adversely impact our business and results of operations. Further restructuring or reorganization activities may also be required in the future beyond what is currently planned, which could further enhance the risks associated with these activities.

We depend on third parties for critical support services.

We depend on third parties for support services vital to our business. Such support services include, but are not limited to, third-party transportation providers, suppliers of drugs for patients participating in clinical trials, suppliers of kits for use in our clinical trial laboratories business, suppliers of reagents for use in our testing equipment and providers of maintenance contracts for our equipment. The failure of any of these third parties to adequately provide the critical support services could have a material adverse effect on our business.

Risks Relating to Our Industry

The biopharmaceutical services industry is highly competitive.

The biopharmaceutical services industry is highly competitive. We often compete for business with other biopharmaceutical services companies, internal discovery departments, development departments, and sales and marketing departments within our customers, some of which could be considered large biopharmaceutical services companies in their own right with greater resources than ours. We also compete with universities and teaching hospitals. If we do not compete successfully, our business will suffer. The industry is highly fragmented, with numerous smaller specialized companies and a handful of full-service companies with global capabilities similar to ours. Increased competition has led to price and other forms of competition, such as acceptance of less favorable contract terms, that could adversely affect our operating results. There are few barriers to entry for smaller specialized companies considering entering the industry. Because of their size and focus, these companies might compete effectively against larger companies such as us, which could have a material adverse impact on our business.

Outsourcing trends in the biopharmaceutical industry and changes in aggregate spending and research and development budgets could adversely affect our operating results and growth rate.

Economic factors and industry trends that affect biopharmaceutical companies affect our business. Biopharmaceutical companies continue to seek long-term strategic collaborations with global CROs with favorable pricing terms. Competition for these collaborations is intense and we may decide to forego an opportunity or we may not be selected, in which case a competitor may enter into the collaboration and our business with the customer, if any, may be limited. In addition, if the biopharmaceutical industry reduces its outsourcing of clinical trials and sales and marketing projects or such outsourcing fails to grow at projected rates, our operations and financial condition could be materially and adversely affected. We may also be negatively impacted by consolidation and other factors in the biopharmaceutical industry, which may slow decision making by our customers or result in the delay or cancellation of clinical trials. Our commercial services may be affected by reductions in new drug launches and increases in the number of drugs losing patent protection. All of these events could adversely affect our business, results of operations or financial condition.

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We may be affected by healthcare reform and potential additional reforms.

The United States Congress continues to consider healthcare reform legislation and impose health industry cost containment measures, which may significantly impact the biopharmaceutical industry. In addition, numerous government bodies are considering or have adopted various healthcare reforms and may undertake, or are in the process of undertaking, efforts to control growing healthcare costs through legislation, regulation and voluntary agreements with medical care providers and biopharmaceutical companies. We are uncertain as to the effects of these recent reforms on our business and are unable to predict what legislative proposals, if any, will be adopted in the future. If regulatory cost containment efforts limit the profitability of new drugs, our customers may reduce their research and development spending or promotional, marketing and sales expenditures, which could reduce the business they outsource to us. Similarly, if regulatory requirements are relaxed or simplified drug approval procedures are adopted, the demand for our services could decrease.

Foreign and domestic government bodies may also adopt healthcare legislation or regulations that are more burdensome than existing regulations. For example, product safety concerns and recommendations by the Drug Safety Oversight Board could change the regulatory environment for drug products, and new or heightened regulatory and licensing requirements may increase our expenses or limit or delay our ability to offer some of our services. Additionally, new or heightened regulatory requirements may have a negative impact on the ability of our customers to conduct industry-sponsored clinical trials, which could reduce the need for our services.

Actions by government regulators or customers to limit a prescription’s scope or withdraw an approved drug from the market could adversely affect our business and result in a loss of revenues.

Government regulators have the authority, after approving a drug, to limit its scope of prescription or withdraw it from the market completely based on safety concerns. Similarly, customers may act to voluntarily limit the scope of prescription of drugs or withdraw them from the market. In the past, we have provided services with respect to drugs that have been limited and/or withdrawn. If we are providing services to customers for drugs that are limited or withdrawn, we may be required to narrow the scope of or terminate our services with respect to such drugs, which would prevent us from earning the full amount of service revenues anticipated under the related service contracts with negative impacts to our financial results.

Current and proposed laws and regulations regarding the protection of personal data could result in increased risks of liability or increased cost to us or could limit our service offerings.

The confidentiality, collection, use and disclosure of personal data, including clinical trial patient-specific information, are subject to governmental regulation generally in the country that the personal data were collected or used. For example, United States federal regulations under the Health Insurance Portability and Accountability Act of 1996, or HIPAA, and as amended in 2014 by the Health Information Technology for Economic and Clinical Health (“HITECH”) Act, require individuals’ written authorization, in addition to any required informed consent, before Protected Health Information may be used for research. Such regulations specify standards for deidentifications and for limited data sets. We are both directly and indirectly affected by the privacy provisions surrounding individual authorizations because many investigators with whom we are involved in clinical trials are directly subject to them as a HIPAA “covered entity” and because we obtain identifiable health information from third parties that are subject to such regulations. As there are some instances where we are a HIPAA “business associate” of a “covered entity,” we can also be directly liable for mishandling protected health information. Under HIPAA’s enforcement scheme, we can be subject to up to $1.5 million in annual civil penalties for each HIPAA violation.

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In the EU personal data includes any information that relates to an identified or identifiable natural person with health information carrying additional obligations, including obtaining the explicit consent from the individual for collection, use or disclosure of the information. In addition, we are subject to EU rules with respect to cross-border transfers of such data out of the EU. The United States, the EU and its member states, and other countries where we have operations, such as Japan, South Korea, Malaysia, the Philippines, Russia and Singapore, continue to issue new privacy and data protection rules and regulations that relate to personal data and health information. Failure to comply with certain certification/registration and annual re-certification/registration provisions associated with these data protection and privacy regulations and rules in various jurisdictions, or to resolve any serious privacy complaints, could subject us to regulatory sanctions, criminal prosecution or civil liability. Federal, state and foreign governments are contemplating or have proposed or adopted additional legislation governing the collection, possession, use or dissemination of personal data, such as personal health information, and personal financial data as well as security breach notification rules for loss or theft of such data. Additional legislation or regulation of this type might, among other things, require us to implement new security measures and processes or bring within the legislation or regulation de-identified health or other personal data, each of which may require substantial expenditures or limit our ability to offer some of our services. Additionally, if we violate applicable laws, regulations or duties relating to the use, privacy or security of personal data, we could be subject to civil liability or criminal prosecution, be forced to alter our business practices and suffer reputational harm. In the next few years, the European data protection framework may be revised as a generally applicable data regulation. The text has not yet been finalized, but it contains new provisions specifically directed at the processing of health information, sanctions of up to 4% of worldwide gross revenue and extra-territoriality measures intended to bring non-EU companies under the proposed regulation.

If we do not keep pace with rapid technological changes, our services may become less competitive or obsolete.

The biopharmaceutical industry generally, and drug development and clinical research more specifically, are subject to rapid technological changes. Our current competitors or other businesses might develop technologies or services that are more effective or commercially attractive than, or render obsolete, our current or future technologies and services. If our competitors introduce superior technologies or services and if we cannot make enhancements to remain competitive, our competitive position would be harmed. If we are unable to compete successfully, we may lose customers or be unable to attract new customers, which could lead to a decrease in our revenue and financial condition.

The biopharmaceutical industry has a history of patent and other intellectual property litigation, and we might be involved in costly intellectual property lawsuits.

The biopharmaceutical industry has a history of intellectual property litigation, and these lawsuits will likely continue in the future. Accordingly, we may face patent infringement suits by companies that have patents for similar business processes or other suits alleging infringement of their intellectual property rights. Legal proceedings relating to intellectual property could be expensive, take significant time and divert management’s attention from other business concerns, regardless of the outcome of the litigation. If we do not prevail in an infringement lawsuit brought against us, we might have to pay substantial damages, and we could be required to stop the infringing activity or obtain a license to use technology on unfavorable terms.

Our customers face intense competition from lower cost generic products, which may lower the amount that they spend on our services.

Our customers face increasing competition from lower cost generic products, which in turn may affect their ability to pursue research and development activities with us. In the United States, EU and Japan, political pressure to reduce spending on prescription drugs has led to legislation and other measures which encourages the use of generic products. In addition, proposals emerge from time to time in the United States and other countries for legislation to further encourage the early and rapid approval of generic drugs. Loss of patent protection for a product typically is followed promptly by generic substitutes, reducing our customers’ sales of that product and their overall profitability. Availability of generic substitutes for our customers’ drugs may adversely affect their results of operations and cash flow, which in turn may mean that they would not have surplus capital to invest in research and development and drug commercialization, including in our services. If competition from generic products impacts our customers’ finances such that they decide to curtail our services, our revenues may decline and this could have a material adverse effect on our business.

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Risks Relating to Our Indebtedness

Our substantial debt could adversely affect our financial condition.

As of December 31, 2015, we had $2.5 billion of total indebtedness, excluding $534.0 million of additional available borrowings under our revolving credit facilities. Our substantial indebtedness could adversely affect our financial condition and thus make it more difficult for us to satisfy our obligations with respect to our indebtedness. If our cash flow is not sufficient to service our debt and adequately fund our business, we may be required to seek further additional financing or refinancing or dispose of assets. We may not be able to implement any of these alternatives on satisfactory terms or at all. Our substantial indebtedness could also:

· increase our vulnerability to adverse general economic and industry conditions;

· require us to dedicate a substantial portion of our cash flows from operations to payments on our indebtedness, thereby reducing the availability of our cash flows to fund working capital, investments, acquisitions, capital expenditures, research and development efforts and other general corporate purposes;

· limit our ability to make required payments under our existing contractual commitments, including our existing long-term indebtedness;

· limit our flexibility in planning for, or reacting to, changes in our business and the industry in which we operate;

· place us at a competitive disadvantage compared to our competitors that have less debt;

· cause us to incur substantial fees from time to time in connection with debt amendments or refinancings;

· increase our exposure to rising interest rates because a portion of our borrowings is at variable interest rates; and

· limit our ability to borrow additional funds or to borrow on terms that are satisfactory to us.

Despite our level of indebtedness, we are able to incur more debt and undertake additional obligations. Incurring such debt or undertaking such additional obligations could further exacerbate the risks to our financial condition.

Although our credit agreement, which governs the senior credit facilities of our wholly owned subsidiary through which we conduct our operations, Quintiles Transnational Corp., or Quintiles Transnational, contains restrictions on the incurrence of additional indebtedness, these restrictions are subject to a number of qualifications and exceptions and the indebtedness incurred in compliance with these restrictions could increase. In addition, the receivables financing agreement for our special purpose subsidiary, Quintiles Funding, LLC, or Quintiles Funding, limits borrowing based on the amount of receivables purchased by Quintiles Funding from certain of our other subsidiaries, but when supported by the value of such purchased receivables, the debt under our receivables financing facility can increase. As of December 31, 2015, we had $534.0 million of additional available borrowings under our revolving credit facilities.

While the credit agreement also contains restrictions on our and our restricted subsidiaries’ ability to make loans and investments, these restrictions are subject to a number of qualifications and exceptions, and the investments incurred in compliance with these restrictions could be substantial.

If we do not comply with the covenants governing our credit facilities and senior notes, we may not have the funds necessary to pay all of our indebtedness that could become due.

The credit agreement governing our senior secured credit facilities requires us to comply with certain covenants. In particular, our credit agreement prohibits us from incurring any additional indebtedness, except in specified circumstances, or amending the terms of agreements relating to certain existing junior indebtedness, if any, in a manner materially adverse to the lenders under our credit agreement, without lender approval. Further, our credit agreement contains customary covenants, including covenants that restrict our ability to acquire and dispose of assets, engage in mergers or reorganizations, pay dividends or make investments. Our credit agreement contains one financial covenant, which is a total leverage ratio that provides for a maximum ratio of consolidated total debt to consolidated EBITDA, as defined in the credit agreement, for any period of four consecutive fiscal quarters, measured as of the end of such period, of 5.75 to 1.00. See Liquidity and Capital Resources included elsewhere in this Annual Report on Form 10-K for more information on our covenants governing our credit facilities. In addition, our credit agreement requires us to make mandatory principal prepayments in certain circumstances, including with a portion of our excess cash flow if Quintiles Transnational’s total leverage ratio (as defined in the credit agreement) exceeds certain levels. A violation of any of these covenants could cause an event of default under our credit agreement.

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The receivables financing agreement for our receivables financing facility requires certain of our subsidiaries to transfer receivables with adequate value to the lender under that facility to support repayment of amounts outstanding. In the event such transferred receivables are insufficient to support such outstanding amounts, we will be required to make prepayments under the receivables financing agreement. Failure to make such prepayments or violations of the covenants in the receivables financing agreement could cause an event of default under the receivables financing agreement.

The indenture governing the senior notes of Quintiles Transnational requires us to comply with certain covenants, including covenants that limit our ability to create liens and enter into sale and lease-back transactions. In addition, upon the occurrence of a change in control of Quintiles Transnational, each holder of senior notes may require Quintiles Transnational to repurchase all or a portion of the senior notes in cash at a price equal to 101% of the aggregate principal amount of the senior notes to be repurchased, plus accrued and unpaid interest thereon. A violation of any of these covenants could cause an event of default under our indenture.

If we default on our senior secured credit agreement, our receivables financing agreement or our senior notes as a result of our failure to pay principal or interest when due, our material breach of any representation, warranty or covenant, or any other reason, all outstanding amounts could become immediately due and payable under any or all of such agreements. In such case, we may not have sufficient funds to repay all the outstanding amounts. In addition, or in the alternative, the lenders under our senior secured credit agreement could exercise their rights under the security documents entered into in connection with the senior secured credit agreement. Any acceleration of amounts due under the credit agreement governing our outstanding indebtedness or the substantial exercise by the lenders under our senior secured credit agreement of their rights under the security documents would likely have a material adverse effect on us.

Interest rate fluctuations may affect our results of operations and financial condition.

Because we have variable rate debt, fluctuations in interest rates affect our business. We attempt to minimize interest rate risk and lower our overall borrowing costs through the utilization of derivative financial instruments, primarily interest rate swaps. We have entered into interest rate swaps with financial institutions that have reset dates and critical terms that match those of our senior secured term loan credit facility. Accordingly, any change in market value associated with the interest rate swaps is offset by the opposite market impact on the related debt. As of December 31, 2015, we had approximately $1.7 billion of variable rate indebtedness. In June 2015, we entered into seven forward starting interest rate swaps with a notional value of $440.0 million which will be effective June 30, 2016 at which time we will have approximately $1.2 billion of variable rate indebtedness. The interest rate swaps expire between March 31, 2017 and March 31, 2020. Because we do not attempt to hedge all of our variable rate debt, we may incur higher interest costs for the portion of our variable rate debt which is not hedged. Once the interest rate swaps are effective, each quarter-point increase or decrease in the variable interest rate would result in our interest expense changing by approximately $3.1 million per year under our unhedged variable rate debt.

Risks Relating to Ownership of Our Common Stock

Provisions of our corporate governance documents could make an acquisition of our company more difficult and may prevent attempts by our shareholders to replace or remove our current management, even if beneficial to our shareholders.

Provisions of our amended and restated articles of incorporation and our amended and restated bylaws may discourage, delay or prevent a merger, acquisition or other change in control of our company that shareholders may consider favorable, including transactions in which you might otherwise receive a premium for your shares. These provisions could also limit the price that investors might be willing to pay in the future for shares of our common stock, thereby depressing the market price of our common stock. In addition, these provisions may frustrate or prevent any attempts by our shareholders to replace or remove members of our Board. Because our Board is responsible for appointing the members of our management team, these provisions could in turn frustrate or prevent any attempt to replace or remove current members of our management team. Among others, these provisions include (i) our ability to issue preferred stock without shareholder approval, (ii) the requirement that our shareholders may not act without a meeting, (iii) requirements for advance notification of shareholder nominations and proposals contained in our bylaws, (iv) the absence of cumulative voting for our directors, (v) requirements for shareholder approval of certain business combinations and (vi) the limitations on director nominations.

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Our operating results and share price may be volatile, which could cause the value of our shareholders’ investments to decline.

Our quarterly and annual operating results may fluctuate in the future, and such fluctuations may be significant. In addition, securities markets worldwide have experienced, and are likely to continue to experience, significant price and volume fluctuations. This market volatility, as well as general economic, market or political conditions, could subject the market price of our shares to wide price fluctuations regardless of our operating performance. Our operating results and the trading price of our shares may fluctuate in response to various factors, including:

· market conditions in the broader stock market;

· actual or anticipated fluctuations in our quarterly and annual financial and operating results;

· introduction of new products or services by us or our competitors;

· issuance of new or changed securities analysts’ reports or recommendations;

· sales, or anticipated sales, of large blocks of our stock;

· additions or departures of key personnel;

· regulatory or political developments;

· litigation and governmental investigations;

· changing economic conditions; and

· exchange rate fluctuations.

These and other factors, many of which are beyond our control, may cause our operating results and the market price for our shares to fluctuate substantially. While we believe that operating results for any particular quarter are not necessarily a meaningful indication of future results, fluctuations in our quarterly operating results could limit or prevent investors from readily selling their shares and may otherwise negatively affect the market price and liquidity of our shares. In addition, in the past, when the market price of a stock has been volatile, holders of that stock have sometimes instituted securities class action litigation against the company that issued the stock. If any of our shareholders brought a lawsuit against us, we could incur substantial costs defending the lawsuit. Such a lawsuit could also divert the time and attention of our management from our business, which could significantly harm our profitability and reputation.

There may be sales of a substantial amount of our common stock by our current shareholders, and these sales could cause the price of our common stock to fall.

As of February 4, 2016, there were 119,384,993 shares of common stock outstanding. Approximately 30.2% of our outstanding common stock is held by parties to the Shareholders Agreement.

Sales of substantial amounts of our common stock in the public market, or the perception that such sales will occur, could adversely affect the market price of our common stock and make it difficult for us to raise funds through securities offerings in the future.

Shareholders that are a party to an amended and restated registration rights agreement, or the Registration Rights Agreement, may require us to register their shares for resale under the federal securities laws. Under the Registration Rights Agreement, we are required to pay the registration expenses associated with the registration of such shares, not including the underwriting discounts, commissions and transfer taxes. Registration of those shares would allow those shareholders to immediately resell their shares in the public market. Any such sales or the anticipation of such sales may cause the market price of our common stock to decline.

Since we have no current plans to pay regular cash dividends on our common stock, shareholders may not receive any return on investment unless they sell their common stock for a price greater than that which they paid for it.

Although we have previously declared dividends to our shareholders, we do not currently anticipate paying any regular cash dividends on our common stock. Any decision to declare and pay dividends in the future will be made at the discretion of our Board and will depend on, among other things, our results of operations, financial condition, cash requirements, contractual restrictions and other factors that our Board may deem relevant. In addition, our ability to pay dividends is, and may be, limited by covenants of existing and any future outstanding indebtedness we or our subsidiaries incur, including under our existing credit facilities. Therefore, any return on investment in our common stock is solely dependent upon the appreciation of the price of our common stock on the open market, which may not occur. See Part II, Item 5 “Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities—Policy” for more detail.

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The parties to the Shareholders Agreement have significant influence over us, including decisions that require the approval of our shareholders, which could limit your ability to influence the outcome of matters submitted to shareholders for a vote.

The parties to the Shareholders Agreement own approximately 30.2% of the outstanding shares of our common stock. Among other things, the Shareholders Agreement requires such shareholders to vote in favor of certain nominees to our Board. As a result, this group potentially has the ability to influence our decisions to enter into any corporate transaction (and the terms thereof), any change in the composition of our Board and any transaction that requires shareholder approval regardless of whether others believe that such change or transaction is in our best interests. Additionally, the parties to the Shareholders Agreement are in the business of making investments in companies and may from time to time acquire and hold interests in businesses that compete directly or indirectly with us. One or more of the parties to the Shareholders Agreement may also pursue acquisition opportunities that may be complementary to our business and, as a result, those acquisition opportunities may not be available to us. So long as the parties to the Shareholders Agreement continue to own a significant amount of our equity, if they exercise their shareholder rights collectively, they will be able to significantly influence our decisions.

Our amended and restated articles of incorporation contain a provision renouncing any interest and expectancy in certain corporate opportunities identified by certain of our affiliates, even if such corporate opportunities are ones that we might reasonably be deemed to have pursued or had the ability or desire to pursue.

Our amended and restated articles of incorporation provide for the allocation of certain corporate opportunities between us, on the one hand, and certain of our shareholders, on the other hand. As set forth in our amended and restated articles of incorporation, neither such shareholders, nor any director, officer, shareholder, member, manager, or employee of such shareholders, have any fiduciary duty or any other duty to refrain from engaging, directly or indirectly, in the same business activities or similar business activities or lines of business in which we operate. To the full extent permitted by applicable law, we have renounced any interest or expectancy in, or in being offered an opportunity to participate in, business opportunities that are from time to time presented to certain of our shareholders, even if the opportunity is one that we might reasonably deem to have pursued or had the ability or desire to pursue, if granted, the opportunity to do so, and each such shareholders shall have no duty to communicate or offer such business opportunity to us and, to the fullest extent permitted by applicable law, shall not be liable to us or, to the extent applicable, any of its or their shareholders, for breach of any fiduciary or other duty, as a director or officer or otherwise, by reason of the fact that such shareholders pursues or acquires such business opportunity, directs such business opportunity to another person or fails to present such business opportunity, or information regarding such business opportunity, to us. Therefore, a director or officer of our company who also serves as a director, officer, member, manager, or employee of such shareholders may pursue certain business opportunities, including acquisitions, that may be complementary to our business and, as a result, such opportunities may not be available to us. These potential conflicts of interest could have a material adverse effect on our business, financial condition, results of operations, or prospects if attractive corporate opportunities are allocated by such shareholders to themselves or their other affiliates instead of to us.

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Item 1B. Unresolved Staff Comments

None.

Item 2. Properties

As of December 31, 2015, we had approximately 120 offices located in approximately 60 countries. Our executive headquarters is located adjacent to Research Triangle Park, North Carolina. We maintain substantial offices serving Product Development in Durham, North Carolina; Marietta, Georgia; Overland Park, Kansas; Reading, England; West Lothian, Scotland; Centurion, South Africa; Tokyo, Japan; Bangalore, India; and Singapore. We also maintain substantial offices serving Integrated Healthcare Services in Parsippany, New Jersey; Mannheim, Germany; Reading, England; and Tokyo, Japan. We own facilities in Gotemba City, Japan (currently unused and held for sale) and Barcelona, Spain that serve Product Development and Integrated Healthcare Services. All of our other offices are leased. None of our leases is individually material to our business operations. Many of our leases have an option to renew, and we believe that we will be able to successfully renew expiring leases on terms satisfactory to us. We believe that our facilities are adequate for our operations and that suitable additional space will be available if needed.

Item 3. Legal Proceedings

We are party to legal proceedings incidental to our business. While the outcome of these matters could differ from management’s expectations, we do not believe that the resolution of these matters is reasonably likely to have a material adverse effect on our financial statements.

Item 4. Mine Safety Disclosures

Not applicable.

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PART II

Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities

Market Information for Common Stock

Our common stock trades on the NYSE under the symbol “Q.” The following table sets forth the high and low sales prices per share of our common stock as reported by the NYSE for the periods indicated.

	High		Low
Fiscal Year 2014
First Quarter	$	55.00	$	45.25
Second Quarter	$	53.55	$	46.27
Third Quarter	$	58.89	$	53.03
Fourth Quarter	$	60.79	$	51.09
	High		Low
Fiscal Year 2015
First Quarter	$	69.97	$	56.46
Second Quarter	$	73.82	$	63.63
Third Quarter	$	80.45	$	67.47
Fourth Quarter	$	72.68	$	63.62

Holders of Record

On February 4, 2016, we had 40 shareholders of record as reported by our transfer agent. Holders of record are defined as those shareholders whose shares are registered in their names in our stock records and do not include beneficial owners of common stock whose shares are held in the names of brokers, dealers or clearing agencies.

Dividend Policy

We do not currently intend to pay dividends on our common stock, and no dividends were declared or paid in 2015 or 2014. However, we expect to reevaluate our dividend policy on a regular basis and may, subject to compliance with the covenants contained in our credit facilities and other considerations, determine to pay dividends in the future. The declaration, amount and payment of any future dividends on shares of our common stock will be at the sole discretion of our Board, which may take into account general and economic conditions, our financial condition and results of operations, our available cash and current and anticipated cash needs, capital requirements, contractual, legal, tax and regulatory restrictions, the implications of the payment of dividends by us to our shareholders or by our subsidiaries to us, and any other factors that our Board may deem relevant. Our long-term debt arrangements contain usual and customary restrictive covenants that, among other things, place limitations on our ability to declare dividends. For additional information regarding these restrictive covenants, see Part II, Item 7 “Management’s Discussion and Analysis of Financial Condition and Results of Operations—Liquidity and Capital Resources” and Note 10 to our audited consolidated financial statements included elsewhere in this Annual Report on Form 10-K.

Recent Sales of Unregistered Securities

We did not sell any unregistered equity securities in 2015.

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Purchases of Equity Securities by the Issuer

On October 31, 2013, we announced that on October 30, 2013 our Board approved an equity repurchase program, or the Repurchase Program, authorizing the repurchase of up to $125.0 million of either our common stock or vested in-the-money employee stock options, or a combination thereof. During 2015, our Board increased the share repurchase authorization under the Repurchase Program by $600.0 million, which increased the total amount that has been authorized under the Repurchase Program to $725.0 million. The Repurchase Program does not obligate us to repurchase any particular amount of common stock or vested in-the-money employee stock options, and it could be modified, suspended or discontinued at any time. The timing and amount of repurchases are determined by our management based on a variety of factors such as the market price of our common stock, our corporate requirements, and overall market conditions. Purchases of our common stock may be made in open market transactions effected through a broker-dealer at prevailing market prices, in block trades, or in privately negotiated transactions. We may also repurchase shares of our common stock pursuant to a trading plan meeting the requirements of Rule 10b5-1 under the Exchange Act, which would permit shares of our common stock to be repurchased when we might otherwise be precluded from doing so by law. Repurchases of vested in-the-money employee stock options were made through transactions between us and our employees (other than our executive officers, who were not eligible to participate in the program), and this aspect of the Repurchase Program expired in November 2013. The Repurchase Program for common stock does not have an end date.

In 2015, we repurchased 7,855,796 shares of common stock for an aggregate purchase price of $515.0 million under the Repurchase Program. From inception through December 31, 2015, we have repurchased a total of $580.5 million of our securities under the Repurchase Program, consisting of $59.1 million of stock options and $521.4 million of common stock. As of December 31, 2015, we have remaining authorization to repurchase up to $144.5 million of our common stock under the Repurchase Program. In addition, from time to time, we have and may continue to repurchase common stock through private or other transactions outside of the Repurchase Program. For additional information regarding our equity repurchases, see Part II, Item 7 “Management’s Discussion and Analysis of Financial Condition and Results of Operations—Liquidity and Capital Resources” and Note 12 to our audited consolidated financial statements included elsewhere in this Annual Report on Form 10-K.

The following table summarizes the equity repurchase program activity for the three months ended December 31, 2015 and the approximate dollar value of shares that may yet be purchased pursuant to the Repurchase Program:

Period	Total Number of Shares Purchased		Average Price Paid per Share		Total Number of Shares Purchased as Part of Publicly Announced Plans or Programs		Approximate Dollar Value of Shares That May Yet Be Purchased Under the Plans or Programs
	(in thousands, except share and per share data)
October 1, 2015 – October 31, 2015		—	$	—		—	$	109,486
November 1, 2015 – November 30, 2015 (1)		3,952,746	$	66.24		3,952,746	$	147,658
December 1, 2015 – December 31, 2015		48,000	$	66.30		48,000	$	144,475
		4,000,746				4,000,746

(1) On November 12, 2015, we completed the repurchase of 3,000,000 shares of our common stock for $66.25 per share from Temasek Life Sciences Private Limited in a private transaction for an aggregate purchase price of approximately $198.8 million. The repurchase price per share of common stock was equal to 98.5% of the closing market price of our common stock on the NYSE on November 10, 2015 (which was $67.26). We funded this private repurchase transaction with cash on hand. The private repurchase transaction was entered into pursuant to the Repurchase Program.

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Stock Performance Graph

This performance graph shall not be deemed “filed” for purposes of Section 18 of the Exchange Act, or incorporated by reference into any filing of Quintiles Transnational Holdings Inc. under the Exchange Act or under the Securities Act, except as shall be expressly set forth by specific reference in such filing.

The following graph shows a comparison from May 9, 2013 (the date our common stock commenced trading on the NYSE) through December 31, 2015 of the cumulative total return for our common stock, the Standard & Poor's Healthcare Sector Index, or S&P 500 Healthcare, and the Standard & Poor’s 500 Stock Index, or S&P 500 Index. The graph assumes that $100 was invested at the market close on May 9, 2013 in the common stock of Quintiles Transnational Holdings Inc., the S&P 500 Index and the S&P 500 Healthcare, and assumes reinvestments of dividends, if any. These indices are included for comparative purposes only. They do not necessarily reflect management’s opinion that such indices are an appropriate measure of the relative performance of the stock involved, and they are not intended to forecast or be indicative of possible future performance of our common stock.

	5/9/2013		12/31/2013		12/31/2014		12/31/2015
Q	$	100	$	110	$	140	$	163
S&P 500 Healthcare	$	100	$	116	$	143	$	151
S&P 500	$	100	$	114	$	127	$	126

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Item 6. Selected Financial Data

We have derived the following consolidated statement of income data for 2015, 2014 and 2013 and consolidated balance sheet data as of December 31, 2015 and 2014 from our audited consolidated financial statements included elsewhere in this Annual Report on Form 10-K. We have derived the following consolidated statement of income data for 2012 and 2011 and consolidated balance sheet data as of December 31, 2013, 2012 and 2011 from our audited consolidated financial statements not included in this Annual Report on Form 10-K. You should read the consolidated financial data set forth below in conjunction with our consolidated financial statements and related notes included elsewhere in this Annual Report on Form 10-K and the information under Part II, Item 7, “Management’s Discussion and Analysis of Financial Condition and Results of Operations.” Our historical results are not necessarily indicative of the results we may achieve in any future period.

	Year Ended December 31,
	2015			2014			2013			2012			2011
	(in thousands, except per share data)
Statement of Income Data:
Service revenues	$	4,326,419		$	4,165,822		$	3,808,340		$	3,692,298		$	3,294,966
Reimbursed expenses		1,411,200			1,294,176			1,291,205			1,173,215			1,032,782
Total revenues		5,737,619			5,459,998			5,099,545			4,865,513			4,327,748
Costs of revenue, service costs		2,725,586			2,684,106			2,471,426			2,459,367			2,153,005
Costs of revenue, reimbursed expenses		1,411,200			1,294,176			1,291,205			1,173,215			1,032,782
Selling, general and administrative		920,985			882,338			860,510			817,755			762,299
Restructuring costs		30,752			8,988			14,071			18,741			22,116
Impairment charges (1)		2,484			—			—			—			12,295
Income from operations		646,612			590,390			462,333			396,435			345,251
Interest expense, net		97,475			97,179			119,571			131,304			105,126
Loss on extinguishment of debt		7,780			—			19,831			1,275			46,377
Other expense (income), net		2,362			(8,978	)		(185	)		(3,572	)		9,073
Income before income taxes and equity in earnings (losses) of unconsolidated affiliates		538,995			502,189			323,116			267,428			184,675
Income tax expense		158,989			150,056			95,965			93,364			15,105
Income before equity in earnings (losses) of unconsolidated affiliates		380,006			352,133			227,151			174,064			169,570
Equity in earnings (losses) of unconsolidated affiliates (2)		8,298			4,368			(1,124	)		2,567			70,757
Net income		388,304			356,501			226,027			176,631			240,327
Net (income) loss attributable to noncontrolling interests		(1,099	)		(118	)		564			915			1,445
Net income attributable to Quintiles Transnational Holdings Inc.	$	387,205		$	356,383		$	226,591		$	177,546		$	241,772
Earnings per share attributable to common shareholders:
Basic	$	3.15		$	2.78		$	1.83		$	1.53		$	2.08
Diluted	$	3.08		$	2.72		$	1.77		$	1.51		$	2.05
Cash dividends declared per common share	$	—		$	—		$	—		$	4.91		$	2.48
Weighted average common shares outstanding:
Basic		123,038			127,994			124,147			115,710			116,232
Diluted		125,630			131,083			127,862			117,796			117,936

	Year Ended December 31,
	2015			2014			2013			2012			2011
	(in thousands)
Statement of Cash Flow Data:
Net cash provided by (used in):
Operating activities	$	475,691		$	431,754		$	393,371		$	335,701		$	160,953
Investing activities		(66,955	)		(173,114	)		(236,176	)		(132,233	)		(224,838	)
Financing activities		(249,246	)		(130,344	)		70,957			(146,873	)		(59,309	)
Other Financial Data:
Capital expenditures	$	(78,391	)	$	(82,650	)	$	(88,347	)	$	(71,336	)	$	(75,679	)
Cash dividend paid to common shareholders		—			—			—			(567,851	)		(288,322	)
Net new business (unaudited) (3)		5,318,800			5,602,400			4,898,900			4,501,200			4,044,100

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	As of December 31,
	2015			2014			2013			2012			2011
	(in thousands)
Balance Sheet Data:
Cash and cash equivalents	$	977,151		$	867,358		$	778,143		$	567,728		$	516,299
Investments in debt, equity and other securities		32,911			34,503			40,349			35,951			22,106
Trade accounts receivable and unbilled services, net		1,165,749			975,255			924,205			745,373			691,038
Property and equipment, net		188,393			190,297			199,578			193,999			185,772
Total assets		3,926,316			3,295,953			3,054,223			2,475,532			2,304,486
Total long-term liabilities		2,667,821			2,528,065			2,239,461			2,525,579			2,091,448
Total debt and capital leases (4)		2,500,781			2,305,696			2,060,994			2,444,886			1,990,196
Total shareholders' deficit		(335,681	)		(704,012	)		(667,485	)		(1,359,044	)		(969,596	)
Other Financial Data:
Backlog (unaudited) (3)	$	12,038,000		$	11,244,400		$	9,855,400		$	8,704,500		$	7,972,900

(1) In 2015 and 2011, we wrote down $2.5 million and $12.2 million, respectively, related to long-lived assets, and in 2011 we incurred other than temporary losses of $145,000 related to a non-marketable equity security.

(2) In November 2011, we sold our investment in Invida Pharmaceutical Holdings Pte. Ltd. for approximately $103.6 million of net proceeds resulting in a gain of approximately $74.9 million.

(3) Net new business is the value of services awarded during the period from projects under signed contracts, letters of intent and, in some cases, pre-contract commitments that are supported by written communications, adjusted for contracts that were modified or canceled during the period. Consistent with our methodology for calculating net new business during a particular period, backlog represents, at a particular point in time, future service revenues from work not yet completed or performed under signed contracts, letters of intent and, in some cases, pre-contract commitments that are supported by written communications. Historically, net new business and backlog denominated in foreign currencies were valued each month throughout the year using foreign exchange rates that were in effect at the beginning of each fiscal year. Beginning with the first quarter of 2015, net new business and backlog denominated in foreign currencies are valued each month using the actual average foreign exchange rates in effect during the month. The application of this new approach to value foreign currency denominated net new business and backlog would not have had a significant impact to any prior period’s reported amounts, therefore historical amounts have not been restated to reflect this change in methodology.

(4) Excludes $33.0 million, $22.3 million, $27.5 million, $46.5 million and $36.8 million of unamortized discounts and debt issuance costs as of December 31, 2015, 2014, 2013, 2012 and 2011, respectively.

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Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations

You should read the following discussion and analysis of our financial condition and results of operations together with our consolidated financial statements and the related notes included elsewhere in this Annual Report on Form 10-K. Some of the information contained in this discussion and analysis or set forth elsewhere in this Annual Report, including information with respect to our plans and strategy for our business, includes forward-looking statements that involve risks and uncertainties. You should read the “Risk Factors” section of this Annual Report for a discussion of important factors that could cause actual results to differ materially from the results described in or implied by the forward-looking statements contained in the following discussion and analysis.

Overview

Our business is currently organized in two reportable segments, Product Development and Integrated Healthcare Services.

For the year ended December 31, 2015, our service revenues increased $160.6 million, or 3.9%, to $4.3 billion at actual foreign exchange rates compared to 2014. Our growth in service revenues excluding the impact of foreign currency fluctuations (“constant currency”) was $372.9 million, or 9.0%, with $223.5 million, or 7.2%, growth in the Product Development segment and $149.4 million, or 14.0%, growth in the Integrated Healthcare Services segment.

For the year ended December 31, 2015, our income from operations was $646.6 million, an increase of $56.2 million (which included a positive impact of approximately $30.6 million from the effects of foreign currency fluctuations).

Our net income attributable to Quintiles Transnational Holdings Inc. was $387.2 million with diluted earnings per share of $3.08 for the year ended December 31, 2015.

Net new business was $5,319 million for the year ended December 31, 2015. This net new business contributed to an ending backlog of $12,038 million at December 31, 2015. “Net new business” and “backlog” are defined under “Net New Business Reporting and Backlog” in Part I, Item 1, “Business” of this Annual Report on Form 10-K.

Product Development

Product Development provides services and expertise that allow biopharmaceutical companies to outsource the clinical development process from first-in-man clinical trials to post-launch monitoring. Our comprehensive service offerings provide the support and functional expertise necessary at each stage of development, as well as the systems and analytical capabilities to help our customers improve product development efficiency and effectiveness. Product Development is comprised of clinical solutions and services and advisory services (formerly consulting services). Clinical solutions and services provides services necessary to develop biopharmaceutical products. These services include project management and clinical monitoring functions for conducting multi-site clinical trials (generally Phase II-IV) (collectively “core clinical”). These also include clinical trial support services that improve clinical trial decision-making, such as global clinical trial laboratories, data management, biostatistical, safety and pharmacovigilance, early clinical development trials (generally Phase I), and strategic planning and design services, which help improve decisions and performance. We also provide functional resourcing services that cover a range of areas. Advisory services provides strategy and management advisory services based on life science expertise and advanced analytics, as well as regulatory and compliance advisory services.

Integrated Healthcare Services

Integrated Healthcare Services provides a broad array of services including commercial services, such as providing contract pharmaceutical sales forces in key geographic markets, as well as a growing number of healthcare business services for the broader healthcare sector. Our customized commercialization services are designed to accelerate the commercial success of biopharmaceutical and other health-related products. Service offerings include commercial services (sales representatives, strategy, marketing communications and other areas related to market access and commercialization), real-world and late phase research (drug therapy analysis, real-world research and evidence-based medicine, including research studies to prove a drug’s value), other healthcare services (comparative and cost-effectiveness research capabilities, decision support services, communication services and health engagement, medication adherence and health outcome optimization services, and web-based systems for measuring quality improvement), and EHR implementation and advisory services.

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Industry Outlook

The potential of the CRO market served by Product Development is primarily a function of two variables: biopharmaceutical research and development spending and the proportion of this spending that is outsourced (outsourcing penetration). We expect outsourced clinical development to CROs to increase 6%-8% annually from 2015 to 2018, and believe this annual growth will be driven largely by increased outsourcing penetration, with up to 2% of this growth coming from increased research and development expenditures over 2015 to 2018. In estimating these growth rates, we monitor the ability of biopharmaceutical companies, including biotechnology companies, to raise capital, as well as the potential impact from merger and acquisition activity between biopharmaceutical companies. We estimate that overall outsourcing penetration of the addressable market in 2015 was 41%, and  believe that our customers will continue to outsource a greater part of their activities to transform their value chain away from a vertically integrated model and focus on their core competencies to lower risk and improve return, with a focus on selecting outsourcing partners that are able to demonstrate the ability to provide flexible and efficient delivery models that leverage patient data to help biopharmaceutical companies deliver more effective patient outcomes. We believe that increased demand will create new opportunities for biopharmaceutical services companies, particularly those with a global reach.

Integrated Healthcare Services historically has focused on biopharmaceutical companies seeking to commercialize their products. The total market served by Integrated Healthcare Services is diverse, which makes it difficult to estimate the current amount of outsourced integrated healthcare services and the expected growth in such services. However, based on our knowledge of these markets we believe that, while the rate of outsourcing penetration varies by market within Integrated Healthcare Services, the overall outsourcing penetration of the estimated $101 billion market is approximately 23%. We believe that the market for real-world and late phase research and other healthcare services will evolve and expand, and as a result, there will be opportunities to grow our revenues and expand our service offerings. As business models continue to evolve in the healthcare sector, we believe, based on industry data, analysis, and our own estimates, that the growth rate for outsourcing across the Integrated Healthcare Services markets should increase 6%-8% annually from 2015 to 2018.

Business Combinations

We completed a number of business combinations in 2013, 2014 and 2015 to enhance our capabilities and offerings in certain areas. In September 2013, we acquired Novella Clinical Inc., or Novella, for approximately $146.6 million (net of approximately $26.2 million of acquired cash) (with contingent consideration of up to $21.0 million) to complement our Product Development segment service offerings through its focus on emerging companies and by adding expertise in oncology and medical devices. In July 2014, we completed the acquisition of Encore for approximately $91.5 million in cash (net of approximately $2.2 million of acquired cash) to enhance our EHR expertise within our Integrated Healthcare Services segment. In July 2015, we combined our global clinical trials laboratory operations in our Product Development segment with the clinical trials laboratory operations of Quest with the resulting combined business referred to as Q² Solutions. We own 60% of Q² Solutions and Quest owns the remaining 40%. See Note 14 to our audited consolidated financial statements included elsewhere in this Annual Report on Form 10-K for additional information with respect to these business combinations. The results of operations of acquired businesses have been included since the date of acquisition and were not significant to our consolidated results of operations.

Sources of Revenue

Total revenues are comprised of service revenues and revenues from reimbursed expenses. Service revenues primarily include the revenue we earn from providing product development and commercialization services to our customers, with Product Development services representing 73.8% of our 2015 service revenues and Integrated Healthcare Services representing 26.2% of our 2015 service revenues. Reimbursed expenses are comprised principally of payments to physicians (investigators) who oversee clinical trials and travel expenses for our clinical monitors and sales representatives. Reimbursed expenses may fluctuate from period-to-period due, in part, to where we are in the lifecycle of the many contracts that are in progress at a particular point in time. For instance, these pass-through costs tend to be higher during the early phases of clinical trials as a result of patient recruitment efforts. As reimbursed expenses are pass-through costs to our customers with little to no profit and we believe that the fluctuations from period-to-period are not meaningful to our underlying performance, we do not provide analysis of the fluctuations in these items or their impact on our financial results.

Costs and Expenses

Our costs and expenses are comprised primarily of our costs of revenues and selling, general and administrative expenses.

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Our costs of revenues consist of service costs and reimbursed expenses. Service costs include compensation and benefits for billable employees, depreciation of assets used in generating revenue and other expenses directly related to service contracts such as courier fees, laboratory supplies, professional services and travel expenses. As noted above, reimbursed expenses are comprised principally of payments to physicians (investigators) who oversee clinical trials and travel expenses for our clinical monitors and sales representatives.

Selling, general and administrative expenses include costs related to administrative functions including compensation and benefits, travel, professional services, training and expenses for advertising, IT, facilities and depreciation and amortization.

Foreign Currency Translation

In 2015, approximately 32% of our service revenues were denominated in currencies other than the United States dollar. Because a large portion of our service revenues and expenses are denominated in currencies other than the United States dollar and our financial statements are reported in United States dollars, changes in foreign currency exchange rates can significantly affect our results of operations. The revenue and expenses of our foreign operations are generally denominated in local currencies and translated into United States dollars for financial reporting purposes. Accordingly, exchange rate fluctuations will affect the translation of foreign results into United States dollars for purposes of reporting our consolidated results. In 2015, foreign exchange rates in certain currencies in which we do business have fluctuated significantly as compared to the prior year, particularly the Euro, the Japanese Yen and the British Pound.

As a result, we believe that providing the impact of fluctuations in foreign currency rates on certain financial results can facilitate analysis of period-to-period comparisons of business performance. The impact from foreign currency fluctuations and constant currency information assumes constant foreign currency exchange rates based on the rates in effect for the comparable prior-year period were used in translation.

Consolidated Results of Operations

For additional information regarding results of operations for Product Development and Integrated Healthcare Services, refer to “Segment Results of Operations” later in this section.

Year ended December 31, 2015 compared to the year ended December 31, 2014 and the year ended December 31, 2014 compared to the year ended December 31, 2013

Backlog and Net New Business

2015 compared to 2014

Backlog at December 31, 2015 was $12,038 million, which was 7% higher than 2014, including the incremental impact from the businesses that Quest contributed to Q² Solutions.

Net new business decreased 5.1% (including a negative impact from foreign currency) in 2015 to $5,319 million from $5,602 million in 2014, driven by decreases in both Product Development and Integrated Healthcare Services. Product Development’s net new business decreased 5.8% in 2015 to $4,121 million from $4,374 million in 2014. Product Development had growth in net new business in 2015 from core clinical services and global clinical trial laboratory services including the incremental impact from the businesses that Quest contributed to Q² Solutions. These increases were more than offset by lower net new business for functional resourcing services primarily because 2014 included renewals for two five-year contracts. Integrated Healthcare Services’ net new business decreased 2.5% in 2015 to $1,198 million from $1,228 million in 2014, related primarily to cancellations in North America as well as lower signings for commercial services in Europe, partially offset by net new business growth from the Encore acquisition which closed in July 2014 and from real-world and late phase research services.

2014 compared to 2013

Backlog at December 31, 2014 was $11,244 million, which was 14% higher than 2013.

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Net new business grew 14% in 2014 to $5,602 million from $4,899 million in 2013, driven by growth in both Product Development and Integrated Healthcare Services. Product Development’s net new business increased 16% in 2014 to $4,374 million from $3,772 million in 2013, led by higher growth in net new business for functional resourcing services, which included renewals of two five-year contracts, growth in net new business for core clinical services in Asia, as well as net new business generated from the Novella acquisition and clinical trial support services, including early clinical development and lifecycle safety. Integrated Healthcare Services’ net new business increased 9% in 2014 to $1,228 million from $1,127 million in 2013, related primarily to growth in commercial services in North America, an increase in new business from real-world and late phase research services, and net new business from the Encore acquisition.

Our backlog at December 31, 2015 was $12,038 million compared to backlog of $11,244 million at December 31, 2014. Although an increase in backlog will generally result in an increase in revenues to be recognized over time (depending on the level of contract modifications), an increase in backlog at a particular point in time does not necessarily correspond directly to an increase in revenues during a particular period. The extent to which contracts in backlog will result in revenue depends on many factors, including but not limited to delivery against projected schedules, the need for scope changes (change orders), contract cancellations and the nature, duration, size, complexity and phase of the contracts, each of which factors can vary significantly from time to time. Revenue recognition occurs over extended periods of time and is subject to unanticipated delays. Fluctuations in our reported backlog and net new business levels may result from a small number of relatively large orders in any given reporting period that may be included in our backlog and net new business. Because of these large orders, our backlog and net new business in that reporting period may reach levels that may not be sustained in subsequent reporting periods. Our $12,038 million of backlog at December 31, 2015 included approximately $8,188 million of backlog that we do not expect to generate revenue in 2016 as compared to our $11,244 million of backlog at December 31, 2014, which included approximately $7,593 million of backlog that we did not expect to generate revenue in 2015. Our ability to grow revenues in the near term at rates comparable to our recent historical results will depend on many factors, including but not limited to the factors affecting the rate at which revenues are derived from backlog, continued growth in net new business that will generate revenue and factors not within our control such as economic conditions and trends in the industry in which we do business.

Service Revenues

	Year Ended December 31,
	2015			2014			2013
	(dollars in millions)
Service revenues	$	4,326.4		$	4,165.8		$	3,808.3
% change from prior year		3.9	%		9.4	%

2015 compared to 2014

In 2015, our service revenues increased $160.6 million, or 3.9%, as compared to 2014. This increase was comprised of constant currency service revenue growth of approximately $372.9 million, or 9.0%, and a negative impact of approximately $212.3 million from the effects of foreign currency fluctuations. The constant currency service revenue growth was comprised of a $223.5 million increase in Product Development, which includes the incremental impact from the businesses that Quest contributed to Q² Solutions, and a $149.4 million increase in Integrated Healthcare Services, which includes the impact from the Encore acquisition which closed in July 2014.

2014 compared to 2013

In 2014, our service revenues increased $357.5 million, or 9.4%, as compared to 2013. This increase is comprised of constant currency revenue growth of approximately $383.2 million, or 10.1%, offset by a negative impact of approximately $25.7 million from the effects of foreign currency fluctuations. The constant currency service revenue growth, which includes the impact from the Novella and Encore acquisitions, is comprised of a $183.2 million increase in Product Development and a $200.0 million increase in Integrated Healthcare Services.

Costs of Revenue, Service Costs

	Year Ended December 31,
	2015			2014			2013
	(dollars in millions)
Costs of revenue, service costs	$	2,725.6		$	2,684.1		$	2,471.4
% of service revenues		63.0	%		64.4	%		64.9	%

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2015 compared to 2014

When compared to 2014, service costs in 2015 increased $41.5 million. This increase included a constant currency increase in expenses of approximately $239.5 million, or 8.9%, partially offset by a positive impact of approximately $198.0 million from the effects of foreign currency fluctuations. The constant currency growth was comprised of a $140.0 million increase in Product Development, which included the incremental impact from the businesses that Quest contributed to Q² Solutions, and a $99.5 million increase in Integrated Healthcare Services, which included the impact from the Encore acquisition which closed in July 2014.

The decrease in service costs as a percent of service revenues for 2015 was primarily as a result of an improvement in constant currency profit margin in both the Product Development and Integrated Healthcare Services segments (as more fully described in the segment discussion later in this section). For 2015, this constant currency profit margin expansion was partially offset by the effect from a higher proportion of consolidated service revenues being contributed by our lower margin Integrated Healthcare Services segment when compared to 2014 as well as a negative impact from foreign currency fluctuations.

2014 compared to 2013

When compared to 2013, service costs in 2014 increased $212.7 million. The increase included a constant currency increase in expenses of approximately $253.5 million, or 10.3%, partially offset by a positive impact of approximately $40.8 million from the effects of foreign currency fluctuations. The constant currency growth was comprised of a $94.0 million increase in Product Development, and a $159.5 million increase in Integrated Healthcare Services, which included the impact from the Encore acquisition which closed in July 2014.

Selling, General and Administrative

	Year Ended December 31,
	2015			2014			2013
	(dollars in millions)
Selling, general and administrative	$	921.0		$	882.3		$	860.5
% of service revenues		21.3	%		21.2	%		22.6	%

2015 compared to 2014

The $38.7 million increase in selling, general and administrative expenses in 2015 included a constant currency increase of $80.8 million, or 9.2%, partially offset by a positive impact of approximately $42.1 million from the effects of foreign currency fluctuations. The constant currency growth was comprised of a $47.2 million increase in Product Development, which included the incremental impact from the businesses that Quest contributed to Q² Solutions, a $20.7 million increase in Integrated Healthcare Services, which included the impact from the Encore acquisition which closed in July 2014, and a $12.9 million increase in general corporate and unallocated expenses. The constant currency increase in 2015 for general corporate and unallocated expenses was primarily due to an increase in share-based compensation and costs associated with the Q² Solutions transaction.

2014 compared to 2013

The $21.8 million increase in selling, general and administrative expenses in 2014 included a constant currency increase of $29.3 million, or 3.4%, partially offset by a positive impact of approximately $7.5 million from the effects of foreign currency fluctuations. The constant currency growth was comprised of a $33.6 million increase in Product Development, which includes the impact from the Novella acquisition which closed in September 2013, and a $13.0 million increase in Integrated Healthcare Services, which includes the impact from the Encore acquisition which closed in July 2014. The constant currency growth was partially offset by a $17.3 million decrease in general corporate and unallocated expenses. The constant currency decrease in 2014 for general corporate and unallocated expenses was primarily due to expenses incurred in 2013 that did not recur in 2014 including a $25.0 million fee paid in connection with the termination of our management agreement with affiliates of certain of our shareholders, approximately $5.3 million of executive separation costs, and a $1.5 million fee paid in connection with the modification of an agreement for the business usage of an airplane owned by GF Management Company, LLC, or GFM, a company controlled by our former Executive Chairman who retired effective December 31, 2015 but remains one of our directors. These decreases in general corporate and unallocated expenses were partially offset by an increase in share-based compensation and increases in compensation and related expenses resulting primarily from annual merit increases and an increase in headcount.

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Restructuring Costs

	Year Ended December 31,
	2015		2014		2013
	(in millions)
Restructuring costs	$	30.8	$	9.0	$	14.1

During 2015, we recognized $30.8 million of restructuring charges, net of reversals for changes in estimates, associated with both the February 2015 restructuring plan and the Q² Solutions restructuring plan. The remaining actions under these plans are expected to occur throughout 2016 and 2017, and are expected to consist of severance, facility closure and other exit-related costs. We believe that these plans will result in annualized cost savings of approximately $50.0 million to $60.0 million.

During 2014, we recognized $9.0 million of restructuring charges, net of reversals for changes in estimates, which was primarily related to our 2014 restructuring plans to better align our resources with our strategic direction.

During 2013, we recognized $14.1 million of restructuring charges, net of reversals for changes in estimates, which was primarily related to our February 2013 restructuring plan to migrate the delivery of services and to reduce anticipated overcapacity in selected areas.

Impairment Charges

	Year Ended December 31,
	2015		2014		2013
	(in millions)
Impairment charges	$	2.5	$	—	$	—

During the fourth quarter of 2015, we exited a training facility in Japan that is being actively marketed for sale, resulting in a $2.5 million impairment of the land and building.

Interest Income and Interest Expense

	Year Ended December 31,
	2015			2014			2013
	(in millions)
Interest income	$	(4.3	)	$	(3.4	)	$	(3.9	)
Interest expense	$	101.8		$	100.6		$	123.5

Interest income included interest received primarily from bank balances and investments.

Interest expense during 2015 was slightly higher than 2014 due to an increase in the average debt outstanding, primarily as a result of the $275.0 million term loan that was issued under the receivables financing facility in December 2014 and our new senior secured credit agreement and senior notes, both of which are described in Liquidity and Capital Resources. This increase was partially offset by a decrease in the average rate of interest incurred on our debt as compared to 2014.

Interest expense during 2014 was lower than 2013 in part due to a decrease in the average rate of interest. The average rate of interest on the term loan under our senior secured credit facility during 2014 was lower than it was during 2013 due to a reduction in the interest rate pursuant to the terms and conditions in the credit agreement as well as from the refinancing transaction we completed in the fourth quarter of 2013. In addition to the lower average rate of interest, interest expense during 2014 also benefited from a decrease in the average debt outstanding as a result of the repayment of the $300.0 million term loan, which Quintiles Transnational Holdings Inc. obtained in February 2012 and paid in full in May 2013, the pay down of $50.0 million of outstanding indebtedness under our senior secured credit facilities in May 2013, the mandatory prepayment of $33.8 million of outstanding indebtedness under our senior secured credit facilities in the first quarter of 2013, and the $25.0 million prepayment of outstanding indebtedness under our senior secured credit facilities in December 2014. These repayments more than offset the impact on the average debt outstanding of the $275.0 million term loan issued under the receivables financing facility in December 2014 and the $150.0 million draw on our line of credit in 2014, which was repaid with the proceeds of the receivables financing facility term loan.

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Loss on Extinguishment of Debt

	Year Ended December 31,
	2015		2014		2013
	(in millions)
Loss on extinguishment of debt	$	7.8	$	—	$	19.8

In May 2015, we recognized a $7.8 million loss on extinguishment of debt related to the refinancing of our senior secured credit facilities. The loss on extinguishment of debt included $1.1 million of unamortized debt issuance costs, $1.3 million of unamortized discount and $5.4 million of related fees and expenses.

In December 2013, we recognized a $3.3 million loss on extinguishment of debt on a portion of the debt retired related to the refinancing of our senior secured credit facilities. The loss on extinguishment of debt included $1.6 million of unamortized debt issuance costs, $1.6 million of unamortized discount and $25,000 of fees and expenses.

In May 2013, we recognized a $16.5 million loss on extinguishment of debt related to payment of all amounts outstanding under the $300.0 million term loan and a $50.0 million pay down of outstanding indebtedness under our senior secured credit facilities. The loss on extinguishment of debt included $5.6 million of unamortized debt issuance costs, $4.8 million of unamortized discount and $6.1 million of fees and expenses.

See “—Liquidity and Capital Resources” for more information on these transactions.

Other Expense (Income), Net

	Year Ended December 31,
	2015		2014			2013
	(in millions)
Other expense (income), net	$	2.4	$	(9.0	)	$	(0.2	)

Other expense (income), net for 2015 primarily consisted of $5.9 million of expense related to the change in fair value of contingent consideration related to an acquisition, partially offset by $4.6 million of foreign currency net gains.

Other expense (income), net for 2014 included income of approximately $8.6 million due to changes in the estimated fair value of contingent consideration from an acquisition as well as a gain from the sale of marketable equity securities of approximately $5.0 million, partially offset by other expenses, primarily consisting of $4.9 million of foreign currency net losses.

Other expense (income), net for 2013 included income of approximately $3.5 million due to changes in the estimated fair value of contingent consideration for two of our acquisitions completed in 2011. In addition, 2013 included approximately $4.0 million of foreign currency net losses.

Income Tax Expense

	Year Ended December 31,
	2015			2014			2013
	(dollars in millions)
Income tax expense	$	159.0		$	150.1		$	96.0
Effective income tax rate		29.5	%		29.9	%		29.7	%

The decrease in the 2015 effective income tax rate was due to an income tax benefit related to the reversal of uncertain tax positions for tax years whose statute of limitations expired in 2015 and also a change in the relative mix of the profitability between taxing jurisdictions. These benefits were partially offset by additional income tax expense related to an increase in the amount of current year earnings of our foreign subsidiaries not considered permanently reinvested.

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The effective income tax rate for 2013 was negatively impacted by the settlement of certain intercompany notes in 2013 that had previously been considered long-term investments, which resulted in $11.1 million of income tax expense. This negative impact was primarily offset by our change in assertion regarding the undistributed earnings of most of our foreign subsidiaries that are considered to be indefinitely reinvested outside of the United States. Prior to June 2013, we had not considered the majority of the undistributed earnings of our foreign subsidiaries to be indefinitely reinvested. We reevaluated this assertion following the IPO, as a portion of the IPO proceeds were used to pay down debt held in the United States and we do not anticipate paying dividends in the foreseeable future, which had been significant in the past. Given our debt balance, and related interest expense and the change in approach related to payment of dividends, we expect to be able to support the cash needs of our domestic subsidiaries without repatriating cash from the affected foreign subsidiaries. We expect to utilize the cash generated outside of the United States to fund growth outside of the United States. As a result of the assertion change, we recorded an $8.1 million income tax benefit in the second quarter of 2013 to reverse the deferred income tax liability previously recorded on undistributed foreign earnings prior to 2013 that are now considered indefinitely reinvested outside of the United States.

Equity in Earnings (Losses) of Unconsolidated Affiliates

	Year Ended December 31,
	2015		2014		2013
	(in millions)
Equity in earnings (losses) of unconsolidated affiliates	$	8.3	$	4.4	$	(1.1	)

Equity in earnings (losses) of unconsolidated affiliates in 2015 primarily included earnings from our investment in NovaQuest Pharma Opportunities Fund III, L.P., or Fund III. The increase in 2014 when compared to 2013 was primarily due to earnings from Fund III partially offset by losses and write-downs incurred on another equity method investment.

Net (Income) Loss Attributable to Noncontrolling Interests

	Year Ended December 31,
	2015			2014			2013
	(in millions)
Net (income) loss attributable to noncontrolling interests	$	(1.1	)	$	(0.1	)	$	0.6

Net (income) loss attributable to noncontrolling interests in 2015 primarily included Quest’s interest in Q² Solutions.

Segment Results of Operations

Service revenues and income from operations by segment are as follows (dollars in millions):

	Service Revenues						Income from Operations									Operating Profit Margin
	2015		2014		2013		2015			2014			2013			2015			2014			2013
Product Development	$	3,191.6	$	3,097.8	$	2,919.7	$	714.6		$	645.2		$	562.3			22.4	%		20.8	%		19.3	%
Integrated Healthcare Services		1,134.8		1,068.0		888.6		84.0			64.8			42.1			7.4			6.1			4.7
Total segments		4,326.4		4,165.8		3,808.3		798.6			710.0			604.4			18.5	%		17.0	%		15.9	%
General corporate and unallocated								(118.7	)		(110.6	)		(128.0	)
Restructuring costs								(30.8	)		(9.0	)		(14.1	)
Impairment charges								(2.5	)		—			—
Consolidated	$	4,326.4	$	4,165.8	$	3,808.3	$	646.6		$	590.4		$	462.3

Certain costs are not allocated to our segments and are reported as general corporate and unallocated expenses. These costs primarily consist of share-based compensation and expenses for corporate office functions such as senior leadership, finance, human resources, IT, facilities and legal, as well as certain expenses incurred in the second quarter of 2013 including the $25.0 million fee incurred in connection with the termination of the management agreement with affiliates of certain shareholders and the $1.5 million fee paid in connection with the modification of an agreement for the business usage of an airplane owned by GFM. We do not allocate restructuring or impairment charges to our segments.

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Product Development

										Change
	2015			2014			2013			2015 vs. 2014				2014 vs. 2013
	(dollars in millions)
Service revenues	$	3,191.6		$	3,097.8		$	2,919.7		$	93.8	3.0	%	$	178.1	6.1	%
Costs of revenue, service costs		1,828.7			1,820.9			1,752.8			7.8	0.4			68.1	3.9
as a percentage of service revenues		57.3	%		58.8	%		60.0	%
Selling, general and administrative		648.3			631.7			604.6			16.6	2.6			27.1	4.5
as a percentage of service revenues		20.3	%		20.4	%		20.7	%
Segment income from operations	$	714.6		$	645.2		$	562.3		$	69.4	10.8	%	$	82.9	14.8	%
as a percentage of service revenues		22.4	%		20.8	%		19.3	%

Service Revenues

2015 compared to 2014

Product Development’s service revenues were $3,191.6 million in 2015, an increase of $93.8 million, or 3.0%, over 2014. This increase was comprised of constant currency service revenue growth of $223.5 million, or 7.2%, partially offset by a negative impact of approximately $129.7 million from the effects of foreign currency fluctuations. The constant currency service revenue growth primarily included $230.7 million from a volume-related increase from clinical solutions and services and the incremental impact from the businesses that Quest contributed to Q² Solutions, which was partially offset by a decrease of $7.2 million from advisory services.

The volume-related service revenue growth was related to core clinical services, clinical solutions provided on a functional resource basis and clinical trial support services. This growth was due largely to execution on the higher backlog in place as we entered the year. In addition, we recognized $16.9 million of revenue in the second quarter of 2015 as a result of the release of deferred revenue upon the early close out of a customer arrangement. Lower revenues from advisory services were primarily due to lower activity on projects related to regulatory compliance remediation.

Constant currency service revenue growth during the year ended December 31, 2015 was also negatively impacted by cancellations from 2014.

2014 compared to 2013

Product Development’s service revenues were $3.1 billion in 2014, an increase of $178.1 million, or 6.1%, over 2013. This increase was comprised of constant currency service revenue growth of $183.2 million, or 6.3%, offset by a negative impact of approximately $5.1 million from the effects of foreign currency fluctuations. The constant currency service revenue growth was primarily a result of a volume-related increase of $100.2 million in clinical solutions and services and $89.6 million from the Novella acquisition, which were partially offset by a decrease of $6.6 from advisory services.

The volume-related service revenue growth from clinical solutions and services was related to an increase in clinical solutions provided on a functional resource basis, clinical trial support services, and core clinical services in Asia and Japan. This growth was due largely to execution on the higher backlog in place as we entered 2014. The rate of year-over-year revenue growth was negatively impacted by the wind-down of a large clinical solutions project delivered throughout 2013.

Costs of Revenue, Service Costs

2015 compared to 2014

Product Development’s service costs increased approximately $7.8 million in 2015 over 2014. This increase included a constant currency increase of $140.0 million, or 7.7%, which included the incremental impact from the businesses that Quest contributed to Q² Solutions, partially offset by $132.2 million from the positive effects of foreign currency fluctuations.

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The constant currency service costs growth was primarily due to the impact from the Q² Solutions transaction and an increase in compensation and related expenses. The increase in compensation and related expenses resulted from an increase in billable headcount as a result of the ramp up of new projects, which we expect to continue, as well as annual merit increases and an increase in competition for qualified personnel in certain markets. Also contributing to the constant currency increase was $17.2 million of expense recognized in the second quarter of 2015 as a result of the release of deferred contract costs upon the early close out of a customer arrangement. Service cost growth was partially offset by an $8.3 million increase in the benefit from research and development credits received in Europe when compared to the same period in the prior year. As a percent of service revenues, Product Development’s service costs were 57.3% and 58.8% in 2015 and 2014, respectively. The decrease in service costs as a percentage of service revenues reflected a favorable impact of 170 basis points from the effects of foreign currency fluctuations and a closer alignment of resources with project requirements, including cost efficiencies gained from restructuring actions taken in prior years, which more than offset the impact of the constant currency service costs growth noted above.

2014 compared to 2013

Product Development’s service costs increased approximately $68.1 million in 2014 over 2013. This increase was comprised of a $94.0 million constant currency increase, or 5.4%, partially offset by a reduction of $25.9 million from the positive effect of foreign currency fluctuations.

The constant currency service costs growth was due to (1) incremental costs resulting from the Novella acquisition, (2) an increase in billable headcount and other expenses directly related to our service contracts to support our higher volume of revenue, and (3) a reduction of an accrual for statutory profit sharing of approximately $5.4 million in 2013 as a result of guidance handed down by an administrative court in France. These increases in service costs were partially offset by a $10.6 million increase in the benefit from research and development grants primarily from France and Austria as well as efficiencies gained from restructuring activities taken in prior years. As a percent of service revenues, Product Development’s service costs were 58.8% and 60.0% in 2014 and 2013, respectively. The decrease in service costs as a percentage of service revenues was primarily a result of a closer alignment of resources with project requirements, including cost efficiencies gained from restructuring actions taken in prior years.

Selling, General and Administrative

2015 compared to 2014

Product Development’s selling, general and administrative expenses increased approximately $16.6 million, or 2.6%, in 2015 as compared to 2014. This increase was primarily caused by a constant currency increase of $47.2 million, which included the incremental impact from the businesses that Quest contributed to Q² Solutions, partially offset by a reduction of $30.6 million from the positive effects of foreign currency fluctuations. As a percent of service revenues, Product Development’s selling, general and administrative expenses were 20.3% and 20.4% in 2015 and 2014, respectively.

The constant currency increase was primarily due to the incremental impact from the businesses that Quest contributed to Q² Solutions, higher compensation and related expenses due to annual merit increases and an increase in headcount.

2014 compared to 2013

Product Development’s selling, general and administrative expenses increased approximately $27.1 million, or 4.5%, in 2014 as compared to 2013. This increase was primarily caused by a constant currency increase of $33.6 million, which included the impact from the Novella acquisition. These increases were partially offset by $8.4 million of costs incurred in 2013 that did not recur in 2014 for severance associated with cost reduction programs as well as a positive impact of approximately $6.5 million from the effects of foreign currency fluctuations. As a percent of service revenues, Product Development’s selling, general and administrative expenses were 20.4% and 20.7% in 2014 and 2013, respectively.

The constant currency increase was primarily caused by the impact from the Novella acquisition, increases in compensation and related expenses resulting from annual merit increases and an increase in headcount, and a growth related increase in IT costs.

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Integrated Healthcare Services

										Change
	2015			2014			2013			2015 vs. 2014				2014 vs. 2013
	(dollars in millions)
Service revenues	$	1,134.8		$	1,068.0		$	888.6		$	66.8	6.3	%	$	179.4	20.2	%
Costs of revenue, service costs		896.9			863.2			718.6			33.7	3.9			144.6	20.1
as a percentage of service revenues		79.0	%		80.8	%		80.9	%
Selling, general and administrative		153.9			140.0			127.9			13.9	9.9			12.1	9.5
as a percentage of service revenues		13.6	%		13.1	%		14.4	%
Segment income from operations	$	84.0		$	64.8		$	42.1		$	19.2	29.7	%	$	22.7	53.8	%
as a percentage of service revenues		7.4	%		6.1	%		4.7	%

Service Revenues

2015 compared to 2014

Integrated Healthcare Services’ service revenues were $1,134.8 million in 2015, an increase of $66.8 million, or 6.3%, over 2014. This increase was comprised of constant currency service revenue growth of $149.4 million, or 14.0%, including $43.8 million from the Encore acquisition which closed in July 2014, partially offset by a negative impact of approximately $82.6 million due to the effects of foreign currency fluctuations.

The increase in constant currency service revenues was due to the impact from the Encore acquisition which closed in July 2014, an increase in commercial services in North America, as well as growth in real-world and late phase research services. In addition, 2015 was impacted by a decline in Europe due to the loss of revenue from an agreement to distribute pharmaceutical products in Italy that ended in the fourth quarter of 2014.

2014 compared to 2013

Integrated Healthcare Services’ service revenues were $1,068.0 million in 2014, an increase of $179.4 million, or 20.2%, over 2013. This increase is comprised of constant currency service revenue growth of $200.0 million, or 22.5%, partially offset by a negative impact of approximately $20.6 million due to the effect of foreign currency fluctuations.

The increase in constant currency service revenues was driven by $35.4 million from the Encore acquisition and an increase in commercial services in North America and Japan, as well as growth in real-world and late phase research services. These increases were partially offset by a decline in Europe due to lower revenue from an agreement to distribute pharmaceutical products in Italy as well as lower commercial services revenues. The agreement to distribute pharmaceutical products in Italy ended in the fourth quarter of 2014.

Costs of Revenue, Service Costs

2015 compared to 2014

Integrated Healthcare Services’ service costs increased approximately $33.7 million in 2015. This increase was comprised of a $99.5 million constant currency increase, or 11.5%, partially offset by a reduction of $65.8 million from the positive effects of foreign currency fluctuations.

The constant currency increase for 2015 was due to the impact of the Encore acquisition and an increase in compensation and related expenses resulting from an increase in billable headcount needed to support the higher volume of constant currency revenue and annual merit increases. These increases in compensation and related expenses were partially offset by a decline in other expenses directly related to the agreement to distribute pharmaceutical products in Italy, which ended in the fourth quarter of 2014.

As a percent of service revenues, costs of revenue was 79.0% in 2015 as compared to 80.8% in the prior year. This improvement in profit margin (as a percent of service revenues) resulted primarily from constant currency profit margin expansion in real-world and late phase research services, and commercial services in Japan as well as in Europe, including the impact from the termination of the low margin agreement to distribute pharmaceutical products in Italy in 2014. This constant currency profit margin expansion was partially offset by a negative impact from foreign currency fluctuations.

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2014 compared to 2013

Integrated Healthcare Services’ service costs increased approximately $144.6 million in 2014. This increase was comprised of a $159.5 million constant currency increase, or 22.2%, partially offset by a reduction of $14.9 million from the positive effect of foreign currency fluctuations.

The constant currency increase was primarily due to the impact from the Encore acquisition and increases in compensation and related expenses resulting from an increase in billable headcount needed to support the higher volume of revenue and annual merit compensation increases. These increases in compensation and related expenses were partially offset by a decline in other expenses directly related to the agreement to distribute pharmaceutical products in Italy, which ended in the fourth quarter of 2014.

Selling, General and Administrative

2015 compared to 2014

Integrated Healthcare Services’ selling, general and administrative expenses increased approximately $13.9 million, or 9.9%, in 2015 as compared to 2014. This increase was comprised of a $20.7 million constant currency increase, or 14.8%, partially offset by a reduction of $6.8 million from the positive effects of foreign currency fluctuations.

The constant currency increase was primarily due to the impact from the Encore acquisition which closed in July 2014 and an increase in compensation and related expenses.

2014 compared to 2013

Integrated Healthcare Services’ selling, general and administrative expenses increased approximately $12.1 million, or 9.5%, in 2014 as compared to 2013. This increase was comprised of a $13.0 million constant currency increase, or 10.2%. This increase was partially offset by $1.6 million of costs incurred in 2013 that did not recur in 2014 for severance associated with cost reduction programs as well as a positive impact of approximately $900,000 from the effects of foreign currency fluctuations.

The constant currency increase was primarily due to the impact from the Encore acquisition which closed in July 2014 and increases in compensation and related expenses. The increase in compensation and related expenses resulted from annual merit increases and an increase in headcount.

Liquidity and Capital Resources

Overview

We assess our liquidity in terms of our ability to generate cash to fund our operating, investing and financing activities. Our principal source of liquidity is operating cash flows. In addition to operating cash flows, other significant factors that affect our overall management of liquidity include: capital expenditures, acquisitions, investments, debt service requirements, dividends, equity repurchases, adequacy of our revolving credit and receivables financing facilities and access to the capital markets.

We manage our worldwide cash requirements by monitoring the funds available among our subsidiaries and determining the extent to which those funds can be accessed on a cost effective basis. The repatriation of cash balances from certain of our subsidiaries could have adverse income tax consequences. The earnings of most of our foreign subsidiaries are considered indefinitely reinvested outside the United States, which limits our ability to repatriate cash from our foreign subsidiaries for the foreseeable future.

We had a cash balance of $977.2 million at December 31, 2015 ($244.9 million of which was in the United States), an increase from $867.4 million at December 31, 2014.

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Based on our current operating plan, we believe that our available cash and cash equivalents, future cash flows from operations and our ability to access funds under our revolving credit and receivables financing facilities will enable us to fund our operating requirements and capital expenditures and meet debt obligations for at least the next 12 months. We regularly evaluate our debt arrangements, as well as market conditions, and from time to time we may explore opportunities to modify our existing debt arrangements or pursue additional financing arrangements that could result in the issuance of new debt securities by us or our affiliates. We may use our existing cash, cash generated from operations or dispositions of assets or businesses and/or proceeds from any new financing arrangements or issuances of debt or equity securities to repay or reduce some of our outstanding obligations, to repurchase shares from our shareholders or for other purposes. As part of our ongoing business strategy, we also are continually evaluating new acquisition, expansion and investment possibilities or other strategic growth opportunities, as well as potential dispositions of assets or businesses, as appropriate, including dispositions that may cause us to recognize a loss on certain assets. Should we elect to pursue any such transaction, we may seek to obtain debt or equity financing to facilitate those activities. Our ability to enter into any such potential transactions and our use of cash or proceeds is limited to varying degrees by the terms and restrictions contained in our senior secured credit facilities. We cannot provide assurances that we will be able to complete any such financing arrangements or other transactions on favorable terms or at all.

Equity Repurchases

Since 2013, we have repurchased approximately $995.6 million of our equity securities as discussed further below.

Equity Repurchase Program

On October 30, 2013, our Board approved the Repurchase Program authorizing the repurchase of up to $125.0 million of either our common stock or vested in-the-money employee stock options, or a combination thereof. During 2015, our Board increased the share repurchase authorization under the Repurchase Program by $600.0 million, which increased the total amount that has been authorized under the Repurchase Program to $725.0 million. The Repurchase Program does not obligate us to repurchase any particular amount of common stock or vested in-the-money employee stock options and it can be modified, suspended or discontinued at any time. Repurchases of vested in-the-money employee stock options were made through transactions between us and our employees (other than our executive officers, who were not eligible to participate in the program), and this aspect of the Repurchase Program expired in November 2013. The Repurchase Program for common stock does not have an end date. Under the Repurchase Program in 2015, we repurchased 7,855,796 shares of common stock for an aggregate purchase price of $515.0 million (representing an average price per share of $65.56). From inception through December 31, 2015, we have repurchased $59.1 million of stock options and $521.4 million of common stock under the Repurchase Program. As of December 31, 2015, we have remaining authorization under the Repurchase Program to repurchase up to $144.5 million of our common stock. Additional information regarding the Repurchase Program is presented in Part II, Item 5 “Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities” and Note 12 to our audited consolidated financial statements included elsewhere in this Annual Report on Form 10-K.

Other Equity Repurchases

On May 28, 2014, we completed the repurchase of 3,287,209 shares of our common stock for $50.23 per share from TPG Quintiles Holdco, L.P., one of our existing shareholders, in a private transaction for an aggregate purchase price of approximately $165.1 million. The repurchase price per share of common stock was equal to 98% of the closing market price of our common stock on the NYSE on May 27, 2014 (which was $51.26). The repurchase of shares from our existing shareholder was authorized in compliance with our related party transactions approval policy. We funded this private repurchase transaction with cash on hand. This private repurchase transaction was separate from and in addition to the Repurchase Program.

On November 10, 2014, we completed the repurchase of 4,303,666 shares of our common stock for $58.09 per share for an aggregate purchase price of approximately $250.0 million. We funded this repurchase transaction with a combination of cash on hand and a $150.0 million draw on our revolving credit facility which was subsequently repaid. This repurchase transaction was separate from and in addition to the Repurchase Program.

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Senior Secured Credit Agreement and Senior Notes

On May 12, 2015, Quintiles Transnational entered into new senior secured credit facilities, or the New Facilities, totaling $1.95 billion. The New Facilities consist of a five-year $500.0 million revolving credit facility, or the New Revolver, and $1.45 billion of term loans ($850 million in Term Loan A due 2020, or Term Loan A, and $600 million in Term Loan B due 2022, or Term Loan B). In addition, Quintiles Transnational issued $800 million of 4.875% senior unsecured notes due 2023, or the Senior Notes, in a private placement. The New Facilities and the Senior Notes are referred to collectively as the “New Debt.” Annual maturities on the Term Loan A and the Term Loan B are 5% and 1%, respectively, of the respective original principal amount with the remaining balances to be repaid on their respective maturity dates. Beginning with the fiscal year ending December 31, 2016, we will be required to make mandatory repayments on Term Loan A and Term Loan B of 50% of excess cash flow (as defined in the credit agreement covering the New Facilities, subject to a reduction to 25% or 0% depending upon our leverage ratio). Based on our current expectations, we do not anticipate any significant mandatory repayments. Mandatory repayments will be allocated pro rata between Term Loan A and Term Loan B (subject to increases in the amount of Term Loan A repayments with amounts declined by Term Loan B lenders), and applied, first, to reduce the next eight quarterly amortization installments in direct order of maturity, and, second, to reduce all remaining amortization installments pro rata. We also will be required to make mandatory repayments with 100% of the net cash proceeds of certain asset dispositions, subject to thresholds and reinvestment rights. Any amounts outstanding under the New Facilities may be voluntarily repaid at any time without penalty. The new senior secured credit facilities arrangements are collateralized by substantially all of the assets of Quintiles Transnational and the assets of Quintiles Transnational’s domestic subsidiaries including 100% of the equity interests of substantially all of Quintiles Transnational’s domestic subsidiaries and 65% of the equity interests of substantially all of the first-tier foreign subsidiaries of Quintiles Transnational and its domestic subsidiaries. Interest on the Senior Notes is paid semiannually on May 15 and November 15 of each year until maturity. The Senior Notes are unsecured senior obligations of Quintiles Transnational and are effectively subordinated in right of payment to all secured obligations of Quintiles Transnational, to the extent of the value of any collateral. We used the proceeds from the New Debt (i) to repay the Term Loan B-3 under our then outstanding senior credit agreement which was due in 2018, (ii) to pay related fees and expenses including $11.0 million of breakage fees associated with the terminated interest rate swaps, and (iii) for general corporate purposes including the share repurchase discussed above.

Receivables Financing Facility

On December 5, 2014, we entered into a four-year arrangement to securitize certain of our accounts receivable. Under the receivables financing facility, certain of our accounts receivable are sold on a non-recourse basis by certain of our consolidated subsidiaries to another of our consolidated subsidiaries, a bankruptcy-remote special purpose entity, or SPE. The SPE obtained a term loan and revolving loan commitment from a third party lender, secured by liens on the assets of the SPE, to finance the purchase of the accounts receivable, which included a $275.0 million term loan and a $25.0 million revolving loan commitment. The revolving loan commitment may be increased by an additional $35.0 million as amounts are repaid under the term loan. Quintiles Transnational has guaranteed the performance of the obligations of existing and future subsidiaries that sell and service the accounts receivable under the receivables financing facility. The assets of the SPE are not available to satisfy any of our obligations or any obligations of our subsidiaries. The interest rate under the receivables financing facility is a reserve-adjusted LIBOR rate for amounts outstanding on the term loan and a reserve-adjusted LIBOR market index rate for amounts outstanding on the revolving loan. Interest is payable monthly. We used the proceeds from the term loan under the receivables financing facility to repay in full the amount outstanding on the revolving credit facility under our senior secured credit agreement ($150.0 million), to repay $25.0 million of the Term Loan B-3 under our then outstanding senior secured credit agreement, to pay related fees and expenses and the remainder was used for general working capital purposes. As of December 31, 2015, the full $25.0 million of revolving loan commitment was available under the receivables financing facility.

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Restrictive Covenants

The credit agreement governing the Quintiles Transnational senior secured credit facilities contains usual and customary restrictive covenants (subject to significant exceptions) that place limitations on Quintiles Transnational’s ability, and the ability of Quintiles Transnational’s restricted subsidiaries, to incur liens; engage in acquisitions, loans and other investments; incur additional indebtedness; merge, dissolve, liquidate or consolidate with or into other persons; sell or otherwise dispose of assets; declare dividends, including to Quintiles Transnational Holdings Inc., and make other restricted payments; engage in businesses that are not related to Quintiles Transnational’s and its restricted subsidiaries’ existing business; transact with affiliates; enter into agreements that restrict subsidiaries from paying intercompany dividends or completing intercompany property transfers or that restrict the ability to create liens in favor of Quintiles Transnational’s lenders; amend or otherwise modify organizational documents or terms and conditions of junior financing documents, if any; change the fiscal year of Quintiles Transnational; prepay, redeem or purchase junior financing, if any; designate any other indebtedness as “designated senior indebtedness” or “senior secured financing”; and engage in sale and leaseback transactions. The credit agreement also contains one financial covenant, which is a total leverage ratio that provides for a maximum ratio of consolidated total debt to consolidated EBITDA, as defined in the credit agreement, for any period of four consecutive fiscal quarters, measured as of the end of such period, of 5.75 to 1.00, and applies at any time that the Term Loan A or New Revolver commitments remain outstanding. Violations of the financial covenant will not entitle the Term Loan B lenders to take any enforcement action prior to an acceleration of the New Revolver and the Term Loan A and, subject to customary limitations, may be cured with an equity contribution.

The agreement governing the Senior Notes limits Quintiles Transnational’s and its restricted subsidiaries’ (as defined in the agreement) ability to create liens and enter into sale and lease-back transactions.

The agreement governing the receivables financing facility contains certain usual and customary covenants and termination events for a securitization transaction, including certain financial reporting covenants and requirements to maintain the existence of the SPE separate from Quintiles Transnational and its other affiliates. An occurrence of an event of default or a termination event under this facility may give rise to the right of the third party lender to terminate this facility.

In 2015, 2014 and 2013, we believe we were in compliance with our restrictive covenants.

As of December 31, 2015, we had $2.5 billion of total indebtedness, excluding $534.0 million of additional available borrowings under our revolving credit facilities. There were no amounts drawn on the revolving credit facilities in 2015. See Note 10 to our audited consolidated financial statements included elsewhere in this Annual Report on Form 10-K for additional details regarding our credit arrangements.

Years ended December 31, 2015, 2014 and 2013

Cash Flow from Operating Activities

	Year Ended December 31,
	2015		2014		2013
	(in millions)
Net cash provided by operating activities	$	475.7	$	431.8	$	393.4

2015 compared to 2014

Cash provided by operating activities increased by $43.9 million in 2015 as compared to 2014. The increase in cash provided by operating activities primarily reflects the increase in net income including adjustments for non-cash items necessary to reconcile net income to cash provided by operating activities. Also contributing to the increase was an increase in accounts payable and accrued expenses ($58.5 million) as well as lower payments for interest ($11.6 million) and income taxes ($18.1 million). These improvements in operating cash flow were partially offset by higher cash used in days sales outstanding, or DSO. The higher cash used in DSO reflects a seven-day increase in DSO in 2015 compared to a two-day increase in DSO in 2014. DSO can shift significantly at each reporting period depending on the timing of cash receipts under contractual payment terms relative to the recognition of revenue over a project lifecycle.

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2014 compared to 2013

Cash provided by operating activities increased by $38.4 million in 2014 as compared to 2013. The increase in operating cash flow reflects an increase in net income, lower payments for interest ($21.6 million), and lower cash used in DSO ($21.1 million) in 2014 as compared to 2013. This lower cash used in DSO reflects a two-day increase in DSO in 2014 compared to a five-day increase in 2013. In addition, net income for 2013 included cash expenses totaling $32.5 million for a fee paid in connection with the termination of our management agreement with affiliates of certain of our shareholders ($25.0 million), a fee paid in connection with the modification of an agreement for the business usage of an airplane owned by GFM ($1.5 million), and a termination fee for the repayment of the $300.0 million term loan ($6.0 million), which did not recur in 2014. These increases in operating cash flow were partially offset by higher payments for income taxes ($67.9 million) and higher cash used for incentive compensation.

Cash Flow from Investing Activities

	Year Ended December 31,
	2015			2014			2013
	(in millions)
Net cash used in investing activities	$	(67.0	)	$	(173.1	)	$	(236.2	)

2015 compared to 2014

Cash used in investing activities decreased by $106.1 million in 2015 as compared to 2014. This decrease was primarily related to cash acquired in the Q² Solutions transaction ($31.7 million) compared to cash used for the acquisition of businesses ($92.2 million) in 2014, partially offset by the termination of interest rate swaps in connection with the refinancing transaction in 2015 ($11.0 million) and higher cash used for investments.

2014 compared to 2013

Cash used in investing activities decreased by $63.1 million to $173.1 million in 2014, as compared to $236.2 million in 2013. This decline in the use of cash in 2014 was primarily related to lower cash used for the acquisition of businesses. Cash used to acquire businesses in 2014 was $92.2 million, consisting primarily of the acquisition of Encore, as compared to 2013 which included the acquisition of Novella for approximately $145.0 million. Also contributing to the decline was lower cash used to acquire property, equipment and software and an increase in proceeds from the sale of equity securities.

Cash Flow from Financing Activities

	Year Ended December 31,
	2015			2014			2013
	(in millions)
Net cash (used in) provided by financing activities	$	(249.2	)	$	(130.3	)	$	71.0

2015 compared to 2014

Cash used in financing activities increased by $118.9 million in 2015 as compared to 2014. The increase in cash used in financing activities in 2015 was primarily related to higher cash used to repurchase common stock ($99.9 million) and lower cash provided by debt issuances, net of repayments ($75.4 million), partially offset by higher cash from stock issued under employee stock purchase and option plans ($29.1 million), and an increase in the excess income tax benefits from share-based award activities ($18.8 million).

2014 compared to 2013

Net cash used in financing activities was $130.3 million in 2014, as compared to cash provided by financing activities of $71.0 million in 2013. The cash used in financing activities in 2014 was primarily related to the repurchase of common stock ($415.1 million), partially offset by the proceeds from issuance of debt ($275.0 million) and the proceeds from stock issued under employee stock purchase and option plans ($35.2 million). The repurchase of common stock was funded, in part, by a $150.0 million draw on our line of credit under our senior secured credit facility. This line of credit draw was repaid in full in 2014 from the proceeds of a $275.0 million term loan under our receivables financing facility, which closed in December 2014. The proceeds from the $275.0 million term loan were also used to repay $25.0 million of outstanding indebtedness on the Term Loan B-3 under our senior secured credit facility.

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Contractual Obligations and Commitments

Below is a summary of our future payment commitments by year under contractual obligations as of December 31, 2015 (in millions):

	2016		2017-2018		2019-2020		Thereafter		Total
Long-term debt, including interest (1)	$	131.9	$	536.1	$	853.3	$	1,489.5	$	3,010.8
Operating leases		84.7		104.4		54.9		111.3		355.3
Purchase obligations (2)		2.3		0.9		0.4		0.2		3.8
Commitments to unconsolidated affiliates (3)		0.8		—		—		—		0.8
Defined benefit plans (4)		5.5		—		—		—		5.5
Uncertain income tax positions (5)		0.3		—		—		—		0.3
Contingent consideration (6)		4.4		—		—		—		4.4
Total	$	229.9	$	641.4	$	908.6	$	1,601.0	$	3,380.9

(1) Interest payments on floating rate debt for the senior secured credit agreement and receivables financing facility are based on the interest rates in effect on December 31, 2015.

(2) Purchase obligations are defined as agreements to purchase goods or services that are enforceable and legally binding and that specify all significant terms, including fixed or minimum quantities to be purchased, fixed, minimum or variable pricing provisions and the approximate timing of the transactions.

(3) We are currently committed to invest $70.0 million in private equity funds. As of December 31, 2015, we have funded approximately $37.3 million of these commitments and we have approximately $32.7 million remaining to be funded.

(4) We made cash contributions totaling approximately $6.0 million to our defined benefit plans in 2015, and we estimate that we will make contributions totaling approximately $5.5 million in 2016. Due to the potential impact of future plan investment performance, changes in interest rates, changes in other economic and demographic assumptions and changes in legislation in foreign jurisdictions, we are not able to reasonably estimate the timing and amount of contributions that may be required to fund our defined benefit plans for periods beyond 2016.

(5) As of December 31, 2015, our liability related to uncertain income tax positions was approximately $32.1 million, $31.8 million of which has not been included in the above table as we are unable to predict when these liabilities will be paid due to the uncertainties in the timing of the settlement of the income tax positions.

(6) Contingent consideration payable in connection with an acquisition.

Subsequent Event

In February 2016, our Board approved a restructuring plan for approximately $22 million, primarily for severance and other exit costs, to align our resources and reduce overcapacity. Some of these actions are subject to certain legal and regulatory requirements. We anticipate that these actions, if implemented, will occur in 2016 and are expected to result in a reduction of approximately $18 million to $20 million of service revenues during the year ended December 31, 2016 when compared to the same period in 2015.

Application of Critical Accounting Policies

Note 1 to the consolidated financial statements provided elsewhere in this Annual Report on Form 10-K describes the significant accounting policies used in the preparation of the consolidated financial statements. The preparation of our consolidated financial statements requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, and the disclosure of contingent assets and liabilities at the date of the financial statements, as well as the reported amounts of revenues and expenses during the period. Our estimates are based on historical experience and various other assumptions we believe are reasonable under the circumstances. We evaluate our estimates on an ongoing basis and make changes to the estimates and related disclosures as experience develops or new information becomes known. Actual results may differ from those estimates.

We believe the following critical accounting policies affect our more significant judgments and estimates used in the preparation of our consolidated financial statements.

56

Revenue Recognition

We recognize revenue when all of the following conditions are satisfied: (1) there is persuasive evidence of an arrangement, (2) the service offering has been delivered to the customer, (3) the collection of fees is probable and (4) the arrangement consideration is fixed or determinable. We do not recognize revenue with respect to start-up activities including contract and scope negotiation, feasibility analysis and conflict of interest review associated with contracts. The costs for these activities are expensed as incurred. For contracts in which portions of revenue are contingent upon the occurrence of uncertain future events we recognize the revenue only after it has been earned and the contingency has been resolved.

The majority of our revenue is recognized based on objective contractual criteria and does not require significant estimates or judgments. However, at any point in time we are working on thousands of active customer projects, which are governed by individual contracts. Most projects are customized based on the needs of the customer, the type of services being provided, therapeutic indication of the drug, geographic locations and other variables. Project specific terms related to pricing, billing terms and the scope and type of services to be provided are generally negotiated and contracted on a project-by-project basis. Changes in the scope of work are common, especially under long-term contracts, and generally result in a change in contract value. In such situations, we enter into negotiations for a contract amendment to reflect the change in scope and the related price. Depending on the complexity of the amendment, the negotiation process can take from a few weeks for a simple adjustment to several months for a complex amendment. Management may authorize the project team to commence work on activities outside the contract scope while we negotiate and finalize the contract amendment. In these limited cases, if we are not able to obtain a contract amendment from the customer, our profit margin on the arrangement may be impacted. This result occurs because our costs of delivery are expensed as they are incurred, while revenue is not recognized unless the customer has agreed to the changes in scope and renegotiated pricing terms, the contract value is amended and all other revenue recognition criteria are met.

For arrangements that include multiple elements, arrangement consideration is allocated to units of accounting based on the relative selling price. The best evidence of selling price of a unit of accounting is vendor-specific objective evidence, or VSOE, which is the price we charge when the deliverable is sold separately. When VSOE is not available to determine selling price, we use relevant third-party evidence, or TPE, of selling price, if available. When neither VSOE nor TPE of selling price exists, we use our best estimate of selling price considering all relevant information that is available without undue cost and effort.

Most contracts are terminable upon 30 to 90 days notice by the customer. Our risk of material loss in these situations is mitigated as these contracts generally require payment to us for expenses to wind down the clinical trial or project, fees earned to date and, in some cases, a termination fee or a payment of some portion of the fees or profits that could have been earned under the contract if it had not been terminated early. In addition, our contract terms provide for payment terms that generally correspond with performance of the services. Termination fees are included in service revenues when realization is assured.

Accounts Receivable and Unbilled Services

Accounts receivable represents amounts billed to customers. Revenues recognized in excess of billings are classified as unbilled services. The realization of these amounts is based on the customer’s willingness and ability to pay us. We have an allowance for doubtful accounts based on management’s estimate of probable losses we expect to incur resulting from a customer failing to pay us. Our allowance for doubtful accounts, and losses from customers failing to pay us, have not been material to our results of operations. If any of these estimates change or actual results differs from expected results, then an adjustment is recorded in the period in which the amounts become reasonably estimable. These adjustments could have a material effect on our results of operations.

Investments in Unconsolidated Affiliates — Equity Method Investments

We have investments in unconsolidated affiliates that are accounted for under the equity method of accounting. Periodically, we review our investments for a decline in value which we believe may be other than temporary. Should we identify such a decline, we will record a loss through earnings to establish a new cost basis for the investment. These losses could have a material adverse effect on our results of operations.

57

Income Taxes

Certain items of income and expense are not recognized on our income tax returns and financial statements in the same year, which creates timing differences. The income tax effect of these timing differences results in (1) deferred income tax assets that create a reduction in future income taxes and (2) deferred income tax liabilities that create an increase in future income taxes. Recognition of deferred income tax assets is based on management’s belief that it is more likely than not that the income tax benefit associated with certain temporary differences, income tax operating loss and capital loss carryforwards and income tax credits, would be realized. We recorded a valuation allowance to reduce our deferred income tax assets for those deferred income tax items for which it was more likely than not that realization would not occur. We determined the amount of the valuation allowance based, in part, on our assessment of future taxable income and in light of our ongoing income tax strategies. If our estimate of future taxable income or tax strategies changes at any time in the future, we would record an adjustment to our valuation allowance. Recording such an adjustment could have a material effect on our financial position.

Income tax expense is based on the distribution of profit before income tax among the various taxing jurisdictions in which we operate, adjusted as required by the income tax laws of each taxing jurisdiction. Changes in the distribution of profits and losses among taxing jurisdictions may have a significant impact on our effective income tax rate. We consider the undistributed earnings of most of our foreign subsidiaries to be indefinitely reinvested outside of the United States. Accordingly, we have not provided a deferred income tax liability related to those undistributed earnings.

Business Combinations

We use the acquisition method to account for business combinations, and accordingly, the identifiable assets acquired, the liabilities assumed and any noncontrolling interest in the acquiree are recorded at their estimated fair values on the date of the acquisition. We use significant judgments, estimates and assumptions in determining the estimated fair value of assets acquired, liabilities assumed and noncontrolling interest including expected future cash flows; discount rates that reflect the risk associated with the expected future cash flows; and estimated useful lives.

When a business combination involves contingent consideration, we recognize a liability equal to the estimated fair value of the contingent consideration obligation at the date of the acquisition. The estimate of fair value of a contingent consideration liability requires subjective assumptions to be made regarding future business results including revenues and net new business, discount rates that reflect the risk associated with the expected future cash flows and probabilities assigned to various potential business result scenarios. We periodically reassess the estimated fair value of the contingent consideration over the term of the arrangement. Any resulting changes are recognized in earnings and could have a material effect on our results of operations.

Goodwill, Tangible and Identifiable Intangible Assets

We have recorded and allocated to our reporting units the excess of the cost over the fair value of the net assets acquired, known as goodwill. The recoverability of the goodwill and indefinite-lived intangible assets are evaluated annually for impairment, or if and when events or circumstances indicate a possible impairment. Goodwill and indefinite-lived intangible assets are not amortized. We review the carrying values of other identifiable intangible assets if the facts and circumstances indicate a possible impairment. Based upon our 2015 annual testing, we believe that the risk of an impairment to goodwill or indefinite-lived intangible assets is currently very low, except for the Encore reporting unit. While we have concluded at this time that it is more likely than not that there is no impairment in the Encore reporting unit and concluded that a quantitative analysis was not necessary, if certain strategic initiatives do not perform as expected during 2016, a quantitative analysis may be required. Other identifiable intangible assets are amortized over their estimated useful lives.

For goodwill, we perform a qualitative analysis to determine whether it is more likely than not that the estimated fair value of a reporting unit is less than its book value. This includes a qualitative analysis of macroeconomic conditions, industry and market considerations, internal cost factors, financial performance, fair value history and other company specific events. If this qualitative analysis indicates that it is more likely than not that estimated fair value is less than the book value for the respective reporting unit, we apply a two-step impairment test in which we determine whether the estimated fair value of the reporting unit is in excess of its carrying value. If the carrying value of the net assets assigned to the reporting unit exceeds the estimated fair value of the reporting unit, we perform the second step of the impairment test to determine the implied estimated fair value of the reporting unit’s goodwill. We determine the implied estimated fair value of goodwill by determining the present value of the estimated future cash flows for each reporting unit and comparing the reporting unit’s risk profile and growth prospects to selected, reasonably similar publicly traded companies. The inherent subjectivity of applying a discounted cash flow and market comparables approach to valuing our assets and liabilities could have a significant impact on our analysis. Any future impairment could have a material adverse effect on our financial condition or results of operations.

58

For indefinite-lived intangible assets, we perform a qualitative analysis to determine whether it is more likely than not that the estimated fair value of the indefinite-lived intangible asset is less than its carrying value. If this qualitative analysis indicates that it is more likely than not that the estimated fair value is less than the carrying value of the indefinite-lived intangible asset, we determine the estimated fair value of the indefinite-lived intangible asset (trade name) by determining the present value of the estimated royalty payments on an after-tax basis that it would be required to pay the owner for the right to use such trade name. If the carrying amount exceeds the estimated fair value, an impairment loss is recognized in an amount equal to the excess. Any future impairment could have a material adverse effect on our financial condition or results of operations.

We review the carrying values of property and equipment if the facts and circumstances suggest that a potential impairment may have occurred. If this review indicates that carrying values will not be recoverable, as determined based on undiscounted cash flows over the remaining depreciation or amortization period, we will reduce carrying values to estimated fair value. The inherent subjectivity of our estimates of future cash flows could have a significant impact on our analysis. Any future write-offs of long-lived assets could have a material adverse effect on our financial condition or results of operations.

Share-based Compensation

We measure compensation cost for most share-based payment awards (stock options and stock appreciation rights) granted to employees and non-employee directors at fair value using the Black-Scholes-Merton option-pricing model. Share-based compensation expense includes share-based awards granted to employees and non-employee directors and has been reported in selling, general and administrative expenses in our consolidated statements of income based upon the classification of the individuals who were granted share-based awards.

The Black-Scholes-Merton option-pricing model requires the use of subjective assumptions, including share price volatility, the expected life of the award, risk-free interest rate and the fair value of the underlying common shares on the date of grant. In developing our assumptions, we take into account the following:

· As a result of our status as a private company prior to our IPO, we do not have sufficient history to estimate the volatility of our common share price. We calculate expected volatility based on reported data for selected reasonably similar publicly traded companies for which the historical information is available. We plan to continue to use the guideline peer group volatility information until the historical volatility of our common shares is relevant to measure expected volatility for future award grants;

· We determine the risk-free interest rate by reference to implied yields available from United States Treasury securities with a remaining term equal to the expected life assumed at the date of grant;

· We estimate the dividend yield to be zero as we do not currently anticipate paying any future dividends;

· We estimate the average expected life of the award based on our historical experience; and

· We estimate forfeitures based on our historical analysis of actual forfeitures.

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Item 7A. Quantitative and Qualitative Disclosures About Market Risk

Market risk is the potential loss arising from adverse changes in market rates and prices, such as foreign currency exchange rates, interest rates and other relevant market rate or price changes. In the ordinary course of business, we are exposed to various market risks, including changes in foreign currency exchange rates and interest rates, and we regularly evaluate our exposure to such changes. Our overall risk management strategy seeks to balance the magnitude of the exposure and the cost and availability of appropriate financial instruments. From time to time, we have utilized forward exchange contracts to manage our foreign currency exchange rate risk. The following analyses present the sensitivity of our financial instruments to hypothetical changes in rates that are reasonably possible over a one-year period.

Foreign Currency Exchange Rates

Approximately 32% and 38% of our service revenues for the years ended December 31, 2015 and 2014, respectively, were denominated in currencies other than the United States dollar. Our financial statements are reported in United States dollars and, accordingly, fluctuations in exchange rates will affect the translation of our revenues and expenses denominated in foreign currencies into United States dollars for purposes of reporting our consolidated financial results. In 2015 and 2014, the most significant currency exchange rate exposures were the Euro, British pound, Singapore dollar, Indian rupee and Japanese Yen. Excluding the impacts from any outstanding or future hedging transactions, a hypothetical change of 10% in average exchange rates used to translate all foreign currencies to United States dollars would have impacted income before income taxes for 2015 by approximately $45.4 million. Accumulated currency translation adjustments recorded as a separate component of shareholders’ deficit were ($116.8) million and ($55.7) million at December 31, 2015 and 2014, respectively. We do not have significant operations in countries in which the economy is considered to be highly-inflationary.

We are subject to foreign currency transaction risk for fluctuations in exchange rates during the period of time between the consummation and cash settlement of a transaction. We earn revenue from our service contracts over a period of several months and, in some cases, over a period of several years. Accordingly, exchange rate fluctuations during this period may affect our profitability with respect to such contracts. We limit our foreign currency transaction risk through exchange rate fluctuation provisions stated in our contracts with customers, or we may hedge our transaction risk with foreign currency exchange contracts. At December 31, 2015, we had 15 open foreign exchange forward contracts relating to service contracts with various amounts maturing monthly through September 2016 with a notional value totaling approximately $117.5 million. At December 31, 2014, we had 13 open foreign exchange forward contracts relating to service contracts with various amounts maturing monthly through September 2015 with a notional value totaling approximately $76.0 million.

Interest Rates

Because we have variable rate debt, fluctuations in interest rates affect our business. We attempt to minimize interest rate risk and lower our overall borrowing costs through the utilization of derivative financial instruments, primarily interest rate swaps. We have entered into interest rate swaps with financial institutions that have reset dates and critical terms that match those of our senior secured term loan credit facility. Accordingly, any change in market value associated with the interest rate swaps is offset by the opposite market impact on the related debt. As of December 31, 2015, we had approximately $1.7 billion of variable rate indebtedness. In June 2015, we entered into seven forward starting interest rate swaps with a notional value of $440.0 million which will be effective June 30, 2016 at which time we will have approximately $1.2 billion of variable rate indebtedness. The interest rate swaps expire between March 31, 2017 and March 31, 2020. Because we do not attempt to hedge all of our variable rate debt, we may incur higher interest costs for the portion of our variable rate debt which is not hedged. Once the interest rate swaps are effective, each quarter-point increase or decrease in the variable interest rate would result in our interest expense changing by approximately $3.1 million per year under our unhedged variable rate debt.

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Item 8. Financial Statements and Supplementary Data

MANAGEMENT’S REPORT ON INTERNAL CONTROL OVER FINANCIAL REPORTING

The management of Quintiles Transnational Holdings Inc. (the “Company”) is responsible for establishing and maintaining adequate internal control over financial reporting. Internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over financial reporting includes those policies and procedures that pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

Management assessed the effectiveness of the Company’s internal control over financial reporting as of December 31, 2015. In making this assessment, management used the framework established in Internal Control — Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). As a result of this assessment and based on the criteria in the COSO framework, management has concluded that, as of December 31, 2015, the Company’s internal control over financial reporting was effective.

The effectiveness of the Company’s internal control over financial reporting as of December 31, 2015 has been audited by PricewaterhouseCoopers LLP, an independent registered public accounting firm, as stated in their report which appears herein.

/s/ Thomas H. Pike	/s/ Michael R. McDonnell
Thomas H. Pike	Michael R. McDonnell
Chief Executive Officer	Executive Vice President and Chief Financial Officer
(Principal Executive Officer)	(Principal Financial Officer)

February 11, 2016

61

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Board of Directors and Shareholders of

Quintiles Transnational Holdings Inc.:

In our opinion, the consolidated financial statements listed in the index appearing under Item 15(a)(1) present fairly, in all material respects, the financial position of Quintiles Transnational Holdings Inc. and its subsidiaries at December 31, 2015 and 2014, and the results of their operations and their cash flows for each of the three years in the period ended December 31, 2015 in conformity with accounting principles generally accepted in the United States of America. In addition, in our opinion, the financial statement schedules listed in the index appearing under Item 15(a)(2) present fairly, in all material respects, the information set forth therein when read in conjunction with the related consolidated financial statements. Also in our opinion, the Company maintained, in all material respects, effective internal control over financial reporting as of December 31, 2015, based on criteria established in Internal Control - Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). The Company’s management is responsible for these financial statements and financial statement schedules, for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of internal control over financial reporting, included in the accompanying Management’s Report on Internal Control over Financial Reporting. Our responsibility is to express opinions on these financial statements, on the financial statement schedules, and on the Company’s internal control over financial reporting based on our audits (which were integrated audits in 2015 and 2014). We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audits to obtain reasonable assurance about whether the financial statements are free of material misstatement and whether effective internal control over financial reporting was maintained in all material respects. Our audits of the financial statements included examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management, and evaluating the overall financial statement presentation. Our audit of internal control over financial reporting included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, and testing and evaluating the design and operating effectiveness of internal control based on the assessed risk. Our audits also included performing such other procedures as we considered necessary in the circumstances. We believe that our audits provide a reasonable basis for our opinions.

A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over financial reporting includes those policies and procedures that (i) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (ii) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (iii) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

/s/ PricewaterhouseCoopers LLP

Raleigh, North Carolina

February 11, 2016

62

QUINTILES TRANSNATIONAL HOLDINGS INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF INCOME

	Year Ended December 31,
	2015			2014			2013
	(in thousands, except per share data)
Service revenues	$	4,326,419		$	4,165,822		$	3,808,340
Reimbursed expenses		1,411,200			1,294,176			1,291,205
Total revenues		5,737,619			5,459,998			5,099,545
Costs of revenue, service costs		2,725,586			2,684,106			2,471,426
Costs of revenue, reimbursed expenses		1,411,200			1,294,176			1,291,205
Selling, general and administrative		920,985			882,338			860,510
Restructuring costs		30,752			8,988			14,071
Impairment charges		2,484			—			—
Income from operations		646,612			590,390			462,333
Interest income		(4,317	)		(3,410	)		(3,937	)
Interest expense		101,792			100,589			123,508
Loss on extinguishment of debt		7,780			—			19,831
Other expense (income), net		2,362			(8,978	)		(185	)
Income before income taxes and equity in earnings (losses) of unconsolidated affiliates		538,995			502,189			323,116
Income tax expense		158,989			150,056			95,965
Income before equity in earnings (losses) of unconsolidated affiliates		380,006			352,133			227,151
Equity in earnings (losses) of unconsolidated affiliates		8,298			4,368			(1,124	)
Net income		388,304			356,501			226,027
Net (income) loss attributable to noncontrolling interests		(1,099	)		(118	)		564
Net income attributable to Quintiles Transnational Holdings Inc.	$	387,205		$	356,383		$	226,591
Earnings per share attributable to common shareholders:
Basic	$	3.15		$	2.78		$	1.83
Diluted	$	3.08		$	2.72		$	1.77
Weighted average common shares outstanding:
Basic		123,038			127,994			124,147
Diluted		125,630			131,083			127,862

The accompanying notes are an integral part of these consolidated financial statements.

63

QUINTILES TRANSNATIONAL HOLDINGS INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME

	Year Ended December 31,
	2015			2014			2013
	(in thousands)
Net income	$	388,304		$	356,501		$	226,027
Comprehensive income adjustments:
Unrealized (losses) gains on marketable securities, net of income taxes of ($168), ($376) and $2,016		(268	)		(600	)		3,225
Unrealized (losses) gains on derivative instruments, net of income taxes of ($3,679), ($1,767) and ($751)		(9,523	)		(5,067	)		358
Defined benefit plan adjustments, net of income taxes of $318, ($2,981) and ($131)		(36	)		(7,237	)		2,278
Foreign currency translation, net of income taxes of ($5,581), ($2,101) and ($2,465)		(60,024	)		(47,807	)		(22,663	)
Reclassification adjustments:
Gains on marketable securities included in net income, net of income taxes of ($1,927)		—			(3,077	)		—
Losses on derivative instruments included in net income, net of income taxes of $5,826, $4,022 and $4,991		12,443			4,608			8,089
Amortization of prior service costs and losses included in net income, net of income taxes of $355, $275 and $389		618			468			655
Comprehensive income		331,514			297,789			217,969
Comprehensive loss (income) attributable to noncontrolling interests		3,416			(121	)		551
Comprehensive income attributable to Quintiles Transnational Holdings Inc.	$	334,930		$	297,668		$	218,520

The accompanying notes are an integral part of these consolidated financial statements.

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QUINTILES TRANSNATIONAL HOLDINGS INC. AND SUBSIDIARIES

CONSOLIDATED BALANCE SHEETS

	December 31,
	2015			2014
	(in thousands, except per share data)
ASSETS
Current assets:
Cash and cash equivalents	$	977,151		$	867,358
Restricted cash		2,478			2,882
Trade accounts receivable and unbilled services, net		1,165,749			975,255
Prepaid expenses		50,624			44,628
Deferred income taxes		100,978			118,515
Income taxes receivable		34,089			45,357
Other current assets and receivables		80,916			92,088
Total current assets		2,411,985			2,146,083
Property and equipment, net		188,393			190,297
Investments in debt, equity and other securities		32,911			34,503
Investments in and advances to unconsolidated affiliates		52,382			31,508
Goodwill		719,740			464,434
Other identifiable intangibles, net		368,106			280,243
Deferred income taxes		42,684			35,972
Deposits and other assets		110,115			112,913
Total assets	$	3,926,316		$	3,295,953
LIABILITIES AND SHAREHOLDERS’ DEFICIT
Current liabilities:
Accounts payable	$	145,484		$	108,743
Accrued expenses		760,757			733,644
Unearned income		584,646			543,305
Income taxes payable		35,173			55,694
Current portion of long-term debt and obligations held under capital leases		48,513			826
Other current liabilities		19,603			29,688
Total current liabilities		1,594,176			1,471,900
Long-term debt and obligations held under capital leases, less current portion		2,419,293			2,282,612
Deferred income taxes		65,702			61,797
Other liabilities		182,826			183,656
Total liabilities		4,261,997			3,999,965
Commitments and contingencies (Note 1)
Shareholders’ deficit:
Common stock and additional paid-in capital, 300,000 shares authorized, $0.01 par value, 119,378 and 124,129 shares issued and outstanding at December 31, 2015 and 2014, respectively		8,784			143,828
Accumulated deficit		(461,635	)		(788,798	)
Accumulated other comprehensive loss		(111,366	)		(59,091	)
Deficit attributable to Quintiles Transnational Holdings Inc.’s shareholders		(564,217	)		(704,061	)
Noncontrolling interests		228,536			49
Total shareholders’ deficit		(335,681	)		(704,012	)
Total liabilities and shareholders’ deficit	$	3,926,316		$	3,295,953

The accompanying notes are an integral part of these consolidated financial statements.

65

QUINTILES TRANSNATIONAL HOLDINGS INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF CASH FLOWS

	Year Ended December 31,
	2015			2014			2013
	(in thousands)
Operating activities:
Net income	$	388,304		$	356,501		$	226,027
Adjustments to reconcile net income to cash provided by operating activities:
Depreciation and amortization		127,742			121,013			107,504
Amortization of debt issuance costs and discount		9,170			6,688			21,825
Amortization of accumulated other comprehensive loss on terminated interest rate swaps		7,881			—			—
Share-based compensation		37,758			30,001			22,826
Gain on disposals of property and equipment, net		(710	)		(975	)		(1,153	)
Impairment of long-lived assets		2,484			—			—
(Earnings) loss from unconsolidated affiliates		(8,265	)		(4,346	)		1,004
Loss (gain) on investments, net		1,012			(4,797	)		(183	)
Provision for (benefit from) deferred income taxes		18,351			(6,168	)		(24,236	)
Excess income tax benefits from share-based award activities		(39,071	)		(20,303	)		(16,204	)
Changes in operating assets and liabilities:
Accounts receivable and unbilled services		(246,028	)		(78,630	)		(151,681	)
Prepaid expenses and other assets		14,436			(40,832	)		(18,576	)
Accounts payable and accrued expenses		104,350			45,804			107,047
Unearned income		53,847			19,943			71,852
Income taxes payable and other liabilities		4,430			7,855			47,319
Net cash provided by operating activities		475,691			431,754			393,371
Investing activities:
Acquisition of property, equipment and software		(78,391	)		(82,650	)		(88,347	)
Acquisition of businesses, net of cash acquired		31,725			(92,201	)		(144,970	)
Proceeds from disposition of property and equipment		2,491			1,611			2,021
Proceeds from sale of equity securities		—			5,861			60
Investments in and advances to unconsolidated affiliates, net of payments received		(12,350	)		(4,472	)		(7,353	)
Termination of interest rate swaps		(10,981	)		—			—
Other		551			(1,263	)		2,413
Net cash used in investing activities		(66,955	)		(173,114	)		(236,176	)
Financing activities:
Proceeds from issuance of debt		2,248,500			275,000			2,060,755
Payment of debt issuance costs		(22,028	)		(1,455	)		(2,607	)
Repayment of debt		(2,056,780	)		(30,157	)		(2,444,600	)
Proceeds from revolving credit facility		—			150,000			—
Repayment of revolving credit facility		—			(150,000	)		—
Principal payments on capital lease obligations		(4,296	)		(2,612	)		(3,812	)
Contingent consideration paid		(3,000	)		(3,000	)		—
Issuance of common stock		—			—			525,000
Payment of common stock issuance costs		—			(105	)		(35,439	)
Stock issued under employee stock purchase and option plans		64,297			35,228			12,539
Repurchase of common stock		(515,010	)		(415,131	)		(6,434	)
Repurchase of stock options		—			(8,415	)		(50,649	)
Excess income tax benefits from share-based award activities		39,071			20,303			16,204
Net cash (used in) provided by financing activities		(249,246	)		(130,344	)		70,957
Effect of foreign currency exchange rate changes on cash		(49,697	)		(39,081	)		(17,737	)
Increase in cash and cash equivalents		109,793			89,215			210,415
Cash and cash equivalents at beginning of period		867,358			778,143			567,728
Cash and cash equivalents at end of period	$	977,151		$	867,358		$	778,143

The accompanying notes are an integral part of these consolidated financial statements.

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QUINTILES TRANSNATIONAL HOLDINGS INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF SHAREHOLDERS’ DEFICIT

	(Accumulated Deficit)			Accumulated Other Comprehensive (Loss) Income			Common Stock			Additional Paid-In Capital			Noncontrolling Interests			Total
	(in thousands, except share data)
Balance, December 31, 2012 (115,763,510 shares)	$	(1,371,772	)	$	7,695		$	1,158		$	3,396		$	479		$	(1,359,044	)
Issuance of common stock (14,041,620 shares)		—			—			141			537,398			—			537,539
Stock issuance costs		—			—			—			(35,439	)		—			(35,439	)
Repurchase of common stock (153,223 shares)		—			—			(2	)		(6,432	)		—			(6,434	)
Repurchase of stock options		—			—			—			(59,064	)		—			(59,064	)
Share-based compensation		—			—			—			20,784			—			20,784
Income tax benefits from share-based award activities		—			—			—			16,204			—			16,204
Net income		226,591			—			—			—			(564	)		226,027
Unrealized gain on marketable securities, net of tax		—			3,225			—			—			—			3,225
Unrealized gain on derivative instruments, net of tax		—			358			—			—			—			358
Defined benefit plan adjustments, net of tax		—			2,278			—			—			—			2,278
Foreign currency translation, net of tax		—			(22,676	)		—			—			13			(22,663	)
Reclassification adjustments, net of tax		—			8,744			—			—			—			8,744
Balance, December 31, 2013 (129,651,907 shares)		(1,145,181	)		(376	)		1,297			476,847			(72	)		(667,485	)
Issuance of common stock (2,068,608 shares)		—			—			21			35,281			—			35,302
Stock issuance costs		—			—			—			(105	)		—			(105	)
Repurchase of common stock (7,591,175 shares)		—			—			(76	)		(415,055	)		—			(415,131	)
Share-based compensation		—			—			—			25,315			—			25,315
Income tax benefits from share-based award activities		—			—			—			20,303			—			20,303
Net income		356,383			—			—			—			118			356,501
Unrealized loss on marketable securities, net of tax		—			(600	)		—			—			—			(600	)
Unrealized loss on derivative instruments, net of tax		—			(5,067	)		—			—			—			(5,067	)
Defined benefit plan adjustments, net of tax		—			(7,237	)		—			—			—			(7,237	)
Foreign currency translation, net of tax		—			(47,810	)		—			—			3			(47,807	)
Reclassification adjustments, net of tax		—			1,999			—			—			—			1,999
Balance, December 31, 2014 (124,129,340 shares)		(788,798	)		(59,091	)		1,242			142,586			49			(704,012	)
Issuance of common stock (3,104,187 shares)		—			—			31			64,583			—			64,614
Repurchase of common stock (7,855,796 shares)		(60,042	)		—			(79	)		(454,889	)		—			(515,010	)
Share-based compensation		—			—			—			31,582			—			31,582
Income tax benefits from share-based award activities		—			—			—			39,071			—			39,071
Q2 Solutions business combination		—			—			—			423,268			—			423,268
Noncontrolling interest related to Q2 Solutions transaction		—			—			—			(231,903	)		231,903			—
Deferred tax impact of the Q2 Solutions transaction		—			—			—			(6,708	)		—			(6,708	)
Net income		387,205			—			—			—			1,099			388,304
Unrealized loss on marketable securities, net of tax		—			(268	)		—			—			—			(268	)
Unrealized loss on derivative instruments, net of tax		—			(9,523	)		—			—			—			(9,523	)
Defined benefit plan adjustments, net of tax		—			(36	)		—			—			—			(36	)
Foreign currency translation, net of tax		—			(55,509	)		—			—			(4,515	)		(60,024	)
Reclassification adjustments, net of tax		—			13,061			—			—			—			13,061
Balance, December 31, 2015 (119,377,731 shares)	$	(461,635	)	$	(111,366	)	$	1,194		$	7,590		$	228,536		$	(335,681	)

The accompanying notes are an integral part of these consolidated financial statements.

67

QUINTILES TRANSNATIONAL HOLDINGS INC. AND SUBSIDIARIES

Notes to Consolidated Financial Statements

1. Summary of Significant Accounting Policies

The Company

Conducting business in approximately 100 countries with approximately 36,100 employees, Quintiles Transnational Holdings Inc. (together with its subsidiaries, the “Company”) is a provider of pharmaceutical development services and commercial outsourcing services that helps its biopharmaceutical customers, as well as customers in the broader healthcare industry, to make decisions regarding drug development, commercialization and drug therapy choices. The Company also offers a number of services designed to address the outcomes and analytical needs of the broader healthcare industry.

Reclassifications

Certain immaterial prior period amounts have been reclassified to conform to the current presentation including the reclassification of debt issuance costs related to non-revolving debt from deposits and other assets to a direct reduction to the carrying amount of the long-term debt on the balance sheet. These changes had no effect on previously reported total revenues, net income, comprehensive income, shareholders’ deficit or cash flows.

Principles of Consolidation

The accompanying consolidated financial statements include the accounts and operations of the Company and its subsidiaries. Amounts pertaining to the noncontrolling ownership interests held in third parties in the operating results and financial position of the Company’s majority-owned subsidiaries are reported as noncontrolling interests. Intercompany accounts and transactions have been eliminated in consolidation.

Use of Estimates

The preparation of financial statements in accordance with generally accepted accounting principles in the United States of America (“GAAP”) requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, and the disclosure of contingent assets and liabilities, at the date of the financial statements, as well as the reported amounts of revenues and expenses during the period. These estimates are based on historical experience and various other assumptions believed reasonable under the circumstances. The Company evaluates its estimates on an ongoing basis and makes changes to the estimates and related disclosures as experience develops or new information becomes known. Actual results may differ from those estimates.

Foreign Currencies

The Company’s financial statements are reported in United States dollars and, accordingly, the Company’s results of operations are impacted by fluctuations in exchange rates that affect the translation of its revenues and expenses denominated in foreign currencies into United States dollars for purposes of reporting its consolidated financial results. Assets and liabilities recorded in foreign currencies on the books of foreign subsidiaries are translated at the exchange rate on the balance sheet date. Revenues, costs and expenses are translated at average rates of exchange during the year. Translation adjustments resulting from this process are charged or credited to the accumulated other comprehensive income (loss) (“AOCI”) component of shareholders’ deficit. The Company is subject to foreign currency transaction risk for fluctuations in exchange rates during the period of time between the consummation and cash settlement of a transaction. The Company earns revenue from its service contracts over a period of several months and, in some cases, over a period of several years. Accordingly, exchange rate fluctuations during this period may affect the Company’s profitability with respect to such contracts. Other expense (income), net includes foreign currency net (gains) losses for 2015, 2014 and 2013 of approximately ($4.6) million, $4.9 million and $4.0 million, respectively.

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Cash Equivalents, Restricted Cash and Investments

The Company considers all highly liquid investments with an initial maturity of three months or less when purchased to be cash equivalents. The Company’s restricted cash primarily consisted of amounts collateralizing standby letters of credit issued in favor of certain suppliers and health insurance funds. Investments in marketable equity securities are classified as available-for-sale and measured at fair market value with net unrealized gains and losses recorded in the AOCI component of shareholders’ deficit until realized. The fair market value is based on the closing price as quoted by the respective stock exchange. In addition, the Company has investments in equity securities of companies for which there are not readily available market values and for which the Company does not exercise significant influence or control; such investments are accounted for using the cost method. Any gains or losses from the sales of investments or other-than-temporary declines in fair value are computed by specific identification.

Equity Method Investments

The Company’s investments in and advances to unconsolidated affiliates are accounted for under the equity method if the Company exercises significant influence or has an investment in a limited partnership that is considered to be greater than minor. These investments and advances are classified as investments in and advances to unconsolidated affiliates on the accompanying consolidated balance sheets. The Company records its pro rata share of the earnings, adjusted for accretion of basis difference, of these investments in equity in earnings of unconsolidated affiliates on the accompanying consolidated statements of income. The Company reviews its investments in and advances to unconsolidated affiliates for impairment whenever events or changes in circumstances indicate that the carrying amounts may not be recoverable.

Derivatives

The Company uses derivative instruments to manage exposures to interest rates and foreign currencies. Derivatives are recorded on the balance sheet at fair value at each balance sheet date utilizing pricing models for non-exchange-traded contracts. At inception, the Company designates whether or not the derivative instrument is an effective hedge of an asset, liability or firm commitment which is then classified as either a cash flow hedge or a fair value hedge. If determined to be an effective cash flow hedge, changes in the fair value of the derivative instrument are recorded as a component of AOCI until realized. We include the impact from these hedges in the same line item as the hedged item on the consolidated statements of cash flows. Changes in fair value of effective fair value hedges are recorded in earnings as an offset to the changes in the fair value of the related hedged item. Hedge ineffectiveness, if any, is immediately recognized in earnings. Changes in the fair values of derivative instruments that are not an effective hedge are recognized in earnings. The Company has entered, and may in the future enter, into derivative contracts (swaps, forwards, calls or puts, warrants, for example) related to its debt, investments in marketable equity securities and forecasted foreign currency transactions.

Billed and Unbilled Services and Unearned Income

In general, prerequisites for billings and payments are established by contractual provisions including predetermined payment schedules, which may or may not correspond to the timing of the performance of services under the contract. Unbilled services arise when services have been rendered for which revenue has been recognized but the customers have not been billed.

In some cases, payments received are in excess of revenue recognized. Payments received in advance of services being provided are deferred as unearned income on the consolidated balance sheet. As the contracted services are subsequently performed and the associated revenue is recognized, the unearned income balance is reduced by the amount of the revenue recognized during the period.

Allowance for Doubtful Accounts

The Company’s allowance for doubtful accounts is determined based on a variety of factors that affect the potential collectability of the related receivables, including length of time the receivables are past due, customer credit ratings, financial stability of the customer, specific one-time events and past customer history. In addition, in circumstances where the Company is made aware of a specific customer’s inability to meet its financial obligations, a specific allowance is established. The accounts are individually evaluated on a regular basis and appropriate reserves are established as deemed appropriate based on the above criteria.

Receivables Financing Facility

Advances received under the Company’s receivables financing facility are accounted for as borrowings secured by the receivables and included in net cash provided by financing activities. The Company services the collateralized accounts receivable and the cash flows for the underlying receivables are included in cash provided by operating activities. The collateralized accounts receivable are included in trade accounts receivable and unbilled services, net.

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Business Combinations

Business combinations are accounted for using the acquisition method, and accordingly, the identifiable assets acquired, the liabilities assumed, and any noncontrolling interest in the acquiree are recorded at their estimated fair values on the date of the acquisition. Goodwill represents the excess of the purchase price over the estimated fair value of the net assets acquired, including the amount assigned to identifiable intangible assets. When a business combination involves contingent consideration, the Company recognizes a liability equal to the estimated fair value of the contingent consideration obligation at the date of the acquisition. Subsequent changes in the estimated fair value of the contingent consideration are recognized in earnings in the period of the change.

Long-Lived Assets

Property and equipment are stated at cost and are depreciated using the straight-line method over the shorter of the asset’s estimated useful life or the lease term, if related to leased property, as follows:

Buildings and leasehold improvements	3 - 40	years
Equipment	3 - 10	years
Furniture and fixtures	5 - 10	years
Motor vehicles	3 - 5	years

Definite-lived identifiable intangible assets are amortized primarily using an accelerated method that reflects the pattern in which the Company expects to benefit from the use of the asset over its estimated remaining useful life as follows:

Trademarks and trade names	2 - 6	years
Non-compete agreements	3	years
Contract backlog and customer relationships	1 - 10	years
Software and related assets	2 - 9	years

Goodwill and indefinite-lived identifiable intangible assets, which consist of certain trade names, are not amortized but evaluated for impairment annually, or more frequently if events or changes in circumstances indicate an impairment.

Included in software and related items is the capitalized cost of internal-use software used in supporting the Company’s business. Qualifying costs incurred during the application development stage are capitalized and amortized over their estimated useful lives. The Company recognized $37.7 million, $33.1 million and $32.2 million of amortization expense in 2015, 2014 and 2013, respectively, related to software and related assets.

The carrying values of property, equipment and intangible and other long-lived assets are reviewed for recoverability if the facts and circumstances suggest that a potential impairment may have occurred. If this review indicates that carrying values will not be recoverable, as determined based on undiscounted cash flow projections, the Company will record an impairment charge to reduce carrying values to estimated fair value. During 2015, the Company recognized a $2.5 million impairment charge for long-lived assets related to a facility closure in Japan. There were no events, facts or circumstances in 2014 and 2013 that resulted in any impairment charges to the Company’s property, equipment, intangible or other long-lived assets.

Revenue Recognition

The Company recognizes revenue when all of the following conditions are satisfied: (1) there is persuasive evidence of an arrangement; (2) the service offering has been delivered to the customer; (3) the collection of the fees is probable; and (4) the arrangement consideration is fixed or determinable. The Company’s arrangements are primarily service contracts that range in duration from a few months to several years. Most contracts may be terminated upon 30 to 90 days notice by the customer, however, in the event of termination, contract provisions typically require payment for services rendered through the date of termination, as well as for subsequent services rendered to close out the contract.

In some cases, contracts provide for consideration that is contingent upon the occurrence of uncertain future events. The Company recognizes contingent revenue when the contingency has been resolved and all other criteria for revenue recognition have been met. The Company treats cash payments to customers as incentives to induce the customers to enter into such a service agreement with the Company. The related asset is amortized as a reduction of revenue over the period the services are performed. The Company records revenues net of any tax assessments by governmental authorities, such as value added taxes, that are imposed on and concurrent with specific revenue generating transactions. The Company does not recognize revenue with respect to start-up activities including contract and scope negotiation, feasibility analysis and conflict of interest review associated with contracts. The costs for these activities are expensed as incurred.

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For the arrangements that include multiple elements, arrangement consideration is allocated to units of accounting based on the relative selling price. The best evidence of selling price of a unit of accounting is vendor-specific objective evidence (“VSOE”), which is the price the Company charges when the deliverable is sold separately. When VSOE is not available to determine selling price, management uses relevant third-party evidence (“TPE”) of selling price, if available. When neither VSOE nor TPE of selling price exists, management uses its best estimate of selling price considering all relevant information that is available without undue cost and effort.

The majority of the Company’s contracts within the Product Development segment are service contracts for clinical research that represent a single unit of accounting. The Company recognizes revenue on its clinical research services contracts as services are performed primarily on a proportional performance basis, generally using output measures that are specific to the service provided. Examples of output measures include among others, number of investigators enrolled, number of site initiation visits and number of monitoring visits completed. Revenue is determined by dividing the actual units of work completed by the total units of work required under the contract and multiplying that ratio by the total contract value. The total contract value, or total contractual payments, represents the aggregate contracted price for each of the agreed upon services to be provided. Changes in the scope of work are common, especially under long-term contracts, and generally result in a change in contract value. Once the customer has agreed to the changes in scope and renegotiated pricing terms, the contract value is amended and revenue is recognized, as described above. To the extent that contracts involve multiple elements, the Company follows the allocation methodology described above and recognizes revenue for each unit of accounting on a proportional performance basis.

The Company derives the majority of its revenues in its Integrated Healthcare Services segment from providing commercialization services on a fee-for-service basis to customers within the biopharmaceutical industry. Fees on these arrangements are billed based on a contractual per-diem or hourly rate basis. The Company recognizes revenue on commercialization services contracts primarily on a time and materials basis. Some of the Company’s commercialization contracts are multiple element arrangements, with elements including recruiting, training and deployment of sales representatives. The nature of the terms of these multiple element arrangements will vary based on the customized needs of the Company’s customers. For contracts that have multiple elements, the Company follows the allocation methodology described above and recognizes revenue for each unit of accounting on a time and materials basis. The Company’s commercialization contracts sometimes include variable fees that are based on a percentage of product sales (royalty payments). The Company recognizes revenue on royalty payments when the variable components become fixed or determinable and all other revenue recognition criteria have been met, which generally only occurs upon the sale of the underlying product(s) and upon the Company’s receipt of information necessary to make a reasonable estimate.

Reimbursed Expenses

The Company includes reimbursed expenses in total revenues and costs of revenue as the Company is deemed to be the primary obligor in the applicable arrangements. These costs include such items as payments to investigators and travel expenses for the Company’s clinical monitors and sales representatives.

Expenses

Costs of revenue include reimbursed expenses, compensation and benefits for billable employees, depreciation of assets used in generating revenue and other expenses directly related to service contracts such as courier fees and laboratory supplies for the Company’s laboratory services, professional services and travel expenses. Selling, general and administrative expenses primarily include costs related to administrative functions such as compensation and benefits, travel, professional services, training and expenses for advertising, information technology, facilities and depreciation and amortization.

Concentration of Credit Risk

Financial instruments that subject the Company to credit risk primarily consist of cash and cash equivalents, marketable securities and accounts receivable. The Company maintains its cash and cash equivalent balances with high-quality financial institutions and, consequently, the Company believes that such funds are subject to minimal credit risk. Investment policies have been implemented that limit purchases of marketable securities to investment grade securities. Substantially all service revenues for Product Development and Integrated Healthcare Services are earned by performing services under contracts with various pharmaceutical, biotechnology, medical device and healthcare companies. The concentration of credit risk is equal to the outstanding accounts receivable and unbilled services balances, less the unearned income related thereto, and such risk is subject to the financial and industry conditions of the Company’s customers. The Company does not require collateral or other securities to support customer receivables. Credit losses have been immaterial and reasonably within management’s expectations. No customer accounted for 10.0% or more of consolidated service revenues in 2015, 2014 or 2013.

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Research and Development Costs

Research and development costs consist primarily of employee compensation and related expenses and information technology contract services and are charged to expense as incurred. The following is a summary of the research and development expenses (in thousands):

	Year Ended December 31,
	2015		2014		2013
Internally developed software applications and computer technology	$	3,198	$	4,980	$	3,955
Funding of customer's research and development activity		139		811		1,000
	$	3,337	$	5,791	$	4,955

Advertising Costs

Advertising costs, which include the development and production of advertising materials and the communication of these materials, are charged to expense as incurred. The Company incurred approximately $12.8 million, $16.0 million and $14.8 million in advertising expense in 2015, 2014 and 2013, respectively.

Restructuring Costs

Restructuring costs, which primarily include termination benefits and facility closure costs, are recorded at estimated fair value. Key assumptions in determining the restructuring costs include the terms and payments that may be negotiated to terminate certain contractual obligations and the timing of employees leaving the Company.

Contingencies

The Company records accruals for claims, suits, investigations and proceedings when it is probable that a liability has been incurred and the amount of the loss can be reasonably estimated. The Company reviews claims, suits, investigations and proceedings at least quarterly and records or adjusts accruals related to such matters to reflect the impact and status of any settlements, rulings, advice of counsel or other information pertinent to a particular matter. Legal costs associated with contingencies are charged to expense as incurred.

The Company is party to legal proceedings incidental to its business. While the outcome of these matters could differ from management’s expectations, the Company does not believe the resolution of these matters has a reasonable possibility of having a material adverse effect to the Company’s financial statements.

Income Taxes

Income tax expense includes United States federal, state and international income taxes. Certain items of income and expense are not reported in income tax returns and financial statements in the same year. The income tax effects of these differences are reported as deferred income taxes. Valuation allowances are provided to reduce the related deferred income tax assets to an amount which will, more likely than not, be realized. Beginning in 2013, the undistributed earnings of most of the Company’s foreign subsidiaries are considered to be indefinitely reinvested outside of the United States. Accordingly, a deferred income tax liability has not been provided related to those undistributed earnings. Interest and penalties related to unrecognized income tax benefits are recognized as a component of income tax expense as discussed further in Note 16.

Employee Stock Compensation

The Company accounts for share-based compensation for stock options and stock appreciation rights (“SARs”) under the fair value method and uses the Black-Scholes-Merton model to estimate the value of such share-based awards granted to its employees and non-executive directors. Expected volatility is based upon the historical volatility of a peer group for a period equal to the expected term, as the Company does not have adequate history to calculate its own volatility and believes the expected volatility will approximate the historical volatility of the peer group. Prior to the completion of the Company’s initial public offering (“IPO”) on May 14, 2013, the expected dividends were based on the historical dividends paid by the Company, excluding dividends that resulted from activities that the Company deemed to be one-time in nature. Following the IPO, the Company does not currently anticipate paying dividends. The expected term represents the period of time the grants are expected to be outstanding. The risk-free interest rate is based on the United States Treasury yield curve in effect at the time of the grant.

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The Company accounts for its share-based compensation for restricted stock units (“RSUs”) and performance awards based on the closing market price of the Company’s common stock on the date of grant.

The Company recognized share-based compensation expense of $37.8 million, $30.0 million and $22.8 million in 2015, 2014 and 2013, respectively. Share-based compensation expense is included in selling, general and administrative expenses on the accompanying consolidated statements of income which is consistent with the classification of all other compensation costs incurred for the employees who were granted the share-based awards. The associated future income tax benefit recognized was $8.9 million, $7.6 million and $8.1 million in 2015, 2014 and 2013, respectively. As of December 31, 2015, there was approximately $38.8 million of total unrecognized share-based compensation expense related to outstanding non-vested share-based compensation arrangements, which the Company expects to recognize over a weighted average period of 1.3 years.

Earnings Per Share

The calculation of earnings per share is based on the weighted average number of common shares or common stock equivalents outstanding during the applicable period. The dilutive effect of common stock equivalents is excluded from basic earnings per share and is included in the calculation of diluted earnings per share. Potentially dilutive securities include outstanding stock options, shares to be purchased under the Company’s employee stock purchase plan (see Note 17) and unvested RSUs.

Recently Issued Accounting Standards

In November 2015, the FASB issued new accounting guidance which requires entities to present deferred tax assets and deferred tax liabilities as noncurrent in a classified balance sheet. The new standard will be effective for annual reporting periods beginning after December 15, 2016. Early adoption is permitted. The Company expects to early adopt this new accounting guidance on January 1, 2016. As of December 31, 2015, the Company had approximately $101.0 million and $148,000 of current deferred income tax assets and current deferred income tax liabilities, respectively.

In September 2015, the FASB issued new guidance that will change the requirements for reporting measurement period adjustments to provisional amounts initially recognized in connection with a business combination. Currently, an acquiring entity is required to retrospectively adjust, in prior period financial statements, the provisional amounts to reflect new information obtained during the measurement period. Under the new guidance, adjustments to the provisional amounts will be reflected in the financial statements for the reporting period in which the adjustments are determined, including by recognizing in current period earnings the full effect of changes in depreciation, amortization or other income effects. The new guidance requires that the acquiring entity either present separately on the face of the current period income statement or disclose in the notes to the current period financial statements, by line item, the amount of the adjustments made during the current period. The Company will adopt the new guidance on January 1, 2016, as required. The adoption is not expected to have a material impact on the Company’s financial statements.

In February 2015, the FASB issued new accounting guidance which changes the analysis in determining whether an entity is considered a variable interest entity (“VIE”) and the identification of the primary beneficiary of the VIE to determine whether the VIE should be included in an entity’s consolidated financial statements. The Company will adopt the new accounting guidance on January 1, 2016, as required. The adoption of the new accounting guidance is not expected to have a material effect on the Company’s financial statements.

In May 2014, the FASB and the International Accounting Standards Board issued a converged standard on the recognition of revenue from contracts with customers. The objective of the new standard is to establish a single comprehensive revenue recognition model that is designed to create greater comparability of financial statements across industries and jurisdictions. Under the new standard, companies will recognize revenue to depict the transfer of goods or services to customers in amounts that reflect the consideration to which the company expects to be entitled in exchange for those goods or services. The new standard also will require expanded disclosures on revenue recognition including information about changes in assets and liabilities that result from contracts with customers. Companies have an option to use either a retrospective approach or a cumulative effect adjustment approach to implement the new guidance. The new standard will be effective for annual reporting periods beginning after December 15, 2017. Early adoption is permitted for annual reporting periods beginning after December 15, 2016. The Company is currently evaluating the impact of this new standard on its consolidated financial statements, the date of adoption, and the transition approach to implement the new guidance.

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2. Accounts Receivable and Unbilled Services

Accounts receivable and unbilled services consist of the following (in thousands):

	December 31,
	2015			2014
Trade:
Billed	$	553,652		$	444,941
Unbilled services		614,381			532,312
		1,168,033			977,253
Allowance for doubtful accounts		(2,284	)		(1,998	)
	$	1,165,749		$	975,255

Substantially all of the Company’s trade accounts receivable and unbilled services are due from companies in the pharmaceutical, biotechnology, medical device and healthcare industries and are a result of contract research, sales, marketing, healthcare consulting and health information management services provided by the Company on a global basis. The percentage of accounts receivable and unbilled services by region is as follows:

	December 31,
	2015			2014
Americas:
United States		58	%		55	%
Other		1			2
Americas		59			57
Europe and Africa:
United Kingdom		23			23
Other		10			11
Europe and Africa		33			34
Asia-Pacific:
Japan		3			4
Other		5			5
Asia-Pacific		8			9
		100	%		100	%

3. Investments – Debt, Equity and Other Securities

The following is a summary of the Company’s debt, equity and other securities (in thousands):

	December 31,
	2015		2014
Marketable securities	$	395	$	831
Cost method		32,516		33,672
	$	32,911	$	34,503

Investments in Marketable Securities:

The following is a summary of available-for-sale securities (in thousands):

	December 31, 2015							December 31, 2014
			Gross							Gross
	Amortized		Unrealized			Market		Amortized		Unrealized			Market
	Cost		Loss			Value		Cost		Loss			Value
Marketable equity	$	1,103	$	(708	)	$	395	$	1,103	$	(272	)	$	831

The Company recognized a $5.0 million gain from the sale of marketable equity securities in 2014. The Company did not recognize any gains from the sale of marketable equity securities in 2015 and 2013. The Company did not recognize any losses from the sale of marketable equity securities in 2015, 2014 and 2013.

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The net after-tax adjustment to unrealized holding gains (losses) on available-for-sale securities included in the AOCI component of shareholders’ deficit was ($438,000), ($170,000) and $3.5 million in 2015, 2014 and 2013, respectively.

The Company’s policy is to continually review declines in fair value of marketable equity securities for declines that may be other than temporary. As part of this review, the Company considers the financial statements of the investee, analysts’ reports, duration of the decline in fair value and general market factors. The Company did not recognize any such losses in 2015, 2014 and 2013.

Investments – Cost Method

The Company has investments in equity securities of companies for which there are not readily available market values and for which the Company does not exercise significant influence or control. These investments are accounted for using the cost method. Below is a summary of the Company’s portfolio of cost method investments (in thousands):

	December 31,
	2015		2014
Equity investments	$	32,516	$	32,516
Convertible notes		—		1,156
	$	32,516	$	33,672

On February 25, 2011, the Company and the Samsung Group entered into an agreement to form a joint venture intended to provide biopharmaceutical contract manufacturing services in South Korea. The Company committed to invest up to $30.0 million for a noncontrolling interest and has funded all of this commitment. As of December 31, 2015 and 2014, the Company has an approximately 2.2% and 3.0%, respectively, ownership interest in the joint venture.

In December 2011, the Company and Intarcia Therapeutics (“Intarcia”) entered into an alliance to develop a new therapy for type 2 diabetes whereby Intarcia will use the Company to conduct Phase III pivotal clinical trials and a cardiovascular outcomes clinical trial. Under the alliance, the Company provided Intarcia a customer incentive of $12.5 million and acquired $5.0 million of preferred stock of Intarcia. The customer incentive is being amortized in proportion to the revenues earned as a reduction of revenue recorded under the service arrangements. As of December 31, 2015 and 2014, the customer incentive of $2.5 million and $7.1 million, respectively, was recorded in deposits and other assets on the accompanying consolidated balance sheets. The $5.0 million investment in preferred stock of Intarcia is recorded in “investments — debt, equity and other securities” on the accompanying consolidated balance sheets.

The Company reviews the carrying value of each individual investment at each balance sheet date to determine whether or not an other-than-temporary decline in fair value has occurred. The Company employs alternative valuation techniques including the following: (i) the review of financial statements including assessments of liquidity, (ii) the review of valuations available to the Company prepared by independent third parties used in raising capital, (iii) the review of publicly available information including press releases and (iv) direct communications with the investee’s management, as appropriate. If the review indicates that such a decline in fair value has occurred, the Company adjusts the carrying value to the estimated fair value of the investment and recognizes a loss for the amount of the adjustment.

4. Investments in and Advances to Unconsolidated Affiliates

The Company accounts for its investments in and advances to unconsolidated affiliates under the equity method of accounting and records its pro rata share of its losses or earnings from these investments in equity in earnings (losses) of unconsolidated affiliates. The following is a summary of the Company’s investments in and advances to unconsolidated affiliates (in thousands):

	December 31,
	2015		2014
NovaQuest Pharma Opportunities Fund III, L.P.	$	39,785	$	22,633
NovaQuest Pharma Opportunities Fund IV, L.P.		2,524		—
CenduitTM		9,478		8,271
Other		595		604
	$	52,382	$	31,508

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NovaQuest Pharma Opportunities Funds

The Company has committed to invest up to $50 million as a limited partner in NovaQuest Pharma Opportunities Fund III, L.P. (“Fund III”). As of December 31, 2015, the Company has funded approximately $34.7 million and has approximately $15.3 million of remaining funding commitments. As of December 31, 2015 and 2014, the Company had a 10.9% ownership interest in Fund III.

In February 2015, the Company committed to invest up to $20 million as a limited partner in a new private equity fund, NovaQuest Pharma Opportunities Fund IV, L.P. (“Fund IV”). As of December 31, 2015, the Company has funded approximately $2.7 million and has approximately $17.3 million of remaining funding commitments. As of December 31, 2015, the Company had a 2.3% ownership interest in Fund IV.

Cenduit™

In May 2007, the Company and Thermo Fisher Scientific Inc. (“Thermo Fisher”) completed the formation of a joint venture, Cenduit™. The Company contributed its Interactive Response Technology operations in India and the United States. Thermo Fisher contributed its Fisher Clinical Services Interactive Response Technology operations in three locations — the United Kingdom, the United States and Switzerland. Additionally, each company contributed $3.5 million in initial capital. The Company and Thermo Fisher each own 50% of Cenduit™.

5. Derivatives

As of December 31, 2015, the Company held the following derivative positions: (i) forward exchange contracts to protect against foreign exchange movements for certain forecasted foreign currency cash flows related to service contracts and (ii) interest rate swaps to hedge the exposure to variability in interest payments on variable interest rate debt. The Company does not use derivative financial instruments for speculative or trading purposes.

As of December 31, 2015, the Company had 15 open foreign exchange forward contracts to hedge certain forecasted foreign currency cash flow transactions occurring in 2016 with notional amounts totaling $117.5 million. As of December 31, 2014, the Company had 13 open foreign exchange forward contracts to hedge certain forecasted foreign currency cash flow transactions occurring in 2015 with notional amounts totaling $76.0 million. These contracts were executed to hedge the risk of the potential volatility in the cash flows resulting from fluctuations in currency exchange rates during the first nine months of 2016. These transactions are accounted for as cash flow hedges, as such, the effective portion of the gain or loss on the contracts is recorded as unrealized gains (losses) on derivatives included in the AOCI component of shareholders’ deficit. These hedges are highly effective. As of December 31, 2015 and 2014, the Company had recorded gross unrealized losses of $5.2 million and $4.6 million, respectively, related to foreign exchange forward contracts. Upon expiration of the hedge instruments in 2016, the Company will reclassify the unrealized holding gains and losses on the derivative instruments included in AOCI into earnings. The unrealized losses are included in other current liabilities on the accompanying consolidated balance sheets as of December 31, 2015 and 2014, respectively.

On June 9, 2011, the Company entered into six interest rate swaps which expired between September 30, 2013 and March 31, 2016 in an effort to limit its exposure to changes in the variable interest rate on its senior secured credit facilities. During May 2015, in conjunction with the debt refinancing described in Note 10, the Company terminated the remaining open interest rate swaps for a cash payment to the counterparty of $12.4 million, which included $1.4 million of accrued interest. Since the hedged forecasted cash transactions continue to be probable of occurring, the accumulated loss ($3.1 million at December 31, 2015) related to the terminated interest rate swaps in AOCI will be reclassified to earnings as a component of interest expense in the same periods as the hedged forecasted transactions occur over the next three months.

On June 3, 2015, the Company entered into seven forward starting interest rate swaps with a notional value of $440.0 million in an effort to limit its exposure to changes in the variable interest rate on its senior secured credit facilities. Interest on the swaps begins to accrue on June 30, 2016 and the interest rate swaps expire between March 31, 2017 and March 31, 2020. The critical terms of the interest rate swaps are substantially the same as those of the Company’s senior secured credit facilities, including quarterly interest settlements. These interest rate swaps are being accounted for as cash flow hedges as these transactions were executed to hedge the Company’s interest payments, and these hedges are deemed to be highly effective. As such, changes in the fair value of these derivative instruments are recorded as unrealized gains (losses) on derivatives included in AOCI. The fair value of these interest rate swaps represents the present value of the anticipated net payments the Company will make to the counterparty, which, when they occur, are reflected as interest expense on the consolidated statements of income. These payments, together with the variable rate of interest incurred on the underlying debt, result in a fixed rate of interest of 2.1% plus the applicable margin on the affected borrowings. These interest rate swaps will result in a total debt mix of approximately 50% fixed rate debt and 50% variable rate debt. The Company expects that $3.2 million of unrealized losses will be reclassified out of AOCI and will form the interest rate swap component of the 2.1% fixed rate of interest incurred over the next 12 months as the underlying net payments are settled.

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The fair values of the Company’s derivative instruments designated as hedging instruments and the line items on the accompanying consolidated balance sheets to which they were recorded are summarized in the following table (in thousands):

		December 31,
	Balance Sheet Classification	2015		2014
Foreign exchange forward contracts	Other current liabilities	$	5,194	$	4,635
Interest rate swaps	Other current liabilities	$	5,698	$	14,424

The effect of the Company’s cash flow hedging instruments on other comprehensive income (loss) is summarized in the following table (in thousands):

	Year Ended December 31,
	2015			2014			2013
Foreign exchange forward contracts	$	(559	)	$	(8,585	)	$	3,485
Interest rate swaps		5,626			10,381			9,202
Total	$	5,067		$	1,796		$	12,687

6. Fair Value Measurements

The Company records certain assets and liabilities at fair value. Fair value is defined as the price that would be received to sell an asset or paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants at the measurement date. A three-level fair value hierarchy that prioritizes the inputs used to measure fair value is described below. This hierarchy requires entities to maximize the use of observable inputs and minimize the use of unobservable inputs. The three levels of inputs used to measure fair value are as follows:

· Level 1 — Quoted prices in active markets for identical assets or liabilities.

· Level 2 — Observable inputs other than quoted prices included in Level 1, such as quoted prices for similar assets and liabilities in active markets; quoted prices for identical or similar assets and liabilities in markets that are not active; or other inputs that are observable or can be corroborated by observable market data.

· Level 3 — Unobservable inputs that are supported by little or no market activity. This includes certain pricing models, discounted cash flow methodologies and similar techniques that use significant unobservable inputs.

Recurring Fair Value Measurements

The following table summarizes the fair value of the Company’s financial assets and liabilities that are measured on a recurring basis as of December 31, 2015 (in thousands):

	Level 1		Level 2		Level 3		Total
Assets:
Marketable equity securities	$	395	$	—	$	—	$	395
Total	$	395	$	—	$	—	$	395
Liabilities:
Foreign exchange forward contracts	$	—	$	5,194	$	—	$	5,194
Interest rate swaps	—			5,698	—			5,698
Contingent consideration	—		—			4,374		4,374
Total	$	—	$	10,892	$	4,374	$	15,266

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The following table summarizes the fair value of the Company’s financial assets and liabilities that are measured on a recurring basis as of December 31, 2014 (in thousands):

	Level 1		Level 2		Level 3		Total
Assets:
Marketable equity securities	$	831	$	—	$	—	$	831
Total	$	831	$	—	$	—	$	831
Liabilities:
Foreign exchange forward contracts	$	—	$	4,635	$	—	$	4,635
Interest rate swaps	—			14,424	—			14,424
Contingent consideration	—		—			1,452		1,452
Total	$	—	$	19,059	$	1,452	$	20,511

Below is a summary of the valuation techniques used in determining fair value:

Marketable equity securities — The Company values marketable equity securities utilizing quoted market prices.

Foreign exchange forward contracts — The Company values foreign exchange forward contracts using quoted market prices for identical instruments in less active markets or using other observable inputs.

Interest rate swaps — The Company values interest rate swaps using market inputs with mid-market pricing as a practical expedient for bid-ask spread.

Contingent consideration — The Company values contingent consideration related to business combinations using a weighted probability calculation of potential payment scenarios discounted at rates reflective of the risks associated with the expected future cash flows. Key assumptions used to estimate the fair value of contingent consideration include revenue, net new business and operating forecasts and the probability of achieving the specific targets.

The following table summarizes the changes in Level 3 financial assets and liabilities measured on a recurring basis for the year ended December 31 (in thousands):

	Contingent Consideration –
	Accrued Expenses and Other Liabilities
	2015			2014			2013
Balance as of January 1	$	1,452		$	13,014		$	3,521
Initial estimate of contingent consideration	—			—				14,300
Contingent consideration paid		(3,000	)		(3,000	)	—
Revaluations included in earnings		5,922			(8,562	)		(4,807	)
Balance as of December 31	$	4,374		$	1,452		$	13,014

The revaluation for the contingent consideration is recognized in other expense (income), net on the accompanying consolidated statements of income.

Non-recurring Fair Value Measurements

Certain assets are carried on the accompanying consolidated balance sheets at cost and are not remeasured to fair value on a recurring basis. These assets include cost and equity method investments and loans that are written down to fair value for declines which are deemed to be other-than-temporary, and goodwill and identifiable intangible assets which are tested for impairment annually and when a triggering event occurs.

As of December 31, 2015, assets carried on the balance sheet and not remeasured to fair value on a recurring basis totaling approximately $1,172.7 million and were identified as Level 3. These assets are comprised of cost and equity method investments of $84.9 million, goodwill of $719.7 million and other identifiable intangibles, net of $368.1 million.

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Cost and Equity Method Investments — The inputs available for valuing investments in non-public portfolio companies are generally not easily observable. The valuation of non-public investments requires significant judgment by the Company due to the absence of quoted market values, inherent lack of liquidity and the long-term nature of such assets. When a triggering event occurs, the Company considers a wide range of available market data when assessing the estimated fair value. Such market data includes observations of the trading multiples of public companies considered comparable to the private companies being valued as well as publicly disclosed merger transactions involving comparable private companies. In addition, valuations are adjusted to account for company-specific issues, the lack of liquidity inherent in a non-public investment and the fact that comparable public companies are not identical to the companies being valued. Such valuation adjustments are necessary because in the absence of a committed buyer and completion of due diligence similar to that performed in an actual negotiated sale process, there may be company-specific issues that are not fully known that may affect value. Further, a variety of additional factors are reviewed by the Company, including, but not limited to, financing and sales transactions with third parties, current operating performance and future expectations of the particular investment, changes in market outlook and the third party financing environment. Because of the inherent uncertainty of valuations, estimated valuations may differ significantly from the values that would have been used had a ready market for the securities existed, and the differences could be material.

Goodwill — Goodwill represents the difference between the purchase price and the fair value of the identifiable tangible and intangible net assets resulting from business combinations. The Company performs a qualitative analysis to determine whether it is more likely than not that the estimated fair value of a reporting unit is less than its book value. This includes a qualitative analysis of macroeconomic conditions, industry and market considerations, internal cost factors, financial performance, fair value history and other company specific events. If this qualitative analysis indicates that it is more likely than not that the estimated fair value is less than the book value for the respective reporting unit, the Company applies a two-step impairment test in which the Company determines whether the estimated fair value of the reporting unit is in excess of its carrying value. If the carrying value of the net assets assigned to the reporting unit exceeds the estimated fair value of the reporting unit, the Company performs the second step of the impairment test to determine the implied estimated fair value of the reporting unit’s goodwill. The Company determines the implied estimated fair value of goodwill by determining the present value of the estimated future cash flows for each reporting unit and comparing the reporting unit’s risk profile and growth prospects to selected, reasonably similar publicly traded companies. No indication of impairment was identified during the Company’s annual review.

Definite-lived Intangible Assets — If a triggering event occurs, the Company determines the estimated fair value of definite-lived intangible assets by determining the present value of the expected cash flows.

Indefinite-lived Intangible Asset — The Company performs a qualitative analysis to determine whether it is more likely than not that the estimated fair value of the indefinite-lived intangible asset is less than its carrying value. If this qualitative analysis indicates that it is more likely than not that the estimated fair value is less than the carrying value of the indefinite-lived intangible asset, the Company determines the estimated fair value of the indefinite-lived intangible asset (trade name) by determining the present value of the estimated royalty payments on an after-tax basis that it would be required to pay the owner for the right to use such trade name. If the carrying amount exceeds the estimated fair value, an impairment loss is recognized in an amount equal to the excess. No indication of impairment was identified during the Company’s annual review.

7. Property and Equipment

The major classes of property and equipment were as follows (in thousands):

	December 31,
	2015			2014
Land, buildings and leasehold improvements	$	187,405		$	185,940
Equipment		257,119			240,227
Furniture and fixtures		52,840			54,615
Motor vehicles		13,348			15,443
		510,712			496,225
Less accumulated depreciation		(322,319	)		(305,928	)
	$	188,393		$	190,297

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8. Goodwill and Identifiable Intangible Assets

As of December 31, 2015, the Company has approximately $368.1 million of identifiable intangible assets, of which approximately $128.2 million, relating to trade names, is deemed to be indefinite-lived and, accordingly, is not being amortized. Amortization expense associated with identifiable definite-lived intangible assets was as follows (in thousands):

	Year Ended December 31,
	2015		2014		2013
Amortization expense	$	66,545	$	58,457	$	51,450

Estimated amortization expense for existing identifiable intangible assets is expected to be approximately $61.7 million, $50.2 million, $39.2 million, $32.5 million and $20.8 million for the years ending December 31, 2016, 2017, 2018, 2019 and 2020, respectively. Estimated amortization expense can be affected by various factors, including future acquisitions or divestitures of product and/or licensing and distribution rights or impairments.

The following is a summary of identifiable intangible assets (in thousands):

	As of December 31, 2015							As of December 31, 2014
	Gross		Accumulated			Net		Gross		Accumulated			Net
	Amount		Amortization			Amount		Amount		Amortization			Amount
Definite-lived identifiable intangible assets:
Product licensing and distribution rights and customer relationships	$	224,149	$	(75,606	)	$	148,543	$	123,227	$	(54,413	)	$	68,814
Trademarks, trade names and other		14,620		(6,081	)		8,539		18,571		(6,399	)		12,172
Software and related assets		279,266		(196,489	)		82,777		260,052		(170,471	)		89,581
	$	518,035	$	(278,176	)	$	239,859	$	401,850	$	(231,283	)	$	170,567
Indefinite-lived identifiable intangible assets:
Trade names	$	128,247	$	—		$	128,247	$	109,676	$	—		$	109,676

Accumulated amortization of identifiable intangible assets includes the impact of amortization expense, foreign exchange fluctuations and disposals of software and related assets.

The following is a summary of goodwill by segment for the years ended December 31, 2015 and 2014 (in thousands):

				Integrated
	Product			Healthcare
	Development			Services			Consolidated
Balance as of December 31, 2013	$	351,144		$	58,482		$	409,626
Business combinations	—				62,778			62,778
Impact of foreign currency fluctuations and other		(4,536	)		(3,434	)		(7,970	)
Balance as of December 31, 2014		346,608			117,826			464,434
Business combinations		262,377		—				262,377
Impact of foreign currency fluctuations and other		(6,879	)		(192	)		(7,071	)
Balance as of December 31, 2015	$	602,106		$	117,634		$	719,740

9. Accrued Expenses

Accrued expenses consist of the following (in thousands):

	December 31,
	2015		2014
Compensation, including bonuses, fringe benefits and payroll taxes	$	400,748	$	403,250
Restructuring		13,564		6,083
Interest		5,115		274
Contract related		271,076		255,530
Other		70,254		68,507
	$	760,757	$	733,644

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10. Credit Arrangements

The following is a summary of the Company’s revolving credit facilities at December 31, 2015:

Facility	Interest Rates
$500.0 million (revolving credit facility)	London Interbank Offer Rate (“LIBOR”) (0.61% at December 31, 2015) plus 1.75%
$25.0 million (receivables financing facility)	LIBOR Market Index Rate (0.43% at December 31, 2015) plus 0.85% to 1.35% depending upon the Company’s debt rating
£10.0 million (approximately $14.8 million) general banking facility with a European headquartered bank	Bank’s base rate (0.5% at December 31, 2015) plus 1%

During 2014, the Company borrowed and repaid $150.0 million from its then outstanding revolving credit facility. The Company did not have any outstanding borrowings under any of the revolving credit facilities at December 31, 2015 or 2014. At December 31, 2015, there were bank guarantees totaling approximately £3.9 million (approximately $5.8 million) issued against the availability of the general banking facility with a European headquartered bank through their operations in the United Kingdom.

Long-term debt consists of the following (in thousands):

	December 31,
	2015			2014
4.875% Senior Notes due 2023	$	800,000		$	—
Term Loan A due 2020 (LIBOR plus 1.75%, or 2.36% at December 31, 2015)		828,750			—
Term Loan B due 2022 (the greater of LIBOR or 0.75% plus 2.50%, or 3.25% at December 31, 2015)		597,000			—
Term Loan B-3 due 2018 (the greater of three month LIBOR or 1.25% plus 2.50%, or 3.75% at December 31, 2014)		—			2,030,606
Receivables financing facility due 2018 (LIBOR plus 1.05%, or 1.48% at December 31, 2015)		275,000			275,000
		2,500,750			2,305,606
Less: unamortized discount		(24,020	)		(12,379	)
Less: unamortized debt issuance costs		(8,955	)		(9,879	)
Less: current portion		(48,500	)		(750	)
	$	2,419,275		$	2,282,598

Contractual maturities of long-term debt at December 31, 2015 are as follows (in thousands):

2016	$	48,500
2017		48,500
2018		323,500
2019		48,500
2020		664,750
Thereafter		1,367,000
	$	2,500,750

The estimated fair value of the Company’s long-term debt approximates its carrying value as of December 31, 2015 and 2014. The estimated fair value of the long-term debt is primarily based on rates in which the debt is traded among banks.

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Senior Secured Credit Agreement

2015 Senior Secured Credit Agreement

On May 12, 2015, the Company through its wholly-owned subsidiary, Quintiles Transnational, entered into new senior secured credit facilities (the “New Facilities”) totaling $1.95 billion. The New Facilities consist of a five-year $500.0 million revolving credit facility (the “New Revolver”) and $1.45 billion of term loans ($850 million in New Term Loan A due 2020 (the “New Term Loan A”) and $600 million in New Term Loan B due in 2022 (the “New Term Loan B”)). In addition, Quintiles Transnational issued $800 million of 4.875% senior unsecured notes due 2023 (the “Senior Notes”) in a private placement. The New Facilities and the Senior Notes are referred to collectively as the “New Debt.”

Annual maturities on the New Term Loan A and the New Term Loan B are 5% and 1%, respectively, of the respective original principal amount with the remaining balance to be repaid on their respective maturity dates. Beginning with the fiscal year ending December 31, 2016, the Company will be required to make mandatory repayments on New Term Loan A and New Term Loan B of 50% of excess cash flow (as defined in the credit agreement covering the New Facilities, subject to a reduction to 25% or 0% depending upon the Company’s leverage ratio). Mandatory repayments will be allocated pro rata between New Term Loan A and New Term Loan B (subject to increases in the amount of New Term Loan A repayments with amounts declined by New Term Loan B lenders), and applied, first, to reduce the next eight quarterly amortization installments in direct order of maturity, and, second, to reduce all remaining amortization installments pro rata. The Company will also be required to make mandatory repayments with 100% of the net cash proceeds of certain asset dispositions, subject to thresholds and reinvestment rights. Any amounts outstanding under the New Facilities may be voluntarily repaid at any time without penalty. The new senior secured credit facilities arrangements are collateralized by substantially all of the assets of Quintiles Transnational and the assets of Quintiles Transnational’s domestic subsidiaries including 100% of the equity interests of substantially all of Quintiles Transnational’s domestic subsidiaries and 65% of the equity interests of substantially all of the first-tier foreign subsidiaries of Quintiles Transnational and its domestic subsidiaries.

Interest on the Senior Notes is paid semiannually on May 15 and November 15 of each year until maturity. The Senior Notes are unsecured senior obligations of Quintiles Transnational and are effectively subordinated in right of payment to all secured obligations of Quintiles Transnational, to the extent of the value of any collateral.

The Company used the proceeds from the New Debt (i) to repay the then outstanding Term Loan B-3 (defined below) which was due in 2018, (ii) to pay related fees and expenses including $11.0 million of breakage fees associated with the terminated interest rate swaps discussed further in Note 5, and (iii) for general corporate purposes including the share repurchase discussed further in Note 12.

2014 Revolving Credit Facility Amendment

On November 7, 2014, the Company entered into an amendment to its then outstanding senior secured credit agreement that increased its revolving credit facility from $300.0 million to $400.0 million and extended the maturity date for most of the then outstanding revolving credit facility by six months. The other terms of the then outstanding senior secured credit agreement were not altered by the amendment. On May 12, 2015, the Company’s then outstanding revolving credit facility was replaced with the New Revolver (defined and discussed above).

2013 Senior Secured Credit Agreement

On December 20, 2013, the Company entered into an amendment to its then outstanding senior secured credit agreement to provide a Term Loan B-3 (the “Term Loan B-3”) with a syndicate of banks for an aggregate principal amount of $2.061 billion due in 2018. The proceeds from the Term Loan B-3 were used to repay the then outstanding balances of the Company’s term loan B-1 and term loan B-2 and related fees and expenses. On May 12, 2015, the Term Loan B-3 was repaid with the proceeds of the New Debt (defined and discussed above).

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Receivables Financing Facility

On December 5, 2014, the Company entered into a four-year arrangement to securitize certain of its accounts receivable. Under the receivables financing facility, certain of the Company’s accounts receivable are sold on a non-recourse basis by certain of its consolidated subsidiaries to another of its consolidated subsidiaries, a bankruptcy-remote special purpose entity (“SPE”). The SPE obtained a term loan and revolving loan commitment from a third party lender, secured by liens on the assets of the SPE, to finance the purchase of the accounts receivable, which included a $275.0 million term loan and a $25.0 million revolving loan commitment. The revolving loan commitment may be increased by an additional $35.0 million as amounts are repaid under the term loan. Quintiles Transnational has guaranteed the performance of the obligations of existing and future subsidiaries that sell and service the accounts receivable under the receivables financing facility. The assets of the SPE are not available to satisfy any of the Company’s obligations or any obligations of its subsidiaries. As of December 31, 2015, $25.0 million of revolving loans were available under the receivables financing facility.

The Company used the proceeds from the term loan under the receivables financing facility to repay in full the amount outstanding on the then outstanding revolving credit facility under its then outstanding senior secured credit agreement ($150.0 million), to repay $25.0 million of the then outstanding Term Loan B-3, to pay related fees and expenses and the remainder was used for general working capital purposes.

Loss on Extinguishment of Debt

On May 12, 2015, the then outstanding Term Loan B-3 was repaid with the proceeds of the New Debt (defined and discussed above). In connection with this refinancing transaction, in 2015 the Company recognized a $7.8 million loss on extinguishment of debt which included $1.1 million of unamortized debt issuance costs, $1.3 million of unamortized discount and $5.4 million of related fees and expenses.

On December 20, 2013, the balance of a then outstanding term loan was repaid with the proceeds from Term Loan B-3 (defined and discussed above). In 2013, in connection with the repayment of debt, the Company recognized a $3.3 million loss on extinguishment of debt which included approximately $1.6 million of unamortized debt issuance costs, approximately $1.6 million of unamortized discount and approximately $25,000 of related fees and expenses.

In May 2013, the Company used $50.0 million of cash to pay down indebtedness under its then outstanding term loan B-1. In connection with this pay down of indebtedness, the Company recognized a $1.0 million loss on extinguishment of debt which included approximately $930,000 of unamortized debt issuance costs and $112,000 of unamortized discount.

Also in May 2013, the Company used $308.9 million of cash to pay all amounts then outstanding under a term loan (including accrued interest and related fees and expenses). In connection with the repayment of debt, the Company recognized a $15.5 million loss on extinguishment of debt which included approximately $4.7 million of unamortized debt issuance costs, $4.7 million of unamortized discount and $6.1 million of related fees and expenses.

Restrictive Covenants

The credit agreement governing the Quintiles Transnational senior secured credit facilities contains usual and customary restrictive covenants (subject to significant exceptions) that place limitations on Quintiles Transnational’s ability, and the ability of Quintiles Transnational’s restricted subsidiaries, to incur liens; engage in acquisitions, loans and other investments; incur additional indebtedness; merge, dissolve, liquidate or consolidate with or into other persons; sell or otherwise dispose of assets; declare dividends, including to Quintiles Transnational Holdings Inc., and make other restricted payments; engage in businesses that are not related to Quintiles Transnational’s and its restricted subsidiaries’ existing business; transact with affiliates; enter into agreements that restrict subsidiaries from paying intercompany dividends or completing intercompany property transfers or that restrict the ability to create liens in favor of Quintiles Transnational’s lenders; amend or otherwise modify organizational documents or terms and conditions of junior financing documents, if any; change the fiscal year of Quintiles Transnational; prepay, redeem or purchase junior financing, if any; designate any other indebtedness as “designated senior indebtedness” or “senior secured financing”; and engage in sale and leaseback transactions. The credit agreement also contains one financial covenant, which is a total leverage ratio that provides for a maximum ratio of consolidated total debt to consolidated EBITDA, as defined in the credit agreement, for any period of four consecutive fiscal quarters, measured as of the end of such period, of 5.75 to 1.00, and applies at any time that the Term Loan A or New Revolver commitments remain outstanding. Violations of the financial covenant will not entitle the Term Loan B lenders to take any enforcement action prior to an acceleration of the New Revolver and the Term Loan A and, subject to customary limitations, may be cured with an equity contribution.

The agreement governing the Senior Notes limits Quintiles Transnational’s and its restricted subsidiaries’ (as defined in the agreement) ability to create liens and enter into sale and lease-back transactions.

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The agreement governing the receivables financing facility contains certain usual and customary covenants and termination events for a securitization transaction, including certain financial reporting covenants and requirements to maintain the existence of the SPE separate from Quintiles Transnational and its other affiliates. An occurrence of an event of default or a termination event under this facility may give rise to the right of the third party lender to terminate this facility.

In 2015, 2014 and 2013, the Company was in compliance with its restrictive covenants.

11. Leases

The Company leases facilities under operating leases, many of which contain renewal and escalation clauses. The Company also leases certain equipment under operating leases. The leases expire at various dates through 2029 with options to cancel certain leases at various intervals. Rental expenses under these agreements were $109.4 million, $114.6 million and $125.6 million in 2015, 2014 and 2013, respectively. The Company leases certain assets, primarily vehicles, under capital leases. Capital lease amortization is included with costs of revenue and accumulated depreciation on the accompanying financial statements.

The following is a summary of future minimum payments under capital and operating leases that have initial or remaining non-cancelable lease terms in excess of one year at December 31, 2015 (in thousands):

	Capital			Operating
	Leases			Leases
2016	$	15		$	84,747
2017		18			62,485
2018	—				41,907
2019	—				29,201
2020	—				25,713
Thereafter	—				111,267
Total minimum lease payments		33		$	355,320
Amounts representing interest		(2	)
Present value of net minimum payments		31
Current portion		(13	)
Long-term capital lease obligations	$	18

12. Shareholders’ Deficit

Initial Public Offering

On May 9, 2013, the Company’s common stock began trading on the New York Stock Exchange (“NYSE”) under the symbol “Q.” On May 14, 2013, the Company completed its IPO of its common stock at a price to the public of $40.00 per share. The Company issued and sold 13,125,000 shares of common stock in the IPO. The selling shareholders offered and sold 14,111,841 shares of common stock in the IPO, including 3,552,631 shares that were offered and sold by the selling shareholders pursuant to the full exercise of the underwriters’ option to purchase additional shares. The IPO raised proceeds to the Company of approximately $489.5 million, after deducting underwriting discounts, commissions and related expenses. The Company did not receive any of the proceeds from the sale of the shares sold by the selling shareholders.

Preferred Stock

The Company is authorized to issue 1.0 million shares of preferred stock, $0.01 per share par value. No shares of preferred stock were issued and outstanding as of December 31, 2015 or 2014.

Equity Repurchases

Since 2013, the Company has repurchased approximately $995.6 million of its equity securities as discussed further below.

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Equity Repurchase Program

On October 30, 2013, the Company’s Board of Directors (the “Board”) approved an equity repurchase program (the “Repurchase Program”) authorizing the repurchase of up to $125.0 million of either the Company’s common stock or vested in-the-money employee stock options, or a combination thereof. During 2015, the Board increased the share repurchase authorization under the Repurchase Program by $600.0 million which increased the total amount that has been authorized under the Repurchase Program to $725.0 million. The Repurchase Program does not obligate the Company to repurchase any particular amount of common stock or vested in-the-money employee stock options, and it could be modified, suspended or discontinued at any time. The timing and amount of repurchases are determined by the Company’s management based on a variety of factors such as the market price of the Company’s common stock, the Company’s corporate requirements, and overall market conditions. Purchases of the Company’s common stock may be made in open market transactions effected through a broker-dealer at prevailing market prices, in block trades, or in privately negotiated transactions. The Company may also repurchase shares of its common stock pursuant to a trading plan meeting the requirements of Rule 10b5-1 under the Exchange Act, which would permit shares of the Company’s common stock to be repurchased when the Company might otherwise be precluded from doing so by law. Repurchases of vested in-the-money employee stock options were made through transactions between the Company and its employees (other than its executive officers, who were not eligible to participate in the program), and this aspect of the Repurchase Program expired in November 2013. The Repurchase Program for common stock does not have an end date.

Below is a summary of the share repurchases made under the Repurchase Program (in thousands except share data):

	Year Ended December 31,
	2015		2014		2013
Number of shares repurchased		7,855,796		300		153,223
Aggregate purchase price	$	515,010	$	14	$	6,434
Average price per share	$	65.56	$	47.51	$	42.01

In addition, in 2013, the Company repurchased 2.0 million of vested in-the-money employee stock options at fair value for an aggregate purchase price of $59.1 million (representing an average market price per share of $43.42 and an average exercise price per option of $13.74). As of December 31, 2015, the Company has remaining authorization under the Repurchase Program to repurchase up to $144.5 million of its common stock.

Other Equity Repurchases

On May 28, 2014, the Company completed the repurchase of 3,287,209 shares of its common stock for $50.23 per share from TPG Quintiles Holdco, L.P., one of its existing shareholders, in a private transaction for an aggregate purchase price of approximately $165.1 million. The repurchase price per share of common stock was equal to 98% of the closing market price of the Company’s common stock on the NYSE on May 27, 2014 (which was $51.26). The repurchase of shares from its existing shareholder was authorized in compliance with the Company’s related party transactions approval policy. The Company funded this private repurchase transaction with cash on hand. This private repurchase transaction was separate from and in addition to the Repurchase Program.

On November 10, 2014, the Company completed the repurchase of 4,303,666 shares of its common stock for $58.09 per share, which was the price per share the underwriter paid to selling shareholders, for an aggregate purchase price of approximately $250.0 million. The Company funded this repurchase transaction with a combination of cash on hand and a $150.0 million draw on its revolving credit facility. This repurchase transaction was separate from and in addition to the Repurchase Program.

Noncontrolling Interests

As discussed further in Note 14, the Company’s contribution of its businesses to the joint venture was recorded at book value (carryover basis) because the Company maintains control of these businesses. As a result, Quest Diagnostics Incorporated (“Quest”) noncontrolling interest in Q² Solutions is equal to 40% of the combined carrying value of the net assets contributed by the Company plus the fair value of the net assets contributed by Quest, or $231.9 million.

13. Management Fees

In January 2008, pursuant to a management agreement with affiliates of certain of the Company’s shareholders, the Company agreed to pay an annual management service fee of $5.0 million in the aggregate to (i) GF Management Company, LLC (“GFM”); (ii) Bain Capital Partners, LLC; (iii) TPG Capital, LP; (iv) 3i Corporation; (v) Cassia Fund Management Pte Ltd; and (vi) Aisling Capital, LLC (“Aisling Capital”). In 2013, the management agreement was terminated, and the Company paid a $25.0 million fee in connection with the termination. In 2013, the Company expensed $27.7 million in management fees under this agreement.

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14. Business Combinations

Quest Diagnostics Incorporated

On July 1, 2015, the Company and Quest closed on a joint venture transaction that resulted in the combination of their respective global clinical trials laboratory operations. The joint venture transaction was effected through the creation of two primary new legal entities that the Company controls. Both the Company’s and Quest’s clinical trials laboratory operations were contributed to these new legal entities. The Company accounted for the contribution of the Quest businesses as a business combination. Quest was issued a 40% equity interest in the legal entities, the fair value of which was $423.3 million (40% of the fair value of all operations contributed by both parties) and represents the purchase price paid by the Company for the clinical trials laboratory operations that Quest contributed to the joint venture transaction. The resulting combined capabilities are designed to provide its customers with globally scaled end-to-end clinical trials laboratory services and the combined business is referred to and marketed as Q² Solutions. The Company controls Q² Solutions and as such, Q² Solutions’ results of operations and financial condition are included in the accompanying consolidated financial statements with a noncontrolling interest recorded for the portion owned by Quest.

Encore Health Resources

On July 1, 2014, the Company completed the acquisition of Encore Health Resources, LLC (“Encore”) effected through a merger for approximately $91.5 million in cash (net of approximately $2.2 million of acquired cash). Encore has operations in the United States, and its business is primarily focused on providing electronic health records (“EHR”) implementation and advisory services to healthcare providers. As part of its Integrated Healthcare Services segment, the Company acquired Encore to enhance its EHR expertise.

Novella Clinical Inc.

On September 16, 2013, the Company completed the acquisition of Novella Clinical Inc. (“Novella”) through the purchase of 100% of Novella’s outstanding stock for approximately $146.6 million in cash (net of approximately $26.2 million of acquired cash) plus potential annual earn-out payments totaling up to $21.0 million contingent upon the achievement of certain revenue and net new business targets for approximately three years following closing. The Company initially recognized a liability of approximately $14.3 million as the estimated acquisition date fair value of the earn-out. Changes in the fair value of the earn-out subsequent to the acquisition date are recognized in earnings in the period of the change. Novella has operations primarily in the United States and Europe and is a clinical research organization focused primarily on emerging oncology customers as well as those in the medical device and diagnostics sectors. As part of its Product Development segment, the Company acquired Novella to complement its clinical service offerings through its focus on emerging companies and by adding expertise in oncology and medical devices.

Accounting for Acquisitions

Acquisitions are accounted for as business combinations and, accordingly, the assets acquired and the liabilities assumed have been recorded at their respective estimated fair values as of the acquisition date. The Company accounted for the contribution of the Quest businesses as a business combination and consolidated the related new legal entities in its financial statements with a noncontrolling interest for the portion owned by Quest. The Company recorded goodwill, primarily attributable to assembled workforce and expected synergies. This business combination is part of the Product Development segment and the resulting goodwill is not deductible for income tax purposes. The Company is continuing to evaluate the initial fair value measurement of the assets acquired and liabilities assumed in the Q² Solutions transaction. Further adjustments may be necessary as additional information related to the fair values of assets acquired and liabilities assumed is assessed during the measurement period (up to one year from the acquisition date). In connection with the Encore acquisition, the Company recorded goodwill, primarily attributable to the assembled workforce of Encore and expected synergies, which was assigned to the Integrated Healthcare Services segment and is deductible for income tax purposes. In connection with the Novella acquisitions, the Company recorded goodwill, primarily attributable to the assembled workforce of Novella and expected synergies, which was assigned to the Product Development segment and is not deductible for income tax purposes. Pro forma information is not presented as the operations of the acquired businesses, individually and in the aggregate, are not significant to the overall operations of the Company. Acquisition-related expenses were immaterial and are also not presented.

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The following table summarizes the estimated fair value of the net assets acquired at the date of the acquisitions (in thousands):

	Quest			Encore			Novella
Assets acquired:
Cash and cash equivalents	$	31,783		$	2,223		$	26,190
Accounts receivable and unbilled services		6,186			17,714			28,644
Prepaid expenses		1,185			—			—
Other current assets		4,426			443			1,441
Property and equipment		16,422			289			9,616
Goodwill		261,710			62,778			116,542
Other identifiable intangibles		125,900			14,150			42,740
Deferred income tax asset – long-term		—			396			—
Other long-term assets		266			—			2,203
Liabilities assumed:
Accounts payable and accrued expenses		(12,790	)		(4,206	)		(12,716	)
Unearned income		—			(31	)		(7,782	)
Other current liabilities		—			—			(132	)
Deferred income tax liability – long-term		(10,412	)		—			(18,364	)
Other long-term liabilities		(1,408	)		—			(1,334	)
Net assets acquired	$	423,268		$	93,756		$	187,048

The other identifiable intangible assets consisted of the following (in thousands):

	Quest		Encore		Novella
Customer relationships	$	74,000	$	8,800	$	20,800
Backlog		32,900		800		14,000
Trade names		19,000		1,100		7,500
Non-compete agreements		—		450		440
Software		—		3,000		—
Total other identifiable intangibles	$	125,900	$	14,150	$	42,740
Amortized over a weighted average useful life (in years)		9		8		7

The acquired Quest trade name is an indefinite-lived intangible asset that is not amortized.

15. Restructuring

2015 Plans

In February 2015, the Board approved a restructuring plan for approximately $30.0 million to align the Company’s resources and reduce overcapacity in certain roles.These actions are expected to continue throughout 2016, and are expected to consist of severance, facility closure and other exit-related costs. In 2015, the Company has recognized approximately $11.8 million, $8.9 million and $749,000 of restructuring costs related to this plan for activities in the Product Development segment, Integrated Healthcare Services segment and corporate activities, respectively.

Also, in connection with consummating the joint venture transaction with Quest, during the third quarter of 2015, a restructuring plan was approved to reduce facility overcapacity and eliminate redundant roles. These actions are expected to continue throughout 2016 and 2017, and are expected to consist of severance, facility closure and other exit-related costs of approximately $14.0 million. During 2015, the Company has recognized approximately $8.7 million of restructuring costs related to this plan for activities in the Product Development segment.

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2014 Plans

In 2014, the Board approved restructuring plans of approximately $13 million to better align resources with the Company’s strategic direction, which resulted in a reduction of approximately 250 positions. Since the start of these plans in 2014, the Company recognized approximately $11.0 million of restructuring costs related to these plans including reversals. All of the restructuring costs are related to severance and lease costs. Of the $11.0 million in total restructuring costs recognized for these plans, approximately $8.0 million and $3.0 million were related to activities in the Product Development and Integrated Healthcare Services segments, respectively.

2013 Plan

In February 2013, the Board approved a restructuring plan of up to $15.0 million to migrate the delivery of services, primarily in the Product Development segment, and to reduce anticipated overcapacity in selected areas, primarily in the Integrated Healthcare Services segment, which resulted in a reduction of approximately 400 positions. Since February 2013, the Company has recognized approximately $13.6 million of restructuring costs related to this plan including reversals. All of the restructuring costs are related to severance costs. Of the $13.6 million in total restructuring costs recognized for this plan, approximately $8.4 million, $4.7 million and $500,000 were related to activities in the Product Development segment, Integrated Healthcare Services segment and corporate activities, respectively.

The following amounts were recorded for the restructuring plans (in thousands):

	Severance and Related Costs			Exit Costs			Total
Balance at December 31, 2013	$	5,276		$	198		$	5,474
Expense, net of reversals		8,421			567			8,988
Payments		(7,998	)		(160	)		(8,158	)
Foreign currency translation		(221	)		—			(221	)
Balance at December 31, 2014		5,478			605			6,083
Expense, net of reversals		29,843			909			30,752
Payments		(22,943	)		(723	)		(23,666	)
Foreign currency translation and other		(199	)		594			395
Balance at December 31, 2015	$	12,179		$	1,385		$	13,564

The reversals were due to changes in estimates primarily resulting from the redeployment of staff and higher than expected voluntary terminations. Restructuring costs are not allocated to the Company’s reportable segments as they are not part of the segment performance measures regularly reviewed by management. The Company expects the majority of the restructuring accruals at December 31, 2015 will be paid in 2016 and 2017.

16. Income Taxes

The components of income before income taxes and equity in earnings of unconsolidated affiliates are as follows (in thousands):

	Year Ended December 31,
	2015		2014		2013
Domestic	$	68,455	$	96,917	$	68,425
Foreign		470,540		405,272		254,691
	$	538,995	$	502,189	$	323,116

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The components of income tax expense attributable to continuing operations are as follows (in thousands):

	Year Ended December 31,
	2015			2014			2013
Current expense (benefit):
Federal	$	47,311		$	58,403		$	38,573
State		3,559			4,618			(4,309	)
Foreign		109,273			95,010			83,744
		160,143			158,031			118,008
Deferred (benefit) expense:
Federal and state		4,613			(4,549	)		(15,807	)
Foreign		(5,767	)		(3,426	)		(6,236	)
		(1,154	)		(7,975	)		(22,043	)
	$	158,989		$	150,056		$	95,965

The differences between the Company’s consolidated income tax expense attributable to continuing operations and the expense computed at the 35% United States statutory income tax rate were as follows (in thousands):

	Year Ended December 31,
	2015			2014			2013
Federal income tax expense at statutory rate	$	188,648		$	175,766		$	113,091
State and local income taxes, net of federal benefit		1,682			2,312			(1,088	)
Research and development		(12,634	)		(16,765	)		(12,788	)
Foreign nontaxable interest income		(9,351	)		(10,217	)		(9,751	)
Gain on note settlement		—			—			10,794
United States taxes recorded on foreign earnings		38,246			18,631			(1,616	)
Foreign rate differential		(49,288	)		(30,734	)		(10,753	)
Tax contingencies		(8,304	)		4,043			(1,012	)
Other		9,990			7,020			9,088
	$	158,989		$	150,056		$	95,965

Prior to June 2013, the Company had not considered the majority of the undistributed earnings of its foreign subsidiaries to be indefinitely reinvested. Management reevaluated this assertion following the IPO, as a portion of the IPO proceeds were used to pay down debt held in the United States as well as the fact the Company does not anticipate paying dividends to shareholders in the foreseeable future, which had been significant in the past. Given the Company’s current debt balance, and related interest expense and the change in approach related to payment of dividends, the Company expects to be able to support the cash needs of the domestic subsidiaries without repatriating cash from the affected foreign subsidiaries. The Company expects to utilize the cash generated outside of the United States to fund growth outside of the United States. As a result of the assertion change, the Company recorded an $8.1 million income tax benefit in the second quarter of 2013 to reverse the deferred income tax liability previously recorded on undistributed foreign earnings prior to 2013 that are now considered indefinitely reinvested outside of the United States. Undistributed earnings of the Company’s foreign subsidiaries amounted to approximately $862.3 million at December 31, 2015. Approximately $283.9 million of this total is not considered to be indefinitely reinvested and would be taxable upon repatriation. The Company has recorded a deferred income tax liability, net of foreign income tax credits that would be generated upon repatriation, of $34.9 million as of December 31, 2015 associated with those earnings based upon the United States federal income tax rate. Upon distribution of those earnings in the form of dividends or otherwise, the Company would be subject to both United States income taxes (subject to an adjustment for foreign tax credits, if available) and withholding taxes payable to the various countries in which the Company’s foreign subsidiaries are located. If the approximately $578.4 million of indefinitely reinvested earnings were repatriated to the United States, it would generate an estimated $94.6 million of additional tax liability for the Company.

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The income tax effects of temporary differences from continuing operations that give rise to significant portions of deferred income tax (liabilities) assets are presented below (in thousands):

	December 31,
	2015			2014
Deferred income tax liabilities:
Undistributed foreign earnings	$	(36,624	)	$	(27,717	)
Depreciation and amortization		(53,171	)		(65,614	)
Other		(11,830	)		(15,346	)
Total deferred income tax liabilities		(101,625	)		(108,677	)
Deferred income tax assets:
Net operating loss, capital loss and tax credit carryforwards		41,707			43,535
Accrued expenses and unearned income		23,315			34,048
Employee benefits		123,775			130,217
Other		12,801			17,784
		201,598			225,584
Valuation allowance for deferred income tax assets		(22,162	)		(24,695	)
Total deferred income tax assets		179,436			200,889
Net deferred income tax assets	$	77,811		$	92,212

The Company has net operating loss and capital loss carryforwards of approximately $44.9 million in various entities within the United Kingdom which have no expiration date and has $40.7 million of net operating loss and capital loss carryforwards from various foreign jurisdictions which have different expiration periods. The Company has United States net operating loss carryforwards of $16.6 million, which were obtained through the acquisitions of Novella, Expression Analysis, Inc., and Advion BioSciences, Inc. in 2013, 2012, and 2011, respectively, and expire through 2023. These losses are subject to IRC Section 382 limitations; however, management expects all losses to be utilized during the carryforward periods. In addition, the Company has approximately $44.0 million of United States state operating loss carryforwards which expire through 2035.

In 2015, the Company decreased its valuation allowance $2.5 million to $22.2 million at December 31, 2015 from $24.7 million at December 31, 2014. The valuation allowance is primarily related to loss carryforwards in various foreign and state jurisdictions.

A reconciliation of the beginning and ending amount of gross unrecognized income tax benefits is presented below (in thousands):

	Year Ended December 31,
	2015			2014			2013
Balance at January 1	$	40,821		$	54,936		$	43,393
Additions based on tax positions related to the current year		2,068			2,807			4,493
Additions for income tax positions of prior years		8,838			1,588			12,854
Impact of changes in exchange rates		(608	)		(376	)		(71	)
Settlements with tax authorities		(121	)		(135	)		(1,052	)
Reductions for income tax positions of prior years		(1,945	)		(6,023	)		(3,520	)
Reductions due to the lapse of the applicable statute of limitations		(19,387	)		(11,976	)		(1,161	)
Balance at December 31	$	29,666		$	40,821		$	54,936

As of December 31, 2015, the Company had total gross unrecognized income tax benefits of $29.7 million associated with over 50 jurisdictions in which the Company conducts business. This amount includes $29.3 million of unrecognized benefits that, if recognized, would reduce the Company’s effective income tax rate. This amount excludes $2.9 million of accrued interest and penalties.

The Company’s policy for recording interest and penalties relating to uncertain income tax positions is to record them as a component of income tax expense in the accompanying consolidated statements of income. In 2015, 2014 and 2013, the amount of interest and penalties recorded as a (reduction)/addition to income tax expense in the accompanying consolidated statements of income was ($2.0) million, $1.3 million and $843,000, respectively. As of December 31, 2015 and 2014, the Company accrued approximately $2.9 million and $4.8 million, respectively, of interest and penalties.

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The Company believes that it is reasonably possible that a decrease of up to $8.1 million in gross unrecognized income tax benefits for federal, state and foreign exposure items may be necessary within the next 12 months due to lapse of statutes of limitations or uncertain tax positions being effectively settled. The Company believes that it is reasonably possible that a decrease of up to $160,000 in gross unrecognized benefits for foreign items may be necessary within the next 12 months due to payments. For the remaining uncertain income tax positions, it is difficult at this time to estimate the timing of the resolution.

The Company conducts business globally and, as a result, files income tax returns in the United States federal jurisdiction and various state and foreign jurisdictions. In the normal course of business, the Company is subject to examination by taxing authorities throughout the world. The following table summarizes the tax years that remain open for examination by tax authorities in the most significant jurisdictions in which the Company operates:

United States	2012-2014
India	2006-2015
Japan	2010-2014
United Kingdom	2014

In certain of the jurisdictions noted above, the Company operates through more than one legal entity, each of which has different open years subject to examination. The table above presents the open years subject to examination for the most material of the legal entities in each jurisdiction. Additionally, it is important to note that tax years are technically not closed until the statute of limitations in each jurisdiction expires. In the jurisdictions noted above, the statute of limitations can extend beyond the open years subject to examination.

Due to the geographic breadth of the Company’s operations, numerous tax audits may be ongoing throughout the world at any point in time. Income tax liabilities are recorded based on estimates of additional income taxes which will be due upon the conclusion of these audits. Estimates of these income tax liabilities are made based upon prior experience and are updated in light of changes in facts and circumstances. However, due to the uncertain and complex application of income tax regulations, it is possible that the ultimate resolution of audits may result in liabilities which could be materially different from these estimates. In such an event, the Company will record additional income tax expense or income tax benefit in the period in which such resolution occurs.

The Company had a tax holiday for Quintiles East Asia Pte. Ltd. in Singapore through June 2015, provided the Company maintains specific levels of spending and employment. The income tax benefit of this holiday was approximately $2.0 million, $2.4 million and $798,000 in 2015, 2014 and 2013, respectively. The Company also had a tax holiday for Outcome Europe Sarl in Switzerland for 2013. The income tax benefit of this holiday was approximately $64,000 in 2013. The tax holiday in 2015 and 2014 increased earnings per share by approximately $0.02. The tax holidays in 2013 did not have a notable impact on earnings per share.

17. Employee Benefit Plans

The Company has numerous employee retirement benefit plans, which cover substantially all eligible employees in the countries where the plans are offered either voluntarily or statutorily. Contributions are primarily discretionary, except in some countries where contributions are contractually required.

Defined Contribution Plans

Defined contribution or profit sharing style plans are offered in Austria, Belgium, Bulgaria, Canada, the Czech Republic, Denmark, Finland, France, Germany, Hungary, India, Ireland, Israel, Malaysia, the Netherlands, Poland, Slovakia, South Africa, Sweden, Switzerland, Thailand, the United States and the United Kingdom. In some cases these plans are required by local laws or regulations.

In the United States, the Company has a 401(k) Plan under which the Company matches employee deferrals at varying percentages, set at the discretion of the Board. In 2015, 2014 and 2013, the Company expensed $36.3 million, $31.2 million and $26.1 million, respectively, related to matching contributions.

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Defined Benefit Plans

Defined benefit plans are offered in Austria, France, Germany, Greece, India, Indonesia, Israel, Japan, Mexico, Philippines, Poland, Turkey and the United Kingdom. The following table summarizes the components of pension expense related to these defined benefit plans (in thousands):

	Year Ended December 31,
	2015			2014			2013
Service cost	$	15,486		$	12,944		$	13,227
Interest cost		3,453			3,821			3,684
Expected return on plan assets		(3,555	)		(4,277	)		(3,442	)
Amortization of prior service costs	—				107			336
Amortization of actuarial losses		973			636			708
	$	16,357		$	13,231		$	14,513

The Company expects to recognize approximately $870,000 in its pension expense in 2016 related to the amortization of net actuarial losses.

The weighted average assumptions used in determining pension expense were as follows:

	Year Ended December 31,
	2015			2014			2013
Discount rate		2.46	%		3.01	%		3.06	%
Rate of compensation increases		4.32	%		4.36	%		4.74	%
Expected return on plan assets		4.05	%		5.21	%		5.33	%

The following table summarizes financial information about the Company’s defined benefit plans (in thousands):

	December 31,
	2015			2014
Projected benefit obligation January 1	$	147,127		$	135,110
Service costs		15,486			12,944
Interest cost		3,453			3,821
Expected return on plan assets		(3,555	)		(4,277	)
Actuarial (gains) losses		(2,306	)		16,396
Business combination		1,746		—
Benefits paid		(6,325	)		(7,409	)
Foreign currency fluctuations and other		(1,732	)		(9,458	)
Projected benefit obligation December 31	$	153,894		$	147,127
Plan assets at fair value, January 1	$	88,420		$	82,787
Actual return on plan assets		1,312			10,004
Contributions		5,982			8,594
Business combination		1,966		—
Benefits paid		(6,325	)		(7,409	)
Foreign currency fluctuations and other		(4,212	)		(5,556	)
Plan assets at fair value, December 31	$	87,143		$	88,420
Unfunded balance	$	66,751		$	58,707

The accumulated benefit obligation for all defined benefit plans was approximately $139.1 million and $127.9 million as of December 31, 2015 and 2014, respectively.

As of December 31, 2015, the projected benefit obligation and accumulated benefit obligation for the defined benefit plans with accumulated benefit obligations in excess of plan assets were $94.6 million and $82.9 million, respectively, and were primarily related to unfunded plans. As of December 31, 2014, the projected benefit obligation and accumulated benefit obligation for the defined benefit plans with accumulated benefit obligations in excess of plan assets were $83.4 million and $66.4 million, respectively, and were primarily related to unfunded plans. As of December 31, 2015 and 2014, the projected benefit obligation exceeded the fair value of the plan assets for each defined benefit plan except for the defined benefit plans in the United Kingdom.

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The following table summarizes the amounts recognized in the consolidated balance sheets related to the defined benefit plans (in thousands):

	December 31,
	2015			2014
Deposits and other assets	$	19,185		$	18,690
Accrued expenses		4,520			6,075
Other long-term liabilities		81,410			71,322
AOCI	$	(13,264	)	$	(14,519	)

The following table summarizes the amounts recognized in AOCI related to the defined benefit plans (in thousands):

	Prior			Actuarial			Deferred
	Service			Net			Income
	Costs			(Gain) Loss			Taxes			Total
Balance as of December 31, 2013	$	(107	)	$	(4,937	)	$	2,956		$	(2,088	)
Reclassification adjustments included in pension expense:
Amortization		107			636			(275	)		468
Amounts arising during the period:
Actuarial changes in benefit obligation	—				(10,218	)		2,981			(7,237	)
Balance as of December 31, 2014		—			(14,519	)		5,662			(8,857	)
Reclassification adjustments included in pension expense:
Amortization	—				973			(355	)		618
Amounts arising during the period:
Actuarial changes in benefit obligation	—				282			(318	)		(36	)
Balance as of December 31, 2015	$	—		$	(13,264	)	$	4,989		$	(8,275	)

The following table summarizes the weighted average assumptions used in determining the pension obligations:

	December 31,
	2015			2014
Discount rate		2.50	%		2.46	%
Rate of compensation increases		4.37	%		4.32	%

The discount rate represents the interest rate used to determine the present value of the future cash flows currently expected to be required to settle the Company’s defined benefit plan obligations. The discount rates are derived using weighted average yield curves on AA-rated corporate bonds. The cash flows from the Company’s expected benefit obligation payments are then matched to the yield curve to derive the discount rates.

The Company’s assumption for the expected return on plan assets was determined by the weighted average of the long-term expected rate of return on each of the asset classes invested as of the balance sheet date. For plan assets invested in government bonds, the expected return was based on the yields on the relevant indices as of the balance sheet date. There is considerable uncertainty for the expected return on plan assets invested in equity and diversified growth funds. The expected return on these plan assets was based on the expected return on long-term fixed interest rate government bonds as of the balance sheet date with a premium of 3% to 5% added to reflect the expected long-term returns expected from these types of investments.

The investment objective for defined benefit plan assets is to meet the plan’s benefit obligations and maintaining adequate funding, while minimizing the potential for future required Company contributions. The defined benefit plans in the United Kingdom, India and Israel are funded. The plan assets of the defined benefit plans in India and Israel are held in a fund which holds debt investments, primarily government bonds in accordance with local laws and regulations. The plan assets of the defined benefit plan in the United Kingdom, which are held in a trust, are primarily held in funds which hold investments in government bonds, equity investments and diversified growth funds. The equity investments are diversified to include domestic (United Kingdom) and global equity investments. A “horizon based” approach is used to determine the asset allocation. Funds intended to meet the plan’s benefit obligation payments in a horizon period are invested in low risk assets such as bond investments. Funds intended to meet the plan’s benefit obligation payments outside of the horizon period are invested in more volatile assets which are expected to provide a higher return such as equity investments and diversified growth funds. The target allocation percentage for 2016 is approximately 45-55% in bond investments, 25-35% in equity investments and 15-25% in diversified growth funds. However, the trustees may reallocate the plan assets between equity investments and bond investments depending upon the actual investment performances.

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The Company’s plan assets have been identified within the fair value hierarchy as Level 2. Funds are valued using the net asset value reported by the managers of the funds. The following table summarizes the fair value of the Company’s defined benefit plans assets (in thousands):

	December 31,
	2015		2014
Funds that hold debt investments primarily government bonds	$	49,355	$	47,473
Funds that hold United Kingdom equity investments		15,700		19,547
Funds that hold global equity investments		6,277		8,255
Diversified growth fund		15,248		12,569
Other		563		576
Total	$	87,143	$	88,420

The Company estimates that it will make contributions totaling approximately $5.5 million to the defined benefit plans in 2016.

The following table summarizes the Company’s expected benefit payments under the defined benefit plans for each of the next five years and the aggregate of the five years thereafter (in thousands):

2016	$	6,684
2017		6,615
2018		7,096
2019		7,802
2020		9,092
Years 2021 through 2025		66,117
	$	103,406

Stock Incentive Plans

The stock incentive plans provide incentives to eligible employees, officers and directors in the form of non-qualified stock options, incentive stock options, SARs, restricted stock, RSUs, performance shares, performance units, covered annual incentive awards, cash-based awards and other share-based awards, in each case subject to the terms of the stock incentive plans. As of December 31, 2015, there were 7,372,127 shares available for future grants under the stock incentive plans.

The following assumptions were used to estimate the fair value of stock options and SARs:

	Year Ended December 31,
	2015		2014		2013
Expected volatility	26 – 41%		26 – 43%		18 – 47%
Weighted average expected volatility		34%		36%		40%
Expected dividends		0.0%		0.0%	0.0 - 5.45%
Expected term (in years)	3.7 – 6.7		1.5 – 6.7		0.25 – 6.4
Risk-free interest rate	1.06 – 2.04%		0.28 – 2.21%		0.04 – 2.24%

Stock Options

The option price is determined by the Board at the date of grant and the options expire 10 years from the date of grant. The vesting schedule for options granted to employees is either (i) 20% per year beginning on the first anniversary of the date of grant; (ii) 25% per year beginning on the first anniversary of the date of grant; or (iii) 33% on the third anniversary of the date of grant and 67% on the fourth anniversary of the date of grant. Options granted to our non-employee directors vest either (i) 100% on the first anniversary of the date of grant; or (ii) 34% on the first anniversary of the date of grant and 33% on the second and third anniversaries of the date of grant.

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The Company’s stock option activity in 2015 is as follows:

				Weighted
	Number			Average		Aggregate
	of			Exercise		Intrinsic
	Options			Price		Value
						(in thousands)
Outstanding at December 31, 2014		9,124,954		$	29.15	$	271,216
Granted		993,600		$	65.05
Exercised		(3,013,190	)	$	19.41
Canceled		(457,365	)	$	42.08
Outstanding at December 31, 2015		6,647,999		$	38.04	$	203,679

The weighted average fair value per share of the options granted in 2015, 2014 and 2013 was $21.96, $18.72 and $14.39, respectively. The total intrinsic value of options exercised was approximately $143.7 million, $77.3 million and $27.1 million in 2015, 2014 and 2013, respectively. The Company received cash of approximately $58.5 million, $33.1 million and $12.5 million in 2015, 2014 and 2013, respectively, from options exercised.

Selected information regarding the Company’s stock options as of December 31, 2015 is as follows:

Options Outstanding											Options Exercisable
									Weighted
							Weighted		Average				Weighted
Number		Exercise					Average		Remaining		Number		Average
of		Price					Exercise		Life		of		Exercise
Options		Range					Price		(in Years)		Options		Price
	1,063,999	$	5.76	-	$	21.69	$	17.58		4.19		947,799	$	17.14
	1,069,630	$	22.01	-	$	23.83	$	23.79		6.32		661,630	$	23.79
	867,197	$	24.59	-	$	30.07	$	25.07		6.30		545,947	$	24.97
	1,241,087	$	40.00	-	$	40.00	$	40.00		7.10		421,837	$	40.00
	1,208,586	$	42.74	-	$	53.26	$	50.76		8.00		261,334	$	50.30
	1,197,500	$	57.00	-	$	77.11	$	63.44		8.87		58,375	$	57.43

The weighted average remaining contractual life of the options outstanding and exercisable as of December 31, 2015 is 6.89 years and 5.90 years, respectively. The total aggregate intrinsic value of the exercisable stock options and the stock options expected to vest as of December 31, 2015 was approximately $201.0 million.

Stock Appreciation Rights

The Company’s SARs require the Company to settle in cash an amount equal to the difference between the fair value of the Company’s common stock on the date of exercise and the grant price, multiplied by the number of SARs being exercised. These awards either (i) vest 25% per year or (ii) vest 33% on the third anniversary of the date of grant and 67% on the fourth anniversary of the date of grant.

The Company’s SAR activity in 2015 is as follows:

				Weighted
	Number			Average		Aggregate
	of			Grant		Intrinsic
	SARs			Price		Value
						(in thousands)
Outstanding at December 31, 2014		418,801		$	43.55	$	6,417
Granted		176,200		$	64.93
Exercised		(33,262	)	$	39.61
Canceled		(31,038	)	$	51.00
Outstanding at December 31, 2015		530,701		$	50.46	$	9,659

As of December 31, 2015, 2014 and 2013, the weighted average fair value per share of the SARs granted was $29.79, $27.17 and $19.07, respectively. The Company paid approximately $967,000, $408,000 and $83,000 to settle exercised SARs in 2015, 2014 and 2013, respectively.

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The weighted average remaining contractual life of the SARs outstanding and exercisable as of December 31, 2015 is 8.1 years and 7.4 years, respectively. The total aggregate intrinsic value of the exercisable SARs and the SARs expected to vest as of December 31, 2015 was approximately $9.5 million.

Restricted Stock Units

The Company’s RSUs will settle in shares of the Company’s common stock within 45 days of the applicable vesting date. RSUs granted to employees vest either (i) 25% per year beginning on the first anniversary of the date of grant; or (ii) 33% on the third anniversary of the date of grant and 67% on the fourth anniversary of the date of grant. RSUs granted to our non-employee directors vest either (i) 100% on the first anniversary of the date of grant; or (ii) 34% on the first anniversary of the date of grant and 33% on the second and third anniversaries of the date of grant.

The Company’s RSU activity in 2015 is as follows:

				Weighted
				Average
	Number			Grant-Date
	of			Fair
	RSUs			Value
Non-vested at December 31, 2014		93,667		$	45.89
Granted		276,922		$	65.61
Vested		(918	)	$	47.87
Canceled		(10,118	)	$	62.77
Non-vested at December 31, 2015		359,553		$	60.60

As of December 31, 2015, there are 359,553 RSUs outstanding with an intrinsic value of approximately $24.7 million.

Performance Units

In March 2015, the Company awarded performance units that contain both service and performance based vesting criteria. Vesting occurs if the recipient remains employed and depends on the degree to which the Company achieves certain cumulative adjusted diluted earnings per share goals during a three-year performance period (as defined in the award agreements). The fair value of these awards is equal to the closing price of the Company’s common stock on the grant date.

The Company’s performance units activity in 2015 is as follows:

				Weighted
	Number			Average
	of			Grant-Date
	Performance			Fair
	Units			Value
Non-vested at December 31, 2014	—			$	—
Granted		51,977		$	64.93
Canceled		(2,310	)	$	64.93
Non-vested at December 31, 2015		49,667		$	64.93

As of December 31, 2015, there are 49,667 performance units outstanding with an intrinsic value of approximately $3.4 million.

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Employee Stock Purchase Plan

The Company sponsors an Employee Stock Purchase Plan (“ESPP”) which allows eligible employees to authorize payroll deductions of up to 10% of their base salary to be applied toward the purchase of full shares of the Company’s common stock on the last day of the offering period. Offering periods under the ESPP are six months in duration. The first two offering periods for the ESPP began March 1, 2014 and September 1, 2014, respectively. In November 2014, the ESPP was amended to change the start of the offering periods to begin on April 1 and October 1 of each year, beginning April 1, 2015. Participating employees purchase shares on the last day of each offering period at a discount of 15% of the closing price of the common stock on such date as reported on the NYSE. The aggregate number of shares of the Company’s common stock that may be issued under the ESPP may not exceed 2,500,000 shares and no one employee may purchase any shares under the ESPP having a collective fair market value greater than $25,000 in any one calendar year. The shares available for purchase under the ESPP will be drawn from authorized but unissued shares of common stock. During 2015 and 2014, the Company issued 90,079 shares and 46,032 shares, respectively, of common stock for purchases under the ESPP.

Other

The Company sponsors a supplemental non-qualified deferred compensation plan, covering certain management employees, and maintains other statutory indemnity plans as required by local laws or regulations.

As of December 31, 2015 and 2014, the Company had a severance accrual included in accrued expenses on the accompanying consolidated balance sheets of $3.3 million and $6.3 million, respectively. The Company recognizes obligations associated with severance related to contractual termination benefits at fair value on the date that it is probable that the affected employees will be entitled to the benefit and the amount can reasonably be estimated. The severance accrual is related to cost reduction programs that will result in severance for approximately 270 positions, which are expected to lower operating costs and improve profitability. In 2015, the Company recognized approximately $1.0 million of net reversals related to these cost reduction programs, primarily as a result of affected individuals transferring into other positions within the Company. Of the $1.0 million decrease from net reversals recognized for these cost reduction programs, approximately $837,000 and $205,000 were related to activities in the Product Development segment and Integrated Healthcare Services segment, respectively. The Company expects the majority of the severance accrual at December 31, 2015 will be paid in 2016.

The following amounts were recorded for the severance associated with cost reduction programs (in thousands):

Balance at December 31, 2014	$	6,274
Expense, net of reversals		(1,042	)
Payments		(1,873	)
Foreign currency translation		(22	)
Balance at December 31, 2015	$	3,337

18. Related Party Transactions

As the Company has done in prior years, the Company reimbursed its former Executive Chairman, who retired effective December 31, 2015 but remains a director of the Company, for business-related travel services he provided for himself and other Company employees with the use of his own airplane. In 2015, 2014 and 2013, the Company expensed approximately $1.3 million, $1.8 million and $2.7 million, respectively, for such business-related travel expenses. In the second quarter of 2013, the Company paid a $1.5 million fee in connection with the modification of the agreement for the business usage of the airplane that limited reimbursements to $2.5 million per year. The Company’s reimbursement obligations terminated effective December 31, 2015 in connection with its former Executive Chairman’s retirement.

In January 2010, the Company entered into a collaboration agreement with a related party, HUYA Bioscience International, LLC (“HUYA”), to fund up to $2.3 million of its research and development activity for a specific compound. Under the agreement, the Company had the potential to receive additional consideration which contractually would not exceed $16.5 million excluding interest if certain events had occurred. In February 2015, the Company and HUYA agreed to terminate the collaboration agreement. In connection with the termination, HUYA paid the Company $5.0 million to satisfy all of HUYA’s various payment obligations under the collaboration agreement.

During 2015, 2014 and 2013, the Company entered into a number of contracts with HUYA, primarily in Asia, in which the Company will provide up to approximately $31.7 million, $416,000 and $19.2 million, respectively, of services on a fee for services basis at arm’s length and at market rates. In 2015, 2014 and 2013, the Company provided approximately $6.9 million, $2.3 million and $772,000, respectively, of services under these agreements.

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During 2014, HUYA subleased office space in Japan from the Company. The nine month sublease ended in September 2014 and the Company recognized $76,000 in sublease income during 2014.

The Company has entered into other transactions with related parties including investments in and advances to unconsolidated affiliates which are discussed in Note 4 and management fees which are discussed in Note 13.

19. Operations by Geographic Location

The table below presents the Company’s operations by geographical location. The Company attributes revenues to geographical locations based upon where the services are performed. The Company’s operations within each geographical region are further broken down to show each country which accounts for 10% or more of the totals (in thousands):

	Year Ended December 31,
	2015		2014		2013
Service revenues:
Americas:
United States	$	1,787,918	$	1,589,402	$	1,351,160
Other		185,583		194,597		181,814
Americas		1,973,501		1,783,999		1,532,974
Europe and Africa:
United Kingdom		409,920		402,184		362,242
Other		1,050,070		1,121,354		1,139,262
Europe and Africa		1,459,990		1,523,538		1,501,504
Asia-Pacific:
Japan		442,957		471,831		438,882
Other		449,971		386,454		334,980
Asia-Pacific		892,928		858,285		773,862
Total service revenues		4,326,419		4,165,822		3,808,340
Reimbursed expenses		1,411,200		1,294,176		1,291,205
Total revenues	$	5,737,619	$	5,459,998	$	5,099,545

	As of December 31,
	2015		2014
Property, equipment and software, net:
Americas:
United States	$	169,674	$	167,890
Other		1,204		1,774
Americas		170,878		169,664
Europe and Africa:
United Kingdom		46,042		48,409
Other		16,615		15,782
Europe and Africa		62,657		64,191
Asia-Pacific:
Japan		12,660		20,752
Other		24,975		25,271
Asia-Pacific		37,635		46,023
Total property, equipment and software, net	$	271,170	$	279,878

20. Segments

The following table presents the Company’s operations by reportable segment. The Company is managed through two reportable segments, Product Development and Integrated Healthcare Services. Product Development, which primarily serves biopharmaceutical customers engaged in research and development, provides clinical research and clinical trial services. Integrated Healthcare Services provides commercialization services to biopharmaceutical customers and research, analytics, real-world and late phase research, and other services to both biopharmaceutical customers and the broader healthcare market.

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Certain costs are not allocated to the Company’s segments and are reported as general corporate and unallocated expenses. These costs primarily consist of share-based compensation and expenses for corporate overhead functions such as finance, human resources, information technology, facilities and legal, as well as certain expenses incurred during 2013, including the $25.0 million fee incurred in connection with the termination of the management agreement with affiliates of certain shareholders and the $1.5 million fee paid in connection with the modification of an agreement for the business usage of an airplane owned by GFM, a company owned by the Company’s former Executive Chairman who retired effective December 31, 2015 but remains a director of the Company. The Company does not allocate restructuring or impairment charges to its segments.

Information presented below is in thousands:

	Year Ended December 31,
	2015			2014			2013
Service revenues
Product Development	$	3,191,630		$	3,097,831		$	2,919,730
Integrated Healthcare Services		1,134,789			1,067,991			888,610
Total service revenues		4,326,419			4,165,822			3,808,340
Costs of revenue, service costs
Product Development		1,828,734			1,820,937			1,752,800
Integrated Healthcare Services		896,852			863,169			718,626
Total costs of revenue, service costs		2,725,586			2,684,106			2,471,426
Selling, general and administrative
Product Development		648,297			631,678			604,663
Integrated Healthcare Services		153,896			140,019			127,860
General corporate and unallocated		118,792			110,641			127,987
Total selling, general and administrative		920,985			882,338			860,510
Income from operations
Product Development		714,599			645,216			562,267
Integrated Healthcare Services		84,041			64,803			42,124
General corporate and unallocated		(118,792	)		(110,641	)		(127,987	)
Restructuring costs		(30,752	)		(8,988	)		(14,071	)
Impairment charges		(2,484	)		—			—
Total income from operations	$	646,612		$	590,390		$	462,333

	As of December 31,
	2015		2014		2013
Assets
Product Development	$	3,343,502	$	2,786,692	$	2,571,502
Integrated Healthcare Services		405,411		330,689		299,284
General corporate and unallocated		177,403		178,572		183,437
Total assets	$	3,926,316	$	3,295,953	$	3,054,223

	Year Ended December 31,
	2015		2014		2013
Expenditures to acquire long-lived assets
Product Development	$	67,660	$	68,187	$	69,375
Integrated Healthcare Services		8,667		8,279		17,398
General corporate and unallocated		2,064		6,184		1,574
Total expenditures to acquire long-lived assets	$	78,391	$	82,650	$	88,347

	Year Ended December 31,
	2015		2014		2013
Depreciation and amortization expense
Product Development	$	100,913	$	95,168	$	82,047
Integrated Healthcare Services		21,961		20,821		20,475
General corporate and unallocated		4,868		5,024		4,982
Total depreciation and amortization expense	$	127,742	$	121,013	$	107,504

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21. Earnings Per Share

The following table reconciles the basic to diluted weighted average shares outstanding (in thousands):

	Year Ended December 31,
	2015		2014		2013
Basic weighted average common shares outstanding		123,038		127,994		124,147
Effect of dilutive stock options and share awards		2,592		3,089		3,715
Diluted weighted average common shares outstanding		125,630		131,083		127,862

The following table shows the weighted average number of outstanding share-based awards not included in the computation of diluted earnings per share as the effect of including such share-based awards in the computation would be anti-dilutive (in thousands):

	Year Ended December 31,
	2015		2014		2013
Weighted average shares subject to anti-dilutive share-based awards		1,058		1,241		1,765

Share-based awards will have a dilutive effect under the treasury method only when the respective period’s average market value of the Company’s common stock exceeds the exercise proceeds.

22. Comprehensive Income

Below is a summary of the components of AOCI (in thousands):

	Foreign Currency Translation			Marketable Securities			Derivative Instruments			Defined Benefit Plans			Income Taxes			Total
Balance at December 31, 2012	$	19,312		$	467		$	(33,542	)	$	(8,235	)	$	29,693		$	7,695
Other comprehensive (loss) income before reclassifications		(25,141	)		5,241			(393	)		2,147			1,331			(16,815	)
Reclassification adjustments		—			—			13,080			1,044			(5,380	)		8,744
Balance at December 31, 2013		(5,829	)		5,708			(20,855	)		(5,044	)		25,644			(376	)
Other comprehensive (loss) income before reclassifications		(49,911	)		(976	)		(6,834	)		(10,218	)		7,225			(60,714	)
Reclassification adjustments		—			(5,004	)		8,630			743			(2,370	)		1,999
Balance at December 31, 2014		(55,740	)		(272	)		(19,059	)		(14,519	)		30,499			(59,091	)
Other comprehensive (loss) income before reclassifications		(61,090	)		(436	)		(13,202	)		282			9,110			(65,336	)
Reclassification adjustments		—			—			18,269			973			(6,181	)		13,061
Balance at December 31, 2015	$	(116,830	)	$	(708	)	$	(13,992	)	$	(13,264	)	$	33,428		$	(111,366	)

100

Below is a summary of the (gains) losses reclassified from AOCI into the consolidated statements of income and the affected financial statement line item (in thousands):

	Affected Financial Statement	Year Ended December 31,
Reclassification Adjustments	Line Item	2015		2014			2013
Marketable securities	Other expense (income), net	$	—	$	(5,004	)	$	—
Total before income taxes			—		(5,004	)		—
Income tax expense			—		(1,927	)		—
Total net of income taxes		$	—	$	(3,077	)	$	—
Derivative instruments:
Interest rate swaps	Interest expense	$	12,333	$	12,424		$	12,582
Foreign exchange forward contracts	Service revenues		5,936		(3,794	)		498
Total before income taxes			18,269		8,630			13,080
Income tax benefit			5,826		4,022			4,991
Total net of income taxes		$	12,443	$	4,608		$	8,089
Defined benefit plans:
Amortization of prior service costs	See Note 17	$	—	$	107		$	336
Amortization of actuarial losses	See Note 17		973		636			708
Total before income taxes			973		743			1,044
Income tax benefit			355		275			389
Total net of income taxes		$	618	$	468		$	655

23. Supplemental Cash Flow Information

The following table presents the Company’s supplemental cash flow information (in thousands):

	Year Ended December 31,
	2015		2014		2013
Supplemental Cash Flow Information:
Interest paid	$	82,333	$	93,912	$	115,494
Income taxes paid, net of refunds		120,804		138,931		70,983
Non-cash Investing Activities:
Acquisition of property and equipment utilizing capital leases	$	4,238	$	2,476	$	3,761
Fair value of contingent consideration payable in connection with acquisitions		—		—		14,300
Fair value of consideration transferred in connection with the Q2 Solutions transaction		423,268		—		—

101

24. Quarterly Financial Data (Unaudited)

The following table summarizes the Company’s unaudited quarterly results of operations (in thousands, except per share data):

	2015
	First Quarter			Second Quarter		Third Quarter			Fourth Quarter
Service revenues	$	1,029,974		$	1,074,366	$	1,093,480		$	1,128,599
Income from operations		143,217			158,389		167,023			177,983
Net income		86,431			84,947		108,839			108,087
Net (income) loss attributable to noncontrolling interests		(33	)		4		2,447			(3,517	)
Net income attributable to Quintiles Transnational Holdings Inc.	$	86,398		$	84,951	$	111,286		$	104,570
Basic earnings per share (1)	$	0.69		$	0.69	$	0.91		$	0.86
Diluted earnings per share (1)	$	0.68		$	0.67	$	0.89		$	0.85
	2014
	First Quarter			Second Quarter		Third Quarter			Fourth Quarter
Service revenues	$	1,005,288		$	1,035,476	$	1,061,013		$	1,064,045
Income from operations		141,316			141,000		149,142			158,932
Net income		90,214			85,110		92,733			88,444
Net (income) loss attributable to noncontrolling interests		(31	)		10		(79	)		(18	)
Net income attributable to Quintiles Transnational Holdings Inc.	$	90,183		$	85,120	$	92,654		$	88,426
Basic earnings per share (1)	$	0.69		$	0.66	$	0.73		$	0.70
Diluted earnings per share (1)	$	0.68		$	0.64	$	0.71		$	0.69

(1) The sum of the quarterly per share amounts may not equal per share amounts reported for year-to-date periods. This is due to changes in the number of weighted average shares outstanding and the effects of rounding for each period.

25. Subsequent Event

In February 2016, the Board approved a restructuring plan for approximately $22 million, primarily for severance and other exit costs, to align its resources and reduce overcapacity. Some of these actions are subject to certain legal and regulatory requirements. These actions, if implemented, are expected to occur in 2016.

102

Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure

None.

Item 9A. Controls and Procedures

Evaluation of Disclosure Controls and Procedures

As required by Rule 13a-15 under the Exchange Act, as amended, we carried out an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures under the supervision and with the participation of our management, including the Chief Executive Officer, or CEO, and Chief Financial Officer, or CFO. There are inherent limitations to the effectiveness of any system of disclosure controls and procedures, including the possibility of human error and the circumvention or overriding of the controls and procedures. Accordingly, even effective disclosure controls and procedures can only provide reasonable assurance of achieving their control objectives. Based upon our evaluation, our CEO and CFO concluded that our disclosure controls and procedures were effective to provide reasonable assurance that information required to be disclosed by us in the reports that we file or submit under the Exchange Act, as amended, is recorded, processed, summarized and reported within the time periods specified in the applicable rules and forms, and that it is accumulated and communicated to our management, including our CEO and CFO, as appropriate, to allow timely decisions regarding required disclosure.

Management’s Report on Internal Control over Financial Reporting

Our management’s report on internal control over financial reporting is set forth in Part II, Item 8 of this Annual Report on Form 10-K and is incorporated herein by reference.

Changes in Internal Control over Financial Reporting

There were no changes in our internal control over financial reporting during the quarter ended December 31, 2015 that materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

Item 9B. Other Information

As previously disclosed, Dr. Dennis Gillings retired as our Executive Chairman as of December 31, 2015 and, as a result of him becoming a non-employee director, the Company and Dr. Gillings entered into the Company's standard indemnity agreement for directors as of February 9, 2016.

103

PART III

Item 10. Directors, Executive Officers and Corporate Governance

The information required by this item is set forth under the headings “Election of Directors” and “Section 16(a) Beneficial Ownership Reporting Compliance” in our 2016 Proxy Statement to be filed with the SEC within 120 days after December 31, 2015 in connection with the solicitation of proxies for our 2016 annual meeting of shareholders, or the 2016 Proxy Statement, and is incorporated herein by reference.

Item 11. Executive Compensation

The information required by this item is set forth under the headings “Election of Directors,” “Executive and Director Compensation,” and “Compensation Committee Interlocks and Insider Participation” in the 2016 Proxy Statement and is incorporated herein by reference.

Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

The information required by this item is set forth under the headings “Executive and Director Compensation” and “Security Ownership of Certain Beneficial Owners and Management” in the 2016 Proxy Statement and is incorporated herein by reference.

Item 13. Certain Relationships and Related Transactions and Director Independence

The information required by this item is set forth under the headings “Election of Directors,” and “Certain Relationships and Related Person Transactions” in the 2016 Proxy Statement and is incorporated herein by reference.

Item 14. Principal Accountant Fees and Services

The information required by this item is set forth under the headings “Election of Directors,” and “Ratification of the Appointment of Independent Registered Public Accounting Firm” in the 2016 Proxy Statement and is incorporated herein by reference.

PART IV

Item 15. Exhibits and Financial Statement Schedules

(a) The following documents are filed as part of this report:

(1) Financial Statements

The following consolidated financial statements of Quintiles Transnational Holdings Inc. and its subsidiaries, and the independent registered public accounting firm’s report thereon, are included in Part II, Item 8 of this report:

	Page
Management’s Report on Internal Control over Financial Reporting	61
Report of Independent Registered Public Accounting Firm	62
Consolidated Statements of Income	63
Consolidated Statements of Comprehensive Income	64
Consolidated Balance Sheets	65
Consolidated Statements of Cash Flows	66
Consolidated Statements of Shareholders’ Deficit	67
Notes to Consolidated Financial Statements	68

(2) Financial Statement Schedules

Schedule I—Condensed Financial Information of Registrant (Parent Company Only)	107
Schedule II—Valuation and Qualifying Accounts	112

All other schedules are omitted, since the required information is not applicable or is not present in amounts sufficient to require submission of the schedule, or because the information required is included in the consolidated financial statements and notes thereto.

104

(3) Exhibits

The exhibits in the accompanying Exhibit Index following the signature page are filed or furnished as a part of this report and are incorporated herein by reference. The Company agrees to furnish to the SEC, upon request, copies of any long-term debt instruments that authorize an amount of securities constituting 10% or less of the total assets of Quintiles Transnational Holdings Inc. and its subsidiaries on a consolidated basis.

105

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

QUINTILES TRANSNATIONAL HOLDINGS INC.

By:	/s/ Michael R. McDonnell
	Name: Michael R. McDonnell Title: Executive Vice President and Chief Financial Officer
Date:	February 11, 2016

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant in the capacities and on the dates indicated.

Signature	Title	Date
/s/ Thomas H. Pike	Chief Executive Officer and Director	February 11, 2016
Thomas H. Pike	(Principal Executive Officer)
/s/ Michael R. McDonnell	Executive Vice President and Chief Financial Officer	February 11, 2016
Michael R. McDonnell	(Principal Financial Officer)
/s/ Charles E. Williams	Senior Vice President, Corporate Controller	February 11, 2016
Charles E. Williams	(Principal Accounting Officer)
/s/ Jack M. Greenberg	Director	February 11, 2016
Jack M. Greenberg
/s/ John P. Connaughton	Director	February 11, 2016
John P. Connaughton
/s/ Jonathan J. Coslet	Director	February 11, 2016
Jonathan J. Coslet
/s/ Michael J. Evanisko	Director	February 11, 2016
Michael J. Evanisko
/s/ Dr. Dennis B. Gillings, CBE	Director	February 11, 2016
Dr. Dennis B. Gillings, CBE
/s/ Annie Hai-yuan Lo	Director	February 11, 2016
Annie Hai-yuan Lo
/s/ John M. Leonard	Director	February 11, 2016
John M. Leonard
/s/ Leonard D. Schaeffer	Director	February 11, 2016
Leonard D. Schaeffer

106

(2) Financial Statement Schedules

Schedule I—Condensed Financial Information of Registrant

QUINTILES TRANSNATIONAL HOLDINGS INC. (PARENT COMPANY ONLY)

CONDENSED STATEMENTS OF INCOME

	Year Ended December 31,
	2015			2014			2013
	(in thousands)
Selling, general and administrative	$	715		$	1,509		$	2
Loss from operations		(715	)		(1,509	)		(2	)
Interest income		(24	)		(52	)		(6	)
Interest expense		—			—			9,242
Loss on extinguishment of debt		—			—			15,501
Other expense, net		7			8			—
Loss before income taxes and equity in earnings of subsidiary		(698	)		(1,465	)		(24,739	)
Income tax benefit		(530	)		(810	)		(9,347	)
Loss before equity in earnings of subsidiary		(168	)		(655	)		(15,392	)
Equity in earnings of subsidiary		387,373			357,038			241,983
Net income	$	387,205		$	356,383		$	226,591

107

QUINTILES TRANSNATIONAL HOLDINGS INC. (PARENT COMPANY ONLY)

CONDENSED STATEMENTS OF COMPREHENSIVE INCOME

	Year Ended December 31,
	2015			2014			2013
	(in thousands)
Net income	$	387,205		$	356,383		$	226,591
Comprehensive income adjustments:
Unrealized (losses) gains on marketable securities, net of income taxes of ($168), ($376) and $2,016		(268	)		(600	)		3,225
Unrealized (losses) gains on derivative instruments, net of income taxes of ($3,679), ($1,767) and ($751)		(9,523	)		(5,067	)		358
Defined benefit plan adjustments, net of income taxes of $318, ($2,981) and ($131)		(36	)		(7,237	)		2,278
Foreign currency translation, net of income taxes of ($5,581), ($2,101) and ($2,465)		(55,509	)		(47,810	)		(22,676	)
Reclassification adjustments:
Gains on marketable securities included in net income, net of income taxes of ($1,927)		—			(3,077	)		—
Losses on derivative instruments included in net income, net of income taxes of $5,826, $4,022 and $4,991		12,443			4,608			8,089
Amortization of prior service costs and losses included in net income, net of income taxes of $355, $275 and $389		618			468			655
Comprehensive income	$	334,930		$	297,668		$	218,520

108

QUINTILES TRANSNATIONAL HOLDINGS INC. (PARENT COMPANY ONLY)

CONDENSED BALANCE SHEETS

	December 31,
	2015			2014
	(in thousands, except per share data)
ASSETS
Current assets:
Cash and cash equivalents	$	4,791		$	11,635
Income taxes receivable		128			546
Other current assets and receivables		16			114
Total current assets		4,935			12,295
Deferred income taxes		—			7
Total assets	$	4,935		$	12,302
LIABILITIES AND SHAREHOLDERS’ DEFICIT
Current liabilities:
Accounts payable	$	7		$	21
Accrued expenses		—			84
Total current liabilities		7			105
Investment in subsidiary		568,785			716,148
Payable to subsidiary		360			110
Total liabilities		569,152			716,363
Commitments and contingencies
Shareholders’ deficit:
Common stock and additional paid-in capital, 300,000 shares authorized, $0.01 par value, 119,378 and 124,129 shares issued and outstanding at December 31, 2015 and 2014, respectively		8,784			143,828
Accumulated deficit		(461,635	)		(788,798	)
Accumulated other comprehensive loss		(111,366	)		(59,091	)
Total shareholders’ deficit		(564,217	)		(704,061	)
Total liabilities and shareholders’ deficit	$	4,935		$	12,302

109

QUINTILES TRANSNATIONAL HOLDINGS INC. (PARENT COMPANY ONLY)

CONDENSED STATEMENTS OF CASH FLOWS

	Year Ended December 31,
	2015			2014			2013
	(in thousands)
Operating activities:
Net income	$	387,205		$	356,383		$	226,591
Adjustments to reconcile net income to cash provided by operating activities:
Amortization of debt issuance costs and discount		—			—			10,346
Subsidiary loss (income)		56,627			(27,623	)		(119,998	)
(Benefit from) provision for deferred income taxes		(335	)		37			304
Change in operating assets and liabilities:
Accounts receivable and unbilled services		—			2,994			(2,995	)
Prepaid expenses and other assets		—			—			(21	)
Accounts payable and accrued expenses		(69	)		65			(62	)
Income taxes payable and other liabilities		(195	)		(847	)		(9,651	)
Net cash provided by operating activities		443,233			331,009			104,514
Investing activities:
Investments in subsidiary, net of payments received		—			—			(179,847	)
Net cash used in investing activities		—			—			(179,847	)
Financing activities:
Repayment of debt		—			—			(300,000	)
Issuance of common stock		—			—			525,000
Payment of common stock issuance costs		—			(105	)		(35,439	)
Stock issued under employee stock purchase and option plans		64,297			35,228			12,539
Repurchase of common stock		(515,010	)		(415,131	)		(6,434	)
Repurchase of stock options		—			(8,415	)		(50,649	)
Intercompany with subsidiary		636			(2,893	)		(153	)
Net cash (used in) provided by financing activities		(450,077	)		(391,316	)		144,864
(Decrease) increase in cash and cash equivalents		(6,844	)		(60,307	)		69,531
Cash and cash equivalents at beginning of period		11,635			71,942			2,411
Cash and cash equivalents at end of period	$	4,791		$	11,635		$	71,942

110

QUINTILES TRANSNATIONAL HOLDINGS INC. (PARENT COMPANY ONLY)

NOTES TO CONDENSED FINANCIAL STATEMENTS

The condensed parent company financial statements have been prepared in accordance with Rule 12-04, Schedule I of Regulation S-X as the restricted net assets of Quintiles Transnational Holdings Inc.’s (the “Company”) wholly-owned subsidiary, Quintiles Transnational Corp. (“Quintiles Transnational”) exceed 25% of the consolidated net assets of the Company. The ability of Quintiles Transnational to pay dividends may be limited due to the restrictive covenants in the agreements governing its credit arrangements.

These condensed parent company financial statements include the accounts of Quintiles Transnational Holdings, Inc. on a standalone basis (the “Parent”) and the equity method of accounting is used to reflect ownership interest in its subsidiary. Refer to the consolidated financial statements and notes presented elsewhere herein for additional information and disclosures with respect to these financial statements.

Since the Parent is part of a group that files a consolidated income tax return, in accordance with ASC 740, a portion of the consolidated amount of current and deferred income tax expense of the Company has been allocated to the Parent. The income tax benefit of $530,000, $810,000 and $9.3 million in 2015, 2014 and 2013, respectively, represents the income tax benefit that will be or were already utilized in the Company’s consolidated United States federal and state income tax returns. If the Parent was not part of these consolidated income tax returns, it would not be able to recognize any income tax benefit, as it generates no revenue against which the losses could be used on a separate filer basis.

Below is a summary of the dividends paid to the Parent by Quintiles Transnational in 2015, 2014 and 2013 (in thousands):

	Amount
Paid in December 2015	$	1,000
Paid in November 2015		223,000
Paid in May 2015		220,000
Total paid in 2015	$	444,000
Paid in November 2014	$	234,000
Paid in May 2014		87,000
Paid in January 2014		8,415
Total paid in 2014	$	329,415
Paid in November and December 2013	$	116,585
Paid in February 2013		5,400
Total paid in 2013	$	121,985

111

Schedule II—Valuation and Qualifying Accounts

Deferred Tax Asset Valuation Allowance

Information presented below is in thousands:

	Balance at		Additions
	Beginning		Charged to					Balance at
	of Year		Expenses		Deductions (a)			End of Year
December 31, 2015	$	24,695	$	1,762	$	(4,295	)	$	22,162
December 31, 2014	$	29,501	$	11,084	$	(15,890	)	$	24,695
December 31, 2013	$	32,344	$	3,611	$	(6,454	)	$	29,501

(a) – Impact of reductions recorded to expense and translation adjustments.

112

EXHIBIT INDEX

			Incorporated by Reference
Exhibit Number	Exhibit Description	Filed Herewith	Form	File No.	Exhibit	Filing Date
3.1	Second Amended and Restated Articles of Incorporation of Quintiles Transnational Holdings Inc.		S-1/A	333-186708	3.1	May 6, 2013
3.2	Third Amended and Restated Bylaws of Quintiles Transnational Holdings Inc.		S-3	333-199843	3.2	November 4, 2014
4.1	Specimen Common Stock Certificate of Quintiles Transnational Holdings Inc.		S-1/A	333-186708	4.1	April 26, 2013
4.2	Second Amended and Restated Registration Rights Agreement, dated May 14, 2013, among Quintiles Transnational Holdings Inc. and the shareholders identified therein.		8-K	001-35907	4.1	May 15, 2013
4.3	Amendment No. 1, dated February 5, 2015, to Second Amended and Restated Registration Rights Agreement, dated May 14, 2013, among Quintiles Transnational Holdings Inc. and the shareholders identified therein.		8-K	001-35907	4.1	February 6, 2015
4.4	Indenture dated as of May 12, 2015, among Quintiles Transnational Corp., the subsidiary guarantors listed therein and U.S. Bank National Association as trustee.		8-K	001-35907	4.1	May 13, 2015
4.5	Form of 4.875% Rule 144A Senior Note due 2023 (incorporated by reference to Exhibit A to Exhibit 4.4).		8-K	001-35907	4.2	May 13, 2015
4.6	Form of 4.875% Regulation S Senior Note due 2023 (incorporated by reference to Exhibit A to Exhibit 4.4).		8-K	001-35907	4.3	May 13, 2015
10.1	Credit Agreement, dated June 8, 2011, among Quintiles Transnational Corp., as the Borrower, each lender from time to time party thereto, and JPMorgan Chase Bank, N.A., as Administrative Agent, Swing Line Lender and L/C Issuer.		S-1	333-186708	10.1	February 15, 2013
10.2	Amendment No. 1, dated October 22, 2012, to Credit Agreement, dated June 8, 2011, among Quintiles Transnational Corp., as the Borrower, each lender from time to time party thereto, and JPMorgan Chase Bank, N.A., as Administrative Agent, Swing Line Lender and L/C Issuer.		S-1	333-186708	10.2	February 15, 2013
10.3	Amendment No. 2, dated December 20, 2012, to Credit Agreement, dated June 8, 2011, among Quintiles Transnational Corp., as the Borrower, each lender from time to time party thereto, and JPMorgan Chase Bank, N.A., as Administrative Agent, Swing Line Lender and L/C Issuer.		S-1	333-186708	10.3	February 15, 2013
10.4	Amendment No. 3, dated December 20, 2013, to Credit Agreement, dated June 8, 2011, among Quintiles Transnational Corp., as the Borrower, each lender from time to time party thereto, and JPMorgan Chase Bank, N.A., as Administrative Agent, Swing Line Lender and L/C Issuer.		8-K	001-35907	10.1	December 20, 2013

113

				Incorporated by Reference
Exhibit Number		Exhibit Description	Filed Herewith	Form	File No.	Exhibit	Filing Date
10.5		Amendment No. 4, dated November 7, 2014, to Credit Agreement, dated June 8, 2011, among Quintiles Transnational Corp., as the Borrower, each lender from time to time party thereto, and JPMorgan Chase Bank, N.A., as Administrative Agent, Swing Line Lender and L/C Issuer.		8-K	001-35907	10.1	November 10, 2014
10.6		Credit Agreement dated May 12, 2015, among Quintiles Transnational Corp., as the borrower, each lender from time to time party thereto, and JPMorgan Chase Bank, N.A., as Administrative Agent, a Swing Line Leader and an L/C Issuer		8-K	001-35907	10.1	May 13, 2015
10.7		Purchase and Sale Agreement, dated December 5, 2014, among Quintiles, Inc., as originator and initial servicer, Quintiles Laboratories, LLC, as originator, Quintiles Commercial US, Inc., as originator, and Quintiles Funding LLC, as buyer.		8-K	001-35907	10.1	December 8, 2014
10.8		Receivables Financing Agreement, dated December 5, 2014, among Quintiles Funding LLC, as borrower, Quintiles, Inc., as initial servicer, PNC Bank, N.A., as administrative agent and lender, and the additional persons from time to time party thereto as lenders.		8-K	001-35907	10.2	December 8, 2014
10.9		Amended and Restated Shareholders Agreement, dated February 5, 2015, among Quintiles Transnational Holdings Inc. and the shareholders identified therein.		8-K	001-35907	10.1	February 6, 2015
10.10		Share Repurchase Agreement, dated May 27, 2014, between Quintiles Transnational Holdings Inc. and TPG Quintiles Holdco, L.P.		8-K	001-35907	10.1	May 28, 2014
10.11		Assignment and Assumption Agreement, dated December 10, 2009, between Quintiles Transnational Corp. and Quintiles Transnational Holdings Inc.		S-1	333-186708	10.12	February 15, 2013
10.12	†	Form of Director Indemnification Agreement.		S-1/A	333-186708	10.13	April 19, 2013
10.13	†	Form of Non-Competition, Non-Solicitation, Confidentiality and IP Agreement.		8-K	001-35907	10.2	October 19, 2015
10.14	†	Quintiles Transnational Holdings Inc. Annual Management Incentive Plan.		S-1/A	333-186708	10.57	April 19, 2013
10.15	†	Quintiles Transnational Holdings Inc. 2003 Stock Incentive Plan.		S-1	333-186708	10.14	February 15, 2013
10.16	†	Form of Stock Option Award Agreement under the Quintiles Transnational Holdings Inc. 2003 Stock Incentive Plan.		S-1	333-186708	10.15	February 15, 2013
10.17	†	Form of Restricted Stock Purchase Agreement under the Quintiles Transnational Holdings Inc. 2003 Stock Incentive Plan.		S-1	333-186708	10.16	February 15, 2013
10.18	†	Quintiles Transnational Holdings Inc. 2008 Stock Incentive Plan.		S-1	333-186708	10.17	February 15, 2013
10.19	†	Form of Stock Option Award Agreement for Senior Executives under the Quintiles Transnational Holdings Inc. 2008 Stock Incentive Plan.		S-1	333-186708	10.18	February 15, 2013

114

				Incorporated by Reference
Exhibit Number		Exhibit Description	Filed Herewith	Form	File No.	Exhibit	Filing Date
10.20	†	Form of Stock Option Award Agreement for Non-Employee Directors under the Quintiles Transnational Holdings Inc. 2008 Stock Incentive Plan.		S-1	333-186708	10.19	February 15, 2013
10.21	†	Quintiles Transnational Corp. Elective Deferred Compensation Plan, as amended and restated.		10-Q	001-35907	10.1	October 28, 2015
10.22	†	Quintiles Transnational Holdings Inc. 2013 Stock Incentive Plan.		S-1/A	333-186708	10.22	April 19, 2013
10.23	†	Form of Award Agreement Awarding Nonqualified Stock Options to Employees under the Quintiles Transnational Holdings Inc. 2013 Stock Incentive Plan.		S-1/A	333-186708	10.23	April 19, 2013
10.24	†	Form of Award Agreement Awarding Incentive Stock Options to Employees under the Quintiles Transnational Holdings Inc. 2013 Stock Incentive Plan.		10-Q	001-35907	10.2	May 1, 2014
10.25	†	Form of Award Agreement Awarding Nonqualified Stock Options to Non-Employee Directors under the Quintiles Transnational Holdings Inc. 2013 Stock Incentive Plan.		S-1/A	333-186708	10.24	April 19, 2013
10.26	†	Form of Award Agreement Awarding Stock Appreciation Rights under the Quintiles Transnational Holdings Inc. 2013 Stock Incentive Plan.		S-1/A	333-186708	10.56	April 19, 2013
10.27	†	Form of Award Agreement Awarding Restricted Stock Units under the Quintiles Transnational Holdings Inc. 2013 Stock Incentive Plan prior to February 2015.		8-K	001-35907	10.1	November 26, 2013
10.28	†	Form of Award Agreement Awarding Restricted Stock Units under the Quintiles Transnational Holdings Inc. 2013 Stock Incentive Plan after February 2015.		10-K	001-35907	10.34	February 12, 2015
10.29	†	Form of Initial Award Agreement Awarding Restricted Stock Units to Michael McDonnell under the Quintiles Transnational Holdings Inc. 2013 Stock Incentive Plan.	X
10.30	†	Form of Award Agreement Awarding Performance Units under the Quintiles Transnational Holdings Inc. 2013 Stock Incentive Plan.		10-K	001-35907	10.35	February 12, 2015
10.31	†	Quintiles Transnational Holdings Inc. Employee Stock Purchase Plan.		S-8	333-193212	10.1	January 6, 2014
10.32	†	First Amendment to Quintiles Transnational Holdings Inc. Employee Stock Purchase Plan.		10-K	001-35907	10.37	February 12, 2015
10.33	†	Sub-Plan to the Employee Stock Purchase Plan, effective 2015.		10-Q	001-35907	10.1	July 29, 2015
10.34	†	Executive Employment Agreement, dated September 25, 2003, among Dennis B. Gillings, Pharma Services Holding, Inc. and Quintiles Transnational Corp.		S-1	333-186708	10.26	February 15, 2013
10.35	†	Assignment and Assumption Agreement, dated March 31, 2006, among Pharma Services Holding, Inc., Quintiles Transnational Corp., and Dennis B. Gillings.		S-1	333-186708	10.27	February 15, 2013
10.36	†	Amendment, dated February 1, 2008, to Executive Employment Agreement, dated September 25, 2003, between Dennis B. Gillings and Quintiles Transnational Corp.		S-1	333-186708	10.28	February 15, 2013

115

				Incorporated by Reference
Exhibit Number		Exhibit Description	Filed Herewith	Form	File No.	Exhibit	Filing Date
10.37	†	Agreement and Amendment, effective December 12, 2008, to Executive Employment Agreement, dated September 25, 2003, between Dennis B. Gillings and Quintiles Transnational Corp.		S-1	333-186708	10.29	February 15, 2013
10.38	†	Third Amendment, dated December 31, 2008, to Executive Employment Agreement, dated September 25, 2003, between Dennis B. Gillings and Quintiles Transnational Corp.		S-1	333-186708	10.30	February 15, 2013
10.39	†	Fourth Amendment, dated December 14, 2009, to Executive Employment Agreement, dated September 25, 2003, between Dennis B. Gillings and Quintiles Transnational Corp.		S-1	333-186708	10.31	February 15, 2013
10.40	†	Fifth Amendment, dated April 18, 2013, to Executive Employment Agreement, dated September 25, 2003, between Dennis B. Gillings and Quintiles Transnational Corp.		S-1/A	333-186708	10.32	April 19, 2013
10.41		Rollover Agreement, dated August 28, 2003, among Pharma Services Holding, Inc., Dennis B. Gillings, Joan H. Gillings, Susan Ashley Gillings, the Gillings Family Foundation, the Gillings Limited Partnership and the GFEF Limited Partnership.		S-1	333-186708	10.33	February 15, 2013
10.42		Amendment No. 1, dated September 23, 2003, to Rollover Agreement, dated August 28, 2003, among Pharma Services Holding, Inc., Dennis B. Gillings, Joan H. Gillings, Susan Ashley Gillings, the Gillings Family Foundation, the Gillings Limited Partnership and the GFEF Limited Partnership.		S-1	333-186708	10.34	February 15, 2013
10.43	†	Stock Option Award Agreement, dated June 30, 2008, between Quintiles Transnational Corp. and Dennis B. Gillings.		S-1	333-186708	10.35	February 15, 2013
10.44	†	Executive Employment Agreement, effective April 30, 2012, between Thomas H. Pike and Quintiles Transnational Corp.		S-1	333-186708	10.36	February 15, 2013
10.45	†	Subscription Agreement, effective May 31, 2012, between Thomas H. Pike and Quintiles Transnational Holdings Inc.		S-1	333-186708	10.37	February 15, 2013
10.46	†	Stock Option Award Agreement, dated May 10, 2012, between Quintiles Transnational Holdings Inc. and Thomas H. Pike.		S-1	333-186708	10.38	February 15, 2013
10.47	†	Stock Option Award Agreement, dated May 31, 2012, between Quintiles Transnational Holdings Inc. and Thomas H. Pike.		S-1	333-186708	10.39	February 15, 2013
10.48	†	Executive Employment Agreement, effective July 30, 2010, between Kevin K. Gordon and Quintiles Transnational Corp.		S-1	333-186708	10.40	February 15, 2013
10.49	†	First Amendment to Employment Agreement, dated November 22, 2010, to Executive Employment Agreement, effective July 30, 2010, between Kevin K. Gordon and Quintiles Transnational Corp.		S-1	333-186708	10.41	February 15, 2013

116

				Incorporated by Reference
Exhibit Number		Exhibit Description	Filed Herewith	Form	File No.	Exhibit	Filing Date
10.50	†	Second Amendment, dated October 14, 2015, to Executive Employment Agreement, effective July 30, 2010, between Kevin K. Gordon and Quintiles Transnational Corp.		8-K	001-35907	10.1	October 19, 2015
10.51	†	Executive Employment Agreement, dated November 1, 2012, between James H. Erlinger III and Quintiles Transnational Corp.		10-K	001-35907	10.63	February 12, 2015
10.52	†	Letter Agreement, dated October 14, 2015, between Michael McDonnell and Quintiles Transnational Corp.		8-K	001-35907	10.3	October 19, 2015
10.53	†	Change of Control Severance Plan, which covers among others our executive officers.		8-K	001-35907	10.1	November 6, 2015
10.54	†	Quintiles Transnational Corp. 401(k) Restoration Plan, effective January 1, 2016		8-K	001-35907	10.1	December 18, 2015
10.55	†	Description of Independent Director Compensation, effective February 5, 2015.		8-K	001-35907	10.2	February 6, 2015
10.56	†	Description of Independent Director Compensation, effective January 1, 2016.	X
21.1		List of Subsidiaries of Quintiles Transnational Holdings Inc.	X
23.1		Consent of PricewaterhouseCoopers LLP.	X
31.1		Certification of Chief Executive Officer, pursuant to Rule 13a-14(a)/15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.	X
31.2		Certification of Executive Vice President and Chief Financial Officer, pursuant to Rule 13a-14(a)/15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.	X
32.1		Certification of Chief Executive Officer, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.	X
32.2		Certification of Executive Vice President and Chief Financial Officer, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.	X
101		Interactive Data Files Pursuant to Rule 405 of Regulation S-T: (i) Consolidated Statements of Income, (ii) Consolidated Statements of Comprehensive Income, (iii) Consolidated Balance Sheets, (iv) Consolidated Statements of Cash Flows, and (v) Notes to Consolidated Financial Statements.	X

† Indicates management contract or compensatory plan or arrangement.

117

EX-10.29

Exhibit 10.29

Quintiles Transnational HOLDINGS INC.

2013 Stock Incentive Plan

AWARD AGREEMENT

(Awarding Initial Restricted Stock Units to McDonnell)

THIS AWARD AGREEMENT (this “Agreement”) is made by and between Quintiles Transnational Holdings Inc., a North Carolina corporation (the “Company”), and MICHAEL MCDONNELL (the “Participant”) pursuant to the provisions of the Quintiles Transnational Holdings Inc. 2013 Stock Incentive Plan (the “Plan”), which is incorporated herein by reference.  Capitalized terms not defined in this Agreement shall have the meanings given to them in the Plan.

WITNESSETH:

WHEREAS, the Participant is providing, or has agreed to provide, services to the Company, or Affiliate or a Subsidiary of the Company, as an Employee, Director or Third Party Service Provider; and

WHEREAS, the Company considers it desirable and in its best interests that the Participant be given a personal stake in the Company’s growth, development and financial success through the grant of Restricted Stock Units (the “RSUs”) that will settle in shares of the $.01 par value common stock of the Company (“Shares”) when and as they vest.  Each RSU represents an unfunded and unsecured right to receive one Share. RSUs are not property or Shares prior to settlement.

NOW, THEREFORE, in consideration of the premises and the mutual agreements set forth herein, the parties agree as follows:

1.Grant of RSUs.  Effective as of «Grant Date» (the “Date of Grant”), the Company hereby grants to the Participant «Number» RSUs, subject to the terms and conditions of the Plan and this Agreement.  

Each RSU represents the right to receive one Share to be issued and delivered at the end of the applicable vesting period, subject to the risk of cancellation described herein and in the Plan.  No rights as a shareholder shall exist with respect to the RSUs as a result of the mere grant of the RSUs.  Such rights shall exist only after issuance of the Shares following the applicable vesting period. The Participant shall not be entitled to receive, currently or on a deferred basis, any payments (i.e., “dividend equivalents”) equivalent to cash, stock or other property paid by the Company as dividends on the Company’s Shares prior to the vesting of the RSUs.

2.Vesting Schedule.  Provided that the Participant continues to render services to the Company through the applicable vesting date, the RSUs shall vest as follows:

«Vesting Schedule»

3.Termination of Service Relationship.   If Participant’s service relationship is terminated in circumstances that would entitle Participant to severance benefits payable upon involuntary separation under the Participant’s Letter Agreement dated October 14, 2015, then RSUs that are not vested shall vest as described herein.  If such termination occurs prior to the first anniversary of the Grant Date, fifty percent (50%) of the RSUs issued under this Agreement will become fully vested and any restrictions thereon will immediately lapse, and if such termination event occurs between the first and second anniversary of the Grant Date, an additional twenty-five percent (25%) of the RSUs issued under this Agreement shall become fully vested and any restrictions thereon will immediately lapse (such that fifty percent (50%) of the RSUs issued under this Agreement will be vested as of such termination), and if such termination occurs after the second anniversary of the Grant Date, an additional fifty percent (50%) of the RSUs issued under this Agreement that are outstanding and unvested as of the date of the termination will become fully vested and any restrictions thereon will immediately lapse.  Except as otherwise provided above, any RSUs that are not vested at the time of the termination of the Participant’s service relationship will be forfeited.

4.Settlement in Shares.  Vested RSUs will settle in Shares within 45 days of when the RSUs vest.  In connection with such settlement, the Company shall withhold Shares that otherwise would have been delivered upon such settlement  to satisfy any obligation the Company has under applicable income tax laws to withhold for income or other taxes due upon or incident to such settlement.  

The Company may make delivery of Shares upon vesting of RSUs either by (i) delivering one or more stock certificates representing such Shares to the Participant, registered in the name of the Participant, or (ii) electronically depositing such Shares into an online securities account maintained for the Participant as an Employee, Director or Third Party Service Provider, as applicable, of the Company with E*Trade Securities LLC (“E*Trade”) or such other brokerage firm as may be designated by the Company in connection with any Company plan or arrangement providing for investment in Shares.  All certificates for Shares and all Shares shall be subject to such stop transfer orders and other restrictions as the Company may deem advisable under the rules, regulations and other requirements of the Securities and Exchange Commission, any stock exchange or quotation system upon which the Shares are then listed or quoted, and any applicable federal or state securities law.

5.Restrictive Legends.  The Participant understands and agrees that the Company may cause the legends set forth below or legends substantially equivalent thereto, to be placed upon any certificate(s) or book-entry notations evidencing ownership of the Shares together with any other legends that may be required by the Company or by state or federal securities laws:

THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO THE QUINTILES TRANSNATIONAL HOLDINGS INC. 2013 STOCK INCENTIVE PLAN, AS SUCH PLAN MAY BE ALTERED, AMENDED, RESTATED OR MODIFIED FROM TIME

TO TIME, AND ANY TRANSFEREE OF THESE SECURITIES SHALL BE SUBJECT TO THE TERMS OF SUCH PLAN.  COPIES OF THE FOREGOING PLAN ARE MAINTAINED WITH THE CORPORATE RECORDS OF THE ISSUER AND ARE AVAILABLE FOR INSPECTION AT THE PRINCIPAL OFFICES OF THE ISSUER.

THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE ALSO SUBJECT TO AN AWARD AGREEMENT BETWEEN THE ISSUER AND THE HOLDER, AS SUCH AGREEMENT MAY BE AMENDED, RESTATED OR MODIFIED FROM TIME TO TIME, AND ANY TRANSFEREE OF THESE SECURITIES SHALL BE SUBJECT TO THE TERMS OF SUCH AGREEMENT.  COPIES OF THE FOREGOING AGREEMENT ARE MAINTAINED WITH THE CORPORATE RECORDS OF THE ISSUER AND ARE AVAILABLE FOR INSPECTION AT THE PRINCIPAL OFFICES OF THE ISSUER.

6.Non-Transferability of RSUs.  Except as may be otherwise determined by the Committee in its sole discretion, the RSUs may not be transferred.  

7.Restrictions on Shares.  This Agreement shall be subject to all applicable laws, rules, and regulations, and to such approvals by any governmental agencies or stock exchange as may be required.  The Participant agrees to take all steps the Committee determines are necessary to comply with all applicable provisions of federal and state securities law in exercising his or her rights under this Agreement.  The Committee may impose such restrictions on any Shares acquired pursuant to the RSUs as it deems advisable, including without limitation, minimum holding period requirements, restrictions under applicable federal securities laws, under the requirements of any stock exchange or market upon which such Shares are then listed or traded, or under any blue sky or state securities laws as may be applicable to such Shares.

8.Forfeiture.  Where a Participant engages in certain competitive activity or is terminated by the Company for Cause, his or her RSUs and Shares are subject to forfeiture conditions under Section 11.3 of the Plan.  Upon the occurrence of any of the events set forth in Section 11.3 of the Plan, in addition to the remedies provided in Section 11.3, the Company shall be entitled to issue a stop transfer order and other document implementing the forfeiture to its transfer agent, the depository or any of its nominees, and any other person with respect to these RSUs and the Shares.

9.Successors and Assigns.  The Company may assign any of its rights under this Agreement to single or multiple assignees, and this Agreement shall inure to the benefit of the successors and assigns of the Company.  Subject to the restrictions on transfer herein set forth, the terms and conditions of the Plan and this Agreement shall be binding upon the Participant and his or her heirs, executors, administrators, successors and assigns.

10.Interpretation.  Any dispute regarding the interpretation of this Agreement shall be submitted by the Participant or by the Company forthwith to the Committee, which shall review such dispute at its next regular meeting.  The resolution of such a dispute by the Committee shall be final and binding on all parties.

11.Tax Consequences.  The delivery of Shares and the subsequent disposition of those Shares may cause the Participant to be subject to federal, state and/or foreign taxation.  The

Participant should consult a tax advisor regarding the tax implications of receiving and disposing of Shares.   

12.Acknowledgement.  The Participant acknowledges and agrees:  (i) that the Plan is discretionary in nature and may be suspended or terminated by the Company at any time; (ii) that the grant of RSUs does not create any contractual or other right to receive future grants of RSUs or any right to continue an employment or other relationship with the Company (for the vesting period or otherwise); (iii) that the Participant remains subject to discharge from such relationship to the same extent as if the RSUs had not been granted; (iv) that all determinations with respect to any such future grants, including, but not limited to, when and on what terms they shall be made, will be at the sole discretion of the Committee; (v) that participation in the Plan is voluntary; (vi) that the value of the RSUs is an extraordinary item of compensation that is outside the scope of the Participant’s employment contract if any; and (vii) that the RSUs are not part of normal or expected compensation for purposes of calculating any severance, resignation, redundancy, end of service payments, bonuses, long-service awards, pension or retirement benefits or similar benefits.

13.Employee Data Privacy.  As a condition of the grant of these RSUs, the Participant consents to the collection, use and transfer of personal data as described in this paragraph.  The Participant understands that the Company and its Affiliates hold certain personal information about the Participant, including but not limited to the Participant’s name, home address and telephone number, date of birth, social security number, salary, nationality, job title, shares of common stock or directorships held in the Company, details of all RSUs or other entitlement to shares of common stock awarded, cancelled, exercised, vested, unvested or outstanding in the Participant’s favor for the purpose of managing and administering the Plan (“Data”).  The Participant further understands that the Company and/or its Affiliates will transfer Data amongst themselves as necessary for the purposes of implementation, administration and management of the Participant’s participation in the Plan, and that the Company and/or any of its Affiliates may each further transfer Data to any third parties assisting the Company in the implementation, administration and management of the Plans.  The Participant understands that these recipients may be located in the Participant’s country of residence or elsewhere.  The Participant authorizes them to receive, possess, use, retain and transfer Data in electronic or other form, for the purposes of implementing, administering and managing the Participant’s participation in the Plan, including any requisite transfer of such Data as may be required for the administration of the Plan and/or the subsequent holding shares of common stock on the Participant’s behalf to a broker or other third party with whom the Shares acquired on settlement may be deposited.  The Participant understands that the Participant may, at any time, view the Data, require any necessary amendments to it or withdraw the consent herein in writing by contacting the local human resources representative.  

14.Confidentiality.  The Participant agrees not to disclose the terms of this Agreement to anyone other than the members of the Participant’s immediate family or the Participant’s counsel or financial advisors and agrees to advise such persons of the confidential nature of this offer.  

15.Entire Agreement; Governing Law.  The Plan is incorporated herein by reference.  The Plan and this Agreement constitute the entire agreement of the parties with respect to the subject matter hereof and supersede in their entirety all prior undertakings and agreements of the Company and the Participant with respect to the subject matter hereof, and may not be modified adversely to the Participant’s interest except by means of a writing signed by the Company and Participant.  This Agreement is governed by the internal substantive laws but not the choice of law rules of North Carolina. 

By signing below, you accept the grant of this Restricted Stock Unit Award and agree that this Restricted Stock Unit Award is subject in all respects to the terms and conditions of the Plan.  Copies of the Plan and a Prospectus containing information concerning the Plan are available upon request.  

PARTICIPANTQUINTILES TRANSNATIONAL HOLDINGS INC.

_____________________________By:___________________________________

SignatureName

Title:  

EX-10.56

Exhibit 10.56

DESCRIPTION OF INDEPENDENT DIRECTOR COMPENSATION

Quintiles Transnational Holdings Inc. (the “Company”) revised its Independent Director Compensation Policy, which is applicable to those directors who (i) are not an employee of the Company or (ii) have not been designated by a shareholder group pursuant to the Amended and Restated Shareholders Agreement dated February 5, 2015 (an “Independent Director”), to incorporate compensation for the Chair of the Board, effective as of January 1, 2016.

Consistent with the current Independent Director Compensation Policy, each Independent Director will receive an annual cash retainer of $65,000, paid quarterly, and meeting fees of $2,250 for attendance (either in person or via teleconference) at each meeting of the Board of Directors (the “Board”) and any Board committees on which he or she serves. The Company will also pay the chair of its Audit Committee an additional $25,000 annual retainer, paid quarterly, and pay those directors who serve as chairs of its other Board committees an additional $20,000 annual retainer, paid quarterly. The Company will also reimburse reasonable travel expenses and other out-of-pocket costs incurred in connection with attendance at Board and committee meetings by each of the Independent Directors.

Under the Independent Director Compensation Policy, each Independent Director is eligible to receive an initial equity grant upon joining the Board and an annual equity grant for continued service on the Board.  Each grant will have an aggregate economic value of $200,000, with 75% of the grant value delivered in the form of stock options and 25% of the grant value delivered in the form of restricted stock units (subject to such limitations in value or grant size imposed by the Company’s 2013 Stock Incentive Plan).  The initial grant will vest over three years and the annual grant will vest over one year.

In recognition for leading the Board, an annual cash retainer of $125,000 will be paid quarterly to the Chair of the Board in addition to the retainer for serving on the Board.  Also an additional annual grant for the Chair of the Board will have an economic value of $125,000 with 75% of the grant value delivered in stock options and 25% of the grant value delivered in the form of restricted stock units (subject to such limitations in value or grant size imposed by the Company’s 2013 Stock Incentive Plan). The annual grant for the Chair will vest over one year.

EX-21.1

Exhibit 21.1

QUINTILES TRANSNATIONAL HOLDINGS INC.

SUBSIDIARIES OF THE REGISTRANT

Subsidiary	Jurisdiction or State of Organization
Benefit Canada, Inc.	Quebec
Benefit Holding, Inc.	North Carolina
Biodesign Gmbh	Germany
BRI International Limited	United Kingdom
Cenduit (India) Services Private Company Limited	India
Cenduit LLC	Delaware
Cenduit Mauritius Holdings Company	Mauritius
Clinical Lab Minority Shareholder Limited	United Kingdom
Clio Science Inc.	Japan
EA Institute, LLC	Delaware
Encore Health Resources, LLC	Texas
Hotel Lot C-8B, LLC	North Carolina
iGuard, Inc.	North Carolina
Innovex Merger Corp.	North Carolina
Innovex Saglik Hizmetleri Arastirma ve Danismanlik Ticaret Limited Sirketi	Turkey
Innovex Saglik Urunleri Pazarlame ve Hizmet Danismanlik Anonim Sirketi	Turkey
Kun Tuo Medical Research & Development (Beijing) Co. Ltd.	China
Laboratorie Novex Pharma Sarl	France
Laboratorio Commuq Pharma SLU	Spain
MG Recherche SARL	France
Novella Clinical LLC	Delaware
Novella Clinical Resourcing, Ltd.	United Kingdom
Novella Clinical, Ltd.	United Kingdom
Novex Pharma GmbH	Germany
Novex Pharma Laboratio S.L.	Spain
Novex Pharma Limited	United Kingdom
Outcome Sciences, LLC	Delaware
Penderwood Limited	United Kingdom
Pharmaforce, S.A. de C.V.	Mexico
Professional Pharmaceutical Marketing Services (Pty.) Ltd.	South Africa
PT Quintiles Indonesia	Indonesia
Q Squared Solutions (Beijing) Co., Ltd.	China
Q Squared Solutions (India) Private Limited	India
Q Squared Solutions (Quest) Limited	United Kingdom
Q Squared Solutions (Quest) LLC	Delaware
Q Squared Solutions B.V.	Amsterdam
Q Squared Solutions BioSciences LLC	Delaware
Q Squared Solutions China (Quest) Limited	United Kingdom
Q Squared Solutions China Limited	United Kingdom

Subsidiary	Jurisdiction or State of Organization
Q Squared Solutions Expression Analysis LLC	Delaware
Q Squared Solutions Holdings B.V.	Amsterdam
Q Squared Solutions Holdings Limited	United Kingdom
Q Squared Solutions Holdings LLC	Delaware
Q Squared Solutions KK	Japan
Q Squared Solutions Limited	United Kingdom
Q Squared Solutions LLC	North Carolina
Q Squared Solutions Proprietary Limited	South Africa
Q Squared Solutions Pte. Ltd.	Singapore
Q Squared Solutions S.A.	Argentina
Quest Diagnostics (Shanghai) Co., Ltd	China
Quintiles (Thailand) Co., Ltd.	Thailand
Quintiles AB	Sweden
Quintiles AG	Switzerland
Quintiles Argentina S.A.	Argentina
Quintiles Asia Pacific Commercial Holdings, LLC	North Carolina
Quintiles Asia, Inc.	North Carolina
Quintiles Austria GmbH	Austria
Quintiles Belgium NV/SA	Belgium
Quintiles Benefit France SNC	France
Quintiles Benin Ltd.	Benin
Quintiles BioSciences Holdings, LLC	Delaware
Quintiles Brasil Ltda.	Brazil
Quintiles BT, Inc.	North Carolina
Quintiles Bulgaria EOOD	Bulgaria
Quintiles Canada, Inc.	Quebec
Quintiles Chile	Chile
Quintiles Clindata (Pty) Limited	South Africa
Quintiles Clindepharm (Pty.) Limited	South Africa
Quintiles Clinical and Commercial Nigeria Limited	Nigeria
Quintiles Colombia Ltda.	Colombia
Quintiles Comercial Brasil Ltda.	Brazil
Quintiles Commercial AB	Sweden
Quintiles Commercial APS	Denmark
Quintiles Commercial Europe Limited	United Kingdom
Quintiles Commercial Germany GmbH	Germany
Quintiles Commercial Italia S.r.l.	Italy
Quintiles Commercial Laboratorio S.L.	Spain
Quintiles Commercial Overseas Holdings Limited	United Kingdom
Quintiles Commercial Oy	Finland
Quintiles Commercial Portugal Unipessoal, Lda.	Portugal
Quintiles Commercial Rus	Russia
Quintiles Commercial South Africa (Pty.) Limited	South Africa

Subsidiary	Jurisdiction or State of Organization
Quintiles Commercial U.S., Inc.	Delaware
Quintiles Commercial UK Limited	United Kingdom
Quintiles Consulting, Inc.	North Carolina
Quintiles Costa Rica, S.A.	Costa Rica
Quintiles Czech Republic, s.r.o.	Czech Republic
Quintiles D.O.O. Beograd	Serbia
Quintiles Denmark	Denmark
Quintiles East Africa Limited	Kenya
Quintiles East Asia Pte. Ltd.	Singapore
Quintiles Eastern Holdings GmbH	Austria
Quintiles Egypt LLC	Egypt
Quintiles Enterprise Management (Shanghai) Co. Ltd.	China
Quintiles Estonia OU	Estonia
Quintiles European Holdings	United Kingdom
Quintiles Federated Services, Inc.	North Carolina
Quintiles Finance Sarl	Luxembourg
Quintiles Finance Uruguay S.r.L.	Uruguay
Quintiles Funding LLC	North Carolina
Quintiles Gesmbh	Austria
Quintiles GmbH	Germany
Quintiles Greece	Greece
Quintiles Guatemala, S.A.	Guatemala
Quintiles Holdings	United Kingdom
Quintiles Holdings S.a.r.l.	Luxembourg
Quintiles Holdings SNC	France
Quintiles Hong Kong Limited	Hong Kong
Quintiles Hungary Ltd.	Hungary
Quintiles Ireland Finance Limited	Ireland
Quintiles Ireland Limited	Ireland
Quintiles Israel Ltd.	Israel
Quintiles Istanbul Saglik Hizmetleri Arastirma ve Danismanlik Limited Sirketi	Turkey
Quintiles Lanka (Private) Limited	Republic of Sri Lanka
Quintiles Latin America Inc.	Argentina
Quintiles Latin America, LLC	North Carolina
Quintiles Latvia SIA	Latvia
Quintiles Limited	United Kingdom
Quintiles Luxembourg - US	North Carolina
Quintiles Luxembourg European Holding S.a.r.l.	Luxembourg
Quintiles Luxembourg European Holding S.a.r.l. - US	North Carolina
Quintiles Luxembourg France Holdings Sarl	Luxembourg
Quintiles Malaysia Sdn. Bhd.	Malaysia
Quintiles Market Intelligence LLC	North Carolina
Quintiles Mauritius Holdings, Inc.	Mauritius

Subsidiary	Jurisdiction or State of Organization
Quintiles Medical Communications  & Consulting, Inc.	New Jersey
Quintiles Medical Development (Dalian) Co. Ltd.	China
Quintiles Medical Development (Shanghai) Co., Ltd.	China
Quintiles Medical Education, Inc.	New York
Quintiles Mexico, S. de R.L. de C.V.	Mexico
Quintiles Netherlands	Netherlands
Quintiles New Zealand	New Zealand
Quintiles Novosibirsk	Russia
Quintiles OY	Finland
Quintiles Panama, Inc.	Panama
Quintiles Peru S.r.l.	Peru
Quintiles Pharma Services Corp.	North Carolina
Quintiles Pharma, Inc.	North Carolina
Quintiles Phase One Clinical Trials India Private Limited	India
Quintiles Phase One Services, LLC	Kansas
Quintiles Philippines, Inc.	Philippines
Quintiles Poland Sp. Zoo	Poland
Quintiles Portugal	Portugal
Quintiles Pty Limited	Australia
Quintiles Puerto Rico, Inc.	Puerto Rico
Quintiles Research (India) Private Limited	India
Quintiles Romania S.R.L.	Romania
Quintiles Russia	Russia
Quintiles S.a.r.l.	Luxembourg
Quintiles S.a.r.L. - US	North Carolina
Quintiles S.L.	Spain
Quintiles Site Services, S.A.	Costa Rica
Quintiles Slovakia Services s.r.o.	Slovakia
Quintiles Slovakia, s. r. o.	Slovakia
Quintiles South Africa (Pty.) Limited	South Africa
Quintiles Srl	Italy
Quintiles St. Petersburg	Russia
Quintiles Staff Services Sp.A.	Italy
Quintiles Support Sarl	France
Quintiles Switzerland Sarl	Switzerland
Quintiles Taiwan Limited	Taiwan
Quintiles Transfer, LLC	Delaware
Quintiles Transnational Corp.	North Carolina
Quintiles Transnational Holdings Inc.	North Carolina
Quintiles Transnational Japan K.K.	Japan
Quintiles Transnational Korea Co., Ltd	Korea
Quintiles Trustees Ltd.	United Kingdom
Quintiles UAB	Lithuania

Subsidiary	Jurisdiction or State of Organization
Quintiles UK Holdings Limited	United Kingdom
Quintiles Ukraine	Ukraine
Quintiles Vietnam LLC	Viet Nam
Quintiles West Africa Limited	Ghana
Quintiles Zagreb d.o.o.	Croatia
Quintiles, Inc.	North Carolina
Rowfarma de Mexico S. de R.L. de C.V.	Mexico
Servicios Clinicos, S.A. de C.V.	Mexico
Targeted Molecular Diagnostics, LLC	Illinois
Temas Srl - Società Unipersonale	Italy
Transforce S.A. de C.V.	Mexico
VCG&A, Inc.	Massachusetts
VCG-Bio, Inc.	Delaware

EX-23.1

Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 (Nos. 333-193212, 333-188431) and Form S-3 (No. 333-199843) of Quintiles Transnational Holdings Inc. of our report dated February 11, 2016 relating to the financial statements, financial statement schedules and the effectiveness of internal control over financial reporting, which appears in this Form 10-K.

/s/ PricewaterhouseCoopers LLP

Raleigh, North Carolina

February 11, 2016

EX-31.1

Exhibit 31.1

CERTIFICATION OF PERIODIC REPORT UNDER SECTION 302 OF

THE SARBANES-OXLEY ACT OF 2002

I, Thomas H. Pike, certify that:

1. I have reviewed this annual report on Form 10-K of Quintiles Transnational Holdings Inc. (the “registrant”);

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: February 11, 2016
	/s/ Thomas H. Pike
	Thomas H. Pike
	Chief Executive Officer
	(Principal Executive Officer)

EX-31.2

Exhibit 31.2

CERTIFICATION OF PERIODIC REPORT UNDER SECTION 302 OF

THE SARBANES-OXLEY ACT OF 2002

I, Michael R. McDonnell, certify that:

1. I have reviewed this annual report on Form 10-K of Quintiles Transnational Holdings Inc. (the “registrant”);

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: February 11, 2016
	/s/ Michael R. McDonnell
	Michael R. McDonnell
	Executive Vice President and Chief Financial Officer
	(Principal Financial Officer)

EX-32.1

Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350

AS ADOPTED PURSUANT TO SECTION 906

OF THE SARBANES-OXLEY ACT OF 2002

I, Thomas H. Pike, Chief Executive Officer of Quintiles Transnational Holdings Inc. (the “Company”), do hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to the best of my knowledge:

(1) the Annual Report on Form 10-K of the Company for the year ended December 31, 2015 (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company for the periods presented therein.

Date: February 11, 2016
	/s/ Thomas H. Pike
	Thomas H. Pike
	Chief Executive Officer
	(Principal Executive Officer )

This certification is being furnished solely to accompany the Report pursuant to 18 U.S.C. § 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, and shall not be deemed “filed” by the Company for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and shall not be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after the date of this Report, irrespective of any general incorporation language contained in such filing.

A signed original of this written statement required by Section 906 of the Sarbanes-Oxley Act of 2002 has been provided to the Company and will be retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.

EX-32.2

Exhibit 32.2

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350

AS ADOPTED PURSUANT TO SECTION 906

OF THE SARBANES-OXLEY ACT OF 2002

I, Michael R. McDonnell, Executive Vice President and Chief Financial Officer of Quintiles Transnational Holdings Inc. (the “Company”), do hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to the best of my knowledge:

(1) the Annual Report on Form 10-K of the Company for the year ended December 31, 2015 (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company for the periods presented therein.

Date: February 11, 2016
	/s/ Michael R. McDonnell
	Michael R. McDonnell
	Executive Vice President and Chief Financial Officer
	(Principal Financial Officer)

This certification is being furnished solely to accompany the Report pursuant to 18 U.S.C. § 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, and shall not be deemed “filed” by the Company for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and shall not be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after the date of this Report, irrespective of any general incorporation language contained in such filing.

A signed original of this written statement required by Section 906 of the Sarbanes-Oxley Act of 2002 has been provided to the Company and will be retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.

XML

Document and Entity Information - USD ($)	12 Months Ended
	Dec. 31, 2015	Feb. 04, 2016	Jun. 30, 2015
Document And Entity Information [Abstract]
Document Type	10-K
Amendment Flag	false
Document Period End Date	Dec. 31, 2015
Document Fiscal Year Focus	2015
Document Fiscal Period Focus	FY
Trading Symbol	Q
Entity Registrant Name	Quintiles Transnational Holdings Inc.
Entity Central Index Key	0001478242
Current Fiscal Year End Date	--12-31
Entity Well-known Seasoned Issuer	Yes
Entity Current Reporting Status	Yes
Entity Voluntary Filers	No
Entity Filer Category	Large Accelerated Filer
Entity Common Stock, Shares Outstanding		119,384,993
Entity Public Float			$ 5,835,192,138

XML

CONSOLIDATED STATEMENTS OF INCOME - USD ($) shares in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Income Statement [Abstract]
Service revenues	$ 4,326,419,000	$ 4,165,822,000	$ 3,808,340,000
Reimbursed expenses	1,411,200,000	1,294,176,000	1,291,205,000
Total revenues	5,737,619,000	5,459,998,000	5,099,545,000
Costs of revenue, service costs	2,725,586,000	2,684,106,000	2,471,426,000
Costs of revenue, reimbursed expenses	1,411,200,000	1,294,176,000	1,291,205,000
Selling, general and administrative	920,985,000	882,338,000	860,510,000
Restructuring costs	30,752,000	8,988,000	14,071,000
Impairment charges	2,484,000	0	0
Income from operations	646,612,000	590,390,000	462,333,000
Interest income	(4,317,000)	(3,410,000)	(3,937,000)
Interest expense	101,792,000	100,589,000	123,508,000
Loss on extinguishment of debt	7,780,000		19,831,000
Other expense (income), net	2,362,000	(8,978,000)	(185,000)
Income before income taxes and equity in earnings (losses) of unconsolidated affiliates	538,995,000	502,189,000	323,116,000
Income tax expense	158,989,000	150,056,000	95,965,000
Income before equity in earnings (losses) of unconsolidated affiliates	380,006,000	352,133,000	227,151,000
Equity in earnings (losses) of unconsolidated affiliates	8,298,000	4,368,000	(1,124,000)
Net income	388,304,000	356,501,000	226,027,000
Net (income) loss attributable to noncontrolling interests	(1,099,000)	(118,000)	564,000
Net income attributable to Quintiles Transnational Holdings Inc.	$ 387,205,000	$ 356,383,000	$ 226,591,000
Earnings per share attributable to common shareholders:
Basic	$ 3.15	$ 2.78	$ 1.83
Diluted	$ 3.08	$ 2.72	$ 1.77
Weighted average common shares outstanding:
Basic	123,038	127,994	124,147
Diluted	125,630	131,083	127,862

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CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Statement Of Income And Comprehensive Income [Abstract]
Net income	$ 388,304	$ 356,501	$ 226,027
Comprehensive income adjustments:
Unrealized (losses) gains on marketable securities, net of income taxes of ($168), ($376) and $2,016	(268)	(600)	3,225
Unrealized (losses) gains on derivative instruments, net of income taxes of ($3,679), ($1,767) and ($751)	(9,523)	(5,067)	358
Defined benefit plan adjustments, net of income taxes of $318, ($2,981) and ($131)	(36)	(7,237)	2,278
Foreign currency translation, net of income taxes of ($5,581), ($2,101) and ($2,465)	(60,024)	(47,807)	(22,663)
Reclassification adjustments:
Gains on marketable securities included in net income, net of income taxes of ($1,927)		(3,077)
Losses on derivative instruments included in net income, net of income taxes of $5,826, $4,022 and $4,991	12,443	4,608	8,089
Amortization of prior service costs and losses included in net income, net of income taxes of $355, $275 and $389	618	468	655
Comprehensive income	331,514	297,789	217,969
Comprehensive loss (income) attributable to noncontrolling interests	3,416	(121)	551
Comprehensive income attributable to Quintiles Transnational Holdings Inc.	$ 334,930	$ 297,668	$ 218,520

XML

CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (Parenthetical) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Statement Of Income And Comprehensive Income [Abstract]
Unrealized (losses) gains on marketable securities, income taxes	$ (168)	$ (376)	$ 2,016
Unrealized (losses) gains on derivative instruments, income taxes	(3,679)	(1,767)	(751)
Defined benefit plan adjustment, income taxes	318	(2,981)	(131)
Foreign currency translation, income taxes	(5,581)	(2,101)	(2,465)
Gains on marketable securities included in net income, income taxes		(1,927)
Losses on derivative instruments included in net income, income taxes	5,826	4,022	4,991
Amortization of prior service costs and losses included in net income, income taxes	$ 355	$ 275	$ 389

XML

CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Current assets:
Cash and cash equivalents	$ 977,151	$ 867,358
Restricted cash	2,478	2,882
Trade accounts receivable and unbilled services, net	1,165,749	975,255
Prepaid expenses	50,624	44,628
Deferred income taxes	100,978	118,515
Income taxes receivable	34,089	45,357
Other current assets and receivables	80,916	92,088
Total current assets	2,411,985	2,146,083
Property and equipment, net	188,393	190,297
Investments in debt, equity and other securities	32,911	34,503
Investments in and advances to unconsolidated affiliates	52,382	31,508
Goodwill	719,740	464,434
Other identifiable intangibles, net	368,106	280,243
Deferred income taxes	42,684	35,972
Deposits and other assets	110,115	112,913
Total assets	3,926,316	3,295,953
Current liabilities:
Accounts payable	145,484	108,743
Accrued expenses	760,757	733,644
Unearned income	584,646	543,305
Income taxes payable	35,173	55,694
Current portion of long-term debt and obligations held under capital leases	48,513	826
Other current liabilities	19,603	29,688
Total current liabilities	1,594,176	1,471,900
Long-term debt and obligations held under capital leases, less current portion	2,419,293	2,282,612
Deferred income taxes	65,702	61,797
Other liabilities	182,826	183,656
Total liabilities	$ 4,261,997	$ 3,999,965
Commitments and contingencies (Note 1)
Shareholders’ deficit:
Common stock and additional paid-in capital, 300,000 shares authorized, $0.01 par value, 119,378 and 124,129 shares issued and outstanding at December 31, 2015 and 2014, respectively	$ 8,784	$ 143,828
Accumulated deficit	(461,635)	(788,798)
Accumulated other comprehensive loss	(111,366)	(59,091)
Deficit attributable to Quintiles Transnational Holdings Inc.’s shareholders	(564,217)	(704,061)
Noncontrolling interests	228,536	49
Total shareholders’ deficit	(335,681)	(704,012)
Total liabilities and shareholders’ deficit	$ 3,926,316	$ 3,295,953

XML

CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Statement Of Financial Position [Abstract]
Common stock, shares authorized	300,000,000	300,000,000
Common stock, par value	$ 0.01	$ 0.01
Common stock, shares issued	119,378,000	124,129,000
Common stock, shares outstanding	119,377,731	124,129,340	129,651,907	115,763,510

XML

CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Operating activities:
Net income	$ 388,304	$ 356,501	$ 226,027
Adjustments to reconcile net income to cash provided by operating activities:
Depreciation and amortization	127,742	121,013	107,504
Amortization of debt issuance costs and discount	9,170	6,688	21,825
Amortization of accumulated other comprehensive loss on terminated interest rate swaps	7,881
Share-based compensation	37,758	30,001	22,826
Gain on disposals of property and equipment, net	(710)	(975)	(1,153)
Impairment of long-lived assets	2,484
(Earnings) loss from unconsolidated affiliates	(8,265)	(4,346)	1,004
Loss (gain) on investments, net	1,012	(4,797)	(183)
Provision for (benefit from) deferred income taxes	18,351	(6,168)	(24,236)
Excess income tax benefits from share-based award activities	(39,071)	(20,303)	(16,204)
Changes in operating assets and liabilities:
Accounts receivable and unbilled services	(246,028)	(78,630)	(151,681)
Prepaid expenses and other assets	14,436	(40,832)	(18,576)
Accounts payable and accrued expenses	104,350	45,804	107,047
Unearned income	53,847	19,943	71,852
Income taxes payable and other liabilities	4,430	7,855	47,319
Net cash provided by operating activities	475,691	431,754	393,371
Investing activities:
Acquisition of property, equipment and software	(78,391)	(82,650)	(88,347)
Acquisition of businesses, net of cash acquired	31,725	(92,201)	(144,970)
Proceeds from disposition of property and equipment	2,491	1,611	2,021
Proceeds from sale of equity securities		5,861	60
Investments in and advances to unconsolidated affiliates, net of payments received	(12,350)	(4,472)	(7,353)
Termination of interest rate swaps	(10,981)
Other	551	(1,263)	2,413
Net cash used in investing activities	(66,955)	(173,114)	(236,176)
Financing activities:
Proceeds from issuance of debt	2,248,500	275,000	2,060,755
Payment of debt issuance costs	(22,028)	(1,455)	(2,607)
Repayment of debt	(2,056,780)	(30,157)	(2,444,600)
Proceeds from revolving credit facility		150,000
Repayment of revolving credit facility		(150,000)
Principal payments on capital lease obligations	(4,296)	(2,612)	(3,812)
Contingent consideration paid	(3,000)	(3,000)
Issuance of common stock			525,000
Payment of common stock issuance costs		(105)	(35,439)
Stock issued under employee stock purchase and option plans	64,297	35,228	12,539
Repurchase of common stock	(515,010)	(415,131)	(6,434)
Repurchase of stock options		(8,415)	(50,649)
Excess income tax benefits from share-based award activities	39,071	20,303	16,204
Net cash (used in) provided by financing activities	(249,246)	(130,344)	70,957
Effect of foreign currency exchange rate changes on cash	(49,697)	(39,081)	(17,737)
Increase (decrease) in cash and cash equivalents	109,793	89,215	210,415
Cash and cash equivalents at beginning of period	867,358	778,143	567,728
Cash and cash equivalents at end of period	$ 977,151	$ 867,358	$ 778,143

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CONSOLIDATED STATEMENTS OF SHAREHOLDERS' DEFICIT - USD ($) $ in Thousands	Total	(Accumulated Deficit) [Member]	Accumulated Other Comprehensive (Loss) Income [Member]	Common Stock [Member]	Additional Paid-in Capital [Member]	Noncontrolling Interest [Member]
Beginning Balance, Value at Dec. 31, 2012	$ (1,359,044)	$ (1,371,772)	$ 7,695	$ 1,158	$ 3,396	$ 479
Issuance of common stock, Value	537,539			141	537,398
Stock issuance costs	(35,439)				(35,439)
Repurchase of common stock, Value	(6,434)			(2)	(6,432)
Repurchase of stock options	(59,064)				(59,064)
Share-based compensation	20,784				20,784
Income tax benefits from share-based award activities	16,204				16,204
Net income	226,027	226,591				(564)
Unrealized gain (loss) on marketable securities, net of tax	3,225		3,225
Unrealized gain (loss) on derivative instruments, net of tax	358		358
Defined benefit plan adjustments, net of tax	2,278		2,278
Foreign currency translation, net of tax	(22,663)		(22,676)			13
Reclassification adjustments, net of tax	8,744		8,744
Ending Balance, Value at Dec. 31, 2013	(667,485)	(1,145,181)	(376)	1,297	476,847	(72)
Issuance of common stock, Value	35,302			21	35,281
Stock issuance costs	(105)				(105)
Repurchase of common stock, Value	(415,131)			(76)	(415,055)
Share-based compensation	25,315				25,315
Income tax benefits from share-based award activities	20,303				20,303
Net income	356,501	356,383				118
Unrealized gain (loss) on marketable securities, net of tax	(600)		(600)
Unrealized gain (loss) on derivative instruments, net of tax	(5,067)		(5,067)
Defined benefit plan adjustments, net of tax	(7,237)		(7,237)
Foreign currency translation, net of tax	(47,807)		(47,810)			3
Reclassification adjustments, net of tax	1,999		1,999
Ending Balance, Value at Dec. 31, 2014	(704,012)	(788,798)	(59,091)	1,242	142,586	49
Issuance of common stock, Value	64,614			31	64,583
Repurchase of common stock, Value	(515,010)	(60,042)		(79)	(454,889)
Share-based compensation	31,582				31,582
Income tax benefits from share-based award activities	39,071				39,071
Q2 Solutions business combination	423,268				423,268
Noncontrolling interest related to Q2 Solutions transaction					(231,903)	231,903
Deferred tax impact of the Q2 Solutions transaction	(6,708)				(6,708)
Net income	388,304	387,205				1,099
Unrealized gain (loss) on marketable securities, net of tax	(268)		(268)
Unrealized gain (loss) on derivative instruments, net of tax	(9,523)		(9,523)
Defined benefit plan adjustments, net of tax	(36)		(36)
Foreign currency translation, net of tax	(60,024)		(55,509)			(4,515)
Reclassification adjustments, net of tax	13,061		13,061
Ending Balance, Value at Dec. 31, 2015	$ (335,681)	$ (461,635)	$ (111,366)	$ 1,194	$ 7,590	$ 228,536

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CONSOLIDATED STATEMENTS OF SHAREHOLDERS' DEFICIT (Parenthetical) - shares	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Statement Of Stockholders Equity [Abstract]
Beginning Balance, Shares	124,129,340	129,651,907	115,763,510
Issuance of common stock, Shares	3,104,187	2,068,608	14,041,620
Repurchase of common stock, Shares	7,855,796	7,591,175	153,223
Ending Balance, Shares	119,377,731	124,129,340	129,651,907

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Summary of Significant Accounting Policies

12 Months Ended

Dec. 31, 2015

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

1. Summary of Significant Accounting Policies

The Company

Conducting business in approximately 100 countries with approximately 36,100 employees, Quintiles Transnational Holdings Inc. (together with its subsidiaries, the “Company”) is a provider of pharmaceutical development services and commercial outsourcing services that helps its biopharmaceutical customers, as well as customers in the broader healthcare industry, to make decisions regarding drug development, commercialization and drug therapy choices. The Company also offers a number of services designed to address the outcomes and analytical needs of the broader healthcare industry.

Reclassifications

Certain immaterial prior period amounts have been reclassified to conform to the current presentation including the reclassification of debt issuance costs related to non-revolving debt from deposits and other assets to a direct reduction to the carrying amount of the long-term debt on the balance sheet. These changes had no effect on previously reported total revenues, net income, comprehensive income, shareholders’ deficit or cash flows.

Principles of Consolidation

The accompanying consolidated financial statements include the accounts and operations of the Company and its subsidiaries. Amounts pertaining to the noncontrolling ownership interests held in third parties in the operating results and financial position of the Company’s majority-owned subsidiaries are reported as noncontrolling interests. Intercompany accounts and transactions have been eliminated in consolidation.

Use of Estimates

The preparation of financial statements in accordance with generally accepted accounting principles in the United States of America (“GAAP”) requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, and the disclosure of contingent assets and liabilities, at the date of the financial statements, as well as the reported amounts of revenues and expenses during the period. These estimates are based on historical experience and various other assumptions believed reasonable under the circumstances. The Company evaluates its estimates on an ongoing basis and makes changes to the estimates and related disclosures as experience develops or new information becomes known. Actual results may differ from those estimates.

Foreign Currencies

The Company’s financial statements are reported in United States dollars and, accordingly, the Company’s results of operations are impacted by fluctuations in exchange rates that affect the translation of its revenues and expenses denominated in foreign currencies into United States dollars for purposes of reporting its consolidated financial results. Assets and liabilities recorded in foreign currencies on the books of foreign subsidiaries are translated at the exchange rate on the balance sheet date. Revenues, costs and expenses are translated at average rates of exchange during the year. Translation adjustments resulting from this process are charged or credited to the accumulated other comprehensive income (loss) (“AOCI”) component of shareholders’ deficit. The Company is subject to foreign currency transaction risk for fluctuations in exchange rates during the period of time between the consummation and cash settlement of a transaction. The Company earns revenue from its service contracts over a period of several months and, in some cases, over a period of several years. Accordingly, exchange rate fluctuations during this period may affect the Company’s profitability with respect to such contracts. Other expense (income), net includes foreign currency net (gains) losses for 2015, 2014 and 2013 of approximately ($4.6) million, $4.9 million and $4.0 million, respectively.

Cash Equivalents, Restricted Cash and Investments

The Company considers all highly liquid investments with an initial maturity of three months or less when purchased to be cash equivalents. The Company’s restricted cash primarily consisted of amounts collateralizing standby letters of credit issued in favor of certain suppliers and health insurance funds. Investments in marketable equity securities are classified as available-for-sale and measured at fair market value with net unrealized gains and losses recorded in the AOCI component of shareholders’ deficit until realized. The fair market value is based on the closing price as quoted by the respective stock exchange. In addition, the Company has investments in equity securities of companies for which there are not readily available market values and for which the Company does not exercise significant influence or control; such investments are accounted for using the cost method. Any gains or losses from the sales of investments or other-than-temporary declines in fair value are computed by specific identification.

Equity Method Investments

The Company’s investments in and advances to unconsolidated affiliates are accounted for under the equity method if the Company exercises significant influence or has an investment in a limited partnership that is considered to be greater than minor. These investments and advances are classified as investments in and advances to unconsolidated affiliates on the accompanying consolidated balance sheets. The Company records its pro rata share of the earnings, adjusted for accretion of basis difference, of these investments in equity in earnings of unconsolidated affiliates on the accompanying consolidated statements of income. The Company reviews its investments in and advances to unconsolidated affiliates for impairment whenever events or changes in circumstances indicate that the carrying amounts may not be recoverable.

Derivatives

The Company uses derivative instruments to manage exposures to interest rates and foreign currencies. Derivatives are recorded on the balance sheet at fair value at each balance sheet date utilizing pricing models for non-exchange-traded contracts. At inception, the Company designates whether or not the derivative instrument is an effective hedge of an asset, liability or firm commitment which is then classified as either a cash flow hedge or a fair value hedge. If determined to be an effective cash flow hedge, changes in the fair value of the derivative instrument are recorded as a component of AOCI until realized. We include the impact from these hedges in the same line item as the hedged item on the consolidated statements of cash flows. Changes in fair value of effective fair value hedges are recorded in earnings as an offset to the changes in the fair value of the related hedged item. Hedge ineffectiveness, if any, is immediately recognized in earnings. Changes in the fair values of derivative instruments that are not an effective hedge are recognized in earnings. The Company has entered, and may in the future enter, into derivative contracts (swaps, forwards, calls or puts, warrants, for example) related to its debt, investments in marketable equity securities and forecasted foreign currency transactions.

Billed and Unbilled Services and Unearned Income

In general, prerequisites for billings and payments are established by contractual provisions including predetermined payment schedules, which may or may not correspond to the timing of the performance of services under the contract. Unbilled services arise when services have been rendered for which revenue has been recognized but the customers have not been billed.

In some cases, payments received are in excess of revenue recognized. Payments received in advance of services being provided are deferred as unearned income on the consolidated balance sheet. As the contracted services are subsequently performed and the associated revenue is recognized, the unearned income balance is reduced by the amount of the revenue recognized during the period.

Allowance for Doubtful Accounts

The Company’s allowance for doubtful accounts is determined based on a variety of factors that affect the potential collectability of the related receivables, including length of time the receivables are past due, customer credit ratings, financial stability of the customer, specific one-time events and past customer history. In addition, in circumstances where the Company is made aware of a specific customer’s inability to meet its financial obligations, a specific allowance is established. The accounts are individually evaluated on a regular basis and appropriate reserves are established as deemed appropriate based on the above criteria.

Receivables Financing Facility

Advances received under the Company’s receivables financing facility are accounted for as borrowings secured by the receivables and included in net cash provided by financing activities. The Company services the collateralized accounts receivable and the cash flows for the underlying receivables are included in cash provided by operating activities. The collateralized accounts receivable are included in trade accounts receivable and unbilled services, net.

Business Combinations

Business combinations are accounted for using the acquisition method, and accordingly, the identifiable assets acquired, the liabilities assumed, and any noncontrolling interest in the acquiree are recorded at their estimated fair values on the date of the acquisition. Goodwill represents the excess of the purchase price over the estimated fair value of the net assets acquired, including the amount assigned to identifiable intangible assets. When a business combination involves contingent consideration, the Company recognizes a liability equal to the estimated fair value of the contingent consideration obligation at the date of the acquisition. Subsequent changes in the estimated fair value of the contingent consideration are recognized in earnings in the period of the change.

Long-Lived Assets

Property and equipment are stated at cost and are depreciated using the straight-line method over the shorter of the asset’s estimated useful life or the lease term, if related to leased property, as follows:

Buildings and leasehold improvements	3 - 40	years
Equipment	3 - 10	years
Furniture and fixtures	5 - 10	years
Motor vehicles	3 - 5	years

Definite-lived identifiable intangible assets are amortized primarily using an accelerated method that reflects the pattern in which the Company expects to benefit from the use of the asset over its estimated remaining useful life as follows:

Trademarks and trade names	2 - 6	years
Non-compete agreements	3	years
Contract backlog and customer relationships	1 - 10	years
Software and related assets	2 - 9	years

Goodwill and indefinite-lived identifiable intangible assets, which consist of certain trade names, are not amortized but evaluated for impairment annually, or more frequently if events or changes in circumstances indicate an impairment.

Included in software and related items is the capitalized cost of internal-use software used in supporting the Company’s business. Qualifying costs incurred during the application development stage are capitalized and amortized over their estimated useful lives. The Company recognized $37.7 million, $33.1 million and $32.2 million of amortization expense in 2015, 2014 and 2013, respectively, related to software and related assets.

The carrying values of property, equipment and intangible and other long-lived assets are reviewed for recoverability if the facts and circumstances suggest that a potential impairment may have occurred. If this review indicates that carrying values will not be recoverable, as determined based on undiscounted cash flow projections, the Company will record an impairment charge to reduce carrying values to estimated fair value. During 2015, the Company recognized a $2.5 million impairment charge for long-lived assets related to a facility closure in Japan. There were no events, facts or circumstances in 2014 and 2013 that resulted in any impairment charges to the Company’s property, equipment, intangible or other long-lived assets.

Revenue Recognition

The Company recognizes revenue when all of the following conditions are satisfied: (1) there is persuasive evidence of an arrangement; (2) the service offering has been delivered to the customer; (3) the collection of the fees is probable; and (4) the arrangement consideration is fixed or determinable. The Company’s arrangements are primarily service contracts that range in duration from a few months to several years. Most contracts may be terminated upon 30 to 90 days notice by the customer, however, in the event of termination, contract provisions typically require payment for services rendered through the date of termination, as well as for subsequent services rendered to close out the contract.

In some cases, contracts provide for consideration that is contingent upon the occurrence of uncertain future events. The Company recognizes contingent revenue when the contingency has been resolved and all other criteria for revenue recognition have been met. The Company treats cash payments to customers as incentives to induce the customers to enter into such a service agreement with the Company. The related asset is amortized as a reduction of revenue over the period the services are performed. The Company records revenues net of any tax assessments by governmental authorities, such as value added taxes, that are imposed on and concurrent with specific revenue generating transactions. The Company does not recognize revenue with respect to start-up activities including contract and scope negotiation, feasibility analysis and conflict of interest review associated with contracts. The costs for these activities are expensed as incurred.

For the arrangements that include multiple elements, arrangement consideration is allocated to units of accounting based on the relative selling price. The best evidence of selling price of a unit of accounting is vendor-specific objective evidence (“VSOE”), which is the price the Company charges when the deliverable is sold separately. When VSOE is not available to determine selling price, management uses relevant third-party evidence (“TPE”) of selling price, if available. When neither VSOE nor TPE of selling price exists, management uses its best estimate of selling price considering all relevant information that is available without undue cost and effort.

The majority of the Company’s contracts within the Product Development segment are service contracts for clinical research that represent a single unit of accounting. The Company recognizes revenue on its clinical research services contracts as services are performed primarily on a proportional performance basis, generally using output measures that are specific to the service provided. Examples of output measures include among others, number of investigators enrolled, number of site initiation visits and number of monitoring visits completed. Revenue is determined by dividing the actual units of work completed by the total units of work required under the contract and multiplying that ratio by the total contract value. The total contract value, or total contractual payments, represents the aggregate contracted price for each of the agreed upon services to be provided. Changes in the scope of work are common, especially under long-term contracts, and generally result in a change in contract value. Once the customer has agreed to the changes in scope and renegotiated pricing terms, the contract value is amended and revenue is recognized, as described above. To the extent that contracts involve multiple elements, the Company follows the allocation methodology described above and recognizes revenue for each unit of accounting on a proportional performance basis.

The Company derives the majority of its revenues in its Integrated Healthcare Services segment from providing commercialization services on a fee-for-service basis to customers within the biopharmaceutical industry. Fees on these arrangements are billed based on a contractual per-diem or hourly rate basis. The Company recognizes revenue on commercialization services contracts primarily on a time and materials basis. Some of the Company’s commercialization contracts are multiple element arrangements, with elements including recruiting, training and deployment of sales representatives. The nature of the terms of these multiple element arrangements will vary based on the customized needs of the Company’s customers. For contracts that have multiple elements, the Company follows the allocation methodology described above and recognizes revenue for each unit of accounting on a time and materials basis. The Company’s commercialization contracts sometimes include variable fees that are based on a percentage of product sales (royalty payments). The Company recognizes revenue on royalty payments when the variable components become fixed or determinable and all other revenue recognition criteria have been met, which generally only occurs upon the sale of the underlying product(s) and upon the Company’s receipt of information necessary to make a reasonable estimate.

Reimbursed Expenses

The Company includes reimbursed expenses in total revenues and costs of revenue as the Company is deemed to be the primary obligor in the applicable arrangements. These costs include such items as payments to investigators and travel expenses for the Company’s clinical monitors and sales representatives.

Expenses

Costs of revenue include reimbursed expenses, compensation and benefits for billable employees, depreciation of assets used in generating revenue and other expenses directly related to service contracts such as courier fees and laboratory supplies for the Company’s laboratory services, professional services and travel expenses. Selling, general and administrative expenses primarily include costs related to administrative functions such as compensation and benefits, travel, professional services, training and expenses for advertising, information technology, facilities and depreciation and amortization.

Concentration of Credit Risk

Financial instruments that subject the Company to credit risk primarily consist of cash and cash equivalents, marketable securities and accounts receivable. The Company maintains its cash and cash equivalent balances with high-quality financial institutions and, consequently, the Company believes that such funds are subject to minimal credit risk. Investment policies have been implemented that limit purchases of marketable securities to investment grade securities. Substantially all service revenues for Product Development and Integrated Healthcare Services are earned by performing services under contracts with various pharmaceutical, biotechnology, medical device and healthcare companies. The concentration of credit risk is equal to the outstanding accounts receivable and unbilled services balances, less the unearned income related thereto, and such risk is subject to the financial and industry conditions of the Company’s customers. The Company does not require collateral or other securities to support customer receivables. Credit losses have been immaterial and reasonably within management’s expectations. No customer accounted for 10.0% or more of consolidated service revenues in 2015, 2014 or 2013.

Research and Development Costs

Research and development costs consist primarily of employee compensation and related expenses and information technology contract services and are charged to expense as incurred. The following is a summary of the research and development expenses (in thousands):

	Year Ended December 31,
	2015		2014		2013
Internally developed software applications and computer technology	$	3,198	$	4,980	$	3,955
Funding of customer's research and development activity		139		811		1,000
	$	3,337	$	5,791	$	4,955

Advertising Costs

Advertising costs, which include the development and production of advertising materials and the communication of these materials, are charged to expense as incurred. The Company incurred approximately $12.8 million, $16.0 million and $14.8 million in advertising expense in 2015, 2014 and 2013, respectively.

Restructuring Costs

Restructuring costs, which primarily include termination benefits and facility closure costs, are recorded at estimated fair value. Key assumptions in determining the restructuring costs include the terms and payments that may be negotiated to terminate certain contractual obligations and the timing of employees leaving the Company.

Contingencies

The Company records accruals for claims, suits, investigations and proceedings when it is probable that a liability has been incurred and the amount of the loss can be reasonably estimated. The Company reviews claims, suits, investigations and proceedings at least quarterly and records or adjusts accruals related to such matters to reflect the impact and status of any settlements, rulings, advice of counsel or other information pertinent to a particular matter. Legal costs associated with contingencies are charged to expense as incurred.

The Company is party to legal proceedings incidental to its business. While the outcome of these matters could differ from management’s expectations, the Company does not believe the resolution of these matters has a reasonable possibility of having a material adverse effect to the Company’s financial statements.

Income Taxes

Income tax expense includes United States federal, state and international income taxes. Certain items of income and expense are not reported in income tax returns and financial statements in the same year. The income tax effects of these differences are reported as deferred income taxes. Valuation allowances are provided to reduce the related deferred income tax assets to an amount which will, more likely than not, be realized. Beginning in 2013, the undistributed earnings of most of the Company’s foreign subsidiaries are considered to be indefinitely reinvested outside of the United States. Accordingly, a deferred income tax liability has not been provided related to those undistributed earnings. Interest and penalties related to unrecognized income tax benefits are recognized as a component of income tax expense as discussed further in Note 16.

Employee Stock Compensation

The Company accounts for share-based compensation for stock options and stock appreciation rights (“SARs”) under the fair value method and uses the Black-Scholes-Merton model to estimate the value of such share-based awards granted to its employees and non-executive directors. Expected volatility is based upon the historical volatility of a peer group for a period equal to the expected term, as the Company does not have adequate history to calculate its own volatility and believes the expected volatility will approximate the historical volatility of the peer group. Prior to the completion of the Company’s initial public offering (“IPO”) on May 14, 2013, the expected dividends were based on the historical dividends paid by the Company, excluding dividends that resulted from activities that the Company deemed to be one-time in nature. Following the IPO, the Company does not currently anticipate paying dividends. The expected term represents the period of time the grants are expected to be outstanding. The risk-free interest rate is based on the United States Treasury yield curve in effect at the time of the grant.

The Company accounts for its share-based compensation for restricted stock units (“RSUs”) and performance awards based on the closing market price of the Company’s common stock on the date of grant.

The Company recognized share-based compensation expense of $37.8 million, $30.0 million and $22.8 million in 2015, 2014 and 2013, respectively. Share-based compensation expense is included in selling, general and administrative expenses on the accompanying consolidated statements of income which is consistent with the classification of all other compensation costs incurred for the employees who were granted the share-based awards. The associated future income tax benefit recognized was $8.9 million, $7.6 million and $8.1 million in 2015, 2014 and 2013, respectively. As of December 31, 2015, there was approximately $38.8 million of total unrecognized share-based compensation expense related to outstanding non-vested share-based compensation arrangements, which the Company expects to recognize over a weighted average period of 1.3 years.

Earnings Per Share

The calculation of earnings per share is based on the weighted average number of common shares or common stock equivalents outstanding during the applicable period. The dilutive effect of common stock equivalents is excluded from basic earnings per share and is included in the calculation of diluted earnings per share. Potentially dilutive securities include outstanding stock options, shares to be purchased under the Company’s employee stock purchase plan (see Note 17) and unvested RSUs.

Recently Issued Accounting Standards

In November 2015, the FASB issued new accounting guidance which requires entities to present deferred tax assets and deferred tax liabilities as noncurrent in a classified balance sheet. The new standard will be effective for annual reporting periods beginning after December 15, 2016. Early adoption is permitted. The Company expects to early adopt this new accounting guidance on January 1, 2016. As of December 31, 2015, the Company had approximately $101.0 million and $148,000 of current deferred income tax assets and current deferred income tax liabilities, respectively.

In September 2015, the FASB issued new guidance that will change the requirements for reporting measurement period adjustments to provisional amounts initially recognized in connection with a business combination. Currently, an acquiring entity is required to retrospectively adjust, in prior period financial statements, the provisional amounts to reflect new information obtained during the measurement period. Under the new guidance, adjustments to the provisional amounts will be reflected in the financial statements for the reporting period in which the adjustments are determined, including by recognizing in current period earnings the full effect of changes in depreciation, amortization or other income effects. The new guidance requires that the acquiring entity either present separately on the face of the current period income statement or disclose in the notes to the current period financial statements, by line item, the amount of the adjustments made during the current period. The Company will adopt the new guidance on January 1, 2016, as required. The adoption is not expected to have a material impact on the Company’s financial statements.

In February 2015, the FASB issued new accounting guidance which changes the analysis in determining whether an entity is considered a variable interest entity (“VIE”) and the identification of the primary beneficiary of the VIE to determine whether the VIE should be included in an entity’s consolidated financial statements. The Company will adopt the new accounting guidance on January 1, 2016, as required. The adoption of the new accounting guidance is not expected to have a material effect on the Company’s financial statements.

In May 2014, the FASB and the International Accounting Standards Board issued a converged standard on the recognition of revenue from contracts with customers. The objective of the new standard is to establish a single comprehensive revenue recognition model that is designed to create greater comparability of financial statements across industries and jurisdictions. Under the new standard, companies will recognize revenue to depict the transfer of goods or services to customers in amounts that reflect the consideration to which the company expects to be entitled in exchange for those goods or services. The new standard also will require expanded disclosures on revenue recognition including information about changes in assets and liabilities that result from contracts with customers. Companies have an option to use either a retrospective approach or a cumulative effect adjustment approach to implement the new guidance. The new standard will be effective for annual reporting periods beginning after December 15, 2017. Early adoption is permitted for annual reporting periods beginning after December 15, 2016. The Company is currently evaluating the impact of this new standard on its consolidated financial statements, the date of adoption, and the transition approach to implement the new guidance.

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Accounts Receivable and Unbilled Services

12 Months Ended

Dec. 31, 2015

Receivables [Abstract]

Accounts Receivable and Unbilled Services

2. Accounts Receivable and Unbilled Services

Accounts receivable and unbilled services consist of the following (in thousands):

	December 31,
	2015			2014
Trade:
Billed	$	553,652		$	444,941
Unbilled services		614,381			532,312
		1,168,033			977,253
Allowance for doubtful accounts		(2,284	)		(1,998	)
	$	1,165,749		$	975,255

Substantially all of the Company’s trade accounts receivable and unbilled services are due from companies in the pharmaceutical, biotechnology, medical device and healthcare industries and are a result of contract research, sales, marketing, healthcare consulting and health information management services provided by the Company on a global basis. The percentage of accounts receivable and unbilled services by region is as follows:

	December 31,
	2015			2014
Americas:
United States		58	%		55	%
Other		1			2
Americas		59			57
Europe and Africa:
United Kingdom		23			23
Other		10			11
Europe and Africa		33			34
Asia-Pacific:
Japan		3			4
Other		5			5
Asia-Pacific		8			9
		100	%		100	%

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Investments-Debt, Equity and Other Securities

12 Months Ended

Dec. 31, 2015

Investments Debt And Equity Securities [Abstract]

Investments-Debt, Equity and Other Securities

3. Investments – Debt, Equity and Other Securities

The following is a summary of the Company’s debt, equity and other securities (in thousands):

	December 31,
	2015		2014
Marketable securities	$	395	$	831
Cost method		32,516		33,672
	$	32,911	$	34,503

Investments in Marketable Securities:

The following is a summary of available-for-sale securities (in thousands):

	December 31, 2015							December 31, 2014
			Gross							Gross
	Amortized		Unrealized			Market		Amortized		Unrealized			Market
	Cost		Loss			Value		Cost		Loss			Value
Marketable equity	$	1,103	$	(708	)	$	395	$	1,103	$	(272	)	$	831

The Company recognized a $5.0 million gain from the sale of marketable equity securities in 2014. The Company did not recognize any gains from the sale of marketable equity securities in 2015 and 2013. The Company did not recognize any losses from the sale of marketable equity securities in 2015, 2014 and 2013.

The net after-tax adjustment to unrealized holding gains (losses) on available-for-sale securities included in the AOCI component of shareholders’ deficit was ($438,000), ($170,000) and $3.5 million in 2015, 2014 and 2013, respectively.

The Company’s policy is to continually review declines in fair value of marketable equity securities for declines that may be other than temporary. As part of this review, the Company considers the financial statements of the investee, analysts’ reports, duration of the decline in fair value and general market factors. The Company did not recognize any such losses in 2015, 2014 and 2013.

Investments – Cost Method

The Company has investments in equity securities of companies for which there are not readily available market values and for which the Company does not exercise significant influence or control. These investments are accounted for using the cost method. Below is a summary of the Company’s portfolio of cost method investments (in thousands):

	December 31,
	2015		2014
Equity investments	$	32,516	$	32,516
Convertible notes		—		1,156
	$	32,516	$	33,672

On February 25, 2011, the Company and the Samsung Group entered into an agreement to form a joint venture intended to provide biopharmaceutical contract manufacturing services in South Korea. The Company committed to invest up to $30.0 million for a noncontrolling interest and has funded all of this commitment. As of December 31, 2015 and 2014, the Company has an approximately 2.2% and 3.0%, respectively, ownership interest in the joint venture.

In December 2011, the Company and Intarcia Therapeutics (“Intarcia”) entered into an alliance to develop a new therapy for type 2 diabetes whereby Intarcia will use the Company to conduct Phase III pivotal clinical trials and a cardiovascular outcomes clinical trial. Under the alliance, the Company provided Intarcia a customer incentive of $12.5 million and acquired $5.0 million of preferred stock of Intarcia. The customer incentive is being amortized in proportion to the revenues earned as a reduction of revenue recorded under the service arrangements. As of December 31, 2015 and 2014, the customer incentive of $2.5 million and $7.1 million, respectively, was recorded in deposits and other assets on the accompanying consolidated balance sheets. The $5.0 million investment in preferred stock of Intarcia is recorded in “investments — debt, equity and other securities” on the accompanying consolidated balance sheets.

The Company reviews the carrying value of each individual investment at each balance sheet date to determine whether or not an other-than-temporary decline in fair value has occurred. The Company employs alternative valuation techniques including the following: (i) the review of financial statements including assessments of liquidity, (ii) the review of valuations available to the Company prepared by independent third parties used in raising capital, (iii) the review of publicly available information including press releases and (iv) direct communications with the investee’s management, as appropriate. If the review indicates that such a decline in fair value has occurred, the Company adjusts the carrying value to the estimated fair value of the investment and recognizes a loss for the amount of the adjustment.

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Investments in and Advances to Unconsolidated Affiliates

12 Months Ended

Dec. 31, 2015

Investments In And Advances To Affiliates Schedule Of Investments [Abstract]

Investments in and Advances to Unconsolidated Affiliates

4. Investments in and Advances to Unconsolidated Affiliates

The Company accounts for its investments in and advances to unconsolidated affiliates under the equity method of accounting and records its pro rata share of its losses or earnings from these investments in equity in earnings (losses) of unconsolidated affiliates. The following is a summary of the Company’s investments in and advances to unconsolidated affiliates (in thousands):

	December 31,
	2015		2014
NovaQuest Pharma Opportunities Fund III, L.P.	$	39,785	$	22,633
NovaQuest Pharma Opportunities Fund IV, L.P.		2,524		—
CenduitTM		9,478		8,271
Other		595		604
	$	52,382	$	31,508

NovaQuest Pharma Opportunities Funds

The Company has committed to invest up to $50 million as a limited partner in NovaQuest Pharma Opportunities Fund III, L.P. (“Fund III”). As of December 31, 2015, the Company has funded approximately $34.7 million and has approximately $15.3 million of remaining funding commitments. As of December 31, 2015 and 2014, the Company had a 10.9% ownership interest in Fund III.

In February 2015, the Company committed to invest up to $20 million as a limited partner in a new private equity fund, NovaQuest Pharma Opportunities Fund IV, L.P. (“Fund IV”). As of December 31, 2015, the Company has funded approximately $2.7 million and has approximately $17.3 million of remaining funding commitments. As of December 31, 2015, the Company had a 2.3% ownership interest in Fund IV.

Cenduit™

In May 2007, the Company and Thermo Fisher Scientific Inc. (“Thermo Fisher”) completed the formation of a joint venture, Cenduit™. The Company contributed its Interactive Response Technology operations in India and the United States. Thermo Fisher contributed its Fisher Clinical Services Interactive Response Technology operations in three locations — the United Kingdom, the United States and Switzerland. Additionally, each company contributed $3.5 million in initial capital. The Company and Thermo Fisher each own 50% of Cenduit™.

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Derivatives

12 Months Ended

Dec. 31, 2015

Derivative Instruments And Hedging Activities Disclosure [Abstract]

Derivatives

5. Derivatives

As of December 31, 2015, the Company held the following derivative positions: (i) forward exchange contracts to protect against foreign exchange movements for certain forecasted foreign currency cash flows related to service contracts and (ii) interest rate swaps to hedge the exposure to variability in interest payments on variable interest rate debt. The Company does not use derivative financial instruments for speculative or trading purposes.

As of December 31, 2015, the Company had 15 open foreign exchange forward contracts to hedge certain forecasted foreign currency cash flow transactions occurring in 2016 with notional amounts totaling $117.5 million. As of December 31, 2014, the Company had 13 open foreign exchange forward contracts to hedge certain forecasted foreign currency cash flow transactions occurring in 2015 with notional amounts totaling $76.0 million. These contracts were executed to hedge the risk of the potential volatility in the cash flows resulting from fluctuations in currency exchange rates during the first nine months of 2016. These transactions are accounted for as cash flow hedges, as such, the effective portion of the gain or loss on the contracts is recorded as unrealized gains (losses) on derivatives included in the AOCI component of shareholders’ deficit. These hedges are highly effective. As of December 31, 2015 and 2014, the Company had recorded gross unrealized losses of $5.2 million and $4.6 million, respectively, related to foreign exchange forward contracts. Upon expiration of the hedge instruments in 2016, the Company will reclassify the unrealized holding gains and losses on the derivative instruments included in AOCI into earnings. The unrealized losses are included in other current liabilities on the accompanying consolidated balance sheets as of December 31, 2015 and 2014, respectively.

On June 9, 2011, the Company entered into six interest rate swaps which expired between September 30, 2013 and March 31, 2016 in an effort to limit its exposure to changes in the variable interest rate on its senior secured credit facilities. During May 2015, in conjunction with the debt refinancing described in Note 10, the Company terminated the remaining open interest rate swaps for a cash payment to the counterparty of $12.4 million, which included $1.4 million of accrued interest. Since the hedged forecasted cash transactions continue to be probable of occurring, the accumulated loss ($3.1 million at December 31, 2015) related to the terminated interest rate swaps in AOCI will be reclassified to earnings as a component of interest expense in the same periods as the hedged forecasted transactions occur over the next three months.

On June 3, 2015, the Company entered into seven forward starting interest rate swaps with a notional value of $440.0 million in an effort to limit its exposure to changes in the variable interest rate on its senior secured credit facilities. Interest on the swaps begins to accrue on June 30, 2016 and the interest rate swaps expire between March 31, 2017 and March 31, 2020. The critical terms of the interest rate swaps are substantially the same as those of the Company’s senior secured credit facilities, including quarterly interest settlements. These interest rate swaps are being accounted for as cash flow hedges as these transactions were executed to hedge the Company’s interest payments, and these hedges are deemed to be highly effective. As such, changes in the fair value of these derivative instruments are recorded as unrealized gains (losses) on derivatives included in AOCI. The fair value of these interest rate swaps represents the present value of the anticipated net payments the Company will make to the counterparty, which, when they occur, are reflected as interest expense on the consolidated statements of income. These payments, together with the variable rate of interest incurred on the underlying debt, result in a fixed rate of interest of 2.1% plus the applicable margin on the affected borrowings. These interest rate swaps will result in a total debt mix of approximately 50% fixed rate debt and 50% variable rate debt. The Company expects that $3.2 million of unrealized losses will be reclassified out of AOCI and will form the interest rate swap component of the 2.1% fixed rate of interest incurred over the next 12 months as the underlying net payments are settled.

The fair values of the Company’s derivative instruments designated as hedging instruments and the line items on the accompanying consolidated balance sheets to which they were recorded are summarized in the following table (in thousands):

		December 31,
	Balance Sheet Classification	2015		2014
Foreign exchange forward contracts	Other current liabilities	$	5,194	$	4,635
Interest rate swaps	Other current liabilities	$	5,698	$	14,424

The effect of the Company’s cash flow hedging instruments on other comprehensive income (loss) is summarized in the following table (in thousands):

	Year Ended December 31,
	2015			2014			2013
Foreign exchange forward contracts	$	(559	)	$	(8,585	)	$	3,485
Interest rate swaps		5,626			10,381			9,202
Total	$	5,067		$	1,796		$	12,687

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Fair Value Measurements

12 Months Ended

Dec. 31, 2015

Fair Value Disclosures [Abstract]

Fair Value Measurements

6. Fair Value Measurements

The Company records certain assets and liabilities at fair value. Fair value is defined as the price that would be received to sell an asset or paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants at the measurement date. A three-level fair value hierarchy that prioritizes the inputs used to measure fair value is described below. This hierarchy requires entities to maximize the use of observable inputs and minimize the use of unobservable inputs. The three levels of inputs used to measure fair value are as follows:

· Level 1 — Quoted prices in active markets for identical assets or liabilities.

· Level 2 — Observable inputs other than quoted prices included in Level 1, such as quoted prices for similar assets and liabilities in active markets; quoted prices for identical or similar assets and liabilities in markets that are not active; or other inputs that are observable or can be corroborated by observable market data.

· Level 3 — Unobservable inputs that are supported by little or no market activity. This includes certain pricing models, discounted cash flow methodologies and similar techniques that use significant unobservable inputs.

Recurring Fair Value Measurements

The following table summarizes the fair value of the Company’s financial assets and liabilities that are measured on a recurring basis as of December 31, 2015 (in thousands):

	Level 1		Level 2		Level 3		Total
Assets:
Marketable equity securities	$	395	$	—	$	—	$	395
Total	$	395	$	—	$	—	$	395
Liabilities:
Foreign exchange forward contracts	$	—	$	5,194	$	—	$	5,194
Interest rate swaps	—			5,698	—			5,698
Contingent consideration	—		—			4,374		4,374
Total	$	—	$	10,892	$	4,374	$	15,266

The following table summarizes the fair value of the Company’s financial assets and liabilities that are measured on a recurring basis as of December 31, 2014 (in thousands):

	Level 1		Level 2		Level 3		Total
Assets:
Marketable equity securities	$	831	$	—	$	—	$	831
Total	$	831	$	—	$	—	$	831
Liabilities:
Foreign exchange forward contracts	$	—	$	4,635	$	—	$	4,635
Interest rate swaps	—			14,424	—			14,424
Contingent consideration	—		—			1,452		1,452
Total	$	—	$	19,059	$	1,452	$	20,511

Below is a summary of the valuation techniques used in determining fair value:

Marketable equity securities — The Company values marketable equity securities utilizing quoted market prices.

Foreign exchange forward contracts — The Company values foreign exchange forward contracts using quoted market prices for identical instruments in less active markets or using other observable inputs.

Interest rate swaps — The Company values interest rate swaps using market inputs with mid-market pricing as a practical expedient for bid-ask spread.

Contingent consideration — The Company values contingent consideration related to business combinations using a weighted probability calculation of potential payment scenarios discounted at rates reflective of the risks associated with the expected future cash flows. Key assumptions used to estimate the fair value of contingent consideration include revenue, net new business and operating forecasts and the probability of achieving the specific targets.

The following table summarizes the changes in Level 3 financial assets and liabilities measured on a recurring basis for the year ended December 31 (in thousands):

	Contingent Consideration –
	Accrued Expenses and Other Liabilities
	2015			2014			2013
Balance as of January 1	$	1,452		$	13,014		$	3,521
Initial estimate of contingent consideration	—			—				14,300
Contingent consideration paid		(3,000	)		(3,000	)	—
Revaluations included in earnings		5,922			(8,562	)		(4,807	)
Balance as of December 31	$	4,374		$	1,452		$	13,014

The revaluation for the contingent consideration is recognized in other expense (income), net on the accompanying consolidated statements of income.

Non-recurring Fair Value Measurements

Certain assets are carried on the accompanying consolidated balance sheets at cost and are not remeasured to fair value on a recurring basis. These assets include cost and equity method investments and loans that are written down to fair value for declines which are deemed to be other-than-temporary, and goodwill and identifiable intangible assets which are tested for impairment annually and when a triggering event occurs.

As of December 31, 2015, assets carried on the balance sheet and not remeasured to fair value on a recurring basis totaling approximately $1,172.7 million and were identified as Level 3. These assets are comprised of cost and equity method investments of $84.9 million, goodwill of $719.7 million and other identifiable intangibles, net of $368.1 million.

Cost and Equity Method Investments — The inputs available for valuing investments in non-public portfolio companies are generally not easily observable. The valuation of non-public investments requires significant judgment by the Company due to the absence of quoted market values, inherent lack of liquidity and the long-term nature of such assets. When a triggering event occurs, the Company considers a wide range of available market data when assessing the estimated fair value. Such market data includes observations of the trading multiples of public companies considered comparable to the private companies being valued as well as publicly disclosed merger transactions involving comparable private companies. In addition, valuations are adjusted to account for company-specific issues, the lack of liquidity inherent in a non-public investment and the fact that comparable public companies are not identical to the companies being valued. Such valuation adjustments are necessary because in the absence of a committed buyer and completion of due diligence similar to that performed in an actual negotiated sale process, there may be company-specific issues that are not fully known that may affect value. Further, a variety of additional factors are reviewed by the Company, including, but not limited to, financing and sales transactions with third parties, current operating performance and future expectations of the particular investment, changes in market outlook and the third party financing environment. Because of the inherent uncertainty of valuations, estimated valuations may differ significantly from the values that would have been used had a ready market for the securities existed, and the differences could be material.

Goodwill — Goodwill represents the difference between the purchase price and the fair value of the identifiable tangible and intangible net assets resulting from business combinations. The Company performs a qualitative analysis to determine whether it is more likely than not that the estimated fair value of a reporting unit is less than its book value. This includes a qualitative analysis of macroeconomic conditions, industry and market considerations, internal cost factors, financial performance, fair value history and other company specific events. If this qualitative analysis indicates that it is more likely than not that the estimated fair value is less than the book value for the respective reporting unit, the Company applies a two-step impairment test in which the Company determines whether the estimated fair value of the reporting unit is in excess of its carrying value. If the carrying value of the net assets assigned to the reporting unit exceeds the estimated fair value of the reporting unit, the Company performs the second step of the impairment test to determine the implied estimated fair value of the reporting unit’s goodwill. The Company determines the implied estimated fair value of goodwill by determining the present value of the estimated future cash flows for each reporting unit and comparing the reporting unit’s risk profile and growth prospects to selected, reasonably similar publicly traded companies. No indication of impairment was identified during the Company’s annual review.

Definite-lived Intangible Assets — If a triggering event occurs, the Company determines the estimated fair value of definite-lived intangible assets by determining the present value of the expected cash flows.

Indefinite-lived Intangible Asset — The Company performs a qualitative analysis to determine whether it is more likely than not that the estimated fair value of the indefinite-lived intangible asset is less than its carrying value. If this qualitative analysis indicates that it is more likely than not that the estimated fair value is less than the carrying value of the indefinite-lived intangible asset, the Company determines the estimated fair value of the indefinite-lived intangible asset (trade name) by determining the present value of the estimated royalty payments on an after-tax basis that it would be required to pay the owner for the right to use such trade name. If the carrying amount exceeds the estimated fair value, an impairment loss is recognized in an amount equal to the excess. No indication of impairment was identified during the Company’s annual review.

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Property and Equipment

12 Months Ended

Dec. 31, 2015

Property Plant And Equipment [Abstract]

Property and Equipment

7. Property and Equipment

The major classes of property and equipment were as follows (in thousands):

	December 31,
	2015			2014
Land, buildings and leasehold improvements	$	187,405		$	185,940
Equipment		257,119			240,227
Furniture and fixtures		52,840			54,615
Motor vehicles		13,348			15,443
		510,712			496,225
Less accumulated depreciation		(322,319	)		(305,928	)
	$	188,393		$	190,297

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Goodwill and Identifiable Intangible Assets

12 Months Ended

Dec. 31, 2015

Goodwill And Intangible Assets Disclosure [Abstract]

Goodwill and Identifiable Intangible Assets

8. Goodwill and Identifiable Intangible Assets

As of December 31, 2015, the Company has approximately $368.1 million of identifiable intangible assets, of which approximately $128.2 million, relating to trade names, is deemed to be indefinite-lived and, accordingly, is not being amortized. Amortization expense associated with identifiable definite-lived intangible assets was as follows (in thousands):

	Year Ended December 31,
	2015		2014		2013
Amortization expense	$	66,545	$	58,457	$	51,450

Estimated amortization expense for existing identifiable intangible assets is expected to be approximately $61.7 million, $50.2 million, $39.2 million, $32.5 million and $20.8 million for the years ending December 31, 2016, 2017, 2018, 2019 and 2020, respectively. Estimated amortization expense can be affected by various factors, including future acquisitions or divestitures of product and/or licensing and distribution rights or impairments.

The following is a summary of identifiable intangible assets (in thousands):

	As of December 31, 2015							As of December 31, 2014
	Gross		Accumulated			Net		Gross		Accumulated			Net
	Amount		Amortization			Amount		Amount		Amortization			Amount
Definite-lived identifiable intangible assets:
Product licensing and distribution rights and customer relationships	$	224,149	$	(75,606	)	$	148,543	$	123,227	$	(54,413	)	$	68,814
Trademarks, trade names and other		14,620		(6,081	)		8,539		18,571		(6,399	)		12,172
Software and related assets		279,266		(196,489	)		82,777		260,052		(170,471	)		89,581
	$	518,035	$	(278,176	)	$	239,859	$	401,850	$	(231,283	)	$	170,567
Indefinite-lived identifiable intangible assets:
Trade names	$	128,247	$	—		$	128,247	$	109,676	$	—		$	109,676

Accumulated amortization of identifiable intangible assets includes the impact of amortization expense, foreign exchange fluctuations and disposals of software and related assets.

The following is a summary of goodwill by segment for the years ended December 31, 2015 and 2014 (in thousands):

				Integrated
	Product			Healthcare
	Development			Services			Consolidated
Balance as of December 31, 2013	$	351,144		$	58,482		$	409,626
Business combinations	—				62,778			62,778
Impact of foreign currency fluctuations and other		(4,536	)		(3,434	)		(7,970	)
Balance as of December 31, 2014		346,608			117,826			464,434
Business combinations		262,377		—				262,377
Impact of foreign currency fluctuations and other		(6,879	)		(192	)		(7,071	)
Balance as of December 31, 2015	$	602,106		$	117,634		$	719,740

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Accrued Expenses

12 Months Ended

Dec. 31, 2015

Payables And Accruals [Abstract]

Accrued Expenses

9. Accrued Expenses

Accrued expenses consist of the following (in thousands):

	December 31,
	2015		2014
Compensation, including bonuses, fringe benefits and payroll taxes	$	400,748	$	403,250
Restructuring		13,564		6,083
Interest		5,115		274
Contract related		271,076		255,530
Other		70,254		68,507
	$	760,757	$	733,644

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Credit Arrangements

12 Months Ended

Dec. 31, 2015

Debt Disclosure [Abstract]

Credit Arrangements

10. Credit Arrangements

The following is a summary of the Company’s revolving credit facilities at December 31, 2015:

Facility	Interest Rates
$500.0 million (revolving credit facility)	London Interbank Offer Rate (“LIBOR”) (0.61% at December 31, 2015) plus 1.75%
$25.0 million (receivables financing facility)	LIBOR Market Index Rate (0.43% at December 31, 2015) plus 0.85% to 1.35% depending upon the Company’s debt rating
£10.0 million (approximately $14.8 million) general banking facility with a European headquartered bank	Bank’s base rate (0.5% at December 31, 2015) plus 1%

During 2014, the Company borrowed and repaid $150.0 million from its then outstanding revolving credit facility. The Company did not have any outstanding borrowings under any of the revolving credit facilities at December 31, 2015 or 2014. At December 31, 2015, there were bank guarantees totaling approximately £3.9 million (approximately $5.8 million) issued against the availability of the general banking facility with a European headquartered bank through their operations in the United Kingdom.

Long-term debt consists of the following (in thousands):

	December 31,
	2015			2014
4.875% Senior Notes due 2023	$	800,000		$	—
Term Loan A due 2020 (LIBOR plus 1.75%, or 2.36% at December 31, 2015)		828,750			—
Term Loan B due 2022 (the greater of LIBOR or 0.75% plus 2.50%, or 3.25% at December 31, 2015)		597,000			—
Term Loan B-3 due 2018 (the greater of three month LIBOR or 1.25% plus 2.50%, or 3.75% at December 31, 2014)		—			2,030,606
Receivables financing facility due 2018 (LIBOR plus 1.05%, or 1.48% at December 31, 2015)		275,000			275,000
		2,500,750			2,305,606
Less: unamortized discount		(24,020	)		(12,379	)
Less: unamortized debt issuance costs		(8,955	)		(9,879	)
Less: current portion		(48,500	)		(750	)
	$	2,419,275		$	2,282,598

Contractual maturities of long-term debt at December 31, 2015 are as follows (in thousands):

2016	$	48,500
2017		48,500
2018		323,500
2019		48,500
2020		664,750
Thereafter		1,367,000
	$	2,500,750

The estimated fair value of the Company’s long-term debt approximates its carrying value as of December 31, 2015 and 2014. The estimated fair value of the long-term debt is primarily based on rates in which the debt is traded among banks.

Senior Secured Credit Agreement

2015 Senior Secured Credit Agreement

On May 12, 2015, the Company through its wholly-owned subsidiary, Quintiles Transnational, entered into new senior secured credit facilities (the “New Facilities”) totaling $1.95 billion. The New Facilities consist of a five-year $500.0 million revolving credit facility (the “New Revolver”) and $1.45 billion of term loans ($850 million in New Term Loan A due 2020 (the “New Term Loan A”) and $600 million in New Term Loan B due in 2022 (the “New Term Loan B”)). In addition, Quintiles Transnational issued $800 million of 4.875% senior unsecured notes due 2023 (the “Senior Notes”) in a private placement. The New Facilities and the Senior Notes are referred to collectively as the “New Debt.”

Annual maturities on the New Term Loan A and the New Term Loan B are 5% and 1%, respectively, of the respective original principal amount with the remaining balance to be repaid on their respective maturity dates. Beginning with the fiscal year ending December 31, 2016, the Company will be required to make mandatory repayments on New Term Loan A and New Term Loan B of 50% of excess cash flow (as defined in the credit agreement covering the New Facilities, subject to a reduction to 25% or 0% depending upon the Company’s leverage ratio). Mandatory repayments will be allocated pro rata between New Term Loan A and New Term Loan B (subject to increases in the amount of New Term Loan A repayments with amounts declined by New Term Loan B lenders), and applied, first, to reduce the next eight quarterly amortization installments in direct order of maturity, and, second, to reduce all remaining amortization installments pro rata. The Company will also be required to make mandatory repayments with 100% of the net cash proceeds of certain asset dispositions, subject to thresholds and reinvestment rights. Any amounts outstanding under the New Facilities may be voluntarily repaid at any time without penalty. The new senior secured credit facilities arrangements are collateralized by substantially all of the assets of Quintiles Transnational and the assets of Quintiles Transnational’s domestic subsidiaries including 100% of the equity interests of substantially all of Quintiles Transnational’s domestic subsidiaries and 65% of the equity interests of substantially all of the first-tier foreign subsidiaries of Quintiles Transnational and its domestic subsidiaries.

Interest on the Senior Notes is paid semiannually on May 15 and November 15 of each year until maturity. The Senior Notes are unsecured senior obligations of Quintiles Transnational and are effectively subordinated in right of payment to all secured obligations of Quintiles Transnational, to the extent of the value of any collateral.

The Company used the proceeds from the New Debt (i) to repay the then outstanding Term Loan B-3 (defined below) which was due in 2018, (ii) to pay related fees and expenses including $11.0 million of breakage fees associated with the terminated interest rate swaps discussed further in Note 5, and (iii) for general corporate purposes including the share repurchase discussed further in Note 12.

2014 Revolving Credit Facility Amendment

On November 7, 2014, the Company entered into an amendment to its then outstanding senior secured credit agreement that increased its revolving credit facility from $300.0 million to $400.0 million and extended the maturity date for most of the then outstanding revolving credit facility by six months. The other terms of the then outstanding senior secured credit agreement were not altered by the amendment. On May 12, 2015, the Company’s then outstanding revolving credit facility was replaced with the New Revolver (defined and discussed above).

2013 Senior Secured Credit Agreement

On December 20, 2013, the Company entered into an amendment to its then outstanding senior secured credit agreement to provide a Term Loan B-3 (the “Term Loan B-3”) with a syndicate of banks for an aggregate principal amount of $2.061 billion due in 2018. The proceeds from the Term Loan B-3 were used to repay the then outstanding balances of the Company’s term loan B-1 and term loan B-2 and related fees and expenses. On May 12, 2015, the Term Loan B-3 was repaid with the proceeds of the New Debt (defined and discussed above).

Receivables Financing Facility

On December 5, 2014, the Company entered into a four-year arrangement to securitize certain of its accounts receivable. Under the receivables financing facility, certain of the Company’s accounts receivable are sold on a non-recourse basis by certain of its consolidated subsidiaries to another of its consolidated subsidiaries, a bankruptcy-remote special purpose entity (“SPE”). The SPE obtained a term loan and revolving loan commitment from a third party lender, secured by liens on the assets of the SPE, to finance the purchase of the accounts receivable, which included a $275.0 million term loan and a $25.0 million revolving loan commitment. The revolving loan commitment may be increased by an additional $35.0 million as amounts are repaid under the term loan. Quintiles Transnational has guaranteed the performance of the obligations of existing and future subsidiaries that sell and service the accounts receivable under the receivables financing facility. The assets of the SPE are not available to satisfy any of the Company’s obligations or any obligations of its subsidiaries. As of December 31, 2015, $25.0 million of revolving loans were available under the receivables financing facility.

The Company used the proceeds from the term loan under the receivables financing facility to repay in full the amount outstanding on the then outstanding revolving credit facility under its then outstanding senior secured credit agreement ($150.0 million), to repay $25.0 million of the then outstanding Term Loan B-3, to pay related fees and expenses and the remainder was used for general working capital purposes.

Loss on Extinguishment of Debt

On May 12, 2015, the then outstanding Term Loan B-3 was repaid with the proceeds of the New Debt (defined and discussed above). In connection with this refinancing transaction, in 2015 the Company recognized a $7.8 million loss on extinguishment of debt which included $1.1 million of unamortized debt issuance costs, $1.3 million of unamortized discount and $5.4 million of related fees and expenses.

On December 20, 2013, the balance of a then outstanding term loan was repaid with the proceeds from Term Loan B-3 (defined and discussed above). In 2013, in connection with the repayment of debt, the Company recognized a $3.3 million loss on extinguishment of debt which included approximately $1.6 million of unamortized debt issuance costs, approximately $1.6 million of unamortized discount and approximately $25,000 of related fees and expenses.

In May 2013, the Company used $50.0 million of cash to pay down indebtedness under its then outstanding term loan B-1. In connection with this pay down of indebtedness, the Company recognized a $1.0 million loss on extinguishment of debt which included approximately $930,000 of unamortized debt issuance costs and $112,000 of unamortized discount.

Also in May 2013, the Company used $308.9 million of cash to pay all amounts then outstanding under a term loan (including accrued interest and related fees and expenses). In connection with the repayment of debt, the Company recognized a $15.5 million loss on extinguishment of debt which included approximately $4.7 million of unamortized debt issuance costs, $4.7 million of unamortized discount and $6.1 million of related fees and expenses.

Restrictive Covenants

The credit agreement governing the Quintiles Transnational senior secured credit facilities contains usual and customary restrictive covenants (subject to significant exceptions) that place limitations on Quintiles Transnational’s ability, and the ability of Quintiles Transnational’s restricted subsidiaries, to incur liens; engage in acquisitions, loans and other investments; incur additional indebtedness; merge, dissolve, liquidate or consolidate with or into other persons; sell or otherwise dispose of assets; declare dividends, including to Quintiles Transnational Holdings Inc., and make other restricted payments; engage in businesses that are not related to Quintiles Transnational’s and its restricted subsidiaries’ existing business; transact with affiliates; enter into agreements that restrict subsidiaries from paying intercompany dividends or completing intercompany property transfers or that restrict the ability to create liens in favor of Quintiles Transnational’s lenders; amend or otherwise modify organizational documents or terms and conditions of junior financing documents, if any; change the fiscal year of Quintiles Transnational; prepay, redeem or purchase junior financing, if any; designate any other indebtedness as “designated senior indebtedness” or “senior secured financing”; and engage in sale and leaseback transactions. The credit agreement also contains one financial covenant, which is a total leverage ratio that provides for a maximum ratio of consolidated total debt to consolidated EBITDA, as defined in the credit agreement, for any period of four consecutive fiscal quarters, measured as of the end of such period, of 5.75 to 1.00, and applies at any time that the Term Loan A or New Revolver commitments remain outstanding. Violations of the financial covenant will not entitle the Term Loan B lenders to take any enforcement action prior to an acceleration of the New Revolver and the Term Loan A and, subject to customary limitations, may be cured with an equity contribution.

The agreement governing the Senior Notes limits Quintiles Transnational’s and its restricted subsidiaries’ (as defined in the agreement) ability to create liens and enter into sale and lease-back transactions.

The agreement governing the receivables financing facility contains certain usual and customary covenants and termination events for a securitization transaction, including certain financial reporting covenants and requirements to maintain the existence of the SPE separate from Quintiles Transnational and its other affiliates. An occurrence of an event of default or a termination event under this facility may give rise to the right of the third party lender to terminate this facility.

In 2015, 2014 and 2013, the Company was in compliance with its restrictive covenants.

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Leases

12 Months Ended

Dec. 31, 2015

Leases [Abstract]

Leases

11. Leases

The Company leases facilities under operating leases, many of which contain renewal and escalation clauses. The Company also leases certain equipment under operating leases. The leases expire at various dates through 2029 with options to cancel certain leases at various intervals. Rental expenses under these agreements were $109.4 million, $114.6 million and $125.6 million in 2015, 2014 and 2013, respectively. The Company leases certain assets, primarily vehicles, under capital leases. Capital lease amortization is included with costs of revenue and accumulated depreciation on the accompanying financial statements.

The following is a summary of future minimum payments under capital and operating leases that have initial or remaining non-cancelable lease terms in excess of one year at December 31, 2015 (in thousands):

	Capital			Operating
	Leases			Leases
2016	$	15		$	84,747
2017		18			62,485
2018	—				41,907
2019	—				29,201
2020	—				25,713
Thereafter	—				111,267
Total minimum lease payments		33		$	355,320
Amounts representing interest		(2	)
Present value of net minimum payments		31
Current portion		(13	)
Long-term capital lease obligations	$	18

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Shareholders' Deficit

12 Months Ended

Dec. 31, 2015

Equity [Abstract]

Shareholders' Deficit

12. Shareholders’ Deficit

Initial Public Offering

On May 9, 2013, the Company’s common stock began trading on the New York Stock Exchange (“NYSE”) under the symbol “Q.” On May 14, 2013, the Company completed its IPO of its common stock at a price to the public of $40.00 per share. The Company issued and sold 13,125,000 shares of common stock in the IPO. The selling shareholders offered and sold 14,111,841 shares of common stock in the IPO, including 3,552,631 shares that were offered and sold by the selling shareholders pursuant to the full exercise of the underwriters’ option to purchase additional shares. The IPO raised proceeds to the Company of approximately $489.5 million, after deducting underwriting discounts, commissions and related expenses. The Company did not receive any of the proceeds from the sale of the shares sold by the selling shareholders.

Preferred Stock

The Company is authorized to issue 1.0 million shares of preferred stock, $0.01 per share par value. No shares of preferred stock were issued and outstanding as of December 31, 2015 or 2014.

Equity Repurchases

Since 2013, the Company has repurchased approximately $995.6 million of its equity securities as discussed further below.

Equity Repurchase Program

On October 30, 2013, the Company’s Board of Directors (the “Board”) approved an equity repurchase program (the “Repurchase Program”) authorizing the repurchase of up to $125.0 million of either the Company’s common stock or vested in-the-money employee stock options, or a combination thereof. During 2015, the Board increased the share repurchase authorization under the Repurchase Program by $600.0 million which increased the total amount that has been authorized under the Repurchase Program to $725.0 million. The Repurchase Program does not obligate the Company to repurchase any particular amount of common stock or vested in-the-money employee stock options, and it could be modified, suspended or discontinued at any time. The timing and amount of repurchases are determined by the Company’s management based on a variety of factors such as the market price of the Company’s common stock, the Company’s corporate requirements, and overall market conditions. Purchases of the Company’s common stock may be made in open market transactions effected through a broker-dealer at prevailing market prices, in block trades, or in privately negotiated transactions. The Company may also repurchase shares of its common stock pursuant to a trading plan meeting the requirements of Rule 10b5-1 under the Exchange Act, which would permit shares of the Company’s common stock to be repurchased when the Company might otherwise be precluded from doing so by law. Repurchases of vested in-the-money employee stock options were made through transactions between the Company and its employees (other than its executive officers, who were not eligible to participate in the program), and this aspect of the Repurchase Program expired in November 2013. The Repurchase Program for common stock does not have an end date.

Below is a summary of the share repurchases made under the Repurchase Program (in thousands except share data):

	Year Ended December 31,
	2015		2014		2013
Number of shares repurchased		7,855,796		300		153,223
Aggregate purchase price	$	515,010	$	14	$	6,434
Average price per share	$	65.56	$	47.51	$	42.01

In addition, in 2013, the Company repurchased 2.0 million of vested in-the-money employee stock options at fair value for an aggregate purchase price of $59.1 million (representing an average market price per share of $43.42 and an average exercise price per option of $13.74). As of December 31, 2015, the Company has remaining authorization under the Repurchase Program to repurchase up to $144.5 million of its common stock.

Other Equity Repurchases

On May 28, 2014, the Company completed the repurchase of 3,287,209 shares of its common stock for $50.23 per share from TPG Quintiles Holdco, L.P., one of its existing shareholders, in a private transaction for an aggregate purchase price of approximately $165.1 million. The repurchase price per share of common stock was equal to 98% of the closing market price of the Company’s common stock on the NYSE on May 27, 2014 (which was $51.26). The repurchase of shares from its existing shareholder was authorized in compliance with the Company’s related party transactions approval policy. The Company funded this private repurchase transaction with cash on hand. This private repurchase transaction was separate from and in addition to the Repurchase Program.

On November 10, 2014, the Company completed the repurchase of 4,303,666 shares of its common stock for $58.09 per share, which was the price per share the underwriter paid to selling shareholders, for an aggregate purchase price of approximately $250.0 million. The Company funded this repurchase transaction with a combination of cash on hand and a $150.0 million draw on its revolving credit facility. This repurchase transaction was separate from and in addition to the Repurchase Program.

Noncontrolling Interests

As discussed further in Note 14, the Company’s contribution of its businesses to the joint venture was recorded at book value (carryover basis) because the Company maintains control of these businesses. As a result, Quest Diagnostics Incorporated (“Quest”) noncontrolling interest in Q² Solutions is equal to 40% of the combined carrying value of the net assets contributed by the Company plus the fair value of the net assets contributed by Quest, or $231.9 million.

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Management Fees

12 Months Ended

Dec. 31, 2015

Management Fees Disclosure [Abstract]

Management Fees

13. Management Fees

In January 2008, pursuant to a management agreement with affiliates of certain of the Company’s shareholders, the Company agreed to pay an annual management service fee of $5.0 million in the aggregate to (i) GF Management Company, LLC (“GFM”); (ii) Bain Capital Partners, LLC; (iii) TPG Capital, LP; (iv) 3i Corporation; (v) Cassia Fund Management Pte Ltd; and (vi) Aisling Capital, LLC (“Aisling Capital”). In 2013, the management agreement was terminated, and the Company paid a $25.0 million fee in connection with the termination. In 2013, the Company expensed $27.7 million in management fees under this agreement.

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Business Combinations

12 Months Ended

Dec. 31, 2015

Business Combinations [Abstract]

Business Combinations

14. Business Combinations

Quest Diagnostics Incorporated

On July 1, 2015, the Company and Quest closed on a joint venture transaction that resulted in the combination of their respective global clinical trials laboratory operations. The joint venture transaction was effected through the creation of two primary new legal entities that the Company controls. Both the Company’s and Quest’s clinical trials laboratory operations were contributed to these new legal entities. The Company accounted for the contribution of the Quest businesses as a business combination. Quest was issued a 40% equity interest in the legal entities, the fair value of which was $423.3 million (40% of the fair value of all operations contributed by both parties) and represents the purchase price paid by the Company for the clinical trials laboratory operations that Quest contributed to the joint venture transaction. The resulting combined capabilities are designed to provide its customers with globally scaled end-to-end clinical trials laboratory services and the combined business is referred to and marketed as Q² Solutions. The Company controls Q² Solutions and as such, Q² Solutions’ results of operations and financial condition are included in the accompanying consolidated financial statements with a noncontrolling interest recorded for the portion owned by Quest.

Encore Health Resources

On July 1, 2014, the Company completed the acquisition of Encore Health Resources, LLC (“Encore”) effected through a merger for approximately $91.5 million in cash (net of approximately $2.2 million of acquired cash). Encore has operations in the United States, and its business is primarily focused on providing electronic health records (“EHR”) implementation and advisory services to healthcare providers. As part of its Integrated Healthcare Services segment, the Company acquired Encore to enhance its EHR expertise.

Novella Clinical Inc.

On September 16, 2013, the Company completed the acquisition of Novella Clinical Inc. (“Novella”) through the purchase of 100% of Novella’s outstanding stock for approximately $146.6 million in cash (net of approximately $26.2 million of acquired cash) plus potential annual earn-out payments totaling up to $21.0 million contingent upon the achievement of certain revenue and net new business targets for approximately three years following closing. The Company initially recognized a liability of approximately $14.3 million as the estimated acquisition date fair value of the earn-out. Changes in the fair value of the earn-out subsequent to the acquisition date are recognized in earnings in the period of the change. Novella has operations primarily in the United States and Europe and is a clinical research organization focused primarily on emerging oncology customers as well as those in the medical device and diagnostics sectors. As part of its Product Development segment, the Company acquired Novella to complement its clinical service offerings through its focus on emerging companies and by adding expertise in oncology and medical devices.

Accounting for Acquisitions

Acquisitions are accounted for as business combinations and, accordingly, the assets acquired and the liabilities assumed have been recorded at their respective estimated fair values as of the acquisition date. The Company accounted for the contribution of the Quest businesses as a business combination and consolidated the related new legal entities in its financial statements with a noncontrolling interest for the portion owned by Quest. The Company recorded goodwill, primarily attributable to assembled workforce and expected synergies. This business combination is part of the Product Development segment and the resulting goodwill is not deductible for income tax purposes. The Company is continuing to evaluate the initial fair value measurement of the assets acquired and liabilities assumed in the Q² Solutions transaction. Further adjustments may be necessary as additional information related to the fair values of assets acquired and liabilities assumed is assessed during the measurement period (up to one year from the acquisition date). In connection with the Encore acquisition, the Company recorded goodwill, primarily attributable to the assembled workforce of Encore and expected synergies, which was assigned to the Integrated Healthcare Services segment and is deductible for income tax purposes. In connection with the Novella acquisitions, the Company recorded goodwill, primarily attributable to the assembled workforce of Novella and expected synergies, which was assigned to the Product Development segment and is not deductible for income tax purposes. Pro forma information is not presented as the operations of the acquired businesses, individually and in the aggregate, are not significant to the overall operations of the Company. Acquisition-related expenses were immaterial and are also not presented.

The following table summarizes the estimated fair value of the net assets acquired at the date of the acquisitions (in thousands):

	Quest			Encore			Novella
Assets acquired:
Cash and cash equivalents	$	31,783		$	2,223		$	26,190
Accounts receivable and unbilled services		6,186			17,714			28,644
Prepaid expenses		1,185			—			—
Other current assets		4,426			443			1,441
Property and equipment		16,422			289			9,616
Goodwill		261,710			62,778			116,542
Other identifiable intangibles		125,900			14,150			42,740
Deferred income tax asset – long-term		—			396			—
Other long-term assets		266			—			2,203
Liabilities assumed:
Accounts payable and accrued expenses		(12,790	)		(4,206	)		(12,716	)
Unearned income		—			(31	)		(7,782	)
Other current liabilities		—			—			(132	)
Deferred income tax liability – long-term		(10,412	)		—			(18,364	)
Other long-term liabilities		(1,408	)		—			(1,334	)
Net assets acquired	$	423,268		$	93,756		$	187,048

The other identifiable intangible assets consisted of the following (in thousands):

	Quest		Encore		Novella
Customer relationships	$	74,000	$	8,800	$	20,800
Backlog		32,900		800		14,000
Trade names		19,000		1,100		7,500
Non-compete agreements		—		450		440
Software		—		3,000		—
Total other identifiable intangibles	$	125,900	$	14,150	$	42,740
Amortized over a weighted average useful life (in years)		9		8		7

The acquired Quest trade name is an indefinite-lived intangible asset that is not amortized.

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Restructuring

12 Months Ended

Dec. 31, 2015

Restructuring And Related Activities [Abstract]

Restructuring

15. Restructuring

2015 Plans

In February 2015, the Board approved a restructuring plan for approximately $30.0 million to align the Company’s resources and reduce overcapacity in certain roles.These actions are expected to continue throughout 2016, and are expected to consist of severance, facility closure and other exit-related costs. In 2015, the Company has recognized approximately $11.8 million, $8.9 million and $749,000 of restructuring costs related to this plan for activities in the Product Development segment, Integrated Healthcare Services segment and corporate activities, respectively.

Also, in connection with consummating the joint venture transaction with Quest, during the third quarter of 2015, a restructuring plan was approved to reduce facility overcapacity and eliminate redundant roles. These actions are expected to continue throughout 2016 and 2017, and are expected to consist of severance, facility closure and other exit-related costs of approximately $14.0 million. During 2015, the Company has recognized approximately $8.7 million of restructuring costs related to this plan for activities in the Product Development segment.

2014 Plans

In 2014, the Board approved restructuring plans of approximately $13 million to better align resources with the Company’s strategic direction, which resulted in a reduction of approximately 250 positions. Since the start of these plans in 2014, the Company recognized approximately $11.0 million of restructuring costs related to these plans including reversals. All of the restructuring costs are related to severance and lease costs. Of the $11.0 million in total restructuring costs recognized for these plans, approximately $8.0 million and $3.0 million were related to activities in the Product Development and Integrated Healthcare Services segments, respectively.

2013 Plan

In February 2013, the Board approved a restructuring plan of up to $15.0 million to migrate the delivery of services, primarily in the Product Development segment, and to reduce anticipated overcapacity in selected areas, primarily in the Integrated Healthcare Services segment, which resulted in a reduction of approximately 400 positions. Since February 2013, the Company has recognized approximately $13.6 million of restructuring costs related to this plan including reversals. All of the restructuring costs are related to severance costs. Of the $13.6 million in total restructuring costs recognized for this plan, approximately $8.4 million, $4.7 million and $500,000 were related to activities in the Product Development segment, Integrated Healthcare Services segment and corporate activities, respectively.

The following amounts were recorded for the restructuring plans (in thousands):

	Severance and Related Costs			Exit Costs			Total
Balance at December 31, 2013	$	5,276		$	198		$	5,474
Expense, net of reversals		8,421			567			8,988
Payments		(7,998	)		(160	)		(8,158	)
Foreign currency translation		(221	)		—			(221	)
Balance at December 31, 2014		5,478			605			6,083
Expense, net of reversals		29,843			909			30,752
Payments		(22,943	)		(723	)		(23,666	)
Foreign currency translation and other		(199	)		594			395
Balance at December 31, 2015	$	12,179		$	1,385		$	13,564

The reversals were due to changes in estimates primarily resulting from the redeployment of staff and higher than expected voluntary terminations. Restructuring costs are not allocated to the Company’s reportable segments as they are not part of the segment performance measures regularly reviewed by management. The Company expects the majority of the restructuring accruals at December 31, 2015 will be paid in 2016 and 2017.

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Income Taxes

12 Months Ended

Dec. 31, 2015

Income Tax Disclosure [Abstract]

Income Taxes

16. Income Taxes

The components of income before income taxes and equity in earnings of unconsolidated affiliates are as follows (in thousands):

	Year Ended December 31,
	2015		2014		2013
Domestic	$	68,455	$	96,917	$	68,425
Foreign		470,540		405,272		254,691
	$	538,995	$	502,189	$	323,116

The components of income tax expense attributable to continuing operations are as follows (in thousands):

	Year Ended December 31,
	2015			2014			2013
Current expense (benefit):
Federal	$	47,311		$	58,403		$	38,573
State		3,559			4,618			(4,309	)
Foreign		109,273			95,010			83,744
		160,143			158,031			118,008
Deferred (benefit) expense:
Federal and state		4,613			(4,549	)		(15,807	)
Foreign		(5,767	)		(3,426	)		(6,236	)
		(1,154	)		(7,975	)		(22,043	)
	$	158,989		$	150,056		$	95,965

The differences between the Company’s consolidated income tax expense attributable to continuing operations and the expense computed at the 35% United States statutory income tax rate were as follows (in thousands):

	Year Ended December 31,
	2015			2014			2013
Federal income tax expense at statutory rate	$	188,648		$	175,766		$	113,091
State and local income taxes, net of federal benefit		1,682			2,312			(1,088	)
Research and development		(12,634	)		(16,765	)		(12,788	)
Foreign nontaxable interest income		(9,351	)		(10,217	)		(9,751	)
Gain on note settlement		—			—			10,794
United States taxes recorded on foreign earnings		38,246			18,631			(1,616	)
Foreign rate differential		(49,288	)		(30,734	)		(10,753	)
Tax contingencies		(8,304	)		4,043			(1,012	)
Other		9,990			7,020			9,088
	$	158,989		$	150,056		$	95,965

Prior to June 2013, the Company had not considered the majority of the undistributed earnings of its foreign subsidiaries to be indefinitely reinvested. Management reevaluated this assertion following the IPO, as a portion of the IPO proceeds were used to pay down debt held in the United States as well as the fact the Company does not anticipate paying dividends to shareholders in the foreseeable future, which had been significant in the past. Given the Company’s current debt balance, and related interest expense and the change in approach related to payment of dividends, the Company expects to be able to support the cash needs of the domestic subsidiaries without repatriating cash from the affected foreign subsidiaries. The Company expects to utilize the cash generated outside of the United States to fund growth outside of the United States. As a result of the assertion change, the Company recorded an $8.1 million income tax benefit in the second quarter of 2013 to reverse the deferred income tax liability previously recorded on undistributed foreign earnings prior to 2013 that are now considered indefinitely reinvested outside of the United States. Undistributed earnings of the Company’s foreign subsidiaries amounted to approximately $862.3 million at December 31, 2015. Approximately $283.9 million of this total is not considered to be indefinitely reinvested and would be taxable upon repatriation. The Company has recorded a deferred income tax liability, net of foreign income tax credits that would be generated upon repatriation, of $34.9 million as of December 31, 2015 associated with those earnings based upon the United States federal income tax rate. Upon distribution of those earnings in the form of dividends or otherwise, the Company would be subject to both United States income taxes (subject to an adjustment for foreign tax credits, if available) and withholding taxes payable to the various countries in which the Company’s foreign subsidiaries are located. If the approximately $578.4 million of indefinitely reinvested earnings were repatriated to the United States, it would generate an estimated $94.6 million of additional tax liability for the Company.

The income tax effects of temporary differences from continuing operations that give rise to significant portions of deferred income tax (liabilities) assets are presented below (in thousands):

	December 31,
	2015			2014
Deferred income tax liabilities:
Undistributed foreign earnings	$	(36,624	)	$	(27,717	)
Depreciation and amortization		(53,171	)		(65,614	)
Other		(11,830	)		(15,346	)
Total deferred income tax liabilities		(101,625	)		(108,677	)
Deferred income tax assets:
Net operating loss, capital loss and tax credit carryforwards		41,707			43,535
Accrued expenses and unearned income		23,315			34,048
Employee benefits		123,775			130,217
Other		12,801			17,784
		201,598			225,584
Valuation allowance for deferred income tax assets		(22,162	)		(24,695	)
Total deferred income tax assets		179,436			200,889
Net deferred income tax assets	$	77,811		$	92,212

The Company has net operating loss and capital loss carryforwards of approximately $44.9 million in various entities within the United Kingdom which have no expiration date and has $40.7 million of net operating loss and capital loss carryforwards from various foreign jurisdictions which have different expiration periods. The Company has United States net operating loss carryforwards of $16.6 million, which were obtained through the acquisitions of Novella, Expression Analysis, Inc., and Advion BioSciences, Inc. in 2013, 2012, and 2011, respectively, and expire through 2023. These losses are subject to IRC Section 382 limitations; however, management expects all losses to be utilized during the carryforward periods. In addition, the Company has approximately $44.0 million of United States state operating loss carryforwards which expire through 2035.

In 2015, the Company decreased its valuation allowance $2.5 million to $22.2 million at December 31, 2015 from $24.7 million at December 31, 2014. The valuation allowance is primarily related to loss carryforwards in various foreign and state jurisdictions.

A reconciliation of the beginning and ending amount of gross unrecognized income tax benefits is presented below (in thousands):

	Year Ended December 31,
	2015			2014			2013
Balance at January 1	$	40,821		$	54,936		$	43,393
Additions based on tax positions related to the current year		2,068			2,807			4,493
Additions for income tax positions of prior years		8,838			1,588			12,854
Impact of changes in exchange rates		(608	)		(376	)		(71	)
Settlements with tax authorities		(121	)		(135	)		(1,052	)
Reductions for income tax positions of prior years		(1,945	)		(6,023	)		(3,520	)
Reductions due to the lapse of the applicable statute of limitations		(19,387	)		(11,976	)		(1,161	)
Balance at December 31	$	29,666		$	40,821		$	54,936

As of December 31, 2015, the Company had total gross unrecognized income tax benefits of $29.7 million associated with over 50 jurisdictions in which the Company conducts business. This amount includes $29.3 million of unrecognized benefits that, if recognized, would reduce the Company’s effective income tax rate. This amount excludes $2.9 million of accrued interest and penalties.

The Company’s policy for recording interest and penalties relating to uncertain income tax positions is to record them as a component of income tax expense in the accompanying consolidated statements of income. In 2015, 2014 and 2013, the amount of interest and penalties recorded as a (reduction)/addition to income tax expense in the accompanying consolidated statements of income was ($2.0) million, $1.3 million and $843,000, respectively. As of December 31, 2015 and 2014, the Company accrued approximately $2.9 million and $4.8 million, respectively, of interest and penalties.

The Company believes that it is reasonably possible that a decrease of up to $8.1 million in gross unrecognized income tax benefits for federal, state and foreign exposure items may be necessary within the next 12 months due to lapse of statutes of limitations or uncertain tax positions being effectively settled. The Company believes that it is reasonably possible that a decrease of up to $160,000 in gross unrecognized benefits for foreign items may be necessary within the next 12 months due to payments. For the remaining uncertain income tax positions, it is difficult at this time to estimate the timing of the resolution.

The Company conducts business globally and, as a result, files income tax returns in the United States federal jurisdiction and various state and foreign jurisdictions. In the normal course of business, the Company is subject to examination by taxing authorities throughout the world. The following table summarizes the tax years that remain open for examination by tax authorities in the most significant jurisdictions in which the Company operates:

United States	2012-2014
India	2006-2015
Japan	2010-2014
United Kingdom	2014

In certain of the jurisdictions noted above, the Company operates through more than one legal entity, each of which has different open years subject to examination. The table above presents the open years subject to examination for the most material of the legal entities in each jurisdiction. Additionally, it is important to note that tax years are technically not closed until the statute of limitations in each jurisdiction expires. In the jurisdictions noted above, the statute of limitations can extend beyond the open years subject to examination.

Due to the geographic breadth of the Company’s operations, numerous tax audits may be ongoing throughout the world at any point in time. Income tax liabilities are recorded based on estimates of additional income taxes which will be due upon the conclusion of these audits. Estimates of these income tax liabilities are made based upon prior experience and are updated in light of changes in facts and circumstances. However, due to the uncertain and complex application of income tax regulations, it is possible that the ultimate resolution of audits may result in liabilities which could be materially different from these estimates. In such an event, the Company will record additional income tax expense or income tax benefit in the period in which such resolution occurs.

The Company had a tax holiday for Quintiles East Asia Pte. Ltd. in Singapore through June 2015, provided the Company maintains specific levels of spending and employment. The income tax benefit of this holiday was approximately $2.0 million, $2.4 million and $798,000 in 2015, 2014 and 2013, respectively. The Company also had a tax holiday for Outcome Europe Sarl in Switzerland for 2013. The income tax benefit of this holiday was approximately $64,000 in 2013. The tax holiday in 2015 and 2014 increased earnings per share by approximately $0.02. The tax holidays in 2013 did not have a notable impact on earnings per share.

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Employee Benefit Plans

12 Months Ended

Dec. 31, 2015

Compensation And Retirement Disclosure [Abstract]

Employee Benefit Plans

17. Employee Benefit Plans

The Company has numerous employee retirement benefit plans, which cover substantially all eligible employees in the countries where the plans are offered either voluntarily or statutorily. Contributions are primarily discretionary, except in some countries where contributions are contractually required.

Defined Contribution Plans

Defined contribution or profit sharing style plans are offered in Austria, Belgium, Bulgaria, Canada, the Czech Republic, Denmark, Finland, France, Germany, Hungary, India, Ireland, Israel, Malaysia, the Netherlands, Poland, Slovakia, South Africa, Sweden, Switzerland, Thailand, the United States and the United Kingdom. In some cases these plans are required by local laws or regulations.

In the United States, the Company has a 401(k) Plan under which the Company matches employee deferrals at varying percentages, set at the discretion of the Board. In 2015, 2014 and 2013, the Company expensed $36.3 million, $31.2 million and $26.1 million, respectively, related to matching contributions.

Defined Benefit Plans

Defined benefit plans are offered in Austria, France, Germany, Greece, India, Indonesia, Israel, Japan, Mexico, Philippines, Poland, Turkey and the United Kingdom. The following table summarizes the components of pension expense related to these defined benefit plans (in thousands):

	Year Ended December 31,
	2015			2014			2013
Service cost	$	15,486		$	12,944		$	13,227
Interest cost		3,453			3,821			3,684
Expected return on plan assets		(3,555	)		(4,277	)		(3,442	)
Amortization of prior service costs	—				107			336
Amortization of actuarial losses		973			636			708
	$	16,357		$	13,231		$	14,513

The Company expects to recognize approximately $870,000 in its pension expense in 2016 related to the amortization of net actuarial losses.

The weighted average assumptions used in determining pension expense were as follows:

	Year Ended December 31,
	2015			2014			2013
Discount rate		2.46	%		3.01	%		3.06	%
Rate of compensation increases		4.32	%		4.36	%		4.74	%
Expected return on plan assets		4.05	%		5.21	%		5.33	%

The following table summarizes financial information about the Company’s defined benefit plans (in thousands):

	December 31,
	2015			2014
Projected benefit obligation January 1	$	147,127		$	135,110
Service costs		15,486			12,944
Interest cost		3,453			3,821
Expected return on plan assets		(3,555	)		(4,277	)
Actuarial (gains) losses		(2,306	)		16,396
Business combination		1,746		—
Benefits paid		(6,325	)		(7,409	)
Foreign currency fluctuations and other		(1,732	)		(9,458	)
Projected benefit obligation December 31	$	153,894		$	147,127
Plan assets at fair value, January 1	$	88,420		$	82,787
Actual return on plan assets		1,312			10,004
Contributions		5,982			8,594
Business combination		1,966		—
Benefits paid		(6,325	)		(7,409	)
Foreign currency fluctuations and other		(4,212	)		(5,556	)
Plan assets at fair value, December 31	$	87,143		$	88,420
Unfunded balance	$	66,751		$	58,707

The accumulated benefit obligation for all defined benefit plans was approximately $139.1 million and $127.9 million as of December 31, 2015 and 2014, respectively.

As of December 31, 2015, the projected benefit obligation and accumulated benefit obligation for the defined benefit plans with accumulated benefit obligations in excess of plan assets were $94.6 million and $82.9 million, respectively, and were primarily related to unfunded plans. As of December 31, 2014, the projected benefit obligation and accumulated benefit obligation for the defined benefit plans with accumulated benefit obligations in excess of plan assets were $83.4 million and $66.4 million, respectively, and were primarily related to unfunded plans. As of December 31, 2015 and 2014, the projected benefit obligation exceeded the fair value of the plan assets for each defined benefit plan except for the defined benefit plans in the United Kingdom.

The following table summarizes the amounts recognized in the consolidated balance sheets related to the defined benefit plans (in thousands):

	December 31,
	2015			2014
Deposits and other assets	$	19,185		$	18,690
Accrued expenses		4,520			6,075
Other long-term liabilities		81,410			71,322
AOCI	$	(13,264	)	$	(14,519	)

The following table summarizes the amounts recognized in AOCI related to the defined benefit plans (in thousands):

	Prior			Actuarial			Deferred
	Service			Net			Income
	Costs			(Gain) Loss			Taxes			Total
Balance as of December 31, 2013	$	(107	)	$	(4,937	)	$	2,956		$	(2,088	)
Reclassification adjustments included in pension expense:
Amortization		107			636			(275	)		468
Amounts arising during the period:
Actuarial changes in benefit obligation	—				(10,218	)		2,981			(7,237	)
Balance as of December 31, 2014		—			(14,519	)		5,662			(8,857	)
Reclassification adjustments included in pension expense:
Amortization	—				973			(355	)		618
Amounts arising during the period:
Actuarial changes in benefit obligation	—				282			(318	)		(36	)
Balance as of December 31, 2015	$	—		$	(13,264	)	$	4,989		$	(8,275	)

The following table summarizes the weighted average assumptions used in determining the pension obligations:

	December 31,
	2015			2014
Discount rate		2.50	%		2.46	%
Rate of compensation increases		4.37	%		4.32	%

The discount rate represents the interest rate used to determine the present value of the future cash flows currently expected to be required to settle the Company’s defined benefit plan obligations. The discount rates are derived using weighted average yield curves on AA-rated corporate bonds. The cash flows from the Company’s expected benefit obligation payments are then matched to the yield curve to derive the discount rates.

The Company’s assumption for the expected return on plan assets was determined by the weighted average of the long-term expected rate of return on each of the asset classes invested as of the balance sheet date. For plan assets invested in government bonds, the expected return was based on the yields on the relevant indices as of the balance sheet date. There is considerable uncertainty for the expected return on plan assets invested in equity and diversified growth funds. The expected return on these plan assets was based on the expected return on long-term fixed interest rate government bonds as of the balance sheet date with a premium of 3% to 5% added to reflect the expected long-term returns expected from these types of investments.

The investment objective for defined benefit plan assets is to meet the plan’s benefit obligations and maintaining adequate funding, while minimizing the potential for future required Company contributions. The defined benefit plans in the United Kingdom, India and Israel are funded. The plan assets of the defined benefit plans in India and Israel are held in a fund which holds debt investments, primarily government bonds in accordance with local laws and regulations. The plan assets of the defined benefit plan in the United Kingdom, which are held in a trust, are primarily held in funds which hold investments in government bonds, equity investments and diversified growth funds. The equity investments are diversified to include domestic (United Kingdom) and global equity investments. A “horizon based” approach is used to determine the asset allocation. Funds intended to meet the plan’s benefit obligation payments in a horizon period are invested in low risk assets such as bond investments. Funds intended to meet the plan’s benefit obligation payments outside of the horizon period are invested in more volatile assets which are expected to provide a higher return such as equity investments and diversified growth funds. The target allocation percentage for 2016 is approximately 45-55% in bond investments, 25-35% in equity investments and 15-25% in diversified growth funds. However, the trustees may reallocate the plan assets between equity investments and bond investments depending upon the actual investment performances.

The Company’s plan assets have been identified within the fair value hierarchy as Level 2. Funds are valued using the net asset value reported by the managers of the funds. The following table summarizes the fair value of the Company’s defined benefit plans assets (in thousands):

	December 31,
	2015		2014
Funds that hold debt investments primarily government bonds	$	49,355	$	47,473
Funds that hold United Kingdom equity investments		15,700		19,547
Funds that hold global equity investments		6,277		8,255
Diversified growth fund		15,248		12,569
Other		563		576
Total	$	87,143	$	88,420

The Company estimates that it will make contributions totaling approximately $5.5 million to the defined benefit plans in 2016.

The following table summarizes the Company’s expected benefit payments under the defined benefit plans for each of the next five years and the aggregate of the five years thereafter (in thousands):

2016	$	6,684
2017		6,615
2018		7,096
2019		7,802
2020		9,092
Years 2021 through 2025		66,117
	$	103,406

Stock Incentive Plans

The stock incentive plans provide incentives to eligible employees, officers and directors in the form of non-qualified stock options, incentive stock options, SARs, restricted stock, RSUs, performance shares, performance units, covered annual incentive awards, cash-based awards and other share-based awards, in each case subject to the terms of the stock incentive plans. As of December 31, 2015, there were 7,372,127 shares available for future grants under the stock incentive plans.

The following assumptions were used to estimate the fair value of stock options and SARs:

	Year Ended December 31,
	2015		2014		2013
Expected volatility	26 – 41%		26 – 43%		18 – 47%
Weighted average expected volatility		34%		36%		40%
Expected dividends		0.0%		0.0%	0.0 - 5.45%
Expected term (in years)	3.7 – 6.7		1.5 – 6.7		0.25 – 6.4
Risk-free interest rate	1.06 – 2.04%		0.28 – 2.21%		0.04 – 2.24%

Stock Options

The option price is determined by the Board at the date of grant and the options expire 10 years from the date of grant. The vesting schedule for options granted to employees is either (i) 20% per year beginning on the first anniversary of the date of grant; (ii) 25% per year beginning on the first anniversary of the date of grant; or (iii) 33% on the third anniversary of the date of grant and 67% on the fourth anniversary of the date of grant. Options granted to our non-employee directors vest either (i) 100% on the first anniversary of the date of grant; or (ii) 34% on the first anniversary of the date of grant and 33% on the second and third anniversaries of the date of grant.

The Company’s stock option activity in 2015 is as follows:

				Weighted
	Number			Average		Aggregate
	of			Exercise		Intrinsic
	Options			Price		Value
						(in thousands)
Outstanding at December 31, 2014		9,124,954		$	29.15	$	271,216
Granted		993,600		$	65.05
Exercised		(3,013,190	)	$	19.41
Canceled		(457,365	)	$	42.08
Outstanding at December 31, 2015		6,647,999		$	38.04	$	203,679

The weighted average fair value per share of the options granted in 2015, 2014 and 2013 was $21.96, $18.72 and $14.39, respectively. The total intrinsic value of options exercised was approximately $143.7 million, $77.3 million and $27.1 million in 2015, 2014 and 2013, respectively. The Company received cash of approximately $58.5 million, $33.1 million and $12.5 million in 2015, 2014 and 2013, respectively, from options exercised.

Selected information regarding the Company’s stock options as of December 31, 2015 is as follows:

Options Outstanding											Options Exercisable
									Weighted
							Weighted		Average				Weighted
Number		Exercise					Average		Remaining		Number		Average
of		Price					Exercise		Life		of		Exercise
Options		Range					Price		(in Years)		Options		Price
	1,063,999	$	5.76	-	$	21.69	$	17.58		4.19		947,799	$	17.14
	1,069,630	$	22.01	-	$	23.83	$	23.79		6.32		661,630	$	23.79
	867,197	$	24.59	-	$	30.07	$	25.07		6.30		545,947	$	24.97
	1,241,087	$	40.00	-	$	40.00	$	40.00		7.10		421,837	$	40.00
	1,208,586	$	42.74	-	$	53.26	$	50.76		8.00		261,334	$	50.30
	1,197,500	$	57.00	-	$	77.11	$	63.44		8.87		58,375	$	57.43

The weighted average remaining contractual life of the options outstanding and exercisable as of December 31, 2015 is 6.89 years and 5.90 years, respectively. The total aggregate intrinsic value of the exercisable stock options and the stock options expected to vest as of December 31, 2015 was approximately $201.0 million.

Stock Appreciation Rights

The Company’s SARs require the Company to settle in cash an amount equal to the difference between the fair value of the Company’s common stock on the date of exercise and the grant price, multiplied by the number of SARs being exercised. These awards either (i) vest 25% per year or (ii) vest 33% on the third anniversary of the date of grant and 67% on the fourth anniversary of the date of grant.

The Company’s SAR activity in 2015 is as follows:

				Weighted
	Number			Average		Aggregate
	of			Grant		Intrinsic
	SARs			Price		Value
						(in thousands)
Outstanding at December 31, 2014		418,801		$	43.55	$	6,417
Granted		176,200		$	64.93
Exercised		(33,262	)	$	39.61
Canceled		(31,038	)	$	51.00
Outstanding at December 31, 2015		530,701		$	50.46	$	9,659

As of December 31, 2015, 2014 and 2013, the weighted average fair value per share of the SARs granted was $29.79, $27.17 and $19.07, respectively. The Company paid approximately $967,000, $408,000 and $83,000 to settle exercised SARs in 2015, 2014 and 2013, respectively.

The weighted average remaining contractual life of the SARs outstanding and exercisable as of December 31, 2015 is 8.1 years and 7.4 years, respectively. The total aggregate intrinsic value of the exercisable SARs and the SARs expected to vest as of December 31, 2015 was approximately $9.5 million.

Restricted Stock Units

The Company’s RSUs will settle in shares of the Company’s common stock within 45 days of the applicable vesting date. RSUs granted to employees vest either (i) 25% per year beginning on the first anniversary of the date of grant; or (ii) 33% on the third anniversary of the date of grant and 67% on the fourth anniversary of the date of grant. RSUs granted to our non-employee directors vest either (i) 100% on the first anniversary of the date of grant; or (ii) 34% on the first anniversary of the date of grant and 33% on the second and third anniversaries of the date of grant.

The Company’s RSU activity in 2015 is as follows:

				Weighted
				Average
	Number			Grant-Date
	of			Fair
	RSUs			Value
Non-vested at December 31, 2014		93,667		$	45.89
Granted		276,922		$	65.61
Vested		(918	)	$	47.87
Canceled		(10,118	)	$	62.77
Non-vested at December 31, 2015		359,553		$	60.60

As of December 31, 2015, there are 359,553 RSUs outstanding with an intrinsic value of approximately $24.7 million.

Performance Units

In March 2015, the Company awarded performance units that contain both service and performance based vesting criteria. Vesting occurs if the recipient remains employed and depends on the degree to which the Company achieves certain cumulative adjusted diluted earnings per share goals during a three-year performance period (as defined in the award agreements). The fair value of these awards is equal to the closing price of the Company’s common stock on the grant date.

The Company’s performance units activity in 2015 is as follows:

				Weighted
	Number			Average
	of			Grant-Date
	Performance			Fair
	Units			Value
Non-vested at December 31, 2014	—			$	—
Granted		51,977		$	64.93
Canceled		(2,310	)	$	64.93
Non-vested at December 31, 2015		49,667		$	64.93

As of December 31, 2015, there are 49,667 performance units outstanding with an intrinsic value of approximately $3.4 million.

Employee Stock Purchase Plan

The Company sponsors an Employee Stock Purchase Plan (“ESPP”) which allows eligible employees to authorize payroll deductions of up to 10% of their base salary to be applied toward the purchase of full shares of the Company’s common stock on the last day of the offering period. Offering periods under the ESPP are six months in duration. The first two offering periods for the ESPP began March 1, 2014 and September 1, 2014, respectively. In November 2014, the ESPP was amended to change the start of the offering periods to begin on April 1 and October 1 of each year, beginning April 1, 2015. Participating employees purchase shares on the last day of each offering period at a discount of 15% of the closing price of the common stock on such date as reported on the NYSE. The aggregate number of shares of the Company’s common stock that may be issued under the ESPP may not exceed 2,500,000 shares and no one employee may purchase any shares under the ESPP having a collective fair market value greater than $25,000 in any one calendar year. The shares available for purchase under the ESPP will be drawn from authorized but unissued shares of common stock. During 2015 and 2014, the Company issued 90,079 shares and 46,032 shares, respectively, of common stock for purchases under the ESPP.

Other

The Company sponsors a supplemental non-qualified deferred compensation plan, covering certain management employees, and maintains other statutory indemnity plans as required by local laws or regulations.

As of December 31, 2015 and 2014, the Company had a severance accrual included in accrued expenses on the accompanying consolidated balance sheets of $3.3 million and $6.3 million, respectively. The Company recognizes obligations associated with severance related to contractual termination benefits at fair value on the date that it is probable that the affected employees will be entitled to the benefit and the amount can reasonably be estimated. The severance accrual is related to cost reduction programs that will result in severance for approximately 270 positions, which are expected to lower operating costs and improve profitability. In 2015, the Company recognized approximately $1.0 million of net reversals related to these cost reduction programs, primarily as a result of affected individuals transferring into other positions within the Company. Of the $1.0 million decrease from net reversals recognized for these cost reduction programs, approximately $837,000 and $205,000 were related to activities in the Product Development segment and Integrated Healthcare Services segment, respectively. The Company expects the majority of the severance accrual at December 31, 2015 will be paid in 2016.

The following amounts were recorded for the severance associated with cost reduction programs (in thousands):

Balance at December 31, 2014	$	6,274
Expense, net of reversals		(1,042	)
Payments		(1,873	)
Foreign currency translation		(22	)
Balance at December 31, 2015	$	3,337

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Related Party Transactions

12 Months Ended

Dec. 31, 2015

Related Party Transactions [Abstract]

Related Party Transactions

18. Related Party Transactions

As the Company has done in prior years, the Company reimbursed its former Executive Chairman, who retired effective December 31, 2015 but remains a director of the Company, for business-related travel services he provided for himself and other Company employees with the use of his own airplane. In 2015, 2014 and 2013, the Company expensed approximately $1.3 million, $1.8 million and $2.7 million, respectively, for such business-related travel expenses. In the second quarter of 2013, the Company paid a $1.5 million fee in connection with the modification of the agreement for the business usage of the airplane that limited reimbursements to $2.5 million per year. The Company’s reimbursement obligations terminated effective December 31, 2015 in connection with its former Executive Chairman’s retirement.

In January 2010, the Company entered into a collaboration agreement with a related party, HUYA Bioscience International, LLC (“HUYA”), to fund up to $2.3 million of its research and development activity for a specific compound. Under the agreement, the Company had the potential to receive additional consideration which contractually would not exceed $16.5 million excluding interest if certain events had occurred. In February 2015, the Company and HUYA agreed to terminate the collaboration agreement. In connection with the termination, HUYA paid the Company $5.0 million to satisfy all of HUYA’s various payment obligations under the collaboration agreement.

During 2015, 2014 and 2013, the Company entered into a number of contracts with HUYA, primarily in Asia, in which the Company will provide up to approximately $31.7 million, $416,000 and $19.2 million, respectively, of services on a fee for services basis at arm’s length and at market rates. In 2015, 2014 and 2013, the Company provided approximately $6.9 million, $2.3 million and $772,000, respectively, of services under these agreements.

During 2014, HUYA subleased office space in Japan from the Company. The nine month sublease ended in September 2014 and the Company recognized $76,000 in sublease income during 2014.

The Company has entered into other transactions with related parties including investments in and advances to unconsolidated affiliates which are discussed in Note 4 and management fees which are discussed in Note 13.

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Operations by Geographic Location

12 Months Ended

Dec. 31, 2015

Operations By Geographic Location [Abstract]

Operations by Geographic Location

19. Operations by Geographic Location

The table below presents the Company’s operations by geographical location. The Company attributes revenues to geographical locations based upon where the services are performed. The Company’s operations within each geographical region are further broken down to show each country which accounts for 10% or more of the totals (in thousands):

	Year Ended December 31,
	2015		2014		2013
Service revenues:
Americas:
United States	$	1,787,918	$	1,589,402	$	1,351,160
Other		185,583		194,597		181,814
Americas		1,973,501		1,783,999		1,532,974
Europe and Africa:
United Kingdom		409,920		402,184		362,242
Other		1,050,070		1,121,354		1,139,262
Europe and Africa		1,459,990		1,523,538		1,501,504
Asia-Pacific:
Japan		442,957		471,831		438,882
Other		449,971		386,454		334,980
Asia-Pacific		892,928		858,285		773,862
Total service revenues		4,326,419		4,165,822		3,808,340
Reimbursed expenses		1,411,200		1,294,176		1,291,205
Total revenues	$	5,737,619	$	5,459,998	$	5,099,545

	As of December 31,
	2015		2014
Property, equipment and software, net:
Americas:
United States	$	169,674	$	167,890
Other		1,204		1,774
Americas		170,878		169,664
Europe and Africa:
United Kingdom		46,042		48,409
Other		16,615		15,782
Europe and Africa		62,657		64,191
Asia-Pacific:
Japan		12,660		20,752
Other		24,975		25,271
Asia-Pacific		37,635		46,023
Total property, equipment and software, net	$	271,170	$	279,878

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Segments

12 Months Ended

Dec. 31, 2015

Segment Reporting [Abstract]

Segments

20. Segments

The following table presents the Company’s operations by reportable segment. The Company is managed through two reportable segments, Product Development and Integrated Healthcare Services. Product Development, which primarily serves biopharmaceutical customers engaged in research and development, provides clinical research and clinical trial services. Integrated Healthcare Services provides commercialization services to biopharmaceutical customers and research, analytics, real-world and late phase research, and other services to both biopharmaceutical customers and the broader healthcare market.

Certain costs are not allocated to the Company’s segments and are reported as general corporate and unallocated expenses. These costs primarily consist of share-based compensation and expenses for corporate overhead functions such as finance, human resources, information technology, facilities and legal, as well as certain expenses incurred during 2013, including the $25.0 million fee incurred in connection with the termination of the management agreement with affiliates of certain shareholders and the $1.5 million fee paid in connection with the modification of an agreement for the business usage of an airplane owned by GFM, a company owned by the Company’s former Executive Chairman who retired effective December 31, 2015 but remains a director of the Company. The Company does not allocate restructuring or impairment charges to its segments.

Information presented below is in thousands:

	Year Ended December 31,
	2015			2014			2013
Service revenues
Product Development	$	3,191,630		$	3,097,831		$	2,919,730
Integrated Healthcare Services		1,134,789			1,067,991			888,610
Total service revenues		4,326,419			4,165,822			3,808,340
Costs of revenue, service costs
Product Development		1,828,734			1,820,937			1,752,800
Integrated Healthcare Services		896,852			863,169			718,626
Total costs of revenue, service costs		2,725,586			2,684,106			2,471,426
Selling, general and administrative
Product Development		648,297			631,678			604,663
Integrated Healthcare Services		153,896			140,019			127,860
General corporate and unallocated		118,792			110,641			127,987
Total selling, general and administrative		920,985			882,338			860,510
Income from operations
Product Development		714,599			645,216			562,267
Integrated Healthcare Services		84,041			64,803			42,124
General corporate and unallocated		(118,792	)		(110,641	)		(127,987	)
Restructuring costs		(30,752	)		(8,988	)		(14,071	)
Impairment charges		(2,484	)		—			—
Total income from operations	$	646,612		$	590,390		$	462,333

	As of December 31,
	2015		2014		2013
Assets
Product Development	$	3,343,502	$	2,786,692	$	2,571,502
Integrated Healthcare Services		405,411		330,689		299,284
General corporate and unallocated		177,403		178,572		183,437
Total assets	$	3,926,316	$	3,295,953	$	3,054,223

	Year Ended December 31,
	2015		2014		2013
Expenditures to acquire long-lived assets
Product Development	$	67,660	$	68,187	$	69,375
Integrated Healthcare Services		8,667		8,279		17,398
General corporate and unallocated		2,064		6,184		1,574
Total expenditures to acquire long-lived assets	$	78,391	$	82,650	$	88,347

	Year Ended December 31,
	2015		2014		2013
Depreciation and amortization expense
Product Development	$	100,913	$	95,168	$	82,047
Integrated Healthcare Services		21,961		20,821		20,475
General corporate and unallocated		4,868		5,024		4,982
Total depreciation and amortization expense	$	127,742	$	121,013	$	107,504

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Earnings Per Share

12 Months Ended

Dec. 31, 2015

Earnings Per Share [Abstract]

Earnings Per Share

21. Earnings Per Share

The following table reconciles the basic to diluted weighted average shares outstanding (in thousands):

	Year Ended December 31,
	2015		2014		2013
Basic weighted average common shares outstanding		123,038		127,994		124,147
Effect of dilutive stock options and share awards		2,592		3,089		3,715
Diluted weighted average common shares outstanding		125,630		131,083		127,862

The following table shows the weighted average number of outstanding share-based awards not included in the computation of diluted earnings per share as the effect of including such share-based awards in the computation would be anti-dilutive (in thousands):

	Year Ended December 31,
	2015		2014		2013
Weighted average shares subject to anti-dilutive share-based awards		1,058		1,241		1,765

Share-based awards will have a dilutive effect under the treasury method only when the respective period’s average market value of the Company’s common stock exceeds the exercise proceeds.

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Comprehensive Income

12 Months Ended

Dec. 31, 2015

Equity [Abstract]

Comprehensive Income

22. Comprehensive Income

Below is a summary of the components of AOCI (in thousands):

	Foreign Currency Translation			Marketable Securities			Derivative Instruments			Defined Benefit Plans			Income Taxes			Total
Balance at December 31, 2012	$	19,312		$	467		$	(33,542	)	$	(8,235	)	$	29,693		$	7,695
Other comprehensive (loss) income before reclassifications		(25,141	)		5,241			(393	)		2,147			1,331			(16,815	)
Reclassification adjustments		—			—			13,080			1,044			(5,380	)		8,744
Balance at December 31, 2013		(5,829	)		5,708			(20,855	)		(5,044	)		25,644			(376	)
Other comprehensive (loss) income before reclassifications		(49,911	)		(976	)		(6,834	)		(10,218	)		7,225			(60,714	)
Reclassification adjustments		—			(5,004	)		8,630			743			(2,370	)		1,999
Balance at December 31, 2014		(55,740	)		(272	)		(19,059	)		(14,519	)		30,499			(59,091	)
Other comprehensive (loss) income before reclassifications		(61,090	)		(436	)		(13,202	)		282			9,110			(65,336	)
Reclassification adjustments		—			—			18,269			973			(6,181	)		13,061
Balance at December 31, 2015	$	(116,830	)	$	(708	)	$	(13,992	)	$	(13,264	)	$	33,428		$	(111,366	)

Below is a summary of the (gains) losses reclassified from AOCI into the consolidated statements of income and the affected financial statement line item (in thousands):

	Affected Financial Statement	Year Ended December 31,
Reclassification Adjustments	Line Item	2015		2014			2013
Marketable securities	Other expense (income), net	$	—	$	(5,004	)	$	—
Total before income taxes			—		(5,004	)		—
Income tax expense			—		(1,927	)		—
Total net of income taxes		$	—	$	(3,077	)	$	—
Derivative instruments:
Interest rate swaps	Interest expense	$	12,333	$	12,424		$	12,582
Foreign exchange forward contracts	Service revenues		5,936		(3,794	)		498
Total before income taxes			18,269		8,630			13,080
Income tax benefit			5,826		4,022			4,991
Total net of income taxes		$	12,443	$	4,608		$	8,089
Defined benefit plans:
Amortization of prior service costs	See Note 17	$	—	$	107		$	336
Amortization of actuarial losses	See Note 17		973		636			708
Total before income taxes			973		743			1,044
Income tax benefit			355		275			389
Total net of income taxes		$	618	$	468		$	655

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Supplemental Cash Flow Information

12 Months Ended

Dec. 31, 2015

Supplemental Cash Flow Elements [Abstract]

Supplemental Cash Flow Information

23. Supplemental Cash Flow Information

The following table presents the Company’s supplemental cash flow information (in thousands):

	Year Ended December 31,
	2015		2014		2013
Supplemental Cash Flow Information:
Interest paid	$	82,333	$	93,912	$	115,494
Income taxes paid, net of refunds		120,804		138,931		70,983
Non-cash Investing Activities:
Acquisition of property and equipment utilizing capital leases	$	4,238	$	2,476	$	3,761
Fair value of contingent consideration payable in connection with acquisitions		—		—		14,300
Fair value of consideration transferred in connection with the Q2 Solutions transaction		423,268		—		—

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Quarterly Financial Data (Unaudited)

12 Months Ended

Dec. 31, 2015

Quarterly Financial Information Disclosure [Abstract]

Quarterly Financial Data (Unaudited)

24. Quarterly Financial Data (Unaudited)

The following table summarizes the Company’s unaudited quarterly results of operations (in thousands, except per share data):

	2015
	First Quarter			Second Quarter		Third Quarter			Fourth Quarter
Service revenues	$	1,029,974		$	1,074,366	$	1,093,480		$	1,128,599
Income from operations		143,217			158,389		167,023			177,983
Net income		86,431			84,947		108,839			108,087
Net (income) loss attributable to noncontrolling interests		(33	)		4		2,447			(3,517	)
Net income attributable to Quintiles Transnational Holdings Inc.	$	86,398		$	84,951	$	111,286		$	104,570
Basic earnings per share (1)	$	0.69		$	0.69	$	0.91		$	0.86
Diluted earnings per share (1)	$	0.68		$	0.67	$	0.89		$	0.85
	2014
	First Quarter			Second Quarter		Third Quarter			Fourth Quarter
Service revenues	$	1,005,288		$	1,035,476	$	1,061,013		$	1,064,045
Income from operations		141,316			141,000		149,142			158,932
Net income		90,214			85,110		92,733			88,444
Net (income) loss attributable to noncontrolling interests		(31	)		10		(79	)		(18	)
Net income attributable to Quintiles Transnational Holdings Inc.	$	90,183		$	85,120	$	92,654		$	88,426
Basic earnings per share (1)	$	0.69		$	0.66	$	0.73		$	0.70
Diluted earnings per share (1)	$	0.68		$	0.64	$	0.71		$	0.69

(1) The sum of the quarterly per share amounts may not equal per share amounts reported for year-to-date periods. This is due to changes in the number of weighted average shares outstanding and the effects of rounding for each period.

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Subsequent Event

12 Months Ended

Dec. 31, 2015

Subsequent Events [Abstract]

Subsequent Event

25. Subsequent Event

In February 2016, the Board approved a restructuring plan for approximately $22 million, primarily for severance and other exit costs, to align its resources and reduce overcapacity. Some of these actions are subject to certain legal and regulatory requirements. These actions, if implemented, are expected to occur in 2016.

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Schedule I - Condensed Financial Information of Registrant

12 Months Ended

Dec. 31, 2015

Condensed Financial Information Of Parent Company Only Disclosure [Abstract]

Schedule I - Condensed Financial Information of Registrant

(2) Financial Statement Schedules

Schedule I—Condensed Financial Information of Registrant

QUINTILES TRANSNATIONAL HOLDINGS INC. (PARENT COMPANY ONLY)

CONDENSED STATEMENTS OF INCOME

	Year Ended December 31,
	2015			2014			2013
	(in thousands)
Selling, general and administrative	$	715		$	1,509		$	2
Loss from operations		(715	)		(1,509	)		(2	)
Interest income		(24	)		(52	)		(6	)
Interest expense		—			—			9,242
Loss on extinguishment of debt		—			—			15,501
Other expense, net		7			8			—
Loss before income taxes and equity in earnings of subsidiary		(698	)		(1,465	)		(24,739	)
Income tax benefit		(530	)		(810	)		(9,347	)
Loss before equity in earnings of subsidiary		(168	)		(655	)		(15,392	)
Equity in earnings of subsidiary		387,373			357,038			241,983
Net income	$	387,205		$	356,383		$	226,591

QUINTILES TRANSNATIONAL HOLDINGS INC. (PARENT COMPANY ONLY)

CONDENSED STATEMENTS OF COMPREHENSIVE INCOME

	Year Ended December 31,
	2015			2014			2013
	(in thousands)
Net income	$	387,205		$	356,383		$	226,591
Comprehensive income adjustments:
Unrealized (losses) gains on marketable securities, net of income taxes of ($168), ($376) and $2,016		(268	)		(600	)		3,225
Unrealized (losses) gains on derivative instruments, net of income taxes of ($3,679), ($1,767) and ($751)		(9,523	)		(5,067	)		358
Defined benefit plan adjustments, net of income taxes of $318, ($2,981) and ($131)		(36	)		(7,237	)		2,278
Foreign currency translation, net of income taxes of ($5,581), ($2,101) and ($2,465)		(55,509	)		(47,810	)		(22,676	)
Reclassification adjustments:
Gains on marketable securities included in net income, net of income taxes of ($1,927)		—			(3,077	)		—
Losses on derivative instruments included in net income, net of income taxes of $5,826, $4,022 and $4,991		12,443			4,608			8,089
Amortization of prior service costs and losses included in net income, net of income taxes of $355, $275 and $389		618			468			655
Comprehensive income	$	334,930		$	297,668		$	218,520

QUINTILES TRANSNATIONAL HOLDINGS INC. (PARENT COMPANY ONLY)

CONDENSED BALANCE SHEETS

	December 31,
	2015			2014
	(in thousands, except per share data)
ASSETS
Current assets:
Cash and cash equivalents	$	4,791		$	11,635
Income taxes receivable		128			546
Other current assets and receivables		16			114
Total current assets		4,935			12,295
Deferred income taxes		—			7
Total assets	$	4,935		$	12,302
LIABILITIES AND SHAREHOLDERS’ DEFICIT
Current liabilities:
Accounts payable	$	7		$	21
Accrued expenses		—			84
Total current liabilities		7			105
Investment in subsidiary		568,785			716,148
Payable to subsidiary		360			110
Total liabilities		569,152			716,363
Commitments and contingencies
Shareholders’ deficit:
Common stock and additional paid-in capital, 300,000 shares authorized, $0.01 par value, 119,378 and 124,129 shares issued and outstanding at December 31, 2015 and 2014, respectively		8,784			143,828
Accumulated deficit		(461,635	)		(788,798	)
Accumulated other comprehensive loss		(111,366	)		(59,091	)
Total shareholders’ deficit		(564,217	)		(704,061	)
Total liabilities and shareholders’ deficit	$	4,935		$	12,302

QUINTILES TRANSNATIONAL HOLDINGS INC. (PARENT COMPANY ONLY)

CONDENSED STATEMENTS OF CASH FLOWS

	Year Ended December 31,
	2015			2014			2013
	(in thousands)
Operating activities:
Net income	$	387,205		$	356,383		$	226,591
Adjustments to reconcile net income to cash provided by operating activities:
Amortization of debt issuance costs and discount		—			—			10,346
Subsidiary loss (income)		56,627			(27,623	)		(119,998	)
(Benefit from) provision for deferred income taxes		(335	)		37			304
Change in operating assets and liabilities:
Accounts receivable and unbilled services		—			2,994			(2,995	)
Prepaid expenses and other assets		—			—			(21	)
Accounts payable and accrued expenses		(69	)		65			(62	)
Income taxes payable and other liabilities		(195	)		(847	)		(9,651	)
Net cash provided by operating activities		443,233			331,009			104,514
Investing activities:
Investments in subsidiary, net of payments received		—			—			(179,847	)
Net cash used in investing activities		—			—			(179,847	)
Financing activities:
Repayment of debt		—			—			(300,000	)
Issuance of common stock		—			—			525,000
Payment of common stock issuance costs		—			(105	)		(35,439	)
Stock issued under employee stock purchase and option plans		64,297			35,228			12,539
Repurchase of common stock		(515,010	)		(415,131	)		(6,434	)
Repurchase of stock options		—			(8,415	)		(50,649	)
Intercompany with subsidiary		636			(2,893	)		(153	)
Net cash (used in) provided by financing activities		(450,077	)		(391,316	)		144,864
(Decrease) increase in cash and cash equivalents		(6,844	)		(60,307	)		69,531
Cash and cash equivalents at beginning of period		11,635			71,942			2,411
Cash and cash equivalents at end of period	$	4,791		$	11,635		$	71,942

QUINTILES TRANSNATIONAL HOLDINGS INC. (PARENT COMPANY ONLY)

NOTES TO CONDENSED FINANCIAL STATEMENTS

The condensed parent company financial statements have been prepared in accordance with Rule 12-04, Schedule I of Regulation S-X as the restricted net assets of Quintiles Transnational Holdings Inc.’s (the “Company”) wholly-owned subsidiary, Quintiles Transnational Corp. (“Quintiles Transnational”) exceed 25% of the consolidated net assets of the Company. The ability of Quintiles Transnational to pay dividends may be limited due to the restrictive covenants in the agreements governing its credit arrangements.

These condensed parent company financial statements include the accounts of Quintiles Transnational Holdings, Inc. on a standalone basis (the “Parent”) and the equity method of accounting is used to reflect ownership interest in its subsidiary. Refer to the consolidated financial statements and notes presented elsewhere herein for additional information and disclosures with respect to these financial statements.

Since the Parent is part of a group that files a consolidated income tax return, in accordance with ASC 740, a portion of the consolidated amount of current and deferred income tax expense of the Company has been allocated to the Parent. The income tax benefit of $530,000, $810,000 and $9.3 million in 2015, 2014 and 2013, respectively, represents the income tax benefit that will be or were already utilized in the Company’s consolidated United States federal and state income tax returns. If the Parent was not part of these consolidated income tax returns, it would not be able to recognize any income tax benefit, as it generates no revenue against which the losses could be used on a separate filer basis.

Below is a summary of the dividends paid to the Parent by Quintiles Transnational in 2015, 2014 and 2013 (in thousands):

	Amount
Paid in December 2015	$	1,000
Paid in November 2015		223,000
Paid in May 2015		220,000
Total paid in 2015	$	444,000
Paid in November 2014	$	234,000
Paid in May 2014		87,000
Paid in January 2014		8,415
Total paid in 2014	$	329,415
Paid in November and December 2013	$	116,585
Paid in February 2013		5,400
Total paid in 2013	$	121,985

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Schedule II - Valuation and Qualifying Accounts

12 Months Ended

Dec. 31, 2015

Valuation And Qualifying Accounts [Abstract]

Schedule II - Valuation and Qualifying Accounts

Schedule II—Valuation and Qualifying Accounts

Deferred Tax Asset Valuation Allowance

Information presented below is in thousands:

	Balance at		Additions
	Beginning		Charged to					Balance at
	of Year		Expenses		Deductions (a)			End of Year
December 31, 2015	$	24,695	$	1,762	$	(4,295	)	$	22,162
December 31, 2014	$	29,501	$	11,084	$	(15,890	)	$	24,695
December 31, 2013	$	32,344	$	3,611	$	(6,454	)	$	29,501

(a) – Impact of reductions recorded to expense and translation adjustments.

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Summary of Significant Accounting Policies (Policies)

12 Months Ended

Dec. 31, 2015

Accounting Policies [Abstract]

Reclassifications

Reclassifications

Certain immaterial prior period amounts have been reclassified to conform to the current presentation including the reclassification of debt issuance costs related to non-revolving debt from deposits and other assets to a direct reduction to the carrying amount of the long-term debt on the balance sheet. These changes had no effect on previously reported total revenues, net income, comprehensive income, shareholders’ deficit or cash flows.

Principles of Consolidation

Principles of Consolidation

The accompanying consolidated financial statements include the accounts and operations of the Company and its subsidiaries. Amounts pertaining to the noncontrolling ownership interests held in third parties in the operating results and financial position of the Company’s majority-owned subsidiaries are reported as noncontrolling interests. Intercompany accounts and transactions have been eliminated in consolidation.

Use of Estimates

Use of Estimates

The preparation of financial statements in accordance with generally accepted accounting principles in the United States of America (“GAAP”) requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, and the disclosure of contingent assets and liabilities, at the date of the financial statements, as well as the reported amounts of revenues and expenses during the period. These estimates are based on historical experience and various other assumptions believed reasonable under the circumstances. The Company evaluates its estimates on an ongoing basis and makes changes to the estimates and related disclosures as experience develops or new information becomes known. Actual results may differ from those estimates.

Foreign Currencies

Foreign Currencies

The Company’s financial statements are reported in United States dollars and, accordingly, the Company’s results of operations are impacted by fluctuations in exchange rates that affect the translation of its revenues and expenses denominated in foreign currencies into United States dollars for purposes of reporting its consolidated financial results. Assets and liabilities recorded in foreign currencies on the books of foreign subsidiaries are translated at the exchange rate on the balance sheet date. Revenues, costs and expenses are translated at average rates of exchange during the year. Translation adjustments resulting from this process are charged or credited to the accumulated other comprehensive income (loss) (“AOCI”) component of shareholders’ deficit. The Company is subject to foreign currency transaction risk for fluctuations in exchange rates during the period of time between the consummation and cash settlement of a transaction. The Company earns revenue from its service contracts over a period of several months and, in some cases, over a period of several years. Accordingly, exchange rate fluctuations during this period may affect the Company’s profitability with respect to such contracts. Other expense (income), net includes foreign currency net (gains) losses for 2015, 2014 and 2013 of approximately ($4.6) million, $4.9 million and $4.0 million, respectively.

Cash Equivalents, Restricted Cash and Investments

Cash Equivalents, Restricted Cash and Investments

The Company considers all highly liquid investments with an initial maturity of three months or less when purchased to be cash equivalents. The Company’s restricted cash primarily consisted of amounts collateralizing standby letters of credit issued in favor of certain suppliers and health insurance funds. Investments in marketable equity securities are classified as available-for-sale and measured at fair market value with net unrealized gains and losses recorded in the AOCI component of shareholders’ deficit until realized. The fair market value is based on the closing price as quoted by the respective stock exchange. In addition, the Company has investments in equity securities of companies for which there are not readily available market values and for which the Company does not exercise significant influence or control; such investments are accounted for using the cost method. Any gains or losses from the sales of investments or other-than-temporary declines in fair value are computed by specific identification.

Equity Method Investments

Equity Method Investments

The Company’s investments in and advances to unconsolidated affiliates are accounted for under the equity method if the Company exercises significant influence or has an investment in a limited partnership that is considered to be greater than minor. These investments and advances are classified as investments in and advances to unconsolidated affiliates on the accompanying consolidated balance sheets. The Company records its pro rata share of the earnings, adjusted for accretion of basis difference, of these investments in equity in earnings of unconsolidated affiliates on the accompanying consolidated statements of income. The Company reviews its investments in and advances to unconsolidated affiliates for impairment whenever events or changes in circumstances indicate that the carrying amounts may not be recoverable.

Derivatives

Derivatives

The Company uses derivative instruments to manage exposures to interest rates and foreign currencies. Derivatives are recorded on the balance sheet at fair value at each balance sheet date utilizing pricing models for non-exchange-traded contracts. At inception, the Company designates whether or not the derivative instrument is an effective hedge of an asset, liability or firm commitment which is then classified as either a cash flow hedge or a fair value hedge. If determined to be an effective cash flow hedge, changes in the fair value of the derivative instrument are recorded as a component of AOCI until realized. We include the impact from these hedges in the same line item as the hedged item on the consolidated statements of cash flows. Changes in fair value of effective fair value hedges are recorded in earnings as an offset to the changes in the fair value of the related hedged item. Hedge ineffectiveness, if any, is immediately recognized in earnings. Changes in the fair values of derivative instruments that are not an effective hedge are recognized in earnings. The Company has entered, and may in the future enter, into derivative contracts (swaps, forwards, calls or puts, warrants, for example) related to its debt, investments in marketable equity securities and forecasted foreign currency transactions.

Billed and Unbilled Services and Unearned Income

Billed and Unbilled Services and Unearned Income

In general, prerequisites for billings and payments are established by contractual provisions including predetermined payment schedules, which may or may not correspond to the timing of the performance of services under the contract. Unbilled services arise when services have been rendered for which revenue has been recognized but the customers have not been billed.

In some cases, payments received are in excess of revenue recognized. Payments received in advance of services being provided are deferred as unearned income on the consolidated balance sheet. As the contracted services are subsequently performed and the associated revenue is recognized, the unearned income balance is reduced by the amount of the revenue recognized during the period.

Allowance for Doubtful Accounts

Allowance for Doubtful Accounts

The Company’s allowance for doubtful accounts is determined based on a variety of factors that affect the potential collectability of the related receivables, including length of time the receivables are past due, customer credit ratings, financial stability of the customer, specific one-time events and past customer history. In addition, in circumstances where the Company is made aware of a specific customer’s inability to meet its financial obligations, a specific allowance is established. The accounts are individually evaluated on a regular basis and appropriate reserves are established as deemed appropriate based on the above criteria.

Receivables Financing Facility

Receivables Financing Facility

Advances received under the Company’s receivables financing facility are accounted for as borrowings secured by the receivables and included in net cash provided by financing activities. The Company services the collateralized accounts receivable and the cash flows for the underlying receivables are included in cash provided by operating activities. The collateralized accounts receivable are included in trade accounts receivable and unbilled services, net.

Business Combinations

Business Combinations

Business combinations are accounted for using the acquisition method, and accordingly, the identifiable assets acquired, the liabilities assumed, and any noncontrolling interest in the acquiree are recorded at their estimated fair values on the date of the acquisition. Goodwill represents the excess of the purchase price over the estimated fair value of the net assets acquired, including the amount assigned to identifiable intangible assets. When a business combination involves contingent consideration, the Company recognizes a liability equal to the estimated fair value of the contingent consideration obligation at the date of the acquisition. Subsequent changes in the estimated fair value of the contingent consideration are recognized in earnings in the period of the change.

Long-Lived Assets

Long-Lived Assets

Property and equipment are stated at cost and are depreciated using the straight-line method over the shorter of the asset’s estimated useful life or the lease term, if related to leased property, as follows:

Buildings and leasehold improvements	3 - 40	years
Equipment	3 - 10	years
Furniture and fixtures	5 - 10	years
Motor vehicles	3 - 5	years

Definite-lived identifiable intangible assets are amortized primarily using an accelerated method that reflects the pattern in which the Company expects to benefit from the use of the asset over its estimated remaining useful life as follows:

Trademarks and trade names	2 - 6	years
Non-compete agreements	3	years
Contract backlog and customer relationships	1 - 10	years
Software and related assets	2 - 9	years

Goodwill and indefinite-lived identifiable intangible assets, which consist of certain trade names, are not amortized but evaluated for impairment annually, or more frequently if events or changes in circumstances indicate an impairment.

Included in software and related items is the capitalized cost of internal-use software used in supporting the Company’s business. Qualifying costs incurred during the application development stage are capitalized and amortized over their estimated useful lives. The Company recognized $37.7 million, $33.1 million and $32.2 million of amortization expense in 2015, 2014 and 2013, respectively, related to software and related assets.

The carrying values of property, equipment and intangible and other long-lived assets are reviewed for recoverability if the facts and circumstances suggest that a potential impairment may have occurred. If this review indicates that carrying values will not be recoverable, as determined based on undiscounted cash flow projections, the Company will record an impairment charge to reduce carrying values to estimated fair value. During 2015, the Company recognized a $2.5 million impairment charge for long-lived assets related to a facility closure in Japan. There were no events, facts or circumstances in 2014 and 2013 that resulted in any impairment charges to the Company’s property, equipment, intangible or other long-lived assets.

Revenue Recognition

Revenue Recognition

The Company recognizes revenue when all of the following conditions are satisfied: (1) there is persuasive evidence of an arrangement; (2) the service offering has been delivered to the customer; (3) the collection of the fees is probable; and (4) the arrangement consideration is fixed or determinable. The Company’s arrangements are primarily service contracts that range in duration from a few months to several years. Most contracts may be terminated upon 30 to 90 days notice by the customer, however, in the event of termination, contract provisions typically require payment for services rendered through the date of termination, as well as for subsequent services rendered to close out the contract.

In some cases, contracts provide for consideration that is contingent upon the occurrence of uncertain future events. The Company recognizes contingent revenue when the contingency has been resolved and all other criteria for revenue recognition have been met. The Company treats cash payments to customers as incentives to induce the customers to enter into such a service agreement with the Company. The related asset is amortized as a reduction of revenue over the period the services are performed. The Company records revenues net of any tax assessments by governmental authorities, such as value added taxes, that are imposed on and concurrent with specific revenue generating transactions. The Company does not recognize revenue with respect to start-up activities including contract and scope negotiation, feasibility analysis and conflict of interest review associated with contracts. The costs for these activities are expensed as incurred.

For the arrangements that include multiple elements, arrangement consideration is allocated to units of accounting based on the relative selling price. The best evidence of selling price of a unit of accounting is vendor-specific objective evidence (“VSOE”), which is the price the Company charges when the deliverable is sold separately. When VSOE is not available to determine selling price, management uses relevant third-party evidence (“TPE”) of selling price, if available. When neither VSOE nor TPE of selling price exists, management uses its best estimate of selling price considering all relevant information that is available without undue cost and effort.

The majority of the Company’s contracts within the Product Development segment are service contracts for clinical research that represent a single unit of accounting. The Company recognizes revenue on its clinical research services contracts as services are performed primarily on a proportional performance basis, generally using output measures that are specific to the service provided. Examples of output measures include among others, number of investigators enrolled, number of site initiation visits and number of monitoring visits completed. Revenue is determined by dividing the actual units of work completed by the total units of work required under the contract and multiplying that ratio by the total contract value. The total contract value, or total contractual payments, represents the aggregate contracted price for each of the agreed upon services to be provided. Changes in the scope of work are common, especially under long-term contracts, and generally result in a change in contract value. Once the customer has agreed to the changes in scope and renegotiated pricing terms, the contract value is amended and revenue is recognized, as described above. To the extent that contracts involve multiple elements, the Company follows the allocation methodology described above and recognizes revenue for each unit of accounting on a proportional performance basis.

The Company derives the majority of its revenues in its Integrated Healthcare Services segment from providing commercialization services on a fee-for-service basis to customers within the biopharmaceutical industry. Fees on these arrangements are billed based on a contractual per-diem or hourly rate basis. The Company recognizes revenue on commercialization services contracts primarily on a time and materials basis. Some of the Company’s commercialization contracts are multiple element arrangements, with elements including recruiting, training and deployment of sales representatives. The nature of the terms of these multiple element arrangements will vary based on the customized needs of the Company’s customers. For contracts that have multiple elements, the Company follows the allocation methodology described above and recognizes revenue for each unit of accounting on a time and materials basis. The Company’s commercialization contracts sometimes include variable fees that are based on a percentage of product sales (royalty payments). The Company recognizes revenue on royalty payments when the variable components become fixed or determinable and all other revenue recognition criteria have been met, which generally only occurs upon the sale of the underlying product(s) and upon the Company’s receipt of information necessary to make a reasonable estimate.

Reimbursed Expenses

Reimbursed Expenses

The Company includes reimbursed expenses in total revenues and costs of revenue as the Company is deemed to be the primary obligor in the applicable arrangements. These costs include such items as payments to investigators and travel expenses for the Company’s clinical monitors and sales representatives.

Expenses

Expenses

Costs of revenue include reimbursed expenses, compensation and benefits for billable employees, depreciation of assets used in generating revenue and other expenses directly related to service contracts such as courier fees and laboratory supplies for the Company’s laboratory services, professional services and travel expenses. Selling, general and administrative expenses primarily include costs related to administrative functions such as compensation and benefits, travel, professional services, training and expenses for advertising, information technology, facilities and depreciation and amortization.

Concentration of Credit Risk

Concentration of Credit Risk

Financial instruments that subject the Company to credit risk primarily consist of cash and cash equivalents, marketable securities and accounts receivable. The Company maintains its cash and cash equivalent balances with high-quality financial institutions and, consequently, the Company believes that such funds are subject to minimal credit risk. Investment policies have been implemented that limit purchases of marketable securities to investment grade securities. Substantially all service revenues for Product Development and Integrated Healthcare Services are earned by performing services under contracts with various pharmaceutical, biotechnology, medical device and healthcare companies. The concentration of credit risk is equal to the outstanding accounts receivable and unbilled services balances, less the unearned income related thereto, and such risk is subject to the financial and industry conditions of the Company’s customers. The Company does not require collateral or other securities to support customer receivables. Credit losses have been immaterial and reasonably within management’s expectations. No customer accounted for 10.0% or more of consolidated service revenues in 2015, 2014 or 2013.

Research and Development Costs

Research and Development Costs

Research and development costs consist primarily of employee compensation and related expenses and information technology contract services and are charged to expense as incurred. The following is a summary of the research and development expenses (in thousands):

	Year Ended December 31,
	2015		2014		2013
Internally developed software applications and computer technology	$	3,198	$	4,980	$	3,955
Funding of customer's research and development activity		139		811		1,000
	$	3,337	$	5,791	$	4,955

Advertising Costs

Advertising Costs

Advertising costs, which include the development and production of advertising materials and the communication of these materials, are charged to expense as incurred. The Company incurred approximately $12.8 million, $16.0 million and $14.8 million in advertising expense in 2015, 2014 and 2013, respectively.

Restructuring Costs

Restructuring Costs

Restructuring costs, which primarily include termination benefits and facility closure costs, are recorded at estimated fair value. Key assumptions in determining the restructuring costs include the terms and payments that may be negotiated to terminate certain contractual obligations and the timing of employees leaving the Company.

Contingencies

Contingencies

The Company records accruals for claims, suits, investigations and proceedings when it is probable that a liability has been incurred and the amount of the loss can be reasonably estimated. The Company reviews claims, suits, investigations and proceedings at least quarterly and records or adjusts accruals related to such matters to reflect the impact and status of any settlements, rulings, advice of counsel or other information pertinent to a particular matter. Legal costs associated with contingencies are charged to expense as incurred.

The Company is party to legal proceedings incidental to its business. While the outcome of these matters could differ from management’s expectations, the Company does not believe the resolution of these matters has a reasonable possibility of having a material adverse effect to the Company’s financial statements.

Income Taxes

Income Taxes

Income tax expense includes United States federal, state and international income taxes. Certain items of income and expense are not reported in income tax returns and financial statements in the same year. The income tax effects of these differences are reported as deferred income taxes. Valuation allowances are provided to reduce the related deferred income tax assets to an amount which will, more likely than not, be realized. Beginning in 2013, the undistributed earnings of most of the Company’s foreign subsidiaries are considered to be indefinitely reinvested outside of the United States. Accordingly, a deferred income tax liability has not been provided related to those undistributed earnings. Interest and penalties related to unrecognized income tax benefits are recognized as a component of income tax expense as discussed further in Note 16.

Employee Stock Compensation

Employee Stock Compensation

The Company accounts for share-based compensation for stock options and stock appreciation rights (“SARs”) under the fair value method and uses the Black-Scholes-Merton model to estimate the value of such share-based awards granted to its employees and non-executive directors. Expected volatility is based upon the historical volatility of a peer group for a period equal to the expected term, as the Company does not have adequate history to calculate its own volatility and believes the expected volatility will approximate the historical volatility of the peer group. Prior to the completion of the Company’s initial public offering (“IPO”) on May 14, 2013, the expected dividends were based on the historical dividends paid by the Company, excluding dividends that resulted from activities that the Company deemed to be one-time in nature. Following the IPO, the Company does not currently anticipate paying dividends. The expected term represents the period of time the grants are expected to be outstanding. The risk-free interest rate is based on the United States Treasury yield curve in effect at the time of the grant.

The Company accounts for its share-based compensation for restricted stock units (“RSUs”) and performance awards based on the closing market price of the Company’s common stock on the date of grant.

The Company recognized share-based compensation expense of $37.8 million, $30.0 million and $22.8 million in 2015, 2014 and 2013, respectively. Share-based compensation expense is included in selling, general and administrative expenses on the accompanying consolidated statements of income which is consistent with the classification of all other compensation costs incurred for the employees who were granted the share-based awards. The associated future income tax benefit recognized was $8.9 million, $7.6 million and $8.1 million in 2015, 2014 and 2013, respectively. As of December 31, 2015, there was approximately $38.8 million of total unrecognized share-based compensation expense related to outstanding non-vested share-based compensation arrangements, which the Company expects to recognize over a weighted average period of 1.3 years.

Earnings Per Share

Earnings Per Share

The calculation of earnings per share is based on the weighted average number of common shares or common stock equivalents outstanding during the applicable period. The dilutive effect of common stock equivalents is excluded from basic earnings per share and is included in the calculation of diluted earnings per share. Potentially dilutive securities include outstanding stock options, shares to be purchased under the Company’s employee stock purchase plan (see Note 17) and unvested RSUs.

Recently Issued Accounting Standards

Recently Issued Accounting Standards

In November 2015, the FASB issued new accounting guidance which requires entities to present deferred tax assets and deferred tax liabilities as noncurrent in a classified balance sheet. The new standard will be effective for annual reporting periods beginning after December 15, 2016. Early adoption is permitted. The Company expects to early adopt this new accounting guidance on January 1, 2016. As of December 31, 2015, the Company had approximately $101.0 million and $148,000 of current deferred income tax assets and current deferred income tax liabilities, respectively.

In September 2015, the FASB issued new guidance that will change the requirements for reporting measurement period adjustments to provisional amounts initially recognized in connection with a business combination. Currently, an acquiring entity is required to retrospectively adjust, in prior period financial statements, the provisional amounts to reflect new information obtained during the measurement period. Under the new guidance, adjustments to the provisional amounts will be reflected in the financial statements for the reporting period in which the adjustments are determined, including by recognizing in current period earnings the full effect of changes in depreciation, amortization or other income effects. The new guidance requires that the acquiring entity either present separately on the face of the current period income statement or disclose in the notes to the current period financial statements, by line item, the amount of the adjustments made during the current period. The Company will adopt the new guidance on January 1, 2016, as required. The adoption is not expected to have a material impact on the Company’s financial statements.

In February 2015, the FASB issued new accounting guidance which changes the analysis in determining whether an entity is considered a variable interest entity (“VIE”) and the identification of the primary beneficiary of the VIE to determine whether the VIE should be included in an entity’s consolidated financial statements. The Company will adopt the new accounting guidance on January 1, 2016, as required. The adoption of the new accounting guidance is not expected to have a material effect on the Company’s financial statements.

In May 2014, the FASB and the International Accounting Standards Board issued a converged standard on the recognition of revenue from contracts with customers. The objective of the new standard is to establish a single comprehensive revenue recognition model that is designed to create greater comparability of financial statements across industries and jurisdictions. Under the new standard, companies will recognize revenue to depict the transfer of goods or services to customers in amounts that reflect the consideration to which the company expects to be entitled in exchange for those goods or services. The new standard also will require expanded disclosures on revenue recognition including information about changes in assets and liabilities that result from contracts with customers. Companies have an option to use either a retrospective approach or a cumulative effect adjustment approach to implement the new guidance. The new standard will be effective for annual reporting periods beginning after December 15, 2017. Early adoption is permitted for annual reporting periods beginning after December 15, 2016. The Company is currently evaluating the impact of this new standard on its consolidated financial statements, the date of adoption, and the transition approach to implement the new guidance.

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Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2015

Accounting Policies [Abstract]

Property and Equipment at Cost Using Straight-Line Method

Property and equipment are stated at cost and are depreciated using the straight-line method over the shorter of the asset’s estimated useful life or the lease term, if related to leased property, as follows:

Buildings and leasehold improvements	3 - 40	years
Equipment	3 - 10	years
Furniture and fixtures	5 - 10	years
Motor vehicles	3 - 5	years

Definite-Lived Identifiable Intangible Assets Amortized

Definite-lived identifiable intangible assets are amortized primarily using an accelerated method that reflects the pattern in which the Company expects to benefit from the use of the asset over its estimated remaining useful life as follows:

Trademarks and trade names	2 - 6	years
Non-compete agreements	3	years
Contract backlog and customer relationships	1 - 10	years
Software and related assets	2 - 9	years

Summary of Research and Development Expenses

The following is a summary of the research and development expenses (in thousands):

	Year Ended December 31,
	2015		2014		2013
Internally developed software applications and computer technology	$	3,198	$	4,980	$	3,955
Funding of customer's research and development activity		139		811		1,000
	$	3,337	$	5,791	$	4,955

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Accounts Receivable and Unbilled Services (Tables)

12 Months Ended

Dec. 31, 2015

Receivables [Abstract]

Accounts Receivable and Unbilled Services

Accounts receivable and unbilled services consist of the following (in thousands):

	December 31,
	2015			2014
Trade:
Billed	$	553,652		$	444,941
Unbilled services		614,381			532,312
		1,168,033			977,253
Allowance for doubtful accounts		(2,284	)		(1,998	)
	$	1,165,749		$	975,255

Percentage of Accounts Receivable and Unbilled Services by Region

The percentage of accounts receivable and unbilled services by region is as follows:

	December 31,
	2015			2014
Americas:
United States		58	%		55	%
Other		1			2
Americas		59			57
Europe and Africa:
United Kingdom		23			23
Other		10			11
Europe and Africa		33			34
Asia-Pacific:
Japan		3			4
Other		5			5
Asia-Pacific		8			9
		100	%		100	%

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Investments-Debt, Equity and Other Securities (Tables)

12 Months Ended

Dec. 31, 2015

Investments Debt And Equity Securities [Abstract]

Summary of the Company's Debt, Equity and Other Securities

The following is a summary of the Company’s debt, equity and other securities (in thousands):

	December 31,
	2015		2014
Marketable securities	$	395	$	831
Cost method		32,516		33,672
	$	32,911	$	34,503

Summary of Available-for-Sale Securities

The following is a summary of available-for-sale securities (in thousands):

	December 31, 2015							December 31, 2014
			Gross							Gross
	Amortized		Unrealized			Market		Amortized		Unrealized			Market
	Cost		Loss			Value		Cost		Loss			Value
Marketable equity	$	1,103	$	(708	)	$	395	$	1,103	$	(272	)	$	831

Summary of the Company's Portfolio of Cost Method Investments

Below is a summary of the Company’s portfolio of cost method investments (in thousands):

	December 31,
	2015		2014
Equity investments	$	32,516	$	32,516
Convertible notes		—		1,156
	$	32,516	$	33,672

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Investments in and Advances to Unconsolidated Affiliates (Tables)

12 Months Ended

Dec. 31, 2015

Investments In And Advances To Affiliates Schedule Of Investments [Abstract]

Investments in and Advances to Unconsolidated Affiliates

The following is a summary of the Company’s investments in and advances to unconsolidated affiliates (in thousands):

	December 31,
	2015		2014
NovaQuest Pharma Opportunities Fund III, L.P.	$	39,785	$	22,633
NovaQuest Pharma Opportunities Fund IV, L.P.		2,524		—
CenduitTM		9,478		8,271
Other		595		604
	$	52,382	$	31,508

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Derivatives (Tables)

12 Months Ended

Dec. 31, 2015

Derivative Instruments And Hedging Activities Disclosure [Abstract]

Summary of Fair Values of Derivative Instruments Designated as Hedges

The fair values of the Company’s derivative instruments designated as hedging instruments and the line items on the accompanying consolidated balance sheets to which they were recorded are summarized in the following table (in thousands):

		December 31,
	Balance Sheet Classification	2015		2014
Foreign exchange forward contracts	Other current liabilities	$	5,194	$	4,635
Interest rate swaps	Other current liabilities	$	5,698	$	14,424

Effect of Cash Flow Hedging Instruments on Other Comprehensive Income (Loss)

The effect of the Company’s cash flow hedging instruments on other comprehensive income (loss) is summarized in the following table (in thousands):

	Year Ended December 31,
	2015			2014			2013
Foreign exchange forward contracts	$	(559	)	$	(8,585	)	$	3,485
Interest rate swaps		5,626			10,381			9,202
Total	$	5,067		$	1,796		$	12,687

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Fair Value Measurements (Tables)

12 Months Ended

Dec. 31, 2015

Fair Value Disclosures [Abstract]

Fair Value of Financial Assets and Liabilities Measured on Recurring Basis

The following table summarizes the fair value of the Company’s financial assets and liabilities that are measured on a recurring basis as of December 31, 2015 (in thousands):

	Level 1		Level 2		Level 3		Total
Assets:
Marketable equity securities	$	395	$	—	$	—	$	395
Total	$	395	$	—	$	—	$	395
Liabilities:
Foreign exchange forward contracts	$	—	$	5,194	$	—	$	5,194
Interest rate swaps	—			5,698	—			5,698
Contingent consideration	—		—			4,374		4,374
Total	$	—	$	10,892	$	4,374	$	15,266

The following table summarizes the fair value of the Company’s financial assets and liabilities that are measured on a recurring basis as of December 31, 2014 (in thousands):

	Level 1		Level 2		Level 3		Total
Assets:
Marketable equity securities	$	831	$	—	$	—	$	831
Total	$	831	$	—	$	—	$	831
Liabilities:
Foreign exchange forward contracts	$	—	$	4,635	$	—	$	4,635
Interest rate swaps	—			14,424	—			14,424
Contingent consideration	—		—			1,452		1,452
Total	$	—	$	19,059	$	1,452	$	20,511

Changes in Level 3 Financial Assets and Liabilities Measured on Recurring Basis

The following table summarizes the changes in Level 3 financial assets and liabilities measured on a recurring basis for the year ended December 31 (in thousands):

	Contingent Consideration –
	Accrued Expenses and Other Liabilities
	2015			2014			2013
Balance as of January 1	$	1,452		$	13,014		$	3,521
Initial estimate of contingent consideration	—			—				14,300
Contingent consideration paid		(3,000	)		(3,000	)	—
Revaluations included in earnings		5,922			(8,562	)		(4,807	)
Balance as of December 31	$	4,374		$	1,452		$	13,014

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Property and Equipment (Tables)

12 Months Ended

Dec. 31, 2015

Property Plant And Equipment [Abstract]

Summary of Major Classes of Property and Equipment

The major classes of property and equipment were as follows (in thousands):

	December 31,
	2015			2014
Land, buildings and leasehold improvements	$	187,405		$	185,940
Equipment		257,119			240,227
Furniture and fixtures		52,840			54,615
Motor vehicles		13,348			15,443
		510,712			496,225
Less accumulated depreciation		(322,319	)		(305,928	)
	$	188,393		$	190,297

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Goodwill and Identifiable Intangible Assets (Tables)

12 Months Ended

Dec. 31, 2015

Goodwill And Intangible Assets Disclosure [Abstract]

Amortization Expense Associated with Identifiable Definite-Lived Intangible Assets

Amortization expense associated with identifiable definite-lived intangible assets was as follows (in thousands)

	Year Ended December 31,
	2015		2014		2013
Amortization expense	$	66,545	$	58,457	$	51,450

Summary of Identifiable Intangible Assets

The following is a summary of identifiable intangible assets (in thousands):

	As of December 31, 2015							As of December 31, 2014
	Gross		Accumulated			Net		Gross		Accumulated			Net
	Amount		Amortization			Amount		Amount		Amortization			Amount
Definite-lived identifiable intangible assets:
Product licensing and distribution rights and customer relationships	$	224,149	$	(75,606	)	$	148,543	$	123,227	$	(54,413	)	$	68,814
Trademarks, trade names and other		14,620		(6,081	)		8,539		18,571		(6,399	)		12,172
Software and related assets		279,266		(196,489	)		82,777		260,052		(170,471	)		89,581
	$	518,035	$	(278,176	)	$	239,859	$	401,850	$	(231,283	)	$	170,567
Indefinite-lived identifiable intangible assets:
Trade names	$	128,247	$	—		$	128,247	$	109,676	$	—		$	109,676

Summary of Goodwill by Segment

The following is a summary of goodwill by segment for the years ended December 31, 2015 and 2014 (in thousands):

				Integrated
	Product			Healthcare
	Development			Services			Consolidated
Balance as of December 31, 2013	$	351,144		$	58,482		$	409,626
Business combinations	—				62,778			62,778
Impact of foreign currency fluctuations and other		(4,536	)		(3,434	)		(7,970	)
Balance as of December 31, 2014		346,608			117,826			464,434
Business combinations		262,377		—				262,377
Impact of foreign currency fluctuations and other		(6,879	)		(192	)		(7,071	)
Balance as of December 31, 2015	$	602,106		$	117,634		$	719,740

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Accrued Expenses (Tables)

12 Months Ended

Dec. 31, 2015

Payables And Accruals [Abstract]

Accrued Expenses

Accrued expenses consist of the following (in thousands):

	December 31,
	2015		2014
Compensation, including bonuses, fringe benefits and payroll taxes	$	400,748	$	403,250
Restructuring		13,564		6,083
Interest		5,115		274
Contract related		271,076		255,530
Other		70,254		68,507
	$	760,757	$	733,644

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Credit Arrangements (Tables)

12 Months Ended

Dec. 31, 2015

Debt Disclosure [Abstract]

Summary of Company's Credit Facilities

The following is a summary of the Company’s revolving credit facilities at December 31, 2015:

Facility	Interest Rates
$500.0 million (revolving credit facility)	London Interbank Offer Rate (“LIBOR”) (0.61% at December 31, 2015) plus 1.75%
$25.0 million (receivables financing facility)	LIBOR Market Index Rate (0.43% at December 31, 2015) plus 0.85% to 1.35% depending upon the Company’s debt rating
£10.0 million (approximately $14.8 million) general banking facility with a European headquartered bank	Bank’s base rate (0.5% at December 31, 2015) plus 1%

Schedule of Long-term Debt

Long-term debt consists of the following (in thousands):

	December 31,
	2015			2014
4.875% Senior Notes due 2023	$	800,000		$	—
Term Loan A due 2020 (LIBOR plus 1.75%, or 2.36% at December 31, 2015)		828,750			—
Term Loan B due 2022 (the greater of LIBOR or 0.75% plus 2.50%, or 3.25% at December 31, 2015)		597,000			—
Term Loan B-3 due 2018 (the greater of three month LIBOR or 1.25% plus 2.50%, or 3.75% at December 31, 2014)		—			2,030,606
Receivables financing facility due 2018 (LIBOR plus 1.05%, or 1.48% at December 31, 2015)		275,000			275,000
		2,500,750			2,305,606
Less: unamortized discount		(24,020	)		(12,379	)
Less: unamortized debt issuance costs		(8,955	)		(9,879	)
Less: current portion		(48,500	)		(750	)
	$	2,419,275		$	2,282,598

Contractual Maturities of Long-term Debt

Contractual maturities of long-term debt at December 31, 2015 are as follows (in thousands):

2016	$	48,500
2017		48,500
2018		323,500
2019		48,500
2020		664,750
Thereafter		1,367,000
	$	2,500,750

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Leases (Tables)

12 Months Ended

Dec. 31, 2015

Leases [Abstract]

Summary of Future Minimum Lease Payments Under Capital and Operating Leases

The following is a summary of future minimum payments under capital and operating leases that have initial or remaining non-cancelable lease terms in excess of one year at December 31, 2015 (in thousands):

	Capital			Operating
	Leases			Leases
2016	$	15		$	84,747
2017		18			62,485
2018	—				41,907
2019	—				29,201
2020	—				25,713
Thereafter	—				111,267
Total minimum lease payments		33		$	355,320
Amounts representing interest		(2	)
Present value of net minimum payments		31
Current portion		(13	)
Long-term capital lease obligations	$	18

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Shareholder's Deficit (Tables)

12 Months Ended

Dec. 31, 2015

Equity [Abstract]

Summary of Share Repurchases Made Under Repurchase Program

Below is a summary of the share repurchases made under the Repurchase Program (in thousands except share data):

	Year Ended December 31,
	2015		2014		2013
Number of shares repurchased		7,855,796		300		153,223
Aggregate purchase price	$	515,010	$	14	$	6,434
Average price per share	$	65.56	$	47.51	$	42.01

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Business Combinations (Tables)

12 Months Ended

Dec. 31, 2015

Business Combinations [Abstract]

Summary of Estimated Fair Value of Net Assets Acquired at the Date of Acquisitions

The following table summarizes the estimated fair value of the net assets acquired at the date of the acquisitions (in thousands):

	Quest			Encore			Novella
Assets acquired:
Cash and cash equivalents	$	31,783		$	2,223		$	26,190
Accounts receivable and unbilled services		6,186			17,714			28,644
Prepaid expenses		1,185			—			—
Other current assets		4,426			443			1,441
Property and equipment		16,422			289			9,616
Goodwill		261,710			62,778			116,542
Other identifiable intangibles		125,900			14,150			42,740
Deferred income tax asset – long-term		—			396			—
Other long-term assets		266			—			2,203
Liabilities assumed:
Accounts payable and accrued expenses		(12,790	)		(4,206	)		(12,716	)
Unearned income		—			(31	)		(7,782	)
Other current liabilities		—			—			(132	)
Deferred income tax liability – long-term		(10,412	)		—			(18,364	)
Other long-term liabilities		(1,408	)		—			(1,334	)
Net assets acquired	$	423,268		$	93,756		$	187,048

Summary Of Identifiable Intangible Assets

The other identifiable intangible assets consisted of the following (in thousands):

	Quest		Encore		Novella
Customer relationships	$	74,000	$	8,800	$	20,800
Backlog		32,900		800		14,000
Trade names		19,000		1,100		7,500
Non-compete agreements		—		450		440
Software		—		3,000		—
Total other identifiable intangibles	$	125,900	$	14,150	$	42,740
Amortized over a weighted average useful life (in years)		9		8		7

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Restructuring (Tables)

12 Months Ended

Dec. 31, 2015

Restructuring And Related Activities [Abstract]

Summary of Amounts Recorded for Restructuring Plans

The following amounts were recorded for the restructuring plans (in thousands):

	Severance and Related Costs			Exit Costs			Total
Balance at December 31, 2013	$	5,276		$	198		$	5,474
Expense, net of reversals		8,421			567			8,988
Payments		(7,998	)		(160	)		(8,158	)
Foreign currency translation		(221	)		—			(221	)
Balance at December 31, 2014		5,478			605			6,083
Expense, net of reversals		29,843			909			30,752
Payments		(22,943	)		(723	)		(23,666	)
Foreign currency translation and other		(199	)		594			395
Balance at December 31, 2015	$	12,179		$	1,385		$	13,564

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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2015

Income Tax Disclosure [Abstract]

Components of Income Before Income Taxes and Equity in Earnings of Unconsolidated Affiliates

The components of income before income taxes and equity in earnings of unconsolidated affiliates are as follows (in thousands):

	Year Ended December 31,
	2015		2014		2013
Domestic	$	68,455	$	96,917	$	68,425
Foreign		470,540		405,272		254,691
	$	538,995	$	502,189	$	323,116

Components of Income Tax Expense Attributable to Continuing Operations

The components of income tax expense attributable to continuing operations are as follows (in thousands):

	Year Ended December 31,
	2015			2014			2013
Current expense (benefit):
Federal	$	47,311		$	58,403		$	38,573
State		3,559			4,618			(4,309	)
Foreign		109,273			95,010			83,744
		160,143			158,031			118,008
Deferred (benefit) expense:
Federal and state		4,613			(4,549	)		(15,807	)
Foreign		(5,767	)		(3,426	)		(6,236	)
		(1,154	)		(7,975	)		(22,043	)
	$	158,989		$	150,056		$	95,965

Effective Income Tax Rate Reconciliation

The differences between the Company’s consolidated income tax expense attributable to continuing operations and the expense computed at the 35% United States statutory income tax rate were as follows (in thousands):

	Year Ended December 31,
	2015			2014			2013
Federal income tax expense at statutory rate	$	188,648		$	175,766		$	113,091
State and local income taxes, net of federal benefit		1,682			2,312			(1,088	)
Research and development		(12,634	)		(16,765	)		(12,788	)
Foreign nontaxable interest income		(9,351	)		(10,217	)		(9,751	)
Gain on note settlement		—			—			10,794
United States taxes recorded on foreign earnings		38,246			18,631			(1,616	)
Foreign rate differential		(49,288	)		(30,734	)		(10,753	)
Tax contingencies		(8,304	)		4,043			(1,012	)
Other		9,990			7,020			9,088
	$	158,989		$	150,056		$	95,965

Income Tax Effects of Temporary Differences from Continuing Operations that Give Rise to Significant Portions of Deferred Income Tax (Liabilities) Assets

The income tax effects of temporary differences from continuing operations that give rise to significant portions of deferred income tax (liabilities) assets are presented below (in thousands):

	December 31,
	2015			2014
Deferred income tax liabilities:
Undistributed foreign earnings	$	(36,624	)	$	(27,717	)
Depreciation and amortization		(53,171	)		(65,614	)
Other		(11,830	)		(15,346	)
Total deferred income tax liabilities		(101,625	)		(108,677	)
Deferred income tax assets:
Net operating loss, capital loss and tax credit carryforwards		41,707			43,535
Accrued expenses and unearned income		23,315			34,048
Employee benefits		123,775			130,217
Other		12,801			17,784
		201,598			225,584
Valuation allowance for deferred income tax assets		(22,162	)		(24,695	)
Total deferred income tax assets		179,436			200,889
Net deferred income tax assets	$	77,811		$	92,212

Reconciliation of Beginning and Ending Amount of Gross Unrecognized Income Tax Benefits

A reconciliation of the beginning and ending amount of gross unrecognized income tax benefits is presented below (in thousands):

	Year Ended December 31,
	2015			2014			2013
Balance at January 1	$	40,821		$	54,936		$	43,393
Additions based on tax positions related to the current year		2,068			2,807			4,493
Additions for income tax positions of prior years		8,838			1,588			12,854
Impact of changes in exchange rates		(608	)		(376	)		(71	)
Settlements with tax authorities		(121	)		(135	)		(1,052	)
Reductions for income tax positions of prior years		(1,945	)		(6,023	)		(3,520	)
Reductions due to the lapse of the applicable statute of limitations		(19,387	)		(11,976	)		(1,161	)
Balance at December 31	$	29,666		$	40,821		$	54,936

Summary of Tax Years Open for Examination

The following table summarizes the tax years that remain open for examination by tax authorities in the most significant jurisdictions in which the Company operates:

United States	2012-2014
India	2006-2015
Japan	2010-2014
United Kingdom	2014

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Employee Benefit Plans (Tables)

12 Months Ended

Dec. 31, 2015

Compensation And Retirement Disclosure [Abstract]

Summary of Components of Pension Expenses Related to Defined Benefit Plans

The following table summarizes the components of pension expense related to these defined benefit plans (in thousands):

	Year Ended December 31,
	2015			2014			2013
Service cost	$	15,486		$	12,944		$	13,227
Interest cost		3,453			3,821			3,684
Expected return on plan assets		(3,555	)		(4,277	)		(3,442	)
Amortization of prior service costs	—				107			336
Amortization of actuarial losses		973			636			708
	$	16,357		$	13,231		$	14,513

Weighted Average Assumptions Used in Determining Pension Expense

The weighted average assumptions used in determining pension expense were as follows:

	Year Ended December 31,
	2015			2014			2013
Discount rate		2.46	%		3.01	%		3.06	%
Rate of compensation increases		4.32	%		4.36	%		4.74	%
Expected return on plan assets		4.05	%		5.21	%		5.33	%

Financial Information About Defined Benefit Plans

The following table summarizes financial information about the Company’s defined benefit plans (in thousands):

	December 31,
	2015			2014
Projected benefit obligation January 1	$	147,127		$	135,110
Service costs		15,486			12,944
Interest cost		3,453			3,821
Expected return on plan assets		(3,555	)		(4,277	)
Actuarial (gains) losses		(2,306	)		16,396
Business combination		1,746		—
Benefits paid		(6,325	)		(7,409	)
Foreign currency fluctuations and other		(1,732	)		(9,458	)
Projected benefit obligation December 31	$	153,894		$	147,127
Plan assets at fair value, January 1	$	88,420		$	82,787
Actual return on plan assets		1,312			10,004
Contributions		5,982			8,594
Business combination		1,966		—
Benefits paid		(6,325	)		(7,409	)
Foreign currency fluctuations and other		(4,212	)		(5,556	)
Plan assets at fair value, December 31	$	87,143		$	88,420
Unfunded balance	$	66,751		$	58,707

Summary of Amounts Recognized in Consolidated Balance Sheets

The following table summarizes the amounts recognized in the consolidated balance sheets related to the defined benefit plans (in thousands):

	December 31,
	2015			2014
Deposits and other assets	$	19,185		$	18,690
Accrued expenses		4,520			6,075
Other long-term liabilities		81,410			71,322
AOCI	$	(13,264	)	$	(14,519	)

Summary of Amounts Recognized in Accumulated Other Comprehensive Income

The following table summarizes the amounts recognized in AOCI related to the defined benefit plans (in thousands):

	Prior			Actuarial			Deferred
	Service			Net			Income
	Costs			(Gain) Loss			Taxes			Total
Balance as of December 31, 2013	$	(107	)	$	(4,937	)	$	2,956		$	(2,088	)
Reclassification adjustments included in pension expense:
Amortization		107			636			(275	)		468
Amounts arising during the period:
Actuarial changes in benefit obligation	—				(10,218	)		2,981			(7,237	)
Balance as of December 31, 2014		—			(14,519	)		5,662			(8,857	)
Reclassification adjustments included in pension expense:
Amortization	—				973			(355	)		618
Amounts arising during the period:
Actuarial changes in benefit obligation	—				282			(318	)		(36	)
Balance as of December 31, 2015	$	—		$	(13,264	)	$	4,989		$	(8,275	)

Weighted Average Assumptions Used in Determining Pension Obligations

The following table summarizes the weighted average assumptions used in determining the pension obligations:

	December 31,
	2015			2014
Discount rate		2.50	%		2.46	%
Rate of compensation increases		4.37	%		4.32	%

Schedule of Fair Value Measurement

The following table summarizes the fair value of the Company’s defined benefit plans assets (in thousands):

	December 31,
	2015		2014
Funds that hold debt investments primarily government bonds	$	49,355	$	47,473
Funds that hold United Kingdom equity investments		15,700		19,547
Funds that hold global equity investments		6,277		8,255
Diversified growth fund		15,248		12,569
Other		563		576
Total	$	87,143	$	88,420

Schedule of Expected Benefit Payments Under the Defined Benefit Plans

The following table summarizes the Company’s expected benefit payments under the defined benefit plans for each of the next five years and the aggregate of the five years thereafter (in thousands):

2016	$	6,684
2017		6,615
2018		7,096
2019		7,802
2020		9,092
Years 2021 through 2025		66,117
	$	103,406

Estimated Fair Value of Stock Options and SARs

The following assumptions were used to estimate the fair value of stock options and SARs:

	Year Ended December 31,
	2015		2014		2013
Expected volatility	26 – 41%		26 – 43%		18 – 47%
Weighted average expected volatility		34%		36%		40%
Expected dividends		0.0%		0.0%	0.0 - 5.45%
Expected term (in years)	3.7 – 6.7		1.5 – 6.7		0.25 – 6.4
Risk-free interest rate	1.06 – 2.04%		0.28 – 2.21%		0.04 – 2.24%

Summary of Stock Option Activity

The Company’s stock option activity in 2015 is as follows:

				Weighted
	Number			Average		Aggregate
	of			Exercise		Intrinsic
	Options			Price		Value
						(in thousands)
Outstanding at December 31, 2014		9,124,954		$	29.15	$	271,216
Granted		993,600		$	65.05
Exercised		(3,013,190	)	$	19.41
Canceled		(457,365	)	$	42.08
Outstanding at December 31, 2015		6,647,999		$	38.04	$	203,679

Schedule of Stock Options Outstanding and Exercisable

Selected information regarding the Company’s stock options as of December 31, 2015 is as follows:

Options Outstanding											Options Exercisable
									Weighted
							Weighted		Average				Weighted
Number		Exercise					Average		Remaining		Number		Average
of		Price					Exercise		Life		of		Exercise
Options		Range					Price		(in Years)		Options		Price
	1,063,999	$	5.76	-	$	21.69	$	17.58		4.19		947,799	$	17.14
	1,069,630	$	22.01	-	$	23.83	$	23.79		6.32		661,630	$	23.79
	867,197	$	24.59	-	$	30.07	$	25.07		6.30		545,947	$	24.97
	1,241,087	$	40.00	-	$	40.00	$	40.00		7.10		421,837	$	40.00
	1,208,586	$	42.74	-	$	53.26	$	50.76		8.00		261,334	$	50.30
	1,197,500	$	57.00	-	$	77.11	$	63.44		8.87		58,375	$	57.43

Schedule of Stock Appreciation Rights Activity

The Company’s SAR activity in 2015 is as follows:

				Weighted
	Number			Average		Aggregate
	of			Grant		Intrinsic
	SARs			Price		Value
						(in thousands)
Outstanding at December 31, 2014		418,801		$	43.55	$	6,417
Granted		176,200		$	64.93
Exercised		(33,262	)	$	39.61
Canceled		(31,038	)	$	51.00
Outstanding at December 31, 2015		530,701		$	50.46	$	9,659

Schedule of Restricted Stock Units Activity

The Company’s RSU activity in 2015 is as follows:

				Weighted
				Average
	Number			Grant-Date
	of			Fair
	RSUs			Value
Non-vested at December 31, 2014		93,667		$	45.89
Granted		276,922		$	65.61
Vested		(918	)	$	47.87
Canceled		(10,118	)	$	62.77
Non-vested at December 31, 2015		359,553		$	60.60

Summary of Performance Units Activity

The Company’s performance units activity in 2015 is as follows:

				Weighted
	Number			Average
	of			Grant-Date
	Performance			Fair
	Units			Value
Non-vested at December 31, 2014	—			$	—
Granted		51,977		$	64.93
Canceled		(2,310	)	$	64.93
Non-vested at December 31, 2015		49,667		$	64.93

Summary of Severance Associated with Cost Reduction Programs

The following amounts were recorded for the severance associated with cost reduction programs (in thousands):

Balance at December 31, 2014	$	6,274
Expense, net of reversals		(1,042	)
Payments		(1,873	)
Foreign currency translation		(22	)
Balance at December 31, 2015	$	3,337

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Operations by Geographic Location (Tables)

12 Months Ended

Dec. 31, 2015

Operations By Geographic Location [Abstract]

Operations within Geographic Region

The table below presents the Company’s operations by geographical location. The Company attributes revenues to geographical locations based upon where the services are performed. The Company’s operations within each geographical region are further broken down to show each country which accounts for 10% or more of the totals (in thousands):

	Year Ended December 31,
	2015		2014		2013
Service revenues:
Americas:
United States	$	1,787,918	$	1,589,402	$	1,351,160
Other		185,583		194,597		181,814
Americas		1,973,501		1,783,999		1,532,974
Europe and Africa:
United Kingdom		409,920		402,184		362,242
Other		1,050,070		1,121,354		1,139,262
Europe and Africa		1,459,990		1,523,538		1,501,504
Asia-Pacific:
Japan		442,957		471,831		438,882
Other		449,971		386,454		334,980
Asia-Pacific		892,928		858,285		773,862
Total service revenues		4,326,419		4,165,822		3,808,340
Reimbursed expenses		1,411,200		1,294,176		1,291,205
Total revenues	$	5,737,619	$	5,459,998	$	5,099,545

Long Lived Assets

	As of December 31,
	2015		2014
Property, equipment and software, net:
Americas:
United States	$	169,674	$	167,890
Other		1,204		1,774
Americas		170,878		169,664
Europe and Africa:
United Kingdom		46,042		48,409
Other		16,615		15,782
Europe and Africa		62,657		64,191
Asia-Pacific:
Japan		12,660		20,752
Other		24,975		25,271
Asia-Pacific		37,635		46,023
Total property, equipment and software, net	$	271,170	$	279,878

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Segments (Tables)

12 Months Ended

Dec. 31, 2015

Segment Reporting [Abstract]

Reconciliation of Revenues and Income from Segments to Consolidated

Information presented below is in thousands:

	Year Ended December 31,
	2015			2014			2013
Service revenues
Product Development	$	3,191,630		$	3,097,831		$	2,919,730
Integrated Healthcare Services		1,134,789			1,067,991			888,610
Total service revenues		4,326,419			4,165,822			3,808,340
Costs of revenue, service costs
Product Development		1,828,734			1,820,937			1,752,800
Integrated Healthcare Services		896,852			863,169			718,626
Total costs of revenue, service costs		2,725,586			2,684,106			2,471,426
Selling, general and administrative
Product Development		648,297			631,678			604,663
Integrated Healthcare Services		153,896			140,019			127,860
General corporate and unallocated		118,792			110,641			127,987
Total selling, general and administrative		920,985			882,338			860,510
Income from operations
Product Development		714,599			645,216			562,267
Integrated Healthcare Services		84,041			64,803			42,124
General corporate and unallocated		(118,792	)		(110,641	)		(127,987	)
Restructuring costs		(30,752	)		(8,988	)		(14,071	)
Impairment charges		(2,484	)		—			—
Total income from operations	$	646,612		$	590,390		$	462,333

Reconciliation of Assets from Segment to Consolidated

	As of December 31,
	2015		2014		2013
Assets
Product Development	$	3,343,502	$	2,786,692	$	2,571,502
Integrated Healthcare Services		405,411		330,689		299,284
General corporate and unallocated		177,403		178,572		183,437
Total assets	$	3,926,316	$	3,295,953	$	3,054,223

Reconciliation of Other Significant Reconciling Items from Segments to Consolidated

	Year Ended December 31,
	2015		2014		2013
Expenditures to acquire long-lived assets
Product Development	$	67,660	$	68,187	$	69,375
Integrated Healthcare Services		8,667		8,279		17,398
General corporate and unallocated		2,064		6,184		1,574
Total expenditures to acquire long-lived assets	$	78,391	$	82,650	$	88,347

Depreciation and Amortization Expense

	Year Ended December 31,
	2015		2014		2013
Depreciation and amortization expense
Product Development	$	100,913	$	95,168	$	82,047
Integrated Healthcare Services		21,961		20,821		20,475
General corporate and unallocated		4,868		5,024		4,982
Total depreciation and amortization expense	$	127,742	$	121,013	$	107,504

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Earnings Per Share (Tables)

12 Months Ended

Dec. 31, 2015

Earnings Per Share [Abstract]

Reconciles the Basic to Diluted Weighted Average Shares Outstanding

The following table reconciles the basic to diluted weighted average shares outstanding (in thousands):

	Year Ended December 31,
	2015		2014		2013
Basic weighted average common shares outstanding		123,038		127,994		124,147
Effect of dilutive stock options and share awards		2,592		3,089		3,715
Diluted weighted average common shares outstanding		125,630		131,083		127,862

Summary of Weighted-Average Outstanding Stock Options Excluded from Computation of Diluted Earnings Per Share

The following table shows the weighted average number of outstanding share-based awards not included in the computation of diluted earnings per share as the effect of including such share-based awards in the computation would be anti-dilutive (in thousands):

	Year Ended December 31,
	2015		2014		2013
Weighted average shares subject to anti-dilutive share-based awards		1,058		1,241		1,765

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Comprehensive Income (Tables)

12 Months Ended

Dec. 31, 2015

Equity [Abstract]

Summary of Components of AOCI

Below is a summary of the components of AOCI (in thousands):

	Foreign Currency Translation			Marketable Securities			Derivative Instruments			Defined Benefit Plans			Income Taxes			Total
Balance at December 31, 2012	$	19,312		$	467		$	(33,542	)	$	(8,235	)	$	29,693		$	7,695
Other comprehensive (loss) income before reclassifications		(25,141	)		5,241			(393	)		2,147			1,331			(16,815	)
Reclassification adjustments		—			—			13,080			1,044			(5,380	)		8,744
Balance at December 31, 2013		(5,829	)		5,708			(20,855	)		(5,044	)		25,644			(376	)
Other comprehensive (loss) income before reclassifications		(49,911	)		(976	)		(6,834	)		(10,218	)		7,225			(60,714	)
Reclassification adjustments		—			(5,004	)		8,630			743			(2,370	)		1,999
Balance at December 31, 2014		(55,740	)		(272	)		(19,059	)		(14,519	)		30,499			(59,091	)
Other comprehensive (loss) income before reclassifications		(61,090	)		(436	)		(13,202	)		282			9,110			(65,336	)
Reclassification adjustments		—			—			18,269			973			(6,181	)		13,061
Balance at December 31, 2015	$	(116,830	)	$	(708	)	$	(13,992	)	$	(13,264	)	$	33,428		$	(111,366	)

Summary of (Gains) Losses Reclassified from AOCI into Condensed Consolidated Statements of Income and Affected Financial Statement Line Item

Below is a summary of the (gains) losses reclassified from AOCI into the consolidated statements of income and the affected financial statement line item (in thousands):

	Affected Financial Statement	Year Ended December 31,
Reclassification Adjustments	Line Item	2015		2014			2013
Marketable securities	Other expense (income), net	$	—	$	(5,004	)	$	—
Total before income taxes			—		(5,004	)		—
Income tax expense			—		(1,927	)		—
Total net of income taxes		$	—	$	(3,077	)	$	—
Derivative instruments:
Interest rate swaps	Interest expense	$	12,333	$	12,424		$	12,582
Foreign exchange forward contracts	Service revenues		5,936		(3,794	)		498
Total before income taxes			18,269		8,630			13,080
Income tax benefit			5,826		4,022			4,991
Total net of income taxes		$	12,443	$	4,608		$	8,089
Defined benefit plans:
Amortization of prior service costs	See Note 17	$	—	$	107		$	336
Amortization of actuarial losses	See Note 17		973		636			708
Total before income taxes			973		743			1,044
Income tax benefit			355		275			389
Total net of income taxes		$	618	$	468		$	655

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Supplemental Cash Flow Information (Tables)

12 Months Ended

Dec. 31, 2015

Supplemental Cash Flow Elements [Abstract]

Supplemental Cash Flow Information

The following table presents the Company’s supplemental cash flow information (in thousands):

	Year Ended December 31,
	2015		2014		2013
Supplemental Cash Flow Information:
Interest paid	$	82,333	$	93,912	$	115,494
Income taxes paid, net of refunds		120,804		138,931		70,983
Non-cash Investing Activities:
Acquisition of property and equipment utilizing capital leases	$	4,238	$	2,476	$	3,761
Fair value of contingent consideration payable in connection with acquisitions		—		—		14,300
Fair value of consideration transferred in connection with the Q2 Solutions transaction		423,268		—		—

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Quarterly Financial Data (Unaudited) (Tables)

12 Months Ended

Dec. 31, 2015

Quarterly Financial Information Disclosure [Abstract]

Unaudited Quarterly Results of Operations

The following table summarizes the Company’s unaudited quarterly results of operations (in thousands, except per share data):

	2015
	First Quarter			Second Quarter		Third Quarter			Fourth Quarter
Service revenues	$	1,029,974		$	1,074,366	$	1,093,480		$	1,128,599
Income from operations		143,217			158,389		167,023			177,983
Net income		86,431			84,947		108,839			108,087
Net (income) loss attributable to noncontrolling interests		(33	)		4		2,447			(3,517	)
Net income attributable to Quintiles Transnational Holdings Inc.	$	86,398		$	84,951	$	111,286		$	104,570
Basic earnings per share (1)	$	0.69		$	0.69	$	0.91		$	0.86
Diluted earnings per share (1)	$	0.68		$	0.67	$	0.89		$	0.85
	2014
	First Quarter			Second Quarter		Third Quarter			Fourth Quarter
Service revenues	$	1,005,288		$	1,035,476	$	1,061,013		$	1,064,045
Income from operations		141,316			141,000		149,142			158,932
Net income		90,214			85,110		92,733			88,444
Net (income) loss attributable to noncontrolling interests		(31	)		10		(79	)		(18	)
Net income attributable to Quintiles Transnational Holdings Inc.	$	90,183		$	85,120	$	92,654		$	88,426
Basic earnings per share (1)	$	0.69		$	0.66	$	0.73		$	0.70
Diluted earnings per share (1)	$	0.68		$	0.64	$	0.71		$	0.69

(1) The sum of the quarterly per share amounts may not equal per share amounts reported for year-to-date periods. This is due to changes in the number of weighted average shares outstanding and the effects of rounding for each period.

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Summary of Significant Accounting Policies - Additional Information (Detail)	12 Months Ended
	Dec. 31, 2015 USD ($) Employee Country Customer	Dec. 31, 2014 USD ($) Customer	Dec. 31, 2013 USD ($) Customer
Summary Of Significant Accounting Policies [Line Items]
Number of countries | Country	100
Number of employees | Employee	36,100
Foreign currency net losses	$ (4,600,000)	$ 4,900,000	$ 4,000,000
Capitalized and amortized expense related to software and related assets	37,700,000	33,100,000	32,200,000
Impairment charges	$ 2,484,000	0	0
Contract termination period	Most contracts may be terminated upon 30 to 90 days notice by the customer, however, in the event of termination, contract provisions typically require payment for services rendered through the date of termination, as well as for subsequent services rendered to close out the contract.
Advertising expense	$ 12,800,000	16,000,000	14,800,000
Share-based compensation expense	37,758,000	30,001,000	22,826,000
Recognized future income tax benefit	8,900,000	7,600,000	$ 8,100,000
Unrecognized non-vested share-based compensation	$ 38,800,000
Weighted average period of share-based compensation	1 year 3 months 18 days
Deferred income tax assets current	$ 100,978,000	$ 118,515,000
Deferred income tax liabilities, current	$ 148,000
Customer Concentration Risk [Member]
Summary Of Significant Accounting Policies [Line Items]
Number of customers served | Customer	0	0	0

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Summary of Significant Accounting Policies - Property and Equipment at Cost Using Straight-Line Method (Detail)	12 Months Ended
	Dec. 31, 2015
Minimum [Member] | Buildings and leasehold improvements [Member]
Property, Plant and Equipment [Line Items]
Estimated useful life, Years	3 years
Minimum [Member] | Equipment [Member]
Property, Plant and Equipment [Line Items]
Estimated useful life, Years	3 years
Minimum [Member] | Furniture and fixtures [Member]
Property, Plant and Equipment [Line Items]
Estimated useful life, Years	5 years
Minimum [Member] | Motor vehicles [Member]
Property, Plant and Equipment [Line Items]
Estimated useful life, Years	3 years
Maximum [Member] | Buildings and leasehold improvements [Member]
Property, Plant and Equipment [Line Items]
Estimated useful life, Years	40 years
Maximum [Member] | Equipment [Member]
Property, Plant and Equipment [Line Items]
Estimated useful life, Years	10 years
Maximum [Member] | Furniture and fixtures [Member]
Property, Plant and Equipment [Line Items]
Estimated useful life, Years	10 years
Maximum [Member] | Motor vehicles [Member]
Property, Plant and Equipment [Line Items]
Estimated useful life, Years	5 years

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Summary of Significant Accounting Policies - Definite-lived identifiable intangible assets amortized (Detail)	12 Months Ended
	Dec. 31, 2015
Trademarks and trade names [Member] | Minimum [Member]
Finite-Lived Intangible Assets [Line Items]
Estimated useful life, Years	2 years
Trademarks and trade names [Member] | Maximum [Member]
Finite-Lived Intangible Assets [Line Items]
Estimated useful life, Years	6 years
Non-compete agreements [Member]
Finite-Lived Intangible Assets [Line Items]
Estimated useful life, Years	3 years
Contract backlog and customer relationships [Member] | Minimum [Member]
Finite-Lived Intangible Assets [Line Items]
Estimated useful life, Years	1 year
Contract backlog and customer relationships [Member] | Maximum [Member]
Finite-Lived Intangible Assets [Line Items]
Estimated useful life, Years	10 years
Software and related assets [Member] | Minimum [Member]
Finite-Lived Intangible Assets [Line Items]
Estimated useful life, Years	2 years
Software and related assets [Member] | Maximum [Member]
Finite-Lived Intangible Assets [Line Items]
Estimated useful life, Years	9 years

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Summary of Significant Accounting Policies - Summary of Research and Development Expenses (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Schedule Of Research And Development [Line Items]
Research and development expenses	$ 3,337	$ 5,791	$ 4,955
Software and related assets [Member]
Schedule Of Research And Development [Line Items]
Research and development expenses	3,198	4,980	3,955
Research and development activity [Member]
Schedule Of Research And Development [Line Items]
Research and development expenses	$ 139	$ 811	$ 1,000

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Accounts Receivable and Unbilled Services - Accounts Receivable and Unbilled Services (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Trade:
Billed	$ 553,652	$ 444,941
Unbilled services	614,381	532,312
Trade accounts receivable and unbilled services, gross	1,168,033	977,253
Allowance for doubtful accounts	(2,284)	(1,998)
Trade accounts receivable and unbilled services, net	$ 1,165,749	$ 975,255

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Accounts Receivable and Unbilled Services - Percentage of Accounts Receivable and Unbilled Services by Region (Detail)	Dec. 31, 2015	Dec. 31, 2014
Accounts Receivable [Line Items]
Percentage of accounts receivables	100.00%	100.00%
United States [Member]
Accounts Receivable [Line Items]
Percentage of accounts receivables	58.00%	55.00%
Other [Member]
Accounts Receivable [Line Items]
Percentage of accounts receivables	1.00%	2.00%
Americas [Member]
Accounts Receivable [Line Items]
Percentage of accounts receivables	59.00%	57.00%
United Kingdom [Member]
Accounts Receivable [Line Items]
Percentage of accounts receivables	23.00%	23.00%
Other [Member]
Accounts Receivable [Line Items]
Percentage of accounts receivables	10.00%	11.00%
Europe and Africa [Member]
Accounts Receivable [Line Items]
Percentage of accounts receivables	33.00%	34.00%
Japan [Member]
Accounts Receivable [Line Items]
Percentage of accounts receivables	3.00%	4.00%
Other [Member]
Accounts Receivable [Line Items]
Percentage of accounts receivables	5.00%	5.00%
Asia-Pacific [Member]
Accounts Receivable [Line Items]
Percentage of accounts receivables	8.00%	9.00%

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Investments - Debt, Equity and Other Securities - Summary of the Company's Debt, Equity and Other Securities (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Investments Debt And Equity Securities [Abstract]
Marketable securities	$ 395	$ 831
Cost method	32,516	33,672
Total	$ 32,911	$ 34,503

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Investments - Debt, Equity and Other Securities - Summary of Available-for-Sale Securities (Detail) - Marketable Equity Securities [Member] - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	$ 1,103	$ 1,103
Gross Unrealized Loss	(708)	(272)
Market Value	$ 395	$ 831

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Investments - Debt, Equity and Other Securities - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Feb. 25, 2011
Investments Debt And Equity Securities [Abstract]
Gains or losses from the sale of marketable equity securities	$ 0	$ 5,000,000	$ 0
Net of tax adjustment to unrealized gain (loss) on available-for-sale securities	(438,000)	(170,000)	3,500,000
Loss on sale of marketable equity securities	$ 0	$ 0	$ 0
Investment in joint venture				$ 30,000,000
Non controlling interest percentage in exchange of investment in joint venture	2.20%	3.00%
Customer incentive	$ 12,500,000
Preferred stock acquired from Intarcia	5,000,000
Total customer incentive	2,500,000	$ 7,100,000
Preferred stock investment	$ 5,000,000

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Investments - Debt, Equity and Other Securities - Summary of the Company's Portfolio of Cost Method Investments (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Schedule Of Cost Method Investments [Line Items]
Cost of investments	$ 32,516	$ 33,672
Equity investments [Member]
Schedule Of Cost Method Investments [Line Items]
Cost of investments	$ 32,516	32,516
Convertible notes [Member]
Schedule Of Cost Method Investments [Line Items]
Cost of investments		$ 1,156

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Investments in and Advances to Unconsolidated Affiliates - Investments in and Advances to Unconsolidated Affiliates (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Investments in and Advances to Affiliates [Line Items]
Investments in and Advances to Affiliates	$ 52,382	$ 31,508
NovaQuest Pharma Opportunities Fund lll, L.P [Member]
Investments in and Advances to Affiliates [Line Items]
Investments in and Advances to Affiliates	39,785	22,633
NovaQuest Pharma Opportunities Fund lV, L.P [Member]
Investments in and Advances to Affiliates [Line Items]
Investments in and Advances to Affiliates	2,524
Cenduit TM [Member]
Investments in and Advances to Affiliates [Line Items]
Investments in and Advances to Affiliates	9,478	8,271
Other [Member]
Investments in and Advances to Affiliates [Line Items]
Investments in and Advances to Affiliates	$ 595	$ 604

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Investments in and Advances to Unconsolidated Affiliates - Additional Information (Detail) $ in Thousands	Dec. 31, 2015 USD ($)	Feb. 28, 2015 USD ($)	Dec. 31, 2014	Feb. 25, 2011 USD ($)	May. 31, 2007 USD ($) Location
Schedule of Investments [Line Items]
Amount of initial capital				$ 30,000
NovaQuest Pharma Opportunities Fund lll, L.P [Member]
Schedule of Investments [Line Items]
Committed to invest fund	$ 50,000
Commitment funded	34,700
Funding commitments	$ 15,300
Beneficial ownership in common stock	10.90%		10.90%
NovaQuest Pharma Opportunities Fund lV, L.P [Member]
Schedule of Investments [Line Items]
Committed to invest fund		$ 20,000
Commitment funded	$ 2,700
Funding commitments	$ 17,300
Beneficial ownership in common stock	2.30%
Cenduit TM [Member]
Schedule of Investments [Line Items]
Ownership interest					50.00%
Number of locations | Location					3
Cenduit TM [Member] | United Kingdom [Member]
Schedule of Investments [Line Items]
Amount of initial capital					$ 3,500
Cenduit TM [Member] | United States [Member]
Schedule of Investments [Line Items]
Amount of initial capital					3,500
Cenduit TM [Member] | Switzerland [Member]
Schedule of Investments [Line Items]
Amount of initial capital					$ 3,500

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Derivatives - Additional Information (Detail)	1 Months Ended	12 Months Ended
	May. 31, 2015 USD ($)	Dec. 31, 2015 USD ($) Derivative	Dec. 31, 2014 USD ($) Derivative	Jun. 03, 2015 USD ($) Agreement	Jun. 09, 2011 Agreement
Derivative Instruments and Hedging Activities Disclosures [Line Items]
Number of foreign exchange forward contracts | Agreement				7	6
Notional amount				$ 440,000,000
Payment to terminate hedge accounting	$ 12,400,000
Interest rate cash flow hedge loss to be reclassified during next nine months, net		$ (3,100,000)
Interest swaps accrual beginning date		Jun. 30, 2016
Derivative fixed interest rate		2.10%
Interest rate cash flow hedge loss to be reclassified during next 12 months, net		$ (3,200,000)
Senior Notes [Member] | Variable Rate Debt [Member]
Derivative Instruments and Hedging Activities Disclosures [Line Items]
Interest rate swaps effectively converted percent		50.00%
Senior Notes [Member] | Fixed Rate Debt [Member]
Derivative Instruments and Hedging Activities Disclosures [Line Items]
Interest rate swaps effectively converted percent		50.00%
Accrued Interest [Member]
Derivative Instruments and Hedging Activities Disclosures [Line Items]
Payment to terminate hedge accounting	$ 1,400,000
Foreign Exchange Forward Contracts [Member]
Derivative Instruments and Hedging Activities Disclosures [Line Items]
Number of foreign exchange forward contracts | Derivative		15	13
Notional amount		$ 117,500,000	$ 76,000,000
Losses related to these foreign exchange forward contracts		$ 5,200,000	$ 4,600,000
Expiration year of hedge instruments		2016	2015
Six Interest Rate Swaps [Member] | Minimum [Member]
Derivative Instruments and Hedging Activities Disclosures [Line Items]
Interest rate swaps expiry date		Sep. 30, 2013
Six Interest Rate Swaps [Member] | Maximum [Member]
Derivative Instruments and Hedging Activities Disclosures [Line Items]
Interest rate swaps expiry date		Mar. 31, 2016
Seven Interest Rate Swaps [Member] | Minimum [Member]
Derivative Instruments and Hedging Activities Disclosures [Line Items]
Interest rate swaps expiry date		Mar. 31, 2017
Seven Interest Rate Swaps [Member] | Maximum [Member]
Derivative Instruments and Hedging Activities Disclosures [Line Items]
Interest rate swaps expiry date		Mar. 31, 2020

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Derivatives - Summary of Fair Values of Derivative Instruments Designated as Hedges (Detail) - Designated as Hedging Instrument [Member] - Other Current Liabilities [Member] - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Foreign Exchange Forward Contracts [Member]
Derivatives Fair Value [Line Items]
Derivative liability fair value	$ 5,194	$ 4,635
Interest Rate Swaps [Member]
Derivatives Fair Value [Line Items]
Derivative liability fair value	$ 5,698	$ 14,424

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Derivatives - Effect of Cash Flow Hedging Instruments on Other Comprehensive Income (Loss) (Detail) - Derivatives Designated As Cash Flow Hedges [Member] - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Derivative Instruments and Hedging Activities Disclosures [Line Items]
Effect of cash flow hedging instruments on other comprehensive income (loss)	$ 5,067	$ 1,796	$ 12,687
Foreign Exchange Forward Contracts [Member]
Derivative Instruments and Hedging Activities Disclosures [Line Items]
Effect of cash flow hedging instruments on other comprehensive income (loss)	(559)	(8,585)	3,485
Interest Rate Swaps [Member]
Derivative Instruments and Hedging Activities Disclosures [Line Items]
Effect of cash flow hedging instruments on other comprehensive income (loss)	$ 5,626	$ 10,381	$ 9,202

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Fair Value Measurements - Fair Value of Financial Assets and Liabilities Measured on Recurring Basis (Detail) - Recurring Fair Value Measurements [Member] - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of assets	$ 395	$ 831
Fair value of liabilities	15,266	20,511
Foreign Exchange Forward Contracts [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of liabilities	5,194	4,635
Interest Rate Swaps [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of liabilities	5,698	14,424
Contingent Consideration [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of liabilities	4,374	1,452
Level 1 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of assets	395	831
Level 2 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of liabilities	10,892	19,059
Level 2 [Member] | Foreign Exchange Forward Contracts [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of liabilities	5,194	4,635
Level 2 [Member] | Interest Rate Swaps [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of liabilities	5,698	14,424
Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of liabilities	4,374	1,452
Level 3 [Member] | Contingent Consideration [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of liabilities	4,374	1,452
Marketable Equity Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of assets	395	831
Marketable Equity Securities [Member] | Level 1 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of assets	$ 395	$ 831

XML

Fair Value Measurements - Changes in Level 3 Financial Assets and Liabilities Measured on Recurring Basis (Detail) - Accounts Payable and Accrued Expenses and Other Liabilities [Member] - Contingent Consideration [Member] - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Beginning Balance, Contingent Consideration	$ 1,452	$ 13,014	$ 3,521
Initial estimate of contingent consideration			14,300
Contingent consideration paid	(3,000)	(3,000)
Revaluations included in earnings	5,922	(8,562)	(4,807)
Ending Balance, Contingent Consideration	$ 4,374	$ 1,452	$ 13,014

XML

Fair Value Measurements - Additional Information (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Other identifiable intangibles, net	$ 368,106	$ 280,243
Non-recurring Fair Value Measurements [Member] | Level 3 [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of assets	1,172,700
Cost and equity method investments	84,900
Goodwill	719,700
Other identifiable intangibles, net	$ 368,100

XML

Property and Equipment - Summary of Major Classes of Property and Equipment (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Property, Plant and Equipment [Line Items]
Property and Equipment, Gross	$ 510,712	$ 496,225
Less accumulated depreciation	(322,319)	(305,928)
Property and Equipment, Net	188,393	190,297
Land, buildings and leasehold improvements [Member]
Property, Plant and Equipment [Line Items]
Property and Equipment, Gross	187,405	185,940
Equipment [Member]
Property, Plant and Equipment [Line Items]
Property and Equipment, Gross	257,119	240,227
Furniture and fixtures [Member]
Property, Plant and Equipment [Line Items]
Property and Equipment, Gross	52,840	54,615
Motor vehicles [Member]
Property, Plant and Equipment [Line Items]
Property and Equipment, Gross	$ 13,348	$ 15,443

XML

Goodwill and Identifiable Intangible Assets - Additional Information (Detail) $ in Millions	Dec. 31, 2015 USD ($)
Goodwill And Intangible Assets Disclosure [Abstract]
Identifiable intangible assets	$ 368.1
Identifiable intangible assets related to trade name	128.2
Estimated amortization expense, 2015	61.7
Estimated amortization expense, 2016	50.2
Estimated amortization expense, 2017	39.2
Estimated amortization expense, 2018	32.5
Estimated amortization expense, 2019	$ 20.8

XML

Goodwill and Identifiable Intangible Assets - Summary of Amortization Expense Associated with Identifiable Definite-Lived Intangible Assets (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Goodwill And Intangible Assets Disclosure [Abstract]
Amortization expense	$ 66,545	$ 58,457	$ 51,450

XML

Goodwill and Identifiable Intangible Assets - Summary of Identifiable Intangible Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Identifiable Intangible Assets [Line Items]
Gross Amount	$ 518,035	$ 401,850
Accumulated Amortization	(278,176)	(231,283)
Net Amount	239,859	170,567
Product licensing and distribution rights and customer relationships [Member]
Identifiable Intangible Assets [Line Items]
Gross Amount	224,149	123,227
Accumulated Amortization	(75,606)	(54,413)
Net Amount	148,543	68,814
Software and related assets [Member]
Identifiable Intangible Assets [Line Items]
Gross Amount	279,266	260,052
Accumulated Amortization	(196,489)	(170,471)
Net Amount	82,777	89,581
Trademarks and trade names [Member]
Identifiable Intangible Assets [Line Items]
Gross Amount	14,620	18,571
Accumulated Amortization	(6,081)	(6,399)
Net Amount	8,539	12,172
Trade names [Member]
Identifiable Intangible Assets [Line Items]
Gross Amount	$ 128,247	$ 109,676

XML

Goodwill and Identifiable Intangible Assets - Summary of Goodwill by Segment (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014
Goodwill [Line Items]
Beginning Balance	$ 464,434	$ 409,626
Business combinations	262,377	62,778
Impact of foreign currency fluctuations and other	(7,071)	(7,970)
Ending Balance	719,740	464,434
Product Development [Member]
Goodwill [Line Items]
Beginning Balance	346,608	351,144
Business combinations	262,377
Impact of foreign currency fluctuations and other	(6,879)	(4,536)
Ending Balance	602,106	346,608
Integrated Healthcare Services [Member]
Goodwill [Line Items]
Beginning Balance	117,826	58,482
Business combinations		62,778
Impact of foreign currency fluctuations and other	(192)	(3,434)
Ending Balance	$ 117,634	$ 117,826

XML

Accrued Expenses - Accrued Expenses (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Other Liabilities Disclosure [Abstract]
Compensation, including bonuses, fringe benefits and payroll taxes	$ 400,748	$ 403,250
Restructuring	13,564	6,083
Interest	5,115	274
Contract related	271,076	255,530
Other	70,254	68,507
Total	$ 760,757	$ 733,644

XML

Credit Arrangements - Summary of Credit Facilities (Detail)	12 Months Ended
	Dec. 31, 2015 USD ($)	Dec. 31, 2015 GBP (£)
Revolving credit facility [Member]
Line Of Credit Facility [Line Items]
Facility	$ 500,000,000
Interest Rate Description	London Interbank Offer Rate (“LIBOR”) (0.61% at December 31, 2015) plus 1.75%
LIBOR [Member] | Revolving credit facility [Member]
Line Of Credit Facility [Line Items]
Rate	0.61%	0.61%
Interest Rate spread on base rate	1.75%
Receivables Financing Facility [Member]
Line Of Credit Facility [Line Items]
Facility	$ 25,000,000
Interest Rate Description	LIBOR Market Index Rate (0.43% at December 31, 2015) plus 0.85% to 1.35% depending upon the Company’s debt rating
Rate	0.43%	0.43%
Receivables Financing Facility [Member] | LIBOR [Member]
Line Of Credit Facility [Line Items]
Rate	1.48%	1.48%
Interest Rate spread on base rate	1.05%
Receivables Financing Facility [Member] | LIBOR [Member] | Minimum [Member]
Line Of Credit Facility [Line Items]
Interest Rate spread on base rate	0.85%
Receivables Financing Facility [Member] | LIBOR [Member] | Maximum [Member]
Line Of Credit Facility [Line Items]
Interest Rate spread on base rate	1.35%
General Banking Facility [Member]
Line Of Credit Facility [Line Items]
Facility	$ 14,800,000	£ 10,000,000
Interest Rate Description	Bank’s base rate (0.5% at December 31, 2015) plus 1%
General Banking Facility [Member] | Base Rate
Line Of Credit Facility [Line Items]
Rate	0.50%	0.50%
Interest Rate spread on base rate	1.00%

XML

Credit Arrangements - Additional Information (Detail) £ in Millions	12 Months Ended
	Dec. 31, 2015 USD ($)	Dec. 31, 2015 GBP (£)	Dec. 31, 2014 USD ($)
Line Of Credit Facility [Line Items]
Outstanding borrowings	$ 0		$ 0
Revolving Credit Facility
Line Of Credit Facility [Line Items]
Credit facility repaid			$ 150,000,000
Outstanding borrowings	150,000,000
General Banking Facility [Member]
Line Of Credit Facility [Line Items]
Bank guarantees	$ 5,800,000	£ 3.9
Term Loan A [Member] | Revolving Credit Facility
Line Of Credit Facility [Line Items]
Debt instrument restrictive covenants, description	The credit agreement also contains one financial covenant, which is a total leverage ratio that provides for a maximum ratio of consolidated total debt to consolidated EBITDA, as defined in the credit agreement, for any period of four consecutive fiscal quarters, measured as of the end of such period, of 5.75 to 1.00, and applies at any time that the Term Loan A or New Revolver commitments remain outstanding.	The credit agreement also contains one financial covenant, which is a total leverage ratio that provides for a maximum ratio of consolidated total debt to consolidated EBITDA, as defined in the credit agreement, for any period of four consecutive fiscal quarters, measured as of the end of such period, of 5.75 to 1.00, and applies at any time that the Term Loan A or New Revolver commitments remain outstanding.
Term Loan A [Member] | Revolving Credit Facility | Maximum [Member]
Line Of Credit Facility [Line Items]
Total debt to consolidated EBITDA	575.00%	575.00%

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Credit Arrangements - Schedule of Long-term Debt (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Debt Instrument [Line Items]
Long-term debt	$ 2,500,750	$ 2,305,606
Less: unamortized discount	(24,020)	(12,379)
Less: unamortized debt issuance costs	(8,955)	(9,879)
Less: current portion	(48,500)	(750)
Long term debt, total	2,419,275	2,282,598
4.875% Senior Notes [Member] | Due in 2023 [Member]
Debt Instrument [Line Items]
Long-term debt	800,000
Term Loan A [Member] | Due in 2020 [Member]
Debt Instrument [Line Items]
Long-term debt	828,750
Term Loan B [Member] | Due in 2022 [Member]
Debt Instrument [Line Items]
Long-term debt	597,000
Term Loan B-3 [Member] | Due in 2018 [Member]
Debt Instrument [Line Items]
Long-term debt		2,030,606
Receivables Financing Facility [Member]
Debt Instrument [Line Items]
Long-term debt	$ 275,000	$ 275,000

XML

Credit Arrangements - Schedule of Long-term Debt (Parenthetical) (Detail)	12 Months Ended
	Dec. 31, 2015	May. 12, 2015
4.875% Senior Notes [Member] | Due in 2023 [Member]
Debt Instrument [Line Items]
Debt instrument interest rate stated percentage	4.875%	4.875%
Debt maturity year	2023
Term Loan A [Member] | Due in 2020 [Member]
Debt Instrument [Line Items]
Debt maturity year	2020
Debt instrument interest rate terms, Description	LIBOR plus 1.75%, or 2.36% at December 31, 2015
Term Loan B [Member] | Due in 2022 [Member]
Debt Instrument [Line Items]
Debt maturity year	2022
Debt instrument interest rate terms, Description	The greater of LIBOR or 0.75% plus 2.50%, or 3.25% at December 31, 2015
Term Loan B-3 [Member] | Due in 2018 [Member]
Debt Instrument [Line Items]
Debt maturity year	2018
Debt instrument interest rate terms, Description	The greater of three month LIBOR or 1.25% plus 2.50%, or 3.75% at December 31, 2014
Receivables Financing Facility [Member]
Debt Instrument [Line Items]
Debt instrument interest rate stated percentage	0.43%
Debt maturity year	2018
Debt instrument interest rate terms, Description	LIBOR plus 1.05%, or 1.48% at December 31, 2015
LIBOR [Member] | Term Loan A [Member]
Debt Instrument [Line Items]
Debt instrument interest rate stated percentage	2.36%
Interest Rate spread on base rate	1.75%
LIBOR [Member] | Term Loan B [Member]
Debt Instrument [Line Items]
Debt instrument interest rate stated percentage	3.25%
LIBOR [Member] | Term Loan B-3 [Member]
Debt Instrument [Line Items]
Debt instrument interest rate stated percentage	3.75%
LIBOR [Member] | Receivables Financing Facility [Member]
Debt Instrument [Line Items]
Debt instrument interest rate stated percentage	1.48%
Interest Rate spread on base rate	1.05%
LIBOR [Member] | Minimum [Member] | Term Loan B [Member]
Debt Instrument [Line Items]
Interest Rate spread on base rate	0.75%
LIBOR [Member] | Minimum [Member] | Term Loan B-3 [Member]
Debt Instrument [Line Items]
Interest Rate spread on base rate	1.25%
LIBOR [Member] | Minimum [Member] | Receivables Financing Facility [Member]
Debt Instrument [Line Items]
Interest Rate spread on base rate	0.85%
LIBOR [Member] | Maximum [Member] | Term Loan B [Member]
Debt Instrument [Line Items]
Interest Rate spread on base rate	2.50%
LIBOR [Member] | Maximum [Member] | Term Loan B-3 [Member]
Debt Instrument [Line Items]
Interest Rate spread on base rate	2.50%
LIBOR [Member] | Maximum [Member] | Receivables Financing Facility [Member]
Debt Instrument [Line Items]
Interest Rate spread on base rate	1.35%

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Credit Arrangements - Contractual Maturities of Long-term Debt (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Debt Disclosure [Abstract]
2016	$ 48,500
2017	48,500
2018	323,500
2019	48,500
2020	664,750
Thereafter	1,367,000
Long-term debt	$ 2,500,750	$ 2,305,606

XML

Credit Arrangements - Senior Secured Credit Agreement - Additional Information (Detail) - USD ($)				12 Months Ended
	May. 12, 2015	Nov. 07, 2014	Dec. 20, 2013	Dec. 31, 2015	Dec. 31, 2014
Line Of Credit Facility [Line Items]
Outstanding borrowings				$ 0	$ 0
Senior Notes [Member]
Line Of Credit Facility [Line Items]
Debt Instrument payment frequency				Interest on the Senior Notes is paid semiannually on May 15 and November 15 of each year until maturity.
Revolving Credit Facility
Line Of Credit Facility [Line Items]
Aggregate maximum principal amount				$ 500,000,000
Outstanding borrowings				$ 150,000,000
Revolving Credit Facility | Minimum [Member] | 2014 Revolving Credit Facility Amendment [Member]
Line Of Credit Facility [Line Items]
Outstanding borrowings		$ 300,000,000
Revolving Credit Facility | Maximum [Member] | 2014 Revolving Credit Facility Amendment [Member]
Line Of Credit Facility [Line Items]
Credit facility arrangement amended date		Nov. 07, 2014
Outstanding borrowings		$ 400,000,000
Senior secured credit facilities [Member]
Line Of Credit Facility [Line Items]
Aggregate maximum principal amount	$ 1,950,000,000
Percentage of excess cash flow for loan repayment	25.00%
Percentage of repayment from cash proceeds of asset disposition	100.00%
Percentage of equity interest of domestic subsidiaries pledged as collateral	100.00%
Percentage of equity interest of foreign subsidiaries pledged as collateral	65.00%
Senior secured credit facilities [Member] | Minimum [Member]
Line Of Credit Facility [Line Items]
Percentage of excess cash flow for loan repayment	0.00%
Senior secured credit facilities [Member] | Term Loans [Member]
Line Of Credit Facility [Line Items]
Aggregate maximum principal amount	$ 1,450,000,000
Senior secured credit facilities [Member] | Revolving Credit Facility
Line Of Credit Facility [Line Items]
Aggregate maximum principal amount	$ 500,000,000
Credit facility maturity period				5 years
Term Loan A [Member]
Line Of Credit Facility [Line Items]
Annual Maturities Percentage	5.00%
Term Loan A [Member] | Term Loans [Member]
Line Of Credit Facility [Line Items]
Aggregate maximum principal amount	$ 850,000,000
Debt maturity year				2020
Term Loan B [Member]
Line Of Credit Facility [Line Items]
Annual Maturities Percentage	1.00%
Term Loan B [Member] | Term Loans [Member]
Line Of Credit Facility [Line Items]
Aggregate maximum principal amount	$ 600,000,000
Debt maturity year				2022
4.875% Senior Notes [Member] | Due in 2023 [Member]
Line Of Credit Facility [Line Items]
Debt maturity year				2023
Notes issued in private placement, amount	$ 800,000,000
Debt instrument interest rate stated percentage	4.875%			4.875%
Term Loan A and B [Member]
Line Of Credit Facility [Line Items]
Term loan maturity dates, description				Annual maturities on the New Term Loan A and the New Term Loan B are 5% and 1%, respectively, of the respective original principal amount with the remaining balance to be repaid on their respective maturity dates
Percentage of excess cash flow for loan repayment	50.00%
Term Loan B-3 [Member] | Due in 2018 [Member]
Line Of Credit Facility [Line Items]
Debt maturity year				2018
Termination of interest rate swaps				$ 11,000,000
Term Loan B-3 [Member] | Due 2018 [Member]
Line Of Credit Facility [Line Items]
Aggregate maximum principal amount			$ 2,061,000,000
Credit facility due			2018

XML

Credit Arrangements - Additional Information - Detail (Detail) - USD ($)	1 Months Ended	12 Months Ended
	May. 31, 2013	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 20, 2013
Line Of Credit Facility [Line Items]
Outstanding borrowings		$ 0	$ 0
Loss on extinguishment of debt		(7,780,000)		$ (19,831,000)
Unamortized debt issuance cost		8,955,000	9,879,000
Unamortized discount		24,020,000	12,379,000
Cash paid to pay down debt		2,056,780,000	$ 30,157,000	2,444,600,000
Revolving Credit Facility
Line Of Credit Facility [Line Items]
Aggregate maximum principal amount		500,000,000
Outstanding borrowings		$ 150,000,000
Term Loans [Member]
Line Of Credit Facility [Line Items]
Loss on extinguishment of debt	$ 15,500,000
Unamortized debt issuance cost	4,700,000
Unamortized discount	4,700,000
Fees and expenses	6,100,000
Cash paid to pay down debt	308,900,000
Term Loan B-1 [Member] | Due 2018 [Member]
Line Of Credit Facility [Line Items]
Loss on extinguishment of debt	(1,000,000)
Unamortized debt issuance cost	930,000,000
Unamortized discount	112,000,000
Cash paid to pay down debt	$ 50,000,000
Receivables Financing Facility [Member]
Line Of Credit Facility [Line Items]
Securitization arrangement initiation date		Dec. 05, 2014
Credit facility maturity period		4 years
Aggregate maximum principal amount		$ 25,000,000
Receivables Financing Facility [Member] | Term Loans [Member]
Line Of Credit Facility [Line Items]
Aggregate maximum principal amount		275,000,000
Receivables Financing Facility [Member] | Revolving Loan Commitment [Member]
Line Of Credit Facility [Line Items]
Aggregate maximum principal amount		25,000,000
Increase in revolving loan commitment		35,000,000
Term Loan B-3 [Member] | Due 2018 [Member]
Line Of Credit Facility [Line Items]
Aggregate maximum principal amount					$ 2,061,000,000
Repayment of term loan		25,000,000
Loss on extinguishment of debt		7,800,000		(3,300,000)
Unamortized debt issuance cost		1,100,000		1,600,000
Unamortized discount		1,300,000		1,600,000
Fees and expenses		$ 5,400,000		$ 25,000,000

XML

Leases - Additional Information (Detail) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Leases [Abstract]
Rental expenses under agreement	$ 109.4	$ 114.6	$ 125.6
Operating lease year of expiry	2029

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Leases - Summary of Future Minimum Lease Payments Under Capital and Operating Leases (Detail) $ in Thousands	Dec. 31, 2015 USD ($)
Leases [Abstract]
Capital leases, future minimum payments due, 2016	$ 15
Capital leases, future minimum payments due, 2017	18
Capital leases, total minimum lease payments	33
Capital leases, Amounts representing interest	(2)
Capital leases, Present value of net minimum payments	31
Capital leases, Current portion	(13)
Capital leases, Long-term capital lease obligations	18
Operating leases, future minimum payments due, 2016	84,747
Operating leases, future minimum payments due, 2017	62,485
Operating leases, future minimum payments due, 2018	41,907
Operating leases, future minimum payments due, 2019	29,201
Operating leases, future minimum payments due, 2020	25,713
Operating leases, future minimum payments due, Thereafter	111,267
Operating leases, total minimum lease payments	$ 355,320

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Shareholders' Deficit - Additional Information (Detail) - USD ($)					12 Months Ended			26 Months Ended
	Nov. 10, 2014	May. 28, 2014	May. 27, 2014	May. 14, 2013	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2015	Oct. 30, 2013
Class Of Stock [Line Items]
Common stock issued					119,378,000	124,129,000		119,378,000
Proceeds from issue of common stock through IPO							$ 525,000,000
Preferred stock, authorized					1,000,000			1,000,000
Preferred stock, par value					$ 0.01			$ 0.01
Preferred stock, shares issued					0	0		0
Preferred stock, shares outstanding					0	0		0
Repurchase of common stock, value					$ 515,010,000	$ 415,131,000	$ 6,434,000	$ 995,600,000
Equity repurchase program authorized amount									$ 125,000,000
Repurchase of common stock, Shares					7,855,796	7,591,175	153,223
Q2 Solutions
Class Of Stock [Line Items]
Percentage of Quest’s noncontrolling interest in Q2 Solutions					40.00%			40.00%
Quest’s noncontrolling interest in Q2 Solutions					$ 231,900,000
Equity Repurchase Program [Member]
Class Of Stock [Line Items]
Repurchase of common stock, value					515,010,000	$ 14,000	$ 6,434,000
Equity repurchase program authorized amount					725,000,000			$ 725,000,000
Equity repurchase program increase in authorized amount					600,000,000
Equity available for repurchase under the repurchase program					$ 144,500,000			$ 144,500,000
Repurchase of common stock, Shares					7,855,796	300	153,223
Other Equity Repurchases [Member]
Class Of Stock [Line Items]
Repurchase of common stock, value	$ 250,000,000	$ 165,100,000
Repurchase of common stock, Shares	4,303,666	3,287,209
Repurchase of common stock, share price	$ 58.09	$ 50.23	$ 51.26
Repurchase price per share percentage			98.00%
Other Equity Repurchases [Member] | Revolving credit facility [Member]
Class Of Stock [Line Items]
Credit facility amount used to fund repurchase	$ 150,000,000
IPO [Member]
Class Of Stock [Line Items]
Common stock price				$ 40.00
Common stock issued				13,125,000
Proceeds from issue of common stock through IPO				$ 489,500,000
Selling Shareholders [Member] | IPO [Member]
Class Of Stock [Line Items]
Sale of common stock				14,111,841
Proceeds from issue of common stock through IPO				$ 0
Selling Shareholders [Member] | IPO [Member] | Underwriters Option [Member]
Class Of Stock [Line Items]
Shares offered and sold by selling shareholders pursuant to the full exercise of the underwriters' option to purchase additional shares				3,552,631
Stock Options [Member]
Class Of Stock [Line Items]
Equity repurchased -vested in-the-money employee stock options, shares							2,000,000
Equity repurchased -vested in-the-money employee stock options, value							$ 59,100,000
Repurchase vested in-the-money employee stock options, average market price							$ 43.42
Repurchase of vested in-the-money employee stock options, average exercise price per option							$ 13.74

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Shareholders' Deficit - Summary of Share Repurchases Made Under Repurchase Program (Detail) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended			26 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2015
Class Of Stock [Line Items]
Repurchase of common stock, Shares	7,855,796	7,591,175	153,223
Aggregate purchase price	$ 515,010	$ 415,131	$ 6,434	$ 995,600
Equity Repurchase Program [Member]
Class Of Stock [Line Items]
Repurchase of common stock, Shares	7,855,796	300	153,223
Aggregate purchase price	$ 515,010	$ 14	$ 6,434
Average price per share	$ 65.56	$ 47.51	$ 42.01

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Management Fees - Additional Information (Detail) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2013	Jan. 31, 2008
Management Fees Disclosure [Abstract]
Annual management service fee agreed to pay		$ 5.0
Termination fee	$ 25.0
Management service fee	$ 27.7

XML

Business Combinations - Additional Information (Detail) - USD ($) $ in Thousands				12 Months Ended
	Jul. 02, 2015	Jul. 02, 2014	Sep. 16, 2013	Dec. 31, 2015
Business Acquisition [Line Items]
Business combination, fair value of consideration transferred				$ 423,268
Quest [Member]
Business Acquisition [Line Items]
Business acquisition, percentage of voting interests acquired	40.00%
Business combination, fair value of consideration transferred	$ 423,300
Encore [Member]
Business Acquisition [Line Items]
Business acquisition through merger		$ 91,500
Date of Acquisition				Jul. 01, 2014
Cash acquired		$ 2,200
Novella [Member]
Business Acquisition [Line Items]
Business acquisition, percentage of voting interests acquired			100.00%
Date of Acquisition				Sep. 16, 2013
Cash acquired			$ 26,200
Outstanding stock value			146,600
Contingent consideration, annual earn out payment			21,000
Liability recognized on acquisition			$ 14,300

XML

Business Combinations - Summary of Estimated Fair Value of Net Assets Acquired at the Date of Acquisitions (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Assets acquired:
Goodwill	$ 719,740	$ 464,434	$ 409,626
Quest [Member]
Assets acquired:
Cash and cash equivalents	31,783
Accounts receivable and unbilled services	6,186
Prepaid expenses	1,185
Other current assets	4,426
Property and equipment	16,422
Goodwill	261,710
Other identifiable intangibles	125,900
Other long-term assets	266
Liabilities assumed:
Accounts payable and accrued expenses	(12,790)
Deferred income tax liability – long-term	(10,412)
Other long-term liabilities	(1,408)
Net assets acquired	423,268
Encore [Member]
Assets acquired:
Cash and cash equivalents	2,223
Accounts receivable and unbilled services	17,714
Other current assets	443
Property and equipment	289
Goodwill	62,778
Other identifiable intangibles	14,150
Deferred income tax asset – long-term	396
Liabilities assumed:
Accounts payable and accrued expenses	(4,206)
Unearned income	(31)
Net assets acquired	93,756
Novella [Member]
Assets acquired:
Cash and cash equivalents	26,190
Accounts receivable and unbilled services	28,644
Other current assets	1,441
Property and equipment	9,616
Goodwill	116,542
Other identifiable intangibles	42,740
Other long-term assets	2,203
Liabilities assumed:
Accounts payable and accrued expenses	(12,716)
Unearned income	(7,782)
Other current liabilities	(132)
Deferred income tax liability – long-term	(18,364)
Other long-term liabilities	(1,334)
Net assets acquired	$ 187,048

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Business Combinations - Summary Of Identifiable Intangible Assets (Detail) $ in Thousands	12 Months Ended
	Dec. 31, 2015 USD ($)
Quest [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	$ 125,900
Amortized over a weighted average useful life (in years)	9 years
Quest [Member] | Trade names [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	$ 19,000
Quest [Member] | Contract backlog and customer relationships [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	74,000
Quest [Member] | Backlog [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	32,900
Encore [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	$ 14,150
Amortized over a weighted average useful life (in years)	8 years
Encore [Member] | Contract backlog and customer relationships [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	$ 8,800
Encore [Member] | Backlog [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	800
Encore [Member] | Finite lived trade name [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	1,100
Encore [Member] | Non-compete agreements [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	450
Encore [Member] | Software and related assets [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	3,000
Novella [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	$ 42,740
Amortized over a weighted average useful life (in years)	7 years
Novella [Member] | Contract backlog and customer relationships [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	$ 20,800
Novella [Member] | Backlog [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	14,000
Novella [Member] | Finite lived trade name [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	7,500
Novella [Member] | Non-compete agreements [Member]
Acquired Intangible Assets [Line Items]
Total other identifiable intangibles	$ 440

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Restructuring - Additional Information (Detail)	1 Months Ended	3 Months Ended	12 Months Ended			24 Months Ended	35 Months Ended
	Feb. 28, 2013 USD ($)	Sep. 30, 2015 USD ($)	Dec. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)	Dec. 31, 2013 USD ($)	Dec. 31, 2015 USD ($)	Dec. 31, 2015 USD ($)	Feb. 28, 2015 USD ($)
Restructuring Cost and Reserve [Line Items]
Restructuring costs			$ 30,752,000	$ 8,988,000	$ 14,071,000
Quest [Member]
Restructuring Cost and Reserve [Line Items]
Severance, facility closure and other exit-related costs		$ 14,000,000
2015 Plan [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring plan approved								$ 30,000,000
2015 Plan [Member] | Operating Segments [Member] | Product Development [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring costs			11,800,000
2015 Plan [Member] | Operating Segments [Member] | Product Development [Member] | Quest [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring costs			8,700,000
2015 Plan [Member] | Operating Segments [Member] | Integrated Healthcare Services [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring costs			8,900,000
2015 Plan [Member] | Corporate, Non-Segment [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring costs			$ 749,000
2014 Plan [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring plan approved				$ 13,000,000
Restructuring costs						$ 11,000,000
Number of positions reduced				250
2014 Plan [Member] | Operating Segments [Member] | Product Development [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring costs						8,000,000
2014 Plan [Member] | Operating Segments [Member] | Integrated Healthcare Services [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring costs						$ 3,000,000
2013 Plan [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring plan approved	$ 15,000,000
Restructuring costs							$ 13,600,000
Number of positions reduced	400
2013 Plan [Member] | Operating Segments [Member] | Product Development [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring costs							8,400,000
2013 Plan [Member] | Operating Segments [Member] | Integrated Healthcare Services [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring costs							4,700,000
2013 Plan [Member] | Corporate, Non-Segment [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring costs							$ 500,000

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Restructuring - Summary of Amounts Recorded for Restructuring Plans (Detail) - USD ($) $ in Thousands	12 Months Ended			24 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2015
Restructuring Cost and Reserve [Line Items]
Restructuring reserves, beginning balance	$ 6,083	$ 5,474		$ 5,474
Expense, net of reversals	30,752	8,988	$ 14,071
Payments	(23,666)	(8,158)
Foreign currency translation		(221)
Foreign currency translation and other	395
Restructuring reserves, ending balance	13,564	6,083	5,474	13,564
Severance and Related Costs [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring reserves, beginning balance	5,478	5,276		5,276
Expense, net of reversals	29,843	8,421
Payments	(22,943)	(7,998)
Foreign currency translation		(221)
Foreign currency translation and other	(199)
Restructuring reserves, ending balance	12,179	5,478	5,276	12,179
Exit Costs [Member]
Restructuring Cost and Reserve [Line Items]
Restructuring reserves, beginning balance	605	198		198
Expense, net of reversals	909	567
Payments	(723)	(160)
Foreign currency translation and other	594
Restructuring reserves, ending balance	$ 1,385	$ 605	$ 198	$ 1,385

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Income Taxes - Components of Income Before Income Taxes and Equity in Earnings of Unconsolidated Affiliates (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Income Before Income Taxes [Line Items]
Income before income taxes and equity in earnings (losses) of unconsolidated affiliates	$ 538,995	$ 502,189	$ 323,116
Domestic [Member]
Income Before Income Taxes [Line Items]
Income before income taxes and equity in earnings (losses) of unconsolidated affiliates	68,455	96,917	68,425
Foreign [Member]
Income Before Income Taxes [Line Items]
Income before income taxes and equity in earnings (losses) of unconsolidated affiliates	$ 470,540	$ 405,272	$ 254,691

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Income Taxes - Components of Income Tax Expense Attributable to Continuing Operations (Detail) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Jun. 30, 2013	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Income Tax Disclosure [Abstract]
Federal		$ 47,311	$ 58,403	$ 38,573
State		3,559	4,618	(4,309)
Foreign		109,273	95,010	83,744
Current Income Tax Expense (Benefit)		160,143	158,031	118,008
Federal and state		4,613	(4,549)	(15,807)
Foreign		(5,767)	(3,426)	(6,236)
Deferred Income Tax Expense (Benefit)		(1,154)	(7,975)	(22,043)
Income Tax Expense (Benefit)	$ (8,100)	$ 158,989	$ 150,056	$ 95,965

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Income Taxes - Additional Information (Detail) - USD ($)	3 Months Ended	12 Months Ended
	Jun. 30, 2013	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Income Tax Examination [Line Items]
Statutory U.S. tax rate		35.00%
Income tax benefit	$ 8,100,000	$ (158,989,000)	$ (150,056,000)	$ (95,965,000)
Undistributed earnings of foreign subsidiaries		862,300,000
Undistributed earnings of foreign subsidiary, taxable upon repatriation		283,900,000
Deferred income tax liability, net of foreign income tax credits upon repatriation		34,900,000
Indefinitely reinvested undistributed earnings of foreign subsidiaries		578,400,000
Additional tax liability on Indefinitely reinvested undistributed earnings of foreign subsidiaries		94,600,000
Net operating loss carryforwards		41,707,000	43,535,000
Decrease in valuation allowances			24,700,000
Unrecognized income tax benefits		29,700,000
Unrecognized benefits		29,300,000
Accrued interest and penalties		2,900,000	4,800,000
(Reduction)/Addition of Interest and penalties recorded		(2,000,000)	1,300,000	843,000
Gross unrecognized income tax benefits		29,666,000	40,821,000	54,936,000	$ 43,393,000
Quintiles East Asia [Member]
Income Tax Examination [Line Items]
Income tax benefit		$ 2,000,000	$ 2,400,000	798,000
Income tax holiday period		Through June 2015
Outcome Europe Sarl [Member]
Income Tax Examination [Line Items]
Income tax benefit				64,000
Earnings per share		$ 0.02	$ 0.02
Minimum [Member]
Income Tax Examination [Line Items]
Decrease in valuation allowances		$ 2,500,000
Maximum [Member]
Income Tax Examination [Line Items]
Decrease in valuation allowances		22,200,000
United Kingdom [Member]
Income Tax Examination [Line Items]
Operating Loss and capital loss carryforwards		44,900,000
Foreign Jurisdictions [Member]
Income Tax Examination [Line Items]
Operating Loss and capital loss carryforwards		40,700,000
United States [Member]
Income Tax Examination [Line Items]
Net operating loss carryforwards		$ 44,000,000
Net operating loss carryforwards expiration year		2035
Novella, EA And Advion BioSciences, Inc. [Member] | United States [Member]
Income Tax Examination [Line Items]
Net operating loss carryforwards				$ 16,600,000	$ 16,600,000	$ 16,600,000
Net operating loss carryforwards expiration year		2023
Federal State And Foreign Tax [Member]
Income Tax Examination [Line Items]
Gross unrecognized income tax benefits		$ 8,100,000
Foreign Tax [Member]
Income Tax Examination [Line Items]
Gross unrecognized income tax benefits		$ 160,000

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Income Taxes - Effective Income Tax Rate Reconciliation (Detail) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Jun. 30, 2013	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Income Tax Disclosure [Abstract]
Federal income tax expense at statutory rate		$ 188,648	$ 175,766	$ 113,091
State and local income taxes, net of federal benefit		1,682	2,312	(1,088)
Research and development		(12,634)	(16,765)	(12,788)
Foreign nontaxable interest income		(9,351)	(10,217)	(9,751)
Gain on note settlement				10,794
United States taxes recorded on foreign earnings		38,246	18,631	(1,616)
Foreign rate differential		(49,288)	(30,734)	(10,753)
Tax contingencies		(8,304)	4,043	(1,012)
Other		9,990	7,020	9,088
Income Tax Expense (Benefit)	$ (8,100)	$ 158,989	$ 150,056	$ 95,965

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Income Taxes - Income Tax Effects of Temporary Differences from Continuing Operations that Give Rise to Significant Portions of Deferred Income Tax (Liabilities) Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Deferred income tax liabilities:
Undistributed foreign earnings	$ (36,624)	$ (27,717)
Depreciation and amortization	(53,171)	(65,614)
Other	(11,830)	(15,346)
Total deferred income tax liabilities	(101,625)	(108,677)
Deferred income tax assets:
Net operating loss, capital loss and tax credit carryforwards	41,707	43,535
Accrued expenses and unearned income	23,315	34,048
Employee benefits	123,775	130,217
Other	12,801	17,784
Deferred Tax Assets, Gross	201,598	225,584
Valuation allowance for deferred income tax assets	(22,162)	(24,695)
Total deferred income tax assets	179,436	200,889
Net deferred income tax assets	$ 77,811	$ 92,212

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Income Taxes - Reconciliation of Beginning and Ending Amount of Gross Unrecognized Income Tax Benefits (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Income Tax Disclosure [Abstract]
Beginning balance	$ 40,821	$ 54,936	$ 43,393
Additions based on tax positions related to the current year	2,068	2,807	4,493
Additions for income tax positions of prior years	8,838	1,588	12,854
Impact of changes in exchange rates	(608)	(376)	(71)
Settlements with tax authorities	(121)	(135)	(1,052)
Reductions for income tax positions of prior years	(1,945)	(6,023)	(3,520)
Reductions due to the lapse of the applicable statute of limitations	(19,387)	(11,976)	(1,161)
Ending balance	$ 29,666	$ 40,821	$ 54,936

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Income Taxes - Summary of Tax Years Open for Examination (Detail)	12 Months Ended
	Dec. 31, 2015
United States [Member] | Earliest Tax Year [Member]
Schedule Of Income Taxes [Line Items]
Open tax year	2012
United States [Member] | Latest Tax Year [Member]
Schedule Of Income Taxes [Line Items]
Open tax year	2014
India [Member] | Earliest Tax Year [Member]
Schedule Of Income Taxes [Line Items]
Open tax year	2006
India [Member] | Latest Tax Year [Member]
Schedule Of Income Taxes [Line Items]
Open tax year	2015
Japan [Member] | Earliest Tax Year [Member]
Schedule Of Income Taxes [Line Items]
Open tax year	2010
Japan [Member] | Latest Tax Year [Member]
Schedule Of Income Taxes [Line Items]
Open tax year	2014
United Kingdom [Member] | Latest Tax Year [Member]
Schedule Of Income Taxes [Line Items]
Open tax year	2014

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Employee Benefit Plans - Defined Contribution Plans And Defined Benefit Plans - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Defined Contribution And Defined Benefit Plans [Line Items]
Expenses related to matching contributions		$ 36,300,000	$ 31,200,000	$ 26,100,000
Amortization of actuarial losses		(973,000)	(636,000)	$ (708,000)
Accumulated benefit obligation		139,100,000	127,900,000
Projected benefit obligation related to unfunded plans		94,600,000	83,400,000
Accumulated benefit obligation related to unfunded plan		$ 82,900,000	$ 66,400,000
Minimum [Member]
Defined Contribution And Defined Benefit Plans [Line Items]
Long term government bonds premium percentage		3.00%
Maximum [Member]
Defined Contribution And Defined Benefit Plans [Line Items]
Long term government bonds premium percentage		5.00%
Scenario, Forecast [Member]
Defined Contribution And Defined Benefit Plans [Line Items]
Amortization of actuarial losses	$ 870,000
Estimated employer contribution to defined benefit plan	$ 5,500,000
Scenario, Forecast [Member] | Bond Investments [Member]
Defined Contribution And Defined Benefit Plans [Line Items]
Defined benefit plan, target allocation percentage, minimum	45.00%
Defined benefit plan, target allocation percentage, maximum	55.00%
Scenario, Forecast [Member] | Equity Investments [Member]
Defined Contribution And Defined Benefit Plans [Line Items]
Defined benefit plan, target allocation percentage, minimum	25.00%
Defined benefit plan, target allocation percentage, maximum	35.00%
Scenario, Forecast [Member] | Diversified Growth Funds [Member]
Defined Contribution And Defined Benefit Plans [Line Items]
Defined benefit plan, target allocation percentage, minimum	15.00%
Defined benefit plan, target allocation percentage, maximum	25.00%

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Employee Benefit Plans - Summary of Components of Pension Expenses Related to Defined Benefit Plans (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Compensation And Retirement Disclosure [Abstract]
Service cost	$ 15,486	$ 12,944	$ 13,227
Interest cost	3,453	3,821	3,684
Expected return on plan assets	(3,555)	(4,277)	(3,442)
Amortization of prior service costs		107	336
Amortization of actuarial losses	973	636	708
Total pension expense related to defined benefit plans	$ 16,357	$ 13,231	$ 14,513

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Employee Benefit Plans - Weighted Average Assumptions Used in Determining Pension Expense (Detail)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Compensation And Retirement Disclosure [Abstract]
Discount rate	2.46%	3.01%	3.06%
Rate of compensation increases	4.32%	4.36%	4.74%
Expected return on plan assets	4.05%	5.21%	5.33%

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Employee Benefit Plans - Financial Information About Defined Benefit Plans (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Defined Benefit Plan, Change in Benefit Obligation [Roll Forward]
Projected benefit obligation January 1	$ 147,127	$ 135,110
Service costs	15,486	12,944	$ 13,227
Interest cost	3,453	3,821	3,684
Expected return on plan assets	(3,555)	(4,277)	(3,442)
Actuarial (gains) losses	(2,306)	16,396
Business combination	1,746
Benefits paid	(6,325)	(7,409)
Foreign currency fluctuations and other	(1,732)	(9,458)
Projected benefit obligation December 31	153,894	147,127	135,110
Defined Benefit Plan, Change in Fair Value of Plan Assets [Roll Forward]
Plan assets at fair value, January 1	88,420	82,787
Actual return on plan assets	1,312	10,004
Contributions	5,982	8,594
Business combination	1,966
Benefits paid	(6,325)	(7,409)
Foreign currency fluctuations and other	(4,212)	(5,556)
Plan assets at fair value, December 31	87,143	88,420	$ 82,787
Unfunded balance	$ 66,751	$ 58,707

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Employee Benefit Plans - Summary of Amounts Recognized in Consolidated Balance Sheets (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Defined Benefit Plan Disclosure [Line Items]
Deposits and other assets	$ 19,185	$ 18,690
Accrued expenses	4,520	6,075
Other long-term liabilities	81,410	71,322
AOCI	(8,275)	(8,857)	$ (2,088)
Actuarial Net (Gain) Loss [Member]
Defined Benefit Plan Disclosure [Line Items]
AOCI	$ (13,264)	$ (14,519)	$ (4,937)

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Employee Benefit Plans - Summary of Amounts Recognized in Accumulated Other Comprehensive Income (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Defined Benefit Plan Disclosure [Line Items]
Beginning balance	$ (8,857)	$ (2,088)
Reclassification adjustments included in pension expense:
Amortization	618	468
Amounts arising during the period:
Actuarial changes in benefit obligation	(36)	(7,237)	$ 2,278
Ending balance	(8,275)	(8,857)	(2,088)
Prior Service Costs [Member]
Defined Benefit Plan Disclosure [Line Items]
Beginning balance		(107)
Reclassification adjustments included in pension expense:
Amortization		107
Amounts arising during the period:
Ending balance			(107)
Actuarial Net (Gain) Loss [Member]
Defined Benefit Plan Disclosure [Line Items]
Beginning balance	(14,519)	(4,937)
Reclassification adjustments included in pension expense:
Amortization	973	636
Amounts arising during the period:
Actuarial changes in benefit obligation	282	(10,218)
Ending balance	(13,264)	(14,519)	(4,937)
Deferred Income Taxes [Member]
Defined Benefit Plan Disclosure [Line Items]
Beginning balance	5,662	2,956
Reclassification adjustments included in pension expense:
Amortization	(355)	(275)
Amounts arising during the period:
Actuarial changes in benefit obligation	(318)	2,981
Ending balance	$ 4,989	$ 5,662	$ 2,956

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Employee Benefit Plans - Weighted Average Assumptions Used in Determining Pension Obligations (Detail)	Dec. 31, 2015	Dec. 31, 2014
Compensation And Retirement Disclosure [Abstract]
Discount rate	2.50%	2.46%
Rate of compensation increases	4.37%	4.32%

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Employee Benefit Plans - Schedule of Fair Value Measurement (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Defined Benefit Plan Disclosure [Line Items]
Defined benefit plan, fair value of plan assets	$ 87,143	$ 88,420	$ 82,787
Funds that hold debt investments primarily government bonds [Member]
Defined Benefit Plan Disclosure [Line Items]
Defined benefit plan, fair value of plan assets	49,355	47,473
Funds that hold United Kingdom equity investments [Member]
Defined Benefit Plan Disclosure [Line Items]
Defined benefit plan, fair value of plan assets	15,700	19,547
Funds that hold global equity investments [Member]
Defined Benefit Plan Disclosure [Line Items]
Defined benefit plan, fair value of plan assets	6,277	8,255
Diversified Growth Funds [Member]
Defined Benefit Plan Disclosure [Line Items]
Defined benefit plan, fair value of plan assets	15,248	12,569
Other [Member]
Defined Benefit Plan Disclosure [Line Items]
Defined benefit plan, fair value of plan assets	$ 563	$ 576

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Employee Benefit Plans - Schedule of Expected Benefit Payments Under the Defined Benefit Plans (Detail) $ in Thousands	Dec. 31, 2015 USD ($)
Compensation And Retirement Disclosure [Abstract]
2016	$ 6,684
2017	6,615
2018	7,096
2019	7,802
2020	9,092
Years 2021 through 2025	66,117
Total	$ 103,406

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Employee Benefit Plans - Stock Incentive Plans - Additional Information (Detail) - USD ($)	1 Months Ended	12 Months Ended
	Jul. 31, 2012	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expiry period of options from grant date		10 years
Percentage of options granted per annum	20.00%
Weighted average remaining contractual life of the options outstanding		6 years 10 months 21 days
Weighted average remaining contractual life of the options exercisable		5 years 10 months 24 days
Aggregate intrinsic value of the exercisable stock options and the stock options expected to vest		$ 201,000,000
Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted average fair value per share of options granted		$ 21.96	$ 18.72	$ 14.39
Total intrinsic value of options exercised		$ 143,700,000	$ 77,300,000	$ 27,100,000
Proceeds from options exercised		$ 58,500,000	$ 33,100,000	$ 12,500,000
Second Anniversary of Grant Date [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options granted per annum		25.00%
Third Anniversary Of Grant Date [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options granted per annum		33.00%
Fourth Anniversary Of Grant Date [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options granted per annum		67.00%
Vesting Scenario One [Member] | First Anniversary Of Grant Date [Member] | Non Employee Director
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options granted per annum		100.00%
Vesting Scenario Two [Member] | Second Anniversary of Grant Date [Member] | Non Employee Director
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options granted per annum		33.00%
Vesting Scenario Two [Member] | Third Anniversary Of Grant Date [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options granted per annum		33.00%
Vesting Scenario Two [Member] | First Anniversary Of Grant Date [Member] | Non Employee Director
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options granted per annum		34.00%
Stock Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares available for future grant		7,372,127
Stock appreciation rights (SARs) [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock appreciation rights vesting description		These awards either (i) vest 25% per year or (ii) vest 33% on the third anniversary of the date of grant and 67% on the fourth anniversary of the date of grant.
Fair value of Stock Appreciation Rights granted		$ 29.79	$ 27.17	$ 19.07
Cash paid to settle exercised SARs		$ 967,000	$ 408,000	$ 83,000
Weighted average remaining contractual life of SARs outstanding		8 years 1 month 6 days
Weighted average remaining contractual life of SARs exercisable		7 years 4 months 24 days
Aggregate intrinsic value of exercisable expected to vest		$ 9,500,000
Number of stock units outstanding		530,701	418,801
Intrinsic value of stock units outstanding		$ 9,659,000	$ 6,417,000
Stock appreciation rights (SARs) [Member] | Third Anniversary Of Grant Date [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options granted per annum		33.00%
Stock appreciation rights (SARs) [Member] | Fourth Anniversary Of Grant Date [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options granted per annum		67.00%
Stock appreciation rights (SARs) [Member] | 25% per year [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options granted per annum		25.00%
Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options granted per annum		25.00%
Number of days for stock units to settle in common stock from vesting date		45 days
Number of stock units outstanding		359,553
Intrinsic value of stock units outstanding		$ 24,700,000
Restricted Stock [Member] | Third Anniversary Of Grant Date [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options granted per annum		33.00%
Restricted Stock [Member] | Fourth Anniversary Of Grant Date [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of options granted per annum		67.00%
Restricted Stock [Member] | Vesting Scenario One [Member] | First Anniversary Of Grant Date [Member] | Non Employee Director
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of RSU granted per annum		100.00%
Restricted Stock [Member] | Vesting Scenario Two [Member] | Second Anniversary of Grant Date [Member] | Non Employee Director
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of RSU granted per annum		33.00%
Restricted Stock [Member] | Vesting Scenario Two [Member] | Third Anniversary Of Grant Date [Member] | Non Employee Director
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of RSU granted per annum		33.00%
Restricted Stock [Member] | Vesting Scenario Two [Member] | First Anniversary Of Grant Date [Member] | Non Employee Director
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of RSU granted per annum		34.00%
Performance Shares [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Fair value of Stock Appreciation Rights granted		$ 64.93
Number of stock units outstanding		49,667
Intrinsic value of stock units outstanding		$ 3,400,000

XML

Employee Benefit Plans - Assumptions Used to Estimate Value of Share-Based Compensation for Stock Options and Stock Appreciation Rights Issued (Detail)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Share based Compensation Arrangement by Share based Payment Award, Fair Value Assumptions, Method Used [Line Items]
Expected volatility, Minimum	26.00%	26.00%	18.00%
Expected volatility, Maximum	41.00%	43.00%	47.00%
Weighted average expected volatility	34.00%	36.00%	40.00%
Expected dividends	0.00%	0.00%
Risk-free interest rate, Minimum	1.06%	0.28%	0.04%
Risk-free interest rate, Maximum	2.04%	2.21%	2.24%
Minimum [Member]
Share based Compensation Arrangement by Share based Payment Award, Fair Value Assumptions, Method Used [Line Items]
Expected dividends			0.00%
Expected term (in years)	3 years 8 months 12 days	1 year 6 months	3 months
Maximum [Member]
Share based Compensation Arrangement by Share based Payment Award, Fair Value Assumptions, Method Used [Line Items]
Expected dividends			5.45%
Expected term (in years)	6 years 8 months 12 days	6 years 8 months 12 days	6 years 4 months 24 days

XML

Employee Benefit Plans - Summary of Stock Option Activity (Detail) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014
Compensation And Retirement Disclosure [Abstract]
Number of Options Outstanding at Beginning Balance	9,124,954
Number of Options, Granted	993,600
Number of Options, Exercised	(3,013,190)
Number of Options, Canceled	(457,365)
Number of Options Outstanding at Ending Balance	6,647,999
Weighted Average Exercise Price Outstanding at Beginning Balance	$ 29.15
Weighted Average Exercise Price, Granted	65.05
Weighted Average Exercise Price, Exercised	19.41
Weighted Average Exercise Price, Canceled	42.08
Weighted Average Exercise Price Outstanding at Ending Balance	$ 38.04
Aggregate Intrinsic Value	$ 203,679	$ 271,216

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Employee Benefit Plans - Schedule of Stock Options Outstanding and Exercisable (Detail)	12 Months Ended
	Dec. 31, 2015 $ / shares shares
Exercise Price Range $5.76 - $21.69 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding | shares	1,063,999
Exercise Price Lower Range Outstanding	$ 5.76
Exercise Price Upper Range Outstanding	21.69
Weighted Average Exercise Price Outstanding	$ 17.58
Weighted Average Remaining Life Outstanding (in years)	4 years 2 months 9 days
Number of Options Exercisable | shares	947,799
Weighted Average Exercise Price	$ 17.14
Exercise Price Range $22.10 - $23.83 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding | shares	1,069,630
Exercise Price Lower Range Outstanding	$ 22.01
Exercise Price Upper Range Outstanding	23.83
Weighted Average Exercise Price Outstanding	$ 23.79
Weighted Average Remaining Life Outstanding (in years)	6 years 3 months 26 days
Number of Options Exercisable | shares	661,630
Weighted Average Exercise Price	$ 23.79
Exercise Price Range $24.59 - $30.07 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding | shares	867,197
Exercise Price Lower Range Outstanding	$ 24.59
Exercise Price Upper Range Outstanding	30.07
Weighted Average Exercise Price Outstanding	$ 25.07
Weighted Average Remaining Life Outstanding (in years)	6 years 3 months 18 days
Number of Options Exercisable | shares	545,947
Weighted Average Exercise Price	$ 24.97
Exercise Price Range $40.00 - $40.00 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding | shares	1,241,087
Exercise Price Lower Range Outstanding	$ 40.00
Exercise Price Upper Range Outstanding	40.00
Weighted Average Exercise Price Outstanding	$ 40.00
Weighted Average Remaining Life Outstanding (in years)	7 years 1 month 6 days
Number of Options Exercisable | shares	421,837
Weighted Average Exercise Price	$ 40.00
Exercise Price Range $42.74 - $53.26 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding | shares	1,208,586
Exercise Price Lower Range Outstanding	$ 42.74
Exercise Price Upper Range Outstanding	53.26
Weighted Average Exercise Price Outstanding	$ 50.76
Weighted Average Remaining Life Outstanding (in years)	8 years
Number of Options Exercisable | shares	261,334
Weighted Average Exercise Price	$ 50.30
Exercise Price Range $57.00 - $77.11 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Options Outstanding | shares	1,197,500
Exercise Price Lower Range Outstanding	$ 57.00
Exercise Price Upper Range Outstanding	77.11
Weighted Average Exercise Price Outstanding	$ 63.44
Weighted Average Remaining Life Outstanding (in years)	8 years 10 months 13 days
Number of Options Exercisable | shares	58,375
Weighted Average Exercise Price	$ 57.43

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Employee Benefit Plans - Schedule of Stock Appreciation Rights Activity (Detail) - Stock appreciation rights (SARs) [Member] - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of SARs Outstanding Beginning Balance	418,801
Number of SARs Granted	176,200
Number of SARs Exercised	(33,262)
Number of SARs Canceled	(31,038)
Number of SARs Outstanding Ending Balance	530,701
Weighted Average Grant Price Outstanding Beginning Balance	$ 43.55
Weighted Average Grant Price Granted	64.93
Weighted Average Grant Price Exercised	39.61
Weighted Average Grant Price Canceled	51.00
Weighted Average Grant Price Outstanding Ending Balance	$ 50.46
Aggregate Intrinsic Value	$ 9,659	$ 6,417

XML

Employee Benefit Plans - Summary of Company's RSU Activity (Detail) - Restricted Stock Units (RSUs) [Member]	12 Months Ended
	Dec. 31, 2015 $ / shares shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Units Non-vested Beginning Balance | shares	93,667
Number of Units Granted | shares	276,922
Number of Units Vested | shares	(918)
Number of Units Canceled | shares	(10,118)
Number of Units Non-vested Ending Balance | shares	359,553
Weighted Average Grant-Date Fair Value Non-vested Beginning Balance | $ / shares	$ 45.89
Weighted Average Grant-Date Fair Value Granted | $ / shares	65.61
Weighted Average Grant-Date Fair Value Vested | $ / shares	47.87
Weighted Average Grant-Date Fair Value Canceled | $ / shares	62.77
Weighted Average Grant-Date Fair Value Non-vested Ending Balance | $ / shares	$ 60.60

XML

Employee Benefit Plans - Summary of Company's Performance Units Activity (Detail) - Performance Shares [Member]	12 Months Ended
	Dec. 31, 2015 $ / shares shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Units Granted | shares	51,977
Number of Units Canceled | shares	(2,310)
Number of Units Non-vested Ending Balance | shares	49,667
Weighted Average Grant-Date Fair Value Granted | $ / shares	$ 64.93
Weighted Average Grant-Date Fair Value Canceled | $ / shares	64.93
Weighted Average Grant-Date Fair Value Non-vested Ending Balance | $ / shares	$ 64.93

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Employee Benefit Plans - Employee Stock Purchase Plan and Other - Additional Information (Detail)	12 Months Ended
	Dec. 31, 2015 USD ($) Position shares	Dec. 31, 2014 USD ($) shares
Employee Stock Purchase Plan And Cost Reduction Initiative Disclosure [Line Items]
Severance expenses payable	$ 3,337,000	$ 6,274,000
Number of positions expected to be eliminated | Position	270
Severance expense, net of reversals	$ (1,042,000)
Product Development [Member]
Employee Stock Purchase Plan And Cost Reduction Initiative Disclosure [Line Items]
Severance expense, net of reversals	(837,000)
Integrated Healthcare Services [Member]
Employee Stock Purchase Plan And Cost Reduction Initiative Disclosure [Line Items]
Severance expense, net of reversals	$ (205,000)
Employee Stock Purchase Plan [Member]
Employee Stock Purchase Plan And Cost Reduction Initiative Disclosure [Line Items]
Employee stock purchase plan payroll deductions percent	10.00%
Discount on closing price of share	15.00%
Fair market value of shares under ESPP	$ 25,000
Number of shares issued for purchases under ESPP | shares	90,079	46,032
Employee stock purchase plan amendment, description	Offering periods under the ESPP are six months in duration. The first two offering periods for the ESPP began March 1, 2014 and September 1, 2014, respectively. In November 2014, the ESPP was amended to change the start of the offering periods to begin on April 1 and October 1 of each year, beginning April 1, 2015.
Employee Stock Purchase Plan [Member] | Maximum [Member]
Employee Stock Purchase Plan And Cost Reduction Initiative Disclosure [Line Items]
Aggregate number of shares that may be issued under ESPP | shares	2,500,000

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Employee Benefit Plans - Summary of Severance Associated with Cost Reduction Programs (Detail) $ in Thousands	12 Months Ended
	Dec. 31, 2015 USD ($)
Compensation And Retirement Disclosure [Abstract]
Severance expenses payable, opening balance	$ 6,274
Severance expense, net of reversals	(1,042)
Severance payments	(1,873)
Severance foreign currency translation	(22)
Severance expenses payable, ending balance	$ 3,337

XML

Related Party Transactions - Additional Information (Detail) - USD ($)		3 Months Ended	12 Months Ended
	Feb. 28, 2015	Jun. 30, 2013	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Board of Directors Chairman [Member]
Related Party Transaction [Line Items]
Business related travel expense			$ 1,300,000	$ 1,800,000	$ 2,700,000
Payment of fee for modification of agreement relating to business usage of airplane		$ 1,500,000
Board of Directors Chairman [Member] | Maximum [Member]
Related Party Transaction [Line Items]
Maximum future annual reimbursements		$ 2,500,000
HUYA Bioscience International, LLC [Member]
Related Party Transaction [Line Items]
Additional consideration agreement			16,500,000
Gain on termination of collaboration agreement	$ 5,000,000
HUYA Bioscience International, LLC [Member] | Maximum [Member]
Related Party Transaction [Line Items]
Related party fund to research and development activity			2,300,000
Affiliated Entity [Member]
Related Party Transaction [Line Items]
Fee for services			6,900,000	2,300,000	772,000
Sublease income				76,000
Affiliated Entity [Member] | Maximum [Member]
Related Party Transaction [Line Items]
Fee for services			$ 31,700,000	$ 416,000	$ 19,200,000

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Operations by Geographic Location - Additional Information (Detail)	12 Months Ended
	Dec. 31, 2015
Operations By Geographic Location [Abstract]
Minimum percentage of revenue account for major country	10.00%

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Operations by Geographic Location - Operations Within Geographic Region (Detail) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Geographic Information [Line Items]
Sales Revenue Services Net	$ 1,128,599	$ 1,093,480	$ 1,074,366	$ 1,029,974	$ 1,064,045	$ 1,061,013	$ 1,035,476	$ 1,005,288	$ 4,326,419	$ 4,165,822	$ 3,808,340
Reimbursed expenses									1,411,200	1,294,176	1,291,205
Total revenues									5,737,619	5,459,998	5,099,545
Americas [Member]
Geographic Information [Line Items]
Sales Revenue Services Net									1,973,501	1,783,999	1,532,974
Americas [Member] | United States [Member]
Geographic Information [Line Items]
Sales Revenue Services Net									1,787,918	1,589,402	1,351,160
Americas [Member] | Other [Member]
Geographic Information [Line Items]
Sales Revenue Services Net									185,583	194,597	181,814
Europe and Africa [Member]
Geographic Information [Line Items]
Sales Revenue Services Net									1,459,990	1,523,538	1,501,504
Europe and Africa [Member] | Other [Member]
Geographic Information [Line Items]
Sales Revenue Services Net									1,050,070	1,121,354	1,139,262
Europe and Africa [Member] | United Kingdom [Member]
Geographic Information [Line Items]
Sales Revenue Services Net									409,920	402,184	362,242
Asia-Pacific [Member]
Geographic Information [Line Items]
Sales Revenue Services Net									892,928	858,285	773,862
Asia-Pacific [Member] | Other [Member]
Geographic Information [Line Items]
Sales Revenue Services Net									449,971	386,454	334,980
Asia-Pacific [Member] | Japan [Member]
Geographic Information [Line Items]
Sales Revenue Services Net									$ 442,957	$ 471,831	$ 438,882

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Operations by Geographic Location - Long Lived Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Long Lived Assets Geographic [Line Items]
Property, equipment and software, net	$ 271,170	$ 279,878
Americas [Member]
Long Lived Assets Geographic [Line Items]
Property, equipment and software, net	170,878	169,664
Americas [Member] | United States [Member]
Long Lived Assets Geographic [Line Items]
Property, equipment and software, net	169,674	167,890
Americas [Member] | Other [Member]
Long Lived Assets Geographic [Line Items]
Property, equipment and software, net	1,204	1,774
Europe and Africa [Member]
Long Lived Assets Geographic [Line Items]
Property, equipment and software, net	62,657	64,191
Europe and Africa [Member] | Other [Member]
Long Lived Assets Geographic [Line Items]
Property, equipment and software, net	16,615	15,782
Europe and Africa [Member] | United Kingdom [Member]
Long Lived Assets Geographic [Line Items]
Property, equipment and software, net	46,042	48,409
Asia-Pacific [Member]
Long Lived Assets Geographic [Line Items]
Property, equipment and software, net	37,635	46,023
Asia-Pacific [Member] | Other [Member]
Long Lived Assets Geographic [Line Items]
Property, equipment and software, net	24,975	25,271
Asia-Pacific [Member] | Japan [Member]
Long Lived Assets Geographic [Line Items]
Property, equipment and software, net	$ 12,660	$ 20,752

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Segments - Additional Information (Detail) $ in Millions	12 Months Ended
	Dec. 31, 2015 Segment	Dec. 31, 2013 USD ($)
Segment Reporting [Abstract]
Number of reportable segments | Segment	2
Management agreement termination fee		$ 25.0
Agreement modification fee		$ 1.5

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Segments - Operations by Reportable Segments (Detail) - USD ($)	3 Months Ended								12 Months Ended
	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Segment Reporting Information [Line Items]
Service revenues	$ 1,128,599,000	$ 1,093,480,000	$ 1,074,366,000	$ 1,029,974,000	$ 1,064,045,000	$ 1,061,013,000	$ 1,035,476,000	$ 1,005,288,000	$ 4,326,419,000	$ 4,165,822,000	$ 3,808,340,000
Costs of revenue, service costs									2,725,586,000	2,684,106,000	2,471,426,000
Selling, general and administrative									920,985,000	882,338,000	860,510,000
Income from operations	$ 177,983,000	$ 167,023,000	$ 158,389,000	$ 143,217,000	$ 158,932,000	$ 149,142,000	$ 141,000,000	$ 141,316,000	646,612,000	590,390,000	462,333,000
Restructuring costs									(30,752,000)	(8,988,000)	(14,071,000)
Impairment charges									(2,484,000)	0	0
Operating Segments [Member] | Product Development [Member]
Segment Reporting Information [Line Items]
Service revenues									3,191,630,000	3,097,831,000	2,919,730,000
Costs of revenue, service costs									1,828,734,000	1,820,937,000	1,752,800,000
Selling, general and administrative									648,297,000	631,678,000	604,663,000
Income from operations									714,599,000	645,216,000	562,267,000
Operating Segments [Member] | Integrated Healthcare Services [Member]
Segment Reporting Information [Line Items]
Service revenues									1,134,789,000	1,067,991,000	888,610,000
Costs of revenue, service costs									896,852,000	863,169,000	718,626,000
Selling, general and administrative									153,896,000	140,019,000	127,860,000
Income from operations									84,041,000	64,803,000	42,124,000
Corporate, Non-Segment [Member]
Segment Reporting Information [Line Items]
Selling, general and administrative									118,792,000	110,641,000	127,987,000
Income from operations									$ (118,792,000)	$ (110,641,000)	$ (127,987,000)

XML

Segments - Reconciliation of Assets from Segments to Consolidated (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Segment Reporting Information [Line Items]
Assets	$ 3,926,316	$ 3,295,953	$ 3,054,223
Operating Segments [Member] | Product Development [Member]
Segment Reporting Information [Line Items]
Assets	3,343,502	2,786,692	2,571,502
Operating Segments [Member] | Integrated Healthcare Services [Member]
Segment Reporting Information [Line Items]
Assets	405,411	330,689	299,284
Corporate, Non-Segment [Member]
Segment Reporting Information [Line Items]
Assets	$ 177,403	$ 178,572	$ 183,437

XML

Segments - Reconciliation of Other Significant Reconciling Items from Segments to Consolidated (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Segment Reporting Information [Line Items]
Expenditures to acquire long-lived assets	$ 78,391	$ 82,650	$ 88,347
Operating Segments [Member] | Product Development [Member]
Segment Reporting Information [Line Items]
Expenditures to acquire long-lived assets	67,660	68,187	69,375
Operating Segments [Member] | Integrated Healthcare Services [Member]
Segment Reporting Information [Line Items]
Expenditures to acquire long-lived assets	8,667	8,279	17,398
Corporate, Non-Segment [Member]
Segment Reporting Information [Line Items]
Expenditures to acquire long-lived assets	$ 2,064	$ 6,184	$ 1,574

XML

Segments - Depreciation and Amortization Expense (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Segment Reporting Information [Line Items]
Depreciation and amortization expense	$ 127,742	$ 121,013	$ 107,504
Operating Segments [Member] | Product Development [Member]
Segment Reporting Information [Line Items]
Depreciation and amortization expense	100,913	95,168	82,047
Operating Segments [Member] | Integrated Healthcare Services [Member]
Segment Reporting Information [Line Items]
Depreciation and amortization expense	21,961	20,821	20,475
Corporate, Non-Segment [Member]
Segment Reporting Information [Line Items]
Depreciation and amortization expense	$ 4,868	$ 5,024	$ 4,982

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Earnings Per Share - Reconciles the Basic to Diluted Weighted Average Shares Outstanding (Detail) - shares shares in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Earnings Per Share [Abstract]
Basic weighted average common shares outstanding	123,038	127,994	124,147
Effect of dilutive stock options and share awards	2,592	3,089	3,715
Diluted weighted average common shares outstanding	125,630	131,083	127,862

XML

Earnings Per Share - Summary of Weighted-Average Outstanding Share-Based Awards Excluded from Computation of Diluted Earnings Per Share (Detail) - shares shares in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Earnings Per Share [Abstract]
Weighted average shares subject to anti-dilutive share-based awards	1,058	1,241	1,765

XML

Comprehensive Income - Summary of Components of AOCI (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Accumulated Other Comprehensive Income (Loss) [Line Items]
Beginning Balance	$ 30,499	$ 25,644	$ 29,693
Other comprehensive (loss) income before reclassifications, tax	9,110	7,225	1,331
Reclassification adjustments, tax	(6,181)	(2,370)	(5,380)
Ending Balance	33,428	30,499	25,644
Beginning Balance	(704,061)
Ending Balance	(564,217)	(704,061)
Foreign Currency Translation [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Beginning Balance	(55,740)	(5,829)	19,312
Other comprehensive (loss) income before reclassifications, before tax	(61,090)	(49,911)	(25,141)
Ending Balance	(116,830)	(55,740)	(5,829)
Marketable Securities [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Beginning Balance	(272)	5,708	467
Other comprehensive (loss) income before reclassifications, before tax	(436)	(976)	5,241
Reclassification adjustments, before tax		(5,004)
Ending Balance	(708)	(272)	5,708
Derivative Instruments [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Beginning Balance	(19,059)	(20,855)	(33,542)
Other comprehensive (loss) income before reclassifications, before tax	(13,202)	(6,834)	(393)
Reclassification adjustments, before tax	18,269	8,630	13,080
Ending Balance	(13,992)	(19,059)	(20,855)
Defined Benefit Plans [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Beginning Balance	(14,519)	(5,044)	(8,235)
Other comprehensive (loss) income before reclassifications, before tax	282	(10,218)	2,147
Reclassification adjustments, before tax	973	743	1,044
Ending Balance	(13,264)	(14,519)	(5,044)
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Beginning Balance	(59,091)	(376)	7,695
Other comprehensive (loss) income before reclassifications, net of tax	(65,336)	(60,714)	(16,815)
Reclassification adjustments, net of tax	13,061	1,999	8,744
Ending Balance	$ (111,366)	$ (59,091)	$ (376)

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Comprehensive Income - Summary of (Gains) Losses Reclassified from AOCI into Condensed Consolidated Statements of Income and Affected Financial Statement Line Item (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Reclassification Adjustment out of Accumulated Other Comprehensive Income [Line Items]
Total before income taxes		$ (5,004)
Income tax expense		(1,927)
Total net of income taxes		(3,077)
Total before income taxes	$ 18,269	8,630	$ 13,080
Income tax benefit	5,826	4,022	4,991
Total net of income taxes	12,443	4,608	8,089
Amortization of prior service costs		107	336
Amortization of actuarial losses	973	636	708
Total before income taxes	973	743	1,044
Income tax benefit	355	275	389
Total net of income taxes	618	468	655
Other Nonoperating Expense (Income), Net [Member]
Reclassification Adjustment out of Accumulated Other Comprehensive Income [Line Items]
Total before income taxes		(5,004)
Interest Rate Swaps [Member] | Interest Expense [Member]
Reclassification Adjustment out of Accumulated Other Comprehensive Income [Line Items]
Total before income taxes	12,333	12,424	12,582
Foreign Exchange Forward Contracts [Member] | Service Revenues [Member]
Reclassification Adjustment out of Accumulated Other Comprehensive Income [Line Items]
Total before income taxes	$ 5,936	$ (3,794)	$ 498

XML

Supplemental Cash Flow Information - Supplemental Cash Flow Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Supplemental Cash Flow Information:
Interest paid	$ 82,333	$ 93,912	$ 115,494
Income taxes paid, net of refunds	120,804	138,931	70,983
Non-cash Investing Activities:
Acquisition of property and equipment utilizing capital leases	4,238	$ 2,476	3,761
Fair value of contingent consideration payable in connection with acquisitions			$ 14,300
Fair value of consideration transferred in connection with acquisitions	423,268
Q2 Solutions
Non-cash Investing Activities:
Fair value of consideration transferred in connection with acquisitions	$ 423,268

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Quarterly Financial Data - Unaudited Quarterly Results of Operations (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Income Statement [Abstract]
Service revenues	$ 1,128,599	$ 1,093,480	$ 1,074,366	$ 1,029,974	$ 1,064,045	$ 1,061,013	$ 1,035,476	$ 1,005,288	$ 4,326,419	$ 4,165,822	$ 3,808,340
Income from operations	177,983	167,023	158,389	143,217	158,932	149,142	141,000	141,316	646,612	590,390	462,333
Net income	108,087	108,839	84,947	86,431	88,444	92,733	85,110	90,214	388,304	356,501	226,027
Net (income) loss attributable to noncontrolling interests	(3,517)	2,447	4	(33)	(18)	(79)	10	(31)	(1,099)	(118)	564
Net income attributable to Quintiles Transnational Holdings Inc.	$ 104,570	$ 111,286	$ 84,951	$ 86,398	$ 88,426	$ 92,654	$ 85,120	$ 90,183	$ 387,205	$ 356,383	$ 226,591
Basic earnings per share	$ 0.86	$ 0.91	$ 0.69	$ 0.69	$ 0.70	$ 0.73	$ 0.66	$ 0.69	$ 3.15	$ 2.78	$ 1.83
Diluted earnings per share	$ 0.85	$ 0.89	$ 0.67	$ 0.68	$ 0.69	$ 0.71	$ 0.64	$ 0.68	$ 3.08	$ 2.72	$ 1.77

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Subsequent Event - Additional Information (Detail) $ in Millions	Feb. 29, 2016 USD ($)
Subsequent Event [Member]
Subsequent Event [Line Items]
Restructuring plan approved	$ 22

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Schedule I - Condensed Statements of Income (Detail) - USD ($) $ in Thousands	3 Months Ended									12 Months Ended
	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Jun. 30, 2013	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Condensed Income Statements, Captions [Line Items]
Selling, general and administrative										$ 920,985	$ 882,338	$ 860,510
Loss from operations	$ 177,983	$ 167,023	$ 158,389	$ 143,217	$ 158,932	$ 149,142	$ 141,000	$ 141,316		646,612	590,390	462,333
Interest income										(4,317)	(3,410)	(3,937)
Interest expense										101,792	100,589	123,508
Loss on extinguishment of debt										7,780		19,831
Other expense, net										2,362	(8,978)	(185)
Income before income taxes and equity in earnings (losses) of unconsolidated affiliates										538,995	502,189	323,116
Income tax expense									$ (8,100)	158,989	150,056	95,965
Net income attributable to Quintiles Transnational Holdings Inc.	$ 104,570	$ 111,286	$ 84,951	$ 86,398	$ 88,426	$ 92,654	$ 85,120	$ 90,183		387,205	356,383	226,591
Parent Company [Member]
Condensed Income Statements, Captions [Line Items]
Selling, general and administrative										715	1,509	2
Loss from operations										(715)	(1,509)	(2)
Interest income										(24)	(52)	(6)
Interest expense												9,242
Loss on extinguishment of debt												15,501
Other expense, net										7	8
Income before income taxes and equity in earnings (losses) of unconsolidated affiliates										(698)	(1,465)	(24,739)
Income tax expense										(530)	(810)	(9,347)
Loss before equity in earnings of subsidiary										(168)	(655)	(15,392)
Equity in earnings of subsidiary										387,373	357,038	241,983
Net income attributable to Quintiles Transnational Holdings Inc.										$ 387,205	$ 356,383	$ 226,591

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Schedule I - Condensed Statements of Comprehensive Income (Detail) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Condensed Income Statements, Captions [Line Items]
Net income	$ 108,087	$ 108,839	$ 84,947	$ 86,431	$ 88,444	$ 92,733	$ 85,110	$ 90,214	$ 388,304	$ 356,501	$ 226,027
Comprehensive income adjustments:
Unrealized gain (loss) on marketable securities, net of tax									(268)	(600)	3,225
Unrealized gain (loss) on derivative instruments, net of tax									(9,523)	(5,067)	358
Defined benefit plan adjustments, net of income taxes of $318, ($2,981) and ($131)									36	7,237	(2,278)
Foreign currency translation, net of income taxes of ($5,581), ($2,101) and ($2,465)									(60,024)	(47,807)	(22,663)
Reclassification adjustments:
Gains on marketable securities included in net income, net of income taxes of ($1,927)										(3,077)
Losses on derivative instruments included in net income, net of income taxes of $5,826, $4,022 and $4,991									12,443	4,608	8,089
Amortization of prior service costs and losses included in net income, net of income taxes of $355, $275 and $389									(618)	(468)
Comprehensive income attributable to Quintiles Transnational Holdings Inc.									334,930	297,668	218,520
Parent Company [Member]
Condensed Income Statements, Captions [Line Items]
Net income									387,205	356,383	226,591
Comprehensive income adjustments:
Unrealized gain (loss) on marketable securities, net of tax									(268)	(600)	3,225
Unrealized gain (loss) on derivative instruments, net of tax									(9,523)	(5,067)	358
Defined benefit plan adjustments, net of income taxes of $318, ($2,981) and ($131)									(36)	(7,237)	2,278
Foreign currency translation, net of income taxes of ($5,581), ($2,101) and ($2,465)									(55,509)	(47,810)	(22,676)
Reclassification adjustments:
Gains on marketable securities included in net income, net of income taxes of ($1,927)										(3,077)
Losses on derivative instruments included in net income, net of income taxes of $5,826, $4,022 and $4,991									12,443	4,608	8,089
Amortization of prior service costs and losses included in net income, net of income taxes of $355, $275 and $389									618	468	655
Comprehensive income attributable to Quintiles Transnational Holdings Inc.									$ 334,930	$ 297,668	$ 218,520

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Schedule I - Condensed Statements of Comprehensive Income (Parenthetical) (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Condensed Income Statements, Captions [Line Items]
Unrealized (losses) gains on marketable securities, income taxes	$ (168)	$ (376)	$ 2,016
Unrealized (losses) gains on derivative instruments, income taxes	(3,679)	(1,767)	(751)
Defined benefit plan adjustment, income taxes	318	(2,981)	(131)
Foreign currency translation, income taxes	(5,581)	(2,101)	(2,465)
Gains on marketable securities included in net income, net of income taxes		1,927
Losses on derivative instruments included in net income, income taxes	5,826	4,022	4,991
Amortization of prior service costs and losses included in net income, income taxes	355	275	389
Parent Company [Member]
Condensed Income Statements, Captions [Line Items]
Unrealized (losses) gains on marketable securities, income taxes	(168)	(376)	2,016
Unrealized (losses) gains on derivative instruments, income taxes	(3,679)	(1,767)	(751)
Defined benefit plan adjustment, income taxes	318	(2,981)	(131)
Foreign currency translation, income taxes	(5,581)	(2,101)	(2,465)
Gains on marketable securities included in net income, net of income taxes		(1,927)
Losses on derivative instruments included in net income, income taxes	5,826	4,022	4,991
Amortization of prior service costs and losses included in net income, income taxes	$ 355	$ 275	$ 389

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Schedule I - Condensed Balance Sheets (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Current assets:
Cash and cash equivalents	$ 977,151	$ 867,358	$ 778,143	$ 567,728
Income taxes receivable	34,089	45,357
Other current assets and receivables	80,916	92,088
Total current assets	2,411,985	2,146,083
Deferred income taxes	42,684	35,972
Total assets	3,926,316	3,295,953	3,054,223
Current liabilities:
Accounts payable	145,484	108,743
Accrued expenses	760,757	733,644
Total current liabilities	1,594,176	1,471,900
Total liabilities	$ 4,261,997	$ 3,999,965
Commitments and contingencies (Note 1)
Shareholders’ deficit:
Common stock and additional paid-in capital, 300,000 shares authorized, $0.01 par value, 119,378 and 124,129 shares issued and outstanding at December 31, 2015 and 2014, respectively	$ 8,784	$ 143,828
Accumulated deficit	(461,635)	(788,798)
Accumulated other comprehensive loss	(111,366)	(59,091)
Deficit attributable to Quintiles Transnational Holdings Inc.’s shareholders	(564,217)	(704,061)
Total liabilities and shareholders’ deficit	3,926,316	3,295,953
Parent Company [Member]
Current assets:
Cash and cash equivalents	4,791	11,635	$ 71,942	$ 2,411
Income taxes receivable	128	546
Other current assets and receivables	16	114
Total current assets	4,935	12,295
Deferred income taxes		7
Total assets	4,935	12,302
Current liabilities:
Accounts payable	7	21
Accrued expenses		84
Total current liabilities	7	105
Investment in subsidiary	568,785	716,148
Payable to subsidiary	360	110
Total liabilities	$ 569,152	$ 716,363
Commitments and contingencies (Note 1)
Shareholders’ deficit:
Common stock and additional paid-in capital, 300,000 shares authorized, $0.01 par value, 119,378 and 124,129 shares issued and outstanding at December 31, 2015 and 2014, respectively	$ 8,784	$ 143,828
Accumulated deficit	(461,635)	(788,798)
Accumulated other comprehensive loss	(111,366)	(59,091)
Deficit attributable to Quintiles Transnational Holdings Inc.’s shareholders	(564,217)	(704,061)
Total liabilities and shareholders’ deficit	$ 4,935	$ 12,302

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Schedule I - Condensed Balance Sheets (Parenthetical) (Detail) - $ / shares	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Condensed Balance Sheet Statements Captions [Line Items]
Common stock, shares authorized	300,000,000	300,000,000
Common stock, par value	$ 0.01	$ 0.01
Common stock, shares issued	119,378,000	124,129,000
Common stock, shares outstanding	119,377,731	124,129,340	129,651,907	115,763,510
Parent Company [Member]
Condensed Balance Sheet Statements Captions [Line Items]
Common stock, shares authorized	300,000,000	300,000,000
Common stock, par value	$ 0.01	$ 0.01
Common stock, shares issued	119,378,000	124,129,000
Common stock, shares outstanding	119,378,000	124,129,000

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Schedule I - Condensed Statements of Cash Flows (Detail) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Operating activities:
Net income	$ 108,087	$ 108,839	$ 84,947	$ 86,431	$ 88,444	$ 92,733	$ 85,110	$ 90,214	$ 388,304	$ 356,501	$ 226,027
Adjustments to reconcile net income to cash provided by operating activities:
Amortization of debt issuance costs and discount									9,170	6,688	21,825
(Benefit from) provision for deferred income taxes									18,351	(6,168)	(24,236)
Changes in operating assets and liabilities:
Accounts receivable and unbilled services									(246,028)	(78,630)	(151,681)
Accounts payable and accrued expenses									104,350	45,804	107,047
Investing activities:
Investments in subsidiary, net of payments received									(12,350)	(4,472)	(7,353)
Net cash used in investing activities									(66,955)	(173,114)	(236,176)
Financing activities:
Repayment of debt									(2,056,780)	(30,157)	(2,444,600)
Issuance of common stock											525,000
Payment of common stock issuance costs										(105)	(35,439)
Stock issued under employee stock purchase and option plans									64,297	35,228	12,539
Repurchase of common stock									(515,010)	(415,131)	(6,434)
Repurchase of stock options										(8,415)	(50,649)
Net cash (used in) provided by financing activities									(249,246)	(130,344)	70,957
Increase (decrease) in cash and cash equivalents									109,793	89,215	210,415
Cash and cash equivalents at beginning of period				867,358				778,143	867,358	778,143	567,728
Cash and cash equivalents at end of period	977,151				867,358				977,151	867,358	778,143
Parent Company [Member]
Operating activities:
Net income									387,205	356,383	226,591
Adjustments to reconcile net income to cash provided by operating activities:
Amortization of debt issuance costs and discount											10,346
Subsidiary loss (income)									56,627	(27,623)	(119,998)
(Benefit from) provision for deferred income taxes									(335)	37	304
Changes in operating assets and liabilities:
Accounts receivable and unbilled services										2,994	(2,995)
Prepaid expenses and other assets											(21)
Accounts payable and accrued expenses									(69)	65	(62)
Income taxes payable and other liabilities									(195)	(847)	(9,651)
Net cash provided by operating activities									443,233	331,009	104,514
Investing activities:
Investments in subsidiary, net of payments received											(179,847)
Net cash used in investing activities											(179,847)
Financing activities:
Repayment of debt											(300,000)
Issuance of common stock											525,000
Payment of common stock issuance costs										(105)	(35,439)
Stock issued under employee stock purchase and option plans									64,297	35,228	12,539
Repurchase of common stock									(515,010)	(415,131)	(6,434)
Repurchase of stock options										(8,415)	(50,649)
Intercompany with subsidiary									636	(2,893)	(153)
Net cash (used in) provided by financing activities									(450,077)	(391,316)	144,864
Increase (decrease) in cash and cash equivalents									(6,844)	(60,307)	69,531
Cash and cash equivalents at beginning of period				$ 11,635				$ 71,942	11,635	71,942	2,411
Cash and cash equivalents at end of period	$ 4,791				$ 11,635				$ 4,791	$ 11,635	$ 71,942

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Schedule I - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Jun. 30, 2013	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Condensed Financial Statements, Captions [Line Items]
Income tax benefit	$ 8,100	$ (158,989)	$ (150,056)	$ (95,965)
Parent Company [Member]
Condensed Financial Statements, Captions [Line Items]
Minimum percentage of restricted net assets of consolidated subsidiaries of consolidated net assets		25.00%
Income tax benefit		$ 530	$ 810	$ 9,347

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Schedule I - Dividends Paid (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Dividends Payable [Line Items]
Cash dividend paid to parent company	$ 444,000	$ 329,415	$ 121,985
Paid in December 2015 [Member]
Dividends Payable [Line Items]
Cash dividend paid to parent company	1,000
Paid in November 2015 [Member]
Dividends Payable [Line Items]
Cash dividend paid to parent company	223,000
Paid in May 2015 [Member]
Dividends Payable [Line Items]
Cash dividend paid to parent company	$ 220,000
Paid in November 2014 [Member]
Dividends Payable [Line Items]
Cash dividend paid to parent company		234,000
Paid in May 2014 [Member]
Dividends Payable [Line Items]
Cash dividend paid to parent company		87,000
Paid in January 2014 [Member]
Dividends Payable [Line Items]
Cash dividend paid to parent company		$ 8,415
Paid in November and December 2013 [Member]
Dividends Payable [Line Items]
Cash dividend paid to parent company			116,585
Paid in February 2013 [Member]
Dividends Payable [Line Items]
Cash dividend paid to parent company			$ 5,400

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Schedule II - Valuation and Qualifying Accounts (Detail) - Valuation Allowance of Deferred Tax Assets [Member] - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Valuation and Qualifying Accounts Disclosure [Line Items]
Balance at Beginning of Year	$ 24,695	$ 29,501	$ 32,344
Addition Charged to Expenses	1,762	11,084	3,611
Deductions	(4,295)	(15,890)	(6,454)
Balance at End of Year	$ 22,162	$ 24,695	$ 29,501