-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 SkpCdaINeKO2ouF8qNipgUI2zGa92sZ2jjDMBSfjfP4mcWf2epOEQGebmadL/pxf
 4tt9v0BxxmFo5yh7qzI0pQ==

<SEC-DOCUMENT>0001209191-11-002019.txt : 20110105
<SEC-HEADER>0001209191-11-002019.hdr.sgml : 20110105
<ACCEPTANCE-DATETIME>20110105182011
ACCESSION NUMBER:		0001209191-11-002019
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20110103
FILED AS OF DATE:		20110105
DATE AS OF CHANGE:		20110105

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Shortall Eugene
		CENTRAL INDEX KEY:			0001483224

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34540
		FILM NUMBER:		11512184

	MAIL ADDRESS:	
		STREET 1:		633 LOWTHER ROAD
		CITY:			LEWISBERRY
		STATE:			PA
		ZIP:			17339

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Unilife Corp
		CENTRAL INDEX KEY:			0001476170
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				271049354
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	BUSINESS ADDRESS:	
		STREET 1:		633 LOWTHER ROAD
		CITY:			LEWISBERRY
		STATE:			PA
		ZIP:			17339
		BUSINESS PHONE:		(717)938-9323

	MAIL ADDRESS:	
		STREET 1:		633 LOWTHER ROAD
		CITY:			LEWISBERRY
		STATE:			PA
		ZIP:			17339
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>c10639_4x0.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2011-01-03</periodOfReport>

    <issuer>
        <issuerCik>0001476170</issuerCik>
        <issuerName>Unilife Corp</issuerName>
        <issuerTradingSymbol>UNIS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001483224</rptOwnerCik>
            <rptOwnerName>Shortall Eugene</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 250 CROSS FARM LANE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>YORK</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>17406</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Sr VP of Business Development</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>5.46</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2011-01-03</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>21978</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2021-01-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>21978</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>21978</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">7,326 options to purchase common stock will vest on the first anniversary of the grant date.  7,326 options to purchase common stock will vest on the second anniversary of the grant date. 7,326 options to purchase common stock will vest on the third anniversary of the grant date.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Deborah Karlak, as Attorney-in-Fact</signatureName>
        <signatureDate>2011-01-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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