-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 BqRlu0d99XB9PdzDMESEUBQSKAuB/ZDZPxfq7L70bq3fsgOh1vAOQcgIPIhyj4lv
 fAtID81TPsI/QRiigZwW5w==

<SEC-DOCUMENT>0001209191-10-040138.txt : 20100729
<SEC-HEADER>0001209191-10-040138.hdr.sgml : 20100729
<ACCEPTANCE-DATETIME>20100729172313
ACCESSION NUMBER:		0001209191-10-040138
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100727
FILED AS OF DATE:		20100729
DATE AS OF CHANGE:		20100729

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Pyers Dennis
		CENTRAL INDEX KEY:			0001497152

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34540
		FILM NUMBER:		10978816

	MAIL ADDRESS:	
		STREET 1:		633 LOWTHER ROAD
		CITY:			LEWISBERRY
		STATE:			PA
		ZIP:			17339

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Unilife Corp
		CENTRAL INDEX KEY:			0001476170
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				271049354
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	BUSINESS ADDRESS:	
		STREET 1:		633 LOWTHER ROAD
		CITY:			LEWISBERRY
		STATE:			PA
		ZIP:			17339
		BUSINESS PHONE:		(717)938-9323

	MAIL ADDRESS:	
		STREET 1:		633 LOWTHER ROAD
		CITY:			LEWISBERRY
		STATE:			PA
		ZIP:			17339
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>c03850_4x0.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-07-27</periodOfReport>

    <issuer>
        <issuerCik>0001476170</issuerCik>
        <issuerName>Unilife Corp</issuerName>
        <issuerTradingSymbol>UNIS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001497152</rptOwnerCik>
            <rptOwnerName>Pyers Dennis</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 633 LOWTHER ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LEWISBERRY</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>17339</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>See Remarks</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>6.19</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2010-07-27</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>80000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-07-27</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>80000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>80000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">20,000 options to purchase common stock will vest on the first anniversary of the grant date.  20,000 options to purchase common stock will vest on the second anniversary of the grant date.  40,000 options to purchase common stock will vest on the third anniversary of the grant date.</footnote>
    </footnotes>

    <remarks>Vice President, Controller and Chief Accounting Officer</remarks>

    <ownerSignature>
        <signatureName>/s/ Deborah Karlak, as Attorney-in-Fact</signatureName>
        <signatureDate>2010-07-29</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----