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Share-based compensation - Assumptions (Details) - $ / shares
6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Share-based compensation    
Expected volatility 85.60% 83.10%
Risk-free interest rate 2.70% 1.10%
Expected term (in years) 5 years 11 months 19 days 6 years 14 days
Fair value of common stock $ 3.64 $ 25.60