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Summary of significant accounting policies - Anti-dilutive (Details) - shares
6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Earnings Per Share, Diluted, Other Disclosures [Abstract]    
Anti-dilutive securities 3,835,756 3,378,217
Stock options    
Earnings Per Share, Diluted, Other Disclosures [Abstract]    
Anti-dilutive securities 2,532,644 2,016,036
Common stock warrants    
Earnings Per Share, Diluted, Other Disclosures [Abstract]    
Anti-dilutive securities 1,303,112 1,362,181