Novan, Inc.

4105 Hopson Road

Morrisville, North Carolina 27560

April 8, 2020

VIA EDGAR TRANSMISSION

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549-0306

Attn:	Mr. Jeffrey Gabor
Re:	Novan, Inc.
	Registration Statement on Form S-3
	Filed February 24, 2020
	File No. 333-236583
	Request for Acceleration

Dear Mr. Gabor:

Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Novan, Inc. hereby requests acceleration of the effective date of the above-referenced Registration Statement on Form S-3 (File No. 333-236583), so that it may be declared effective at 9:00 a.m., Eastern Time on Friday, April 10, 2020, or as soon thereafter as is practicable.

If you have any questions, please contact me at (919) 485-8080. Thank you in advance for your assistance.

Sincerely,

/s/ John M. Gay

John M. Gay

VP, Finance and Corporate Secretary

cc:	Paula Brown Stafford, President and Chief Executive Officer
	Amy M. Batten, Partner, Smith, Anderson, Blount, Dorsett, Mitchell & Jernigan, L.L.P.