February 26, 2020

Paula Brown Stafford
President and Chief Executive Officer
Novan, Inc.
4105 Hopson Road
Morrisville, NC 27560

       Re: Novan, Inc.
           Registration Statement on Form S-3
           Filed February 24, 2020
           File No. 333-236583

Dear Ms. Stafford:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Jeffrey Gabor at 202-551-2544 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of Life
Sciences
cc:    Amy Meyers Batten, Esq.