The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 11,966 1,536,016 SH   OTR   1,536,016 0 0
AKERO THERAPEUTICS INC COM 00973Y108 18,584 831,495 SH   OTR   831,495 0 0
ALIGOS THERAPEUTICS COM 01626L105 23,669 1,526,048 SH   OTR   1,526,048 0 0
AMICUS THERAPEUTICS INC COM 03152W109 22,204 2,325,000 SH   OTR   2,325,000 0 0
ANAPTYSBIO INC COM 032724106 35,256 1,300,000 SH   OTR   1,300,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109 72,700 2,084,883 SH   OTR   2,084,883 0 0
ARGENX SE SPONSORED ADR 04016X101 51,620 170,926 SH   OTR   170,926 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 5,220 1,500,000 SH   OTR   1,500,000 0 0
ATRECA INC CL A COM 04965G109 13,721 2,202,333 SH   OTR   2,202,333 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 27,618 1,121,327 SH   OTR   1,121,327 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 4,980 500,000 SH   OTR   500,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 277,400 764,188 SH   OTR   764,188 0 0
BELLUS HEALTH INC COM NEW 07987C204 18,267 2,975,000 SH   OTR   2,975,000 0 0
BIOATLA INC COM 09077B104 20,206 686,347 SH   OTR   686,347 0 0
BIOMEA FUSION INC COM CL A 09077A106 24,998 2,088,405 SH   OTR   2,088,405 0 0
BLACK DIAMOND THERAPEUTICS INC COM 09203E105 17,046 2,014,858 SH   OTR   2,014,858 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 43,694 425,000 SH   OTR   425,000 0 0
CABALETTA BIO INC COM 12674W109 19,497 1,603,361 SH   OTR   1,603,361 0 0
CELLECTAR BIOSCIENCES INC COM PAR 15117F500 851 920,000 SH   OTR   920,000 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 22,282 1,334,227 SH   OTR   1,334,227 0 0
CODIAK BIOSCIENCES INC COM 192010106 16,821 1,030,065 SH   OTR   1,030,065 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 50,430 2,081,323 SH   OTR   2,081,323 0 0
CULLINAN ONCOLOGY INC COM 230031106 24,242 1,074,082 SH   OTR   1,074,082 0 0
CYTOKINETICS INC COM NEW 23282W605 75,054 2,100,000 SH   OTR   2,100,000 0 0
DAY ONE BIOPHARMACEUTICALS INC COM 23954D109 28,237 1,189,943 SH   OTR   1,189,943 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 36,920 7,534,598 SH   OTR   7,534,598 0 0
DIREXION SHS ETF TR DAILY S&P BIOTEC 25460G716 3,195 150,000 SH   OTR   150,000 0 0
ELEVATION ONCOLOGY INC COM 28623U101 10,451 1,341,530 SH   OTR   1,341,530 0 0
ERASCA INC COM 29479A108 9,549 450,000 SH   OTR   450,000 0 0
ESSA PHARMA INC COM NEW 29668H708 5,496 687,000 SH   OTR   687,000 0 0
F-STAR THERAPEUTICS INC COM 30315R107 12,820 1,751,428 SH   OTR   1,751,428 0 0
FULCRUM THERAPEUTICS INC COM 359616109 35,263 1,250,000 SH   OTR   1,250,000 0 0
GEMINI THERAPEUTICS INC COM 36870G105 5,252 1,300,000 SH   OTR   1,300,000 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 2,178 1,134,453 SH   OTR   1,134,453 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 22,356 1,013,399 SH   OTR   1,013,399 0 0
GOSSAMER BIO INC COM 38341P102 30,952 2,462,358 SH   OTR   2,462,358 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 3,956 400,000 SH   OTR   400,000 0 0
HELIX ACQUISITION CORP COM CL A G4444C102 3,980 400,000 SH   OTR   400,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 56,150 2,202,812 SH   OTR   2,202,812 0 0
IMMUTEP LTD SPONSORED ADS 45257L108 9,675 2,500,000 SH   OTR   2,500,000 0 0
IOVANCE BIOTHERAPETUICS INC COM 462260100 27,126 1,100,000 SH   OTR   1,100,000 0 0
ITEOS THERAPEUTICS INC COM 46565G104 117,315 4,345,016 SH   OTR   4,345,016 0 0
JIYA ACQUISITION CORP COM CL A 47760M102 4,875 500,000 SH   OTR   500,000 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 3,310 290,577 SH   OTR   290,577 0 0
KINNATE BIOPHARMA INC COM 49705R105 42,531 1,847,559 SH   OTR   1,847,559 0 0
KURA ONCOLOGY INC. COM 50127T109 19,672 1,050,289 SH   OTR   1,050,289 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 3,554 890,700 SH   OTR   890,700 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 1,960 200,000 SH   OTR   200,000 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200 27,312 2,400,000 SH   OTR   2,400,000 0 0
MEI PHARMA INC COM NEW 55279B202 8,040 2,913,091 SH   OTR   2,913,091 0 0
MERUS N V COM N5749R100 41,800 1,900,000 SH   OTR   1,900,000 0 0
MILESTONE PHARMACEUTICALS INC COM 59935V107 14,687 2,572,194 SH   OTR   2,572,194 0 0
MIRATI THERAPEUTICS INC COM 60468T105 353,820 2,000,000 SH   OTR   2,000,000 0 0
MODERNA INC PUT 60770K957 253 10,000 SH Put OTR   10,000 0 0
NUVALENT INC COM 670703107 27,290 1,210,192 SH   OTR   1,210,192 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 4,605 750,000 SH   OTR   750,000 0 0
NEOLEUKIN THERAPEUTICS INC COM 64049K104 10,853 1,501,058 SH   OTR   1,501,058 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 10,510 500,000 SH   OTR   500,000 0 0
NURIX THERAPEUTICS INC COM 67080M103 36,698 1,224,892 SH   OTR   1,224,892 0 0
NUVATION BIO INC COM CL A 67080N101 43,150 4,341,009 SH   OTR   4,341,009 0 0
NUVATION BIO INC *W EXP 07/07/202 67080N119 683 266,666 SH   OTR   266,666 0 0
ODONATE THERAPEUTICS INC COM 676079106 16,317 5,607,086 SH   OTR   5,607,086 0 0
OMEGA ALPHA SPAC CL A G6749V107 1,947 200,000 SH   OTR   200,000 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 4,182 200,000 SH   OTR   200,000 0 0
PANACEA ACQUISITION CORP II CL A SHS G6882C106 4,885 500,000 SH   OTR   500,000 0 0
PASSAGE BIO INC COM 702712100 19,206 1,928,315 SH   OTR   1,928,315 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 67,593 2,268,236 SH   OTR   2,268,236 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 19,225 2,500,000 SH   OTR   2,500,000 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 1,448 209,227 SH   OTR   209,227 0 0
PROTHENA CORP PLC SHS G72800108 21,369 300,000 SH   OTR   300,000 0 0
RAIN THERAPEUTICS INC COM 75082Q105 17,578 1,175,000 SH   OTR   1,175,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 40,804 1,294,132 SH   OTR   1,294,132 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 4,925 500,000 SH   OTR   500,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 95,852 3,484,264 SH   OTR   3,484,264 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 43,820 1,466,051 SH   OTR   1,466,051 0 0
SAGE THERAPEUTICS INC COM 78667J108 48,475 1,094,000 SH   OTR   1,094,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 13,662 3,284,072 SH   OTR   3,284,072 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 16,720 1,675,377 SH   OTR   1,675,377 0 0
SOLID BIOSCIENCES INC COM 83422E105 8,926 3,734,574 SH   OTR   3,734,574 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 131,695 2,075,905 SH   OTR   2,075,905 0 0
SURROZEN INC COM 86889P109 1,416 200,000 SH   OTR   200,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 43,720 2,287,782 SH   OTR   2,287,782 0 0
TALIS BIOMEDICAL CORP COM 87424L108 9,694 1,550,998 SH   OTR   1,550,998 0 0
TANGO THERAPEUTICS INC COM 87583X109 88,850 6,871,642 SH   OTR   6,871,642 0 0
TURNING POINT THERAPEUTICS INC COM 90041T108 34,876 525,000 SH   OTR   525,000 0 0
TYRA BIOSCIENCES INC COM 90240B106 111,228 6,323,359 SH   OTR   6,323,359 0 0
VINCERX PHARMA INC COM NEW 92731L106 7,277 450,000 SH   OTR   450,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 13,095 857,000 SH   OTR   857,000 0 0