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License Agreements - Additional Information (Details) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
May 31, 2018
Research And Development Arrangement Contract To Perform For Others [Line Items]          
Research and development expense $ 15,198,000 $ 9,213,000 $ 28,223,000 $ 16,183,000  
Commercial Agreements          
Research And Development Arrangement Contract To Perform For Others [Line Items]          
Funding provided for the research and development under the agreement in period     2020-02    
Research and development expense     $ 300,000 $ 300,000  
Commercial Agreements | Clinical Stage Biopharmaceutical Company | Maximum          
Research And Development Arrangement Contract To Perform For Others [Line Items]          
Contingent consideration additional common stock issued     666,670    
Milestone payments     $ 70,300,000    
Funding provided for the research and development under the agreement 2,000,000   2,000,000    
Commercial Agreements | Affiliate of Clinical-Stage Biopharmaceutical Company          
Research And Development Arrangement Contract To Perform For Others [Line Items]          
Aggregate purchase price     500,000    
Additional amount invested         $ 500,000
Commercial Agreements And Compound Library And Option Agreement | Clinical Stage Biopharmaceutical Company          
Research And Development Arrangement Contract To Perform For Others [Line Items]          
Contingent consideration liability 1,800,000   1,800,000    
Other Licensing Agreements with Research Institutions          
Research And Development Arrangement Contract To Perform For Others [Line Items]          
Contingent consideration, milestone or royalty payments $ 0   $ 0