SI-BONE, Inc.

471 El Camino Real, Suite 101

Santa Clara, California 95050

December 30, 2019

Via Email and Edgar

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Mail Stop 3720

Washington, D.C. 20549

Attn: Irene Paik

RE: SI-BONE, Inc.

Registration Statement on Form S-3

File No. 333-235714

Ladies and Gentlemen:

SI-BONE, Inc. (the “Registrant”) hereby requests that the Securities and Exchange Commission (the “Commission”) take appropriate action to cause the above-referenced Registration Statement on Form S-3 to become effective on January 2, 2020, at 4:00 p.m., Eastern Time, or as soon thereafter as is practicable thereafter.

Once the Registration Statement has been declared effective, please orally confirm that event with Matthew Hemington of Cooley LLP, counsel to the Registrant, at (650) 843-5062, or in his absence, Brett White at (650) 843-5191.

Very truly yours,

SI-BONE, Inc.
By:	/s/ Jeffrey W. Dunn
Name:	Jeffrey W. Dunn
Title:	President and Chief Executive Officer

cc:	Michael A. Pisetsky, SI-BONE, Inc.
	Matthew B. Hemington, Cooley LLP
	Brett D. White, Cooley LLP