Organization and Operations - Liquidity (Details) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended	3 Months Ended	9 Months Ended
	Jun. 30, 2021	Nov. 30, 2022	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Dec. 31, 2022
Liquidity
Accumulated deficit				$ 549,124		$ 507,643
Cash, cash equivalents and short-term investments				$ 188,800
Exercise price (in dollars per share)				$ 37.50
Common stock
Liquidity
Issuance of common stock for at-the-market offerings, net of issuance costs (in shares)			2,715,166
Pre-funded warrants
Liquidity
Exercise price (in dollars per share)				0.001
Common stock warrants
Liquidity
Exercise price (in dollars per share)				$ 8.025
ATM Program | Common stock
Liquidity
Net proceeds from issuance of common stock			$ 24,300		$ 24,300
Gross proceeds from issuance of stock			25,000		25,000
Underwritten public offering
Liquidity
Number of shares issued				8,253,895
Gross proceeds from issuance of stock				$ 64,000
Underwritten public offering | Common stock warrants
Liquidity
Number of warrants to purchase common stock				6,190,418
Underwritten public offering | Pre-funded warrants
Liquidity
Number of warrants to purchase common stock				1,571,093
Underwritten public offering | Common stock warrants
Liquidity
Number of warrants to purchase common stock				1,178,320
Jefferies | ATM Program
Liquidity
Maximum aggregate value of common shares which can be issued under the agreement	$ 25,000		50,000		50,000
Percentage of commission paid to underwriter based on proceeds from common stock	3.00%
Amount of common stock available for future issuance		$ 50,000	$ 30,500		$ 30,500
Aggregate offering price		$ 88,100
Amount of common stock remains available for sale under ATM program				$ 50,000
Issuance of common stock for at-the-market offerings, net of issuance costs (in shares)			2,715,166		2,715,166