Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Common stock [Member] Series X Preferred Stock	Common stock [Member]	Additional paid-in capital	Accumulated deficit	Accumulated other comprehensive loss	Series X Preferred Stock	Total
Mezzanine equity, beginning balance at Dec. 31, 2020						$ 0
Mezzanine equity, beginning balance (in shares) at Dec. 31, 2020						0
Series X redeemable convertible preferred stock
Issuance of preferred stock in a private offering of public equity, net of issuance costs						$ 84,696
Issuance of preferred stock in a private offering of public equity, net of issuance costs (in shares)						35,573
Issuance of common stock upon the conversion of preferred stock	$ (168,920)	$ 9	$ 168,911
Issuance of common stock upon the conversion of preferred stock (in shares)	(54,622)	9,103,664
Issuance of preferred stock and common stock upon acquisition of Quellis						$ (156,185)
Issuance of preferred stock and common stock upon acquisition of Quellis (in shares)						50,504
Reclassification of preferred stock to permanent equity						$ (240,881)
Beginning balance at Dec. 31, 2020	$ 0	$ 4	301,562	$ (260,897)	$ 0		$ 40,669
Beginning balance (in shares) at Dec. 31, 2020	0	3,347,386
Increase (Decrease) in Shareholders' Equity
Issuance of preferred stock in a private offering of public equity, net of issuance costs			19,565				19,565
Issuance of preferred stock and common stock upon acquisition of Quellis			8,098				8,098
Issuance of preferred stock and common stock upon acquisition of Quellis (in shares)		555,444
Reclassification of preferred stock to permanent equity	$ 240,881						240,881
Reclassification of preferred stock to permanent equity (in shares)	86,077
Issuance of common stock upon the conversion of preferred stock	$ (168,920)	$ 9	168,911
Accretion of preferred stock discount	24,437		(24,437)
Reclassification of equity classified warrants			3,468				3,468
Proceeds from exercises of options			23				23
Issuance of common stock upon exercise of options (in shares)		10,470
Expense related to warrants inherited in acquisition of Quellis			1,157				1,157
Stock-based compensation expense			3,362				3,362
Fractional shares eliminated pursuant to reverse stock split		(9)
Net loss				(194,912)			(194,912)
Ending balance at Dec. 31, 2021	$ 96,398	$ 13	481,709	(455,809)			122,311
Ending balance (in shares) at Dec. 31, 2021	31,455	13,016,955
Series X redeemable convertible preferred stock
Reclassification of preferred stock to permanent equity (in shares)						(86,077)
Issuance of common stock upon the conversion of preferred stock (in shares)						9,103,664
Increase (Decrease) in Shareholders' Equity
Issuance of common stock for at-the-market offerings, net of issuance costs		$ 4	36,987				36,991
Issuance of common stock for at-the-market offerings, net of issuance costs (in shares)		4,012,003
Proceeds from exercises of options		$ 1	84				85
Issuance of common stock upon exercise of options (in shares)		27,332
Expense related to warrants inherited in acquisition of Quellis			1,542				1,542
Issuance of common stock pursuant to an Underwriting Agreement, net of underwriter's discount and issuance costs		$ 10	107,636				107,646
Issuance of common stock pursuant to an Underwriting Agreement, net of underwriter's discount and issuance costs (in shares)		10,445,050
Stock-based compensation expense			4,554				4,554
Unrealized loss on short-term investments					(79,000)		(79)
Net loss				(51,834)			(51,834)
Ending balance at Dec. 31, 2022	$ 96,398	$ 28	$ 632,512	$ (507,643)	$ (79,000)		$ 221,216
Ending balance (in shares) at Dec. 31, 2022	31,455	27,501,340