Organization and Operations - Reverse Stock Split, Agreement and Plan of Merger (Details) - USD ($) $ / shares in Units, $ in Millions		12 Months Ended
	Jan. 28, 2021	Dec. 31, 2021	Dec. 31, 2022	Jun. 02, 2021
Agreement and Plan of Merger
Common stock, par value (in dollars per share)		$ 0.001	$ 0.001
Exercise price (in dollars per share)			$ 41.75
Series X redeemable convertible preferred stock
Agreement and Plan of Merger
Issuance of preferred stock and common stock upon acquisition of Quellis (in shares)		50,504
Common stock
Agreement and Plan of Merger
Issuance of preferred stock and common stock upon acquisition of Quellis (in shares)		555,444
Warrant or right to purchase number of shares			467,500	467,500
Exercise price (in dollars per share)			$ 2.10	$ 2.10
Quellis Biosciences, Inc | Series X redeemable convertible preferred stock
Agreement and Plan of Merger
Issuance of preferred stock and common stock upon acquisition of Quellis (in shares)	50,504
Conversion value on closing date	$ 122.7
Warrant or right to purchase number of shares	2,805		2,805
Exercise price (in dollars per share)	$ 341.70		$ 341.70
Quellis Biosciences, Inc | Common stock
Agreement and Plan of Merger
Issuance of preferred stock and common stock upon acquisition of Quellis (in shares)	555,444
Common stock, par value (in dollars per share)	$ 0.001
Number of options assumed in Quellis acquisition	55,414
Warrant or right to purchase number of shares	30,856
Exercise price (in dollars per share)	$ 2.10